NEJM â Collection Updates for Cardiomyopathy/Myocarditis

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 2-2010 â A 47-Year-Old Man with Abdominal and Flank Pain

Thu, 21Â JanÂ 2010 00:00:00 -05:00

Dr. Rima A. Arnaout (Medicine): A 47-year-old man was admitted to this hospital because of abdominal pain.

The patient was in his usual state of health until 5 weeks before admission,...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 39-2009 â A 28-Year-Old Pregnant Woman with Acute Cardiac Failure

Thu, 17Â DecÂ 2009 00:00:00 -05:00

Dr. Brad W. Butcher (Medicine): A 28-year-old woman was admitted to this hospital 2 days post partum because of cardiac failure.

The patient had been well, except for gestational diabetes mellitus,...

IMAGES IN CLINICAL MEDICINE: Large Atrial Myxoma

Aman Mundi, M.D. — Thu, 26Â NovÂ 2009 00:00:00 -05:00

A 57-year-old woman with no notable medical history presented with a 4-month history of leg swelling and dyspnea on exertion. Her symptoms had been progressively worsening for 2 weeks before...

IMAGES IN CLINICAL MEDICINE: Prosthetic Mitral Valve with Partial Thrombosis

David T. Schachter, M.D. — Thu, 16Â AprÂ 2009 00:00:00 -05:00

A 63-year-old woman presented for evaluation after 2 weeks of progressive dyspnea. She had a history of dilated cardiomyopathy, and a St. Jude prosthetic valve had been inserted in the...

REVIEW ARTICLE: Myocarditis

Leslie T. Cooper, Jr., M.D. — Thu, 09Â AprÂ 2009 00:00:00 -05:00

Myocarditis may present with a wide range of symptoms, ranging from mild dyspnea or chest pain that resolves without specific therapy to cardiogenic shock and death. Dilated cardiomyopathy with chronic...

ORIGINAL ARTICLE: A New Diagnostic Test for Arrhythmogenic Right Ventricular Cardiomyopathy

Thu, 12Â MarÂ 2009 00:00:00 -05:00

Background: The diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) can be challenging because the clinical presentation is highly variable and genetic penetrance is often low.

Methods: To determine whether a change...

CORRESPONDENCE: Cardiac Amyloidosis with the Mutation of the Fibrinogen A Î±-Chain

Georges Mourad, M.D., Jean-Philippe Delabre, M.D., and ValÃ©rie Garrigue, M.D. — Thu, 25Â DecÂ 2008 00:00:00 -05:00

To the Editor: Proteinuria developed in a 48-year-old man in 2003. His mother had died 10 years earlier from renal amyloidosis. Laboratory tests showed isolated nephrotic-range proteinuria (urinary protein excretion,...

IMAGES IN CLINICAL MEDICINE: Mapping the Atrioventricular Node

Andrew E. Epstein, M.D. and James K. Kirklin, M.D. — Thu, 27Â DecÂ 2007 00:00:00 -05:00

A 75-year-old woman presented with dyspnea, an awareness of rapid heart action, and permanent atrial fibrillation with a rapid ventricular response that had been resistant to treatment with beta-blockers, calcium-channel...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 36-2007 â A 31-Year-Old Woman with Rash, Fever, and Hypotension

Thu, 22Â NovÂ 2007 00:00:00 -05:00

Dr. Jeffrey O. Greenberg (Medicine): A 31-year-old woman was admitted to this hospital because of facial swelling, fever, and hypotension.

The patient had relapsing and remitting multiple sclerosis, associated with severe...

ORIGINAL ARTICLE: Cardiomyopathy and Exercise Intolerance in Muscle Glycogen Storage Disease 0

Thu, 11Â OctÂ 2007 00:00:00 -05:00

Storage of glycogen is essential for glucose homeostasis and for energy supply during bursts of activity and sustained muscle work. We describe three siblings with profound muscle and heart glycogen...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 26-2005 â A 48-Year-Old Man with Sudden Loss of Consciousness while Jogging

Thu, 25Â AugÂ 2005 00:00:00 -05:00

An unidentified black man who appeared to be approximately 40 years of age was brought to the emergency department of this hospital after suddenly losing consciousness. Witnesses had seen the...

IMAGES IN CLINICAL MEDICINE: A Medical Mystery â Bradycardia

Ralph Rosenberg, M.D. — Thu, 02Â JunÂ 2005 00:00:00 -05:00

At an office visit in June 2004, a 49-year-old man reported fatigue, arthralgia, and headache, along with a two-day history of chest pain. The patient had hypercholesterolemia, for which he...

CLINICAL PROBLEM-SOLVING: One Surprise after Another

Thu, 07Â AprÂ 2005 00:00:00 -05:00

A previously healthy 22-year-old man presented to an emergency department reporting that he had had three days of intermittent abdominal pain. Although the pain was initially mild and crampy and...

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Attacking Amyloid

Jeffery W. Kelly, Ph.D. — Thu, 17Â FebÂ 2005 00:00:00 -05:00

Protein aggregation seems to cause numerous neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and familial amyloid polyneuropathy and cardiomyopathy. Once initiated, the aggregation of individual proteins into amyloid fibrils...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 5-2005 â A 53-Year-Old Man with Depression and Sudden Shortness of Breath

Thu, 17Â FebÂ 2005 00:00:00 -05:00

Dr. Daniel Egan (Emergency Medicine, Massachusetts General Hospital and Brigham and Women's Hospital): A 53-year-old man came to the emergency department because of symptoms of depression.

The patient had been in...

ORIGINAL ARTICLE: Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress

Thu, 10Â FebÂ 2005 00:00:00 -05:00

Background: Reversible left ventricular dysfunction precipitated by emotional stress has been reported, but the mechanism remains unknown.

Methods: We evaluated 19 patients who presented with left ventricular dysfunction after sudden emotional...

ORIGINAL ARTICLE: Glycogen Storage Diseases Presenting as Hypertrophic Cardiomyopathy

Thu, 27Â JanÂ 2005 00:00:00 -05:00

Background: Unexplained left ventricular hypertrophy often prompts the diagnosis of hypertrophic cardiomyopathy, a sarcomere-protein gene disorder. Because mutations in the gene for AMP-activated protein kinase Î³2 (PRKAG2) cause an accumulation...

ORIGINAL ARTICLE: Mutation of Perinatal Myosin Heavy Chain Associated with a Carney Complex Variant

Thu, 29Â JulÂ 2004 00:00:00 -05:00

Background: Familial cardiac myxomas occur in the hereditary syndrome Carney complex. Although PRKAR1A mutations can cause the Carney complex, the disorder is genetically heterogeneous. To identify the cause of a...

PERSPECTIVE: Myosin at the Heart of the Problem

Jil C. Tardiff, M.D., Ph.D. — Thu, 29Â JulÂ 2004 00:00:00 -05:00

In humans, myosins comprise a superfamily of more than 30 individual proteins. Structurally, myosin contains a highly conserved globular head, which, in turn, contains the ATPase and actin-binding sites, and...

ORIGINAL ARTICLE: The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia

Thu, 08Â JulÂ 2004 00:00:00 -05:00

Background: Doxorubicin chemotherapy is very effective in children with acute lymphoblastic leukemia (ALL) but also injures myocardial cells. Dexrazoxane, a free-radical scavenger, may protect the heart from doxorubicin-associated damage.

Methods: To...

ORIGINAL ARTICLE: Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy

Thu, 20Â MayÂ 2004 00:00:00 -05:00

Background: Patients with nonischemic dilated cardiomyopathy are at substantial risk for sudden death from cardiac causes. However, the value of prophylactic implantation of an implantable cardioverterâdefibrillator (ICD) to prevent sudden...

CLINICAL PRACTICE: Hypertrophic Obstructive Cardiomyopathy

Rick A. Nishimura, M.D., and David R. Holmes, Jr., M.D. — Thu, 25Â MarÂ 2004 00:00:00 -05:00

A 28-year-old man presents with a two-year history of increasing dyspnea on strenuous exertion and is found to have hypertrophic cardiomyopathy, with a septal thickness of 23 mm and a...

ORIGINAL ARTICLE: EffusiveâConstrictive Pericarditis

Thu, 29Â JanÂ 2004 00:00:00 -05:00

Background: Effusiveâconstrictive pericarditis is an uncommon pericardial syndrome characterized by concomitant tamponade, caused by tense pericardial effusion, and constriction, caused by the visceral pericardium. We conducted a prospective study of...

PERSPECTIVE: A Clearer View of EffusiveâConstrictive Pericarditis

E. William Hancock, M.D. — Thu, 29Â JanÂ 2004 00:00:00 -05:00

In the 1920s and 1930s, when pericardiectomy first became an established therapy for constrictive pericarditis, surgeons recognized the condition in which pericardial effusion coexists with a visceral constrictive pericarditis (or...

ORIGINAL ARTICLE: Coronary Microvascular Dysfunction and Prognosis in Hypertrophic Cardiomyopathy

Thu, 11Â SepÂ 2003 00:00:00 -05:00

Background: Microvascular dysfunction, reflected by an inadequate increase in myocardial blood flow in response to dipyridamole infusion, is a recognized feature of hypertrophic cardiomyopathy. Its long-term effect on the prognosis...

PERSPECTIVE: Assessing Risk in Hypertrophic Cardiomyopathy

Richard O. Cannon III, M.D. — Thu, 11Â SepÂ 2003 00:00:00 -05:00

Hypertrophic cardiomyopathy has fascinated clinicians and clinical investigators since its initial description almost 50 years ago because of the unique physical findings, often bizarre electrocardiographic aspects, unusual shape of the...

ORIGINAL ARTICLE: Successful Cardiac Transplantation in an HIV-1âInfected Patient with Advanced Disease

Thu, 05Â JunÂ 2003 00:00:00 -05:00

Advances in the management of human immunodeficiency virus (HIV) infection â specifically, the introduction of highly active antiretroviral therapy â have dramatically delayed the progression of disease, enhanced immunologic function,...

EDITORIAL: Pediatric Cardiomyopathy â A Long Way to Go

Arnold Strauss, M.D., and James E. Lock, M.D. — Thu, 24Â AprÂ 2003 00:00:00 -05:00

Improvements in the treatment of congenital heart disease are among the most impressive medical achievements of the second half of the 20th century. In 1950, patent ductus arteriosus and aortic...

ORIGINAL ARTICLE: The Incidence of Pediatric Cardiomyopathy in Two Regions of the United States

Thu, 24Â AprÂ 2003 00:00:00 -05:00

Background: Population-based data on the incidence of pediatric cardiomyopathy are rare because of the lack of large, prospective studies.

Methods: Since 1996 the Pediatric Cardiomyopathy Registry sponsored by the National Heart,...

ORIGINAL ARTICLE: The Epidemiology of Childhood Cardiomyopathy in Australia

Thu, 24Â AprÂ 2003 00:00:00 -05:00

Background: The incidence and age distribution of primary cardiomyopathy in children are not well defined. We undertook a population-based, retrospective cohort study in Australia to document the epidemiology of childhood...

ORIGINAL ARTICLE: Effect of Left Ventricular Outflow Tract Obstruction on Clinical Outcome in Hypertrophic Cardiomyopathy

Thu, 23Â JanÂ 2003 00:00:00 -05:00

Background: The influence of left ventricular outflow tract obstruction on the clinical outcome of hypertrophic cardiomyopathy remains unresolved.

Methods: We assessed the effect of outflow tract obstruction on morbidity and mortality...

ORIGINAL ARTICLE: Effects of the Amount and Intensity of Exercise on Plasma Lipoproteins

Thu, 07Â NovÂ 2002 00:00:00 -05:00

Background: Increased physical activity is related to reduced risk of cardiovascular disease, possibly because it leads to improvement in the lipoprotein profile. However, the amount of exercise training required for...

ORIGINAL ARTICLE: Nonsurgical Reduction of the Interventricular Septum in Patients with Hypertrophic Cardiomyopathy

Thu, 24Â OctÂ 2002 00:00:00 -05:00

Background: In patients with hypertrophic cardiomyopathy and obstruction of the left ventricular outflow tract, nonsurgical reduction of the septum is a treatment option when medical therapy has failed. We investigated...

PERSPECTIVE: Hypertrophic Cardiomyopathy â The Benefits of a Multidisciplinary Approach

Thu, 24Â OctÂ 2002 00:00:00 -05:00

In the late 1950s, two sets of observations led to the recognition of a new cardiac disease. One was the discovery, by cardiovascular surgeons and cardiologists, of patients with subaortic...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 17-2002 â A 55-Year-Old Man with Second-Degree Atrioventricular Block and Chest Pain

Roger J. Hajjar and Richard L. Kradin — Thu, 30Â MayÂ 2002 00:00:00 -05:00

A 55-year-old man was admitted to the hospital because of second-degree atrioventricular block.

The patient had been considered well until the day of admission, when a scheduled transurethral resection of the...

ORIGINAL ARTICLE: Myocardial Gene Expression in Dilated Cardiomyopathy Treated with Beta-Blocking Agents

Thu, 02Â MayÂ 2002 00:00:00 -05:00

Background: Beta-blocker therapy may improve cardiac function in patients with idiopathic dilated cardiomyopathy. We tested the hypothesis that beta-blocker therapy produces favorable functional effects in dilated cardiomyopathy by altering the...

EDITORIAL: Peripartum Cardiomyopathy

Thu, 24Â MayÂ 2001 00:00:00 -05:00

Peripartum cardiomyopathy is a poorly understood condition whose incidence in the United States is 1 per 3000 to 4000 live births.1 Previous descriptions of the disorder were based on a...

ORIGINAL ARTICLE: Maternal and Fetal Outcomes of Subsequent Pregnancies in Women with Peripartum Cardiomyopathy

Thu, 24Â MayÂ 2001 00:00:00 -05:00

Background: Peripartum cardiomyopathy is a rare but sometimes fatal form of heart failure. Little is known about the outcomes of subsequent pregnancies in women who have had the disorder.

Methods: Through...

ORIGINAL ARTICLE: Mutations in Sarcomere Protein Genes as a Cause of Dilated Cardiomyopathy

Thu, 07Â DecÂ 2000 00:00:00 -05:00

Background: The molecular basis of idiopathic dilated cardiomyopathy, a primary myocardial disorder that results in reduced contractile function, is largely unknown. Some cases of familial dilated cardiomyopathy are caused by...

REVIEW ARTICLE: Myocarditis

Arthur M. Feldman, M.D., Ph.D., and Dennis McNamara, M.D. — Thu, 09Â NovÂ 2000 00:00:00 -05:00

Myocarditis is defined clinically as inflammation of the heart muscle. First introduced into the medical literature at the beginning of the 19th century, the term âmyocarditisâ was initially used to...

ORIGINAL ARTICLE: Magnitude of Left Ventricular Hypertrophy and Risk of Sudden Death in Hypertrophic Cardiomyopathy

Thu, 15Â JunÂ 2000 00:00:00 -05:00

Background: Sudden death is a possible consequence of hypertrophic cardiomyopathy. Quantification of the risk of sudden death, however, remains imprecise for most patients with this disease.

Methods: We assessed the relation...

ORIGINAL ARTICLE: Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy

Thu, 13Â AprÂ 2000 00:00:00 -05:00

Background: Previous studies of the prognosis of patients with heart failure due to cardiomyopathy categorized patients according to whether they had ischemic or nonischemic disease. The prognostic value of identifying...

ORIGINAL ARTICLE: Desmin Myopathy, a Skeletal Myopathy with Cardiomyopathy Caused by Mutations in the Desmin Gene

Thu, 16Â MarÂ 2000 00:00:00 -05:00

Background: Myofibrillar myopathies are a heterogeneous group of inherited or sporadic skeletal myopathies associated with cardiomyopathy. Among the myofibrillar proteins that accumulate within the muscle fibers of affected patients, the...

EDITORIAL: Fulminant Myocarditis

Thu, 09Â MarÂ 2000 00:00:00 -05:00

âSick patients dieâ is a refrain familiar to all clinicians. It can easily be applied to patients with severe congestive heart failure or cardiogenic shock resulting from an acute inflammatory...

ORIGINAL ARTICLE: Long-Term Outcome of Fulminant Myocarditis as Compared with Acute (Nonfulminant) Myocarditis

Thu, 09Â MarÂ 2000 00:00:00 -05:00

Background: Lymphocytic myocarditis causes left ventricular dysfunction that may be persistent or reversible. There are no clinical criteria that predict which patients will recover ventricular function and which cases will...

EDITORIAL: Sudden Death in Hypertrophic Cardiomyopathy

Thu, 10Â FebÂ 2000 00:00:00 -05:00

Few problems are harder for physicians and patients alike than having the ability to predict, but not to avert, adverse events; few adverse events are harder to deal with than...

ORIGINAL ARTICLE: Efficacy of Implantable CardioverterâDefibrillators for the Prevention of Sudden Death in Patients with Hypertrophic Cardiomyopathy

Thu, 10Â FebÂ 2000 00:00:00 -05:00

Background: Hypertrophic cardiomyopathy is a genetic disease associated with a risk of ventricular tachyarrhythmias and sudden death, especially in young patients.

Methods: We conducted a retrospective multicenter study of the efficacy...

EDITORIAL: Pathogenesis of Inherited Forms of Dilated Cardiomyopathy

Thu, 02Â DecÂ 1999 00:00:00 -05:00

In 1990, Geisterfer-Lowrance et al. reported the first evidence of a gene defect underlying a form of intrinsic heart-muscle disease. They found that a mutation in the gene encoding the...

ORIGINAL ARTICLE: Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease

Thu, 02Â DecÂ 1999 00:00:00 -05:00

Background: Inherited mutations cause approximately 35 percent of cases of dilated cardiomyopathy; however, few genes associated with this disease have been identified. Previously, we located a gene defect that was...

REVIEW ARTICLE: Signaling Pathways for Cardiac Hypertrophy and Failure

John J. Hunter, M.D., and Kenneth R. Chien, M.D., Ph.D. — Thu, 21Â OctÂ 1999 00:00:00 -05:00

Heart failure is a leading cause of mortality in the United States. As a result of advances in genetic technology, a molecular basis of heart failure is emerging.12 This review...

REVIEW ARTICLE: Implantable Left Ventricular Assist Devices

Daniel J. Goldstein, M.D., Mehmet C. Oz, M.D., and Eric A. Rose, M.D. — Thu, 19Â NovÂ 1998 00:00:00 -05:00

Congestive heart failure affects about 1 percent of adults in the United States1 and is a contributing factor in over 250,000 deaths annually.2 It is diagnosed in 400,000 Americans each...

ORIGINAL ARTICLE: Myocardial Bridging in Children with Hypertrophic Cardiomyopathy â A Risk Factor for Sudden Death

Thu, 22Â OctÂ 1998 00:00:00 -05:00

Background: Myocardial bridging may cause compression of a coronary artery, and it has been suggested that myocardial ischemia may result. The clinical significance and prognostic value of myocardial bridging of...

EDITORIAL: Dilated Cardiomyopathy in HIV-Infected Patients

Thu, 15Â OctÂ 1998 00:00:00 -05:00

In this issue of the Journal, Barbaro and colleagues present the results of a large, prospective study of dilated cardiomyopathy in adults with human immunodeficiency virus (HIV) infection.1 This study...

ORIGINAL ARTICLE: Incidence of Dilated Cardiomyopathy and Detection of HIV in Myocardial Cells of HIV-Positive Patients

Thu, 15Â OctÂ 1998 00:00:00 -05:00

Background: Human immunodeficiency virus (HIV) infection is increasingly recognized as an important cause of dilated cardiomyopathy. However, the pathogenesis of the heart-muscle disease in the acquired immunodeficiency syndrome is unclear.

Methods:...

REVIEW ARTICLE: Doxorubicin-Induced Cardiomyopathy

Pawan K. Singal, D.Sc., and Natasha Iliskovic, M.D. — Thu, 24Â SepÂ 1998 00:00:00 -05:00

Doxorubicin (Adriamycin) has been used in oncologic practice since the late 1960s. It held promise as a powerful drug in the fight against cancer. The tumors most commonly responding to...

ORIGINAL ARTICLE: Screening for Hypertrophic Cardiomyopathy in Young Athletes

Thu, 06Â AugÂ 1998 00:00:00 -05:00

Background: For more than 20 years in Italy, young athletes have been screened before participating in competitive sports. We assessed whether this strategy results in the prevention of sudden death...

EDITORIAL: Hypertrophic Cardiomyopathy â Beyond the Sarcomere

Thu, 30Â AprÂ 1998 00:00:00 -05:00

Remodeling of the left ventricle by the process of hypertrophy is usually a response to increased afterload. This adaptive reaction maintains cardiac output. The most common pattern of hypertrophy is...

ORIGINAL ARTICLE: Mutations in the Gene for Cardiac Myosin-Binding Protein C and Late-Onset Familial Hypertrophic Cardiomyopathy

Thu, 30Â AprÂ 1998 00:00:00 -05:00

Background: Mutations in the gene for cardiac myosin-binding protein C account for approximately 15 percent of cases of familial hypertrophic cardiomyopathy. The spectrum of disease-causing mutations and the associated clinical...

CLINICAL IMPLICATIONS OF BASIC RESEARCH: The Genetics of Dilated Cardiomyopathy â Emerging Clues to the Puzzle

Thu, 09Â OctÂ 1997 00:00:00 -05:00

Despite recent advances in both medical and surgical therapies, dilated cardiomyopathy remains a leading cause of cardiovascular morbidity and mortality. This syndrome consists of ventricular enlargement, abnormal systolic and diastolic...

ORIGINAL ARTICLE: Idiopathic Giant-Cell Myocarditis â Natural History and Treatment

Thu, 26Â JunÂ 1997 00:00:00 -05:00

Background: Idiopathic giant-cell myocarditis is a rare and frequently fatal disorder. We used a multicenter data base to define the natural history of giant-cell myocarditis and the effect of treatment.

Methods:...

REVIEW ARTICLE: The Management of Hypertrophic Cardiomyopathy

Thu, 13Â MarÂ 1997 00:00:00 -05:00

Hypertrophic cardiomyopathy is a complex cardiac disease with unique pathophysiologic characteristics and a great diversity of morphologic, functional, and clinical features.12345678 The heterogeneity of the disease is accentuated by the...

EDITORIAL: Autonomic Disorders and Their Recognition

Thu, 06Â MarÂ 1997 00:00:00 -05:00

The autonomic nervous system, through the sympathetic and parasympathetic pathways, supplies and influences every organ in the body. It closely integrates vital processes, such as blood pressure and body temperature....

ORIGINAL ARTICLE: Sympathetic Cardioneuropathy in Dysautonomias

Thu, 06Â MarÂ 1997 00:00:00 -05:00

Background: The classification of dysautonomias has been confusing, and the pathophysiology obscure. We examined sympathetic innervation of the heart in patients with acquired, idiopathic dysautonomias using thoracic positron-emission tomography and...

ORIGINAL ARTICLE: Mutations in the Sarcoglycan Genes in Patients with Myopathy

Thu, 27Â FebÂ 1997 00:00:00 -05:00

Background: Some patients with autosomal recessive limb-girdle muscular dystrophy have mutations in the genes coding for the sarcoglycan proteins (Î±-, Î²-, Î³-, and Î´-sarcoglycan). To determine the frequency of sarcoglycan-gene...

EDITORIAL: End of the Oldest Controversy in Medicine â Are We Ready to Conclude the Debate on Digitalis?

Thu, 20Â FebÂ 1997 00:00:00 -05:00

The role of digitalis in treating cardiovascular disease has been at the center of the oldest continuing controversy in the history of medicine. Ever since its clinical introduction by William...

EDITORIAL: Aging, Amyloid, and Cardiomyopathy

Thu, 13Â FebÂ 1997 00:00:00 -05:00

In past decades, rheumatic heart disease, syphilitic heart disease, hypertensive heart disease, and even nutritional deficiencies were common enough for physicians to consider these diagnoses in patients presenting with congestive...

ORIGINAL ARTICLE: Variant-Sequence Transthyretin (Isoleucine 122) in Late-Onset Cardiac Amyloidosis in Black Americans

Thu, 13Â FebÂ 1997 00:00:00 -05:00

Background: After the age of 60, isolated cardiac amyloidosis is four times more common among blacks than whites in the United States; 3.9 percent of blacks are heterozygous for an...

REVIEW ARTICLE: Restrictive Cardiomyopathy

Thu, 23Â JanÂ 1997 00:00:00 -05:00

Restrictive cardiomyopathy is defined as heart-muscle disease that results in impaired ventricular filling, with normal or decreased diastolic volume of either or both ventricles. Systolic function usually remains normal, at...

ORIGINAL ARTICLE: Effect of Amlodipine on Morbidity and Mortality in Severe Chronic Heart Failure

Thu, 10Â OctÂ 1996 00:00:00 -05:00

Background: Previous studies have shown that calcium-channel blockers increase morbidity and mortality in patients with chronic heart failure. We studied the effect of a new calcium-channel blocker, amlodipine, in patients...

ORIGINAL ARTICLE: The Effect of the Ingestion of Ethanol on Obstruction of the Left Ventricular Outflow Tract in Hypertrophic Cardiomyopathy

Thu, 26Â SepÂ 1996 00:00:00 -05:00

Background: Ethanol causes vasodilatation, which might have an adverse effect, due to increased obstruction of the left ventricular outflow tract, in patients with hypertrophic obstructive cardiomyopathy. We assessed the hemodynamic...

EDITORIAL: Growth Hormone for Heart Failure â Cause for Cautious Optimism

Thu, 28Â MarÂ 1996 00:00:00 -05:00

Idiopathic dilated cardiomyopathy is characterized by left ventricular dilatation, insufficient compensatory hypertrophy of the left ventricle, interstitial fibrosis in the myocardium, and increased stress on the wall of the left...

ORIGINAL ARTICLE: A Preliminary Study of Growth Hormone in the Treatment of Dilated Cardiomyopathy

Thu, 28Â MarÂ 1996 00:00:00 -05:00

Background: Cardiac hypertrophy is a physiologic response that allows the heart to adapt to an excess hemodynamic load. We hypothesized that inducing cardiac hypertrophy with recombinant human growth hormone might...

ORIGINAL ARTICLE: Deficiency of a Dystrophin-Associated Glycoprotein (Adhalin) in a Patient with Muscular Dystrophy and Cardiomyopathy

Thu, 08Â FebÂ 1996 00:00:00 -05:00

Cardiac muscle is commonly affected in muscular dystrophies.1234 X-linked Duchenne's muscular dystrophy and Becker's muscular dystrophy are caused by mutations in the gene encoding dystrophin,56 a membrane cytoskeletal protein.7 In...

NEJM â Collection Updates for Cardiomyopathy/Myocarditis

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 2-2010 â A 47-Year-Old Man with Abdominal and Flank Pain

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 39-2009 â A 28-Year-Old Pregnant Woman with Acute Cardiac Failure

IMAGES IN CLINICAL MEDICINE: Large Atrial Myxoma

IMAGES IN CLINICAL MEDICINE: Prosthetic Mitral Valve with Partial Thrombosis

REVIEW ARTICLE: Myocarditis

ORIGINAL ARTICLE: A New Diagnostic Test for Arrhythmogenic Right Ventricular Cardiomyopathy

CORRESPONDENCE: Cardiac Amyloidosis with the Mutation of the Fibrinogen A Î±-Chain

IMAGES IN CLINICAL MEDICINE: Mapping the Atrioventricular Node

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 36-2007 â A 31-Year-Old Woman with Rash, Fever, and Hypotension

ORIGINAL ARTICLE: Cardiomyopathy and Exercise Intolerance in Muscle Glycogen Storage Disease 0

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 26-2005 â A 48-Year-Old Man with Sudden Loss of Consciousness while Jogging

IMAGES IN CLINICAL MEDICINE: A Medical Mystery â Bradycardia

CLINICAL PROBLEM-SOLVING: One Surprise after Another

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Attacking Amyloid

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 5-2005 â A 53-Year-Old Man with Depression and Sudden Shortness of Breath

ORIGINAL ARTICLE: Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress

ORIGINAL ARTICLE: Glycogen Storage Diseases Presenting as Hypertrophic Cardiomyopathy

ORIGINAL ARTICLE: Mutation of Perinatal Myosin Heavy Chain Associated with a Carney Complex Variant

PERSPECTIVE: Myosin at the Heart of the Problem

ORIGINAL ARTICLE: The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia

ORIGINAL ARTICLE: Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy

CLINICAL PRACTICE: Hypertrophic Obstructive Cardiomyopathy

ORIGINAL ARTICLE: EffusiveâConstrictive Pericarditis

PERSPECTIVE: A Clearer View of EffusiveâConstrictive Pericarditis

ORIGINAL ARTICLE: Coronary Microvascular Dysfunction and Prognosis in Hypertrophic Cardiomyopathy

PERSPECTIVE: Assessing Risk in Hypertrophic Cardiomyopathy

ORIGINAL ARTICLE: Successful Cardiac Transplantation in an HIV-1âInfected Patient with Advanced Disease

EDITORIAL: Pediatric Cardiomyopathy â A Long Way to Go

ORIGINAL ARTICLE: The Incidence of Pediatric Cardiomyopathy in Two Regions of the United States

ORIGINAL ARTICLE: The Epidemiology of Childhood Cardiomyopathy in Australia

ORIGINAL ARTICLE: Effect of Left Ventricular Outflow Tract Obstruction on Clinical Outcome in Hypertrophic Cardiomyopathy

ORIGINAL ARTICLE: Effects of the Amount and Intensity of Exercise on Plasma Lipoproteins

ORIGINAL ARTICLE: Nonsurgical Reduction of the Interventricular Septum in Patients with Hypertrophic Cardiomyopathy

PERSPECTIVE: Hypertrophic Cardiomyopathy â The Benefits of a Multidisciplinary Approach

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 17-2002 â A 55-Year-Old Man with Second-Degree Atrioventricular Block and Chest Pain

ORIGINAL ARTICLE: Myocardial Gene Expression in Dilated Cardiomyopathy Treated with Beta-Blocking Agents

EDITORIAL: Peripartum Cardiomyopathy

ORIGINAL ARTICLE: Maternal and Fetal Outcomes of Subsequent Pregnancies in Women with Peripartum Cardiomyopathy

ORIGINAL ARTICLE: Mutations in Sarcomere Protein Genes as a Cause of Dilated Cardiomyopathy

REVIEW ARTICLE: Myocarditis

ORIGINAL ARTICLE: Magnitude of Left Ventricular Hypertrophy and Risk of Sudden Death in Hypertrophic Cardiomyopathy

ORIGINAL ARTICLE: Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy

ORIGINAL ARTICLE: Desmin Myopathy, a Skeletal Myopathy with Cardiomyopathy Caused by Mutations in the Desmin Gene

EDITORIAL: Fulminant Myocarditis

ORIGINAL ARTICLE: Long-Term Outcome of Fulminant Myocarditis as Compared with Acute (Nonfulminant) Myocarditis

EDITORIAL: Sudden Death in Hypertrophic Cardiomyopathy

ORIGINAL ARTICLE: Efficacy of Implantable CardioverterâDefibrillators for the Prevention of Sudden Death in Patients with Hypertrophic Cardiomyopathy

EDITORIAL: Pathogenesis of Inherited Forms of Dilated Cardiomyopathy

ORIGINAL ARTICLE: Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease

REVIEW ARTICLE: Signaling Pathways for Cardiac Hypertrophy and Failure

REVIEW ARTICLE: Implantable Left Ventricular Assist Devices

ORIGINAL ARTICLE: Myocardial Bridging in Children with Hypertrophic Cardiomyopathy â A Risk Factor for Sudden Death

EDITORIAL: Dilated Cardiomyopathy in HIV-Infected Patients

ORIGINAL ARTICLE: Incidence of Dilated Cardiomyopathy and Detection of HIV in Myocardial Cells of HIV-Positive Patients

REVIEW ARTICLE: Doxorubicin-Induced Cardiomyopathy

ORIGINAL ARTICLE: Screening for Hypertrophic Cardiomyopathy in Young Athletes

EDITORIAL: Hypertrophic Cardiomyopathy â Beyond the Sarcomere

ORIGINAL ARTICLE: Mutations in the Gene for Cardiac Myosin-Binding Protein C and Late-Onset Familial Hypertrophic Cardiomyopathy

CLINICAL IMPLICATIONS OF BASIC RESEARCH: The Genetics of Dilated Cardiomyopathy â Emerging Clues to the Puzzle

ORIGINAL ARTICLE: Idiopathic Giant-Cell Myocarditis â Natural History and Treatment

REVIEW ARTICLE: The Management of Hypertrophic Cardiomyopathy

EDITORIAL: Autonomic Disorders and Their Recognition

ORIGINAL ARTICLE: Sympathetic Cardioneuropathy in Dysautonomias

ORIGINAL ARTICLE: Mutations in the Sarcoglycan Genes in Patients with Myopathy

EDITORIAL: End of the Oldest Controversy in Medicine â Are We Ready to Conclude the Debate on Digitalis?

EDITORIAL: Aging, Amyloid, and Cardiomyopathy

ORIGINAL ARTICLE: Variant-Sequence Transthyretin (Isoleucine 122) in Late-Onset Cardiac Amyloidosis in Black Americans

REVIEW ARTICLE: Restrictive Cardiomyopathy

ORIGINAL ARTICLE: Effect of Amlodipine on Morbidity and Mortality in Severe Chronic Heart Failure

ORIGINAL ARTICLE: The Effect of the Ingestion of Ethanol on Obstruction of the Left Ventricular Outflow Tract in Hypertrophic Cardiomyopathy

EDITORIAL: Growth Hormone for Heart Failure â Cause for Cautious Optimism

ORIGINAL ARTICLE: A Preliminary Study of Growth Hormone in the Treatment of Dilated Cardiomyopathy

ORIGINAL ARTICLE: Deficiency of a Dystrophin-Associated Glycoprotein (Adhalin) in a Patient with Muscular Dystrophy and Cardiomyopathy

NEJM â Collection Updates for Cardiomyopathy/Myocarditis

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 2-2010 â A 47-Year-Old Man with Abdominal and Flank Pain

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 39-2009 â A 28-Year-Old Pregnant Woman with Acute Cardiac Failure

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 36-2007 â A 31-Year-Old Woman with Rash, Fever, and Hypotension

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 26-2005 â A 48-Year-Old Man with Sudden Loss of Consciousness while Jogging

IMAGES IN CLINICAL MEDICINE: A Medical Mystery â Bradycardia

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 5-2005 â A 53-Year-Old Man with Depression and Sudden Shortness of Breath

ORIGINAL ARTICLE: EffusiveâConstrictive Pericarditis

PERSPECTIVE: A Clearer View of EffusiveâConstrictive Pericarditis

ORIGINAL ARTICLE: Successful Cardiac Transplantation in an HIV-1âInfected Patient with Advanced Disease

EDITORIAL: Pediatric Cardiomyopathy â A Long Way to Go

PERSPECTIVE: Hypertrophic Cardiomyopathy â The Benefits of a Multidisciplinary Approach

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 17-2002 â A 55-Year-Old Man with Second-Degree Atrioventricular Block and Chest Pain

ORIGINAL ARTICLE: Efficacy of Implantable CardioverterâDefibrillators for the Prevention of Sudden Death in Patients with Hypertrophic Cardiomyopathy

ORIGINAL ARTICLE: Myocardial Bridging in Children with Hypertrophic Cardiomyopathy â A Risk Factor for Sudden Death

EDITORIAL: Hypertrophic Cardiomyopathy â Beyond the Sarcomere

CLINICAL IMPLICATIONS OF BASIC RESEARCH: The Genetics of Dilated Cardiomyopathy â Emerging Clues to the Puzzle

ORIGINAL ARTICLE: Idiopathic Giant-Cell Myocarditis â Natural History and Treatment

EDITORIAL: End of the Oldest Controversy in Medicine â Are We Ready to Conclude the Debate on Digitalis?

EDITORIAL: Growth Hormone for Heart Failure â Cause for Cautious Optimism