http://content.nejm.org/ The New England Journal of Medicine (NEJM) RSS feed — collection updates for Infectious Diseases. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. http://content.nejm.org/icons/nejm_name_220.gifhttp://content.nejm.org/The New England Journal of Medicine is owned, published, and copyrighted © 2010 Massachusetts Medical Society. All rights reserved.en-usA 42-year-old man presented with a 1-week history of intensely pruritic eruption on the dorsum of his right foot. He had gone for a barefoot stroll on the beach a...http://content.nejm.org/cgi/content/short/362/4/e10?rss=1&ssource=collectionSearchRss&queryTerm=5Chia Chun Ang, M.D.Thu, 28  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/4/e10?rss=1&ssource=collectionSearchRss&queryTerm=5In this decade, the prevention and control of Clostridium difficile infection in health care settings has become a global public health challenge. Infection rates have increased dramatically, and several large...http://content.nejm.org/cgi/content/short/362/3/264?rss=1&ssource=collectionSearchRss&queryTerm=5Lorraine Kyne, M.D., M.P.H.Thu, 21  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/3/264?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Rima A. Arnaout (Medicine): A 47-year-old man was admitted to this hospital because of abdominal pain.<br/><br/>The patient was in his usual state of health until 5 weeks before admission,...http://content.nejm.org/cgi/content/short/362/3/254?rss=1&ssource=collectionSearchRss&queryTerm=5Eric M. Isselbacher, M.D., Seth J. Kligerman, M.D., Kaitlyn M. Lam, M.B., B.S., and Rocio M. Hurtado, M.D.Thu, 21  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/3/254?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> New therapies are needed to manage the increasing incidence, severity, and high rate of recurrence of Clostridium difficile infection.<br/><br/><em>Methods:</em> We performed a randomized, double-blind, placebo-controlled study of two neutralizing,...http://content.nejm.org/cgi/content/short/362/3/197?rss=1&ssource=collectionSearchRss&queryTerm=5Israel Lowy, M.D., Ph.D., Deborah C. Molrine, M.D., M.P.H., Brett A. Leav, M.D., Barbra M. Blair, M.D., Roger Baxter, M.D., Dale N. Gerding, M.D., Geoffrey Nichol, M.B., Ch.B., William D. Thomas, Jr., Ph.D., Mark Leney, Ph.D., Susan Sloan, Ph.D., Catherine A. Hay, Ph.D., and Donna M. Ambrosino, M.D.Thu, 21  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/3/197?rss=1&ssource=collectionSearchRss&queryTerm=5Nosocomial bacterial meningitis may result from invasive procedures (e.g., craniotomy, placement of internal or external ventricular catheters, lumbar puncture, intrathecal infusions of medications, or spinal anesthesia), complicated head trauma, or...http://content.nejm.org/cgi/content/short/362/2/146?rss=1&ssource=collectionSearchRss&queryTerm=5Diederik van de Beek, M.D., Ph.D., James M. Drake, M.B., B.Ch., and Allan R. Tunkel, M.D., Ph.D.Thu, 14  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/2/146?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Nasal carriers of Staphylococcus aureus are at increased risk for health care–associated infections with this organism. Decolonization of nasal and extranasal sites on hospital admission may reduce this risk.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/362/1/9?rss=1&ssource=collectionSearchRss&queryTerm=5Lonneke G.M. Bode, M.D., Jan A.J.W. Kluytmans, M.D., Ph.D., Heiman F.L. Wertheim, M.D., Ph.D., Diana Bogaers, I.C.P., Christina M.J.E. Vandenbroucke-Grauls, M.D., Ph.D., Robert Roosendaal, Ph.D., Annet Troelstra, M.D., Ph.D., Adrienne T.A. Box, B.A.Sc., Andreas Voss, M.D., Ph.D., Ingeborg van der Tweel, Ph.D., Alex van Belkum, Ph.D., Henri A. Verbrugh, M.D., Ph.D., and Margreet C. Vos, M.D., Ph.D.Thu, 07  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/1/9?rss=1&ssource=collectionSearchRss&queryTerm=5Primitive ancestors of Homo sapiens and their colonizing bacteria have coevolved for approximately 500,000 years; some experts estimate that the total number of human cells is 1013 and the total...http://content.nejm.org/cgi/content/short/362/1/75?rss=1&ssource=collectionSearchRss&queryTerm=5Richard P. Wenzel, M.D.Thu, 07  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/1/75?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Since the patient's skin is a major source of pathogens that cause surgical-site infection, optimization of preoperative skin antisepsis may decrease postoperative infections. We hypothesized that preoperative skin cleansing...http://content.nejm.org/cgi/content/short/362/1/18?rss=1&ssource=collectionSearchRss&queryTerm=5Rabih O. Darouiche, M.D., Matthew J. Wall, Jr., M.D., Kamal M.F. Itani, M.D., Mary F. Otterson, M.D., Alexandra L. Webb, M.D., Matthew M. Carrick, M.D., Harold J. Miller, M.D., Samir S. Awad, M.D., Cynthia T. Crosby, B.S., Michael C. Mosier, Ph.D., Atef AlSharif, M.D., and David H. Berger, M.D.Thu, 07  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/1/18?rss=1&ssource=collectionSearchRss&queryTerm=5The cause-and-effect relationship between severe infections and death suggests that microbial pathogens are evolutionary sculptors of the genome. However, the genetic component of susceptibility to infections in the general population...http://content.nejm.org/cgi/content/short/361/27/2666?rss=1&ssource=collectionSearchRss&queryTerm=5Erwin Schurr, Ph.D., and Philippe Gros, Ph.D.Thu, 31  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/27/2666?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old man is brought to the emergency department with abdominal pain, fever (temperature, 102.9°F), and dyspnea. His medical history includes an appendectomy 8 years earlier. Abdominal radiography shows free...http://content.nejm.org/cgi/content/short/361/27/2646?rss=1&ssource=collectionSearchRss&queryTerm=5Susanne Toussaint, M.D., M.A., and Herwig Gerlach, M.D., Ph.D.Thu, 31  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/27/2646?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on and the biologic understanding of leprosy. Host...http://content.nejm.org/cgi/content/short/361/27/2609?rss=1&ssource=collectionSearchRss&queryTerm=5Fu-Ren Zhang, M.D., Ph.D., Wei Huang, Ph.D., Shu-Min Chen, M.D., Ph.D., Liang-Dan Sun, M.D., Ph.D., Hong Liu, M.D., Yi Li, Ph.D., Yong Cui, M.D., Ph.D., Xiao-Xiao Yan, M.D., Hai-Tao Yang, M.D., Rong-De Yang, M.D., Tong-Sheng Chu, M.D., Chi Zhang, M.D., Lin Zhang, M.D., Jian-Wen Han, M.D., Gong-Qi Yu, B.S., Cheng Quan, M.D., Yong-Xiang Yu, B.S., Zheng Zhang, M.D., Ben-Qing Shi, M.D., Lian-Hua Zhang, M.D., Hui Cheng, M.D., Chang-Yuan Wang, M.D., Yan Lin, M.D., Hou-Feng Zheng, M.D., Xi-An Fu, M.D., Xian-Bo Zuo, M.S., Qiang Wang, M.D., Heng Long, M.D., Yi-Ping Sun, M.D., Yi-Lin Cheng, M.S., Hong-Qing Tian, M.D., Fu-Sheng Zhou, B.S., Hua-Xu Liu, M.D., Ph.D., Wen-Sheng Lu, M.D., Su-Min He, M.D., Wen-Li Du, B.S., Min Shen, B.S., Qi-Yi Jin, B.S., Ying Wang, Ph.D., Hui-Qi Low, B.S., Tantoso Erwin, B.S., Ning-Han Yang, B.S., Jin-Yong Li, M.D., Xin Zhao, M.D., Yue-Lin Jiao, M.D., Li-Guo Mao, M.D., Gang Yin, M.D., Zhen-Xia Jiang, M.D., Xiao-Dong Wang, M.D., Jing-Ping Yu, M.D., Zong-Hou Hu, M.D., Cui-Hua Gong, M.D., Yu-Qiang Liu, M.D., Rui-Yu Liu, M.D., De-Min Wang, M.D., Dong Wei, M.D., Jin-Xian Liu, M.D., Wei-Kun Cao, M.D., Hong-Zhong Cao, M.D., Yong-Ping Li, M.D., Wei-Guo Yan, M.D., Shi-Yu Wei, M.D., Kui-Jun Wang, M.D., Martin L. Hibberd, Ph.D., Sen Yang, M.D., Ph.D., Xue-Jun Zhang, M.D., Ph.D., and Jian-Jun Liu, Ph.D.Thu, 31  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/27/2609?rss=1&ssource=collectionSearchRss&queryTerm=5Coughing can transmit infectious agents, such as influenza virus, and it has been assumed that wearing a mask limits transmission of these agents. Schlieren optics can effectively visualize the dispersion...http://content.nejm.org/cgi/content/short/361/26/e62?rss=1&ssource=collectionSearchRss&queryTerm=5Julian Wei-Tze Tang, M.D. and Gary Settles, Ph.D.Thu, 24  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/26/e62?rss=1&ssource=collectionSearchRss&queryTerm=5To the Editor: Rates of invasive pneumococcal disease in the United States increase dramatically, or “spike,” during winter holidays.1 We analyzed population-based surveillance data to determine whether spikes may be...http://content.nejm.org/cgi/content/short/361/26/2584?rss=1&ssource=collectionSearchRss&queryTerm=5Nicholas D. Walter, M.D., Thomas H. Taylor, Jr., M.S., Scott F. Dowell, M.D., M.P.H., Saundra Mathis, B.S., and Matthew R. Moore, M.D., M.P.H.Thu, 24  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/26/2584?rss=1&ssource=collectionSearchRss&queryTerm=5To the Editor: A review of recut lung-tissue specimens and published autopsy series from the 1918 influenza pandemic suggests that secondary bacterial pneumonia1 was an important cause of death, consistent...http://content.nejm.org/cgi/content/short/361/26/2582?rss=1&ssource=collectionSearchRss&queryTerm=5Yu-Wen Chien, M.D., M.S.P.H., Keith P. Klugman, M.D., Ph.D., and David M. Morens, M.D.Thu, 24  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/26/2582?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Wilson Tak-Yu Kwong (Medicine): A 29-year-old man was admitted in July 2009 to the critical care unit of this hospital because of fever and respiratory failure.<br/><br/>The patient had been...http://content.nejm.org/cgi/content/short/361/26/2558?rss=1&ssource=collectionSearchRss&queryTerm=5Timothy M. Uyeki, M.D., M.P.H., M.P.P., Amita Sharma, M.D., and John A. Branda, M.D.Thu, 24  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/26/2558?rss=1&ssource=collectionSearchRss&queryTerm=5“Policy decisions regarding influenza rest on judgments about the behavior of the virus, the impact of the disease and our ability to interdict its course. But the virus is capricious,...http://content.nejm.org/cgi/content/short/361/25/e59?rss=1&ssource=collectionSearchRss&queryTerm=5Kathleen M. Neuzil, M.D., M.P.H.Thu, 17  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/25/e59?rss=1&ssource=collectionSearchRss&queryTerm=5Establishing a diagnosis of 2009 pandemic influenza A (H1N1) virus infection in hospitalized patients can be challenging, especially in patients presenting late in their clinical course. Although real-time reverse-transcriptase polymerase...http://content.nejm.org/cgi/content/short/361/25/e114?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 17  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/25/e114?rss=1&ssource=collectionSearchRss&queryTerm=5To the Editor: Faix et al. (Aug. 13 issue)1 highlight the moderate sensitivity of rapid antigen tests as compared with reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assays in detecting the 2009 pandemic influenza A...http://content.nejm.org/cgi/content/short/361/25/2493?rss=1&ssource=collectionSearchRss&queryTerm=5Christopher C. Blyth, M.B., B.S., Jonathan R. Iredell, M.B., B.S., Ph.D., and Dominic E. Dwyer, M.B., B.S., M.D.Thu, 17  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/25/2493?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The 2009 pandemic influenza A (H1N1) virus has emerged to cause the first pandemic of the 21st century. Development of effective vaccines is a public health priority.<br/><br/><em>Methods:</em> We conducted...http://content.nejm.org/cgi/content/short/361/25/2424?rss=1&ssource=collectionSearchRss&queryTerm=5Tristan W. Clark, M.R.C.P., Manish Pareek, M.R.C.P., Katja Hoschler, Ph.D., Helen Dillon, M.R.C.P., Karl G. Nicholson, M.D., F.R.C.P., Nicola Groth, M.D., and Iain Stephenson, M.D., F.R.C.P.Thu, 17  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/25/2424?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> There is an urgent need for a vaccine that is effective against the 2009 pandemic influenza A (H1N1) virus.<br/><br/><em>Methods:</em> A split-virus, inactivated candidate vaccine against the 2009 H1N1 virus...http://content.nejm.org/cgi/content/short/361/25/2414?rss=1&ssource=collectionSearchRss&queryTerm=5Feng-Cai Zhu, M.D., Hua Wang, M.D., Han-Hua Fang, M.D., Jian Guo Yang, M.D., Xiao Jun Lin, M.D., Xiao-Feng Liang, M.D., Xue-Feng Zhang, M.D., Hong-Xing Pan, M.D., Fan-Yue Meng, M.D., Yue Mei Hu, M.D., Wen-Dong Liu, M.D., Chang-Gui Li, M.D., Wei Li, M.D., Xiang Zhang, M.D., Jin Mei Hu, M.D., Wei Bing Peng, M.D., Bao Ping Yang, M.D., Pei Xi, M.D., Hua-Qing Wang, M.D., and Jing-Shan Zheng, M.D.Thu, 17  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/25/2414?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> A novel 2009 influenza A (H1N1) virus is responsible for the first influenza pandemic in 41 years. A safe and effective vaccine is needed. A randomized, observer-blind, parallel-group trial...http://content.nejm.org/cgi/content/short/361/25/2405?rss=1&ssource=collectionSearchRss&queryTerm=5Michael E. Greenberg, M.D., M.P.H., Michael H. Lai, B.Med.Sc., M.B., B.S., M.Med.Sc., Gunter F. Hartel, M.S., Ph.D., Christine H. Wichems, Ph.D., Charmaine Gittleson, B.Sc., M.B., B.Ch., Jillian Bennet, M.Sc., M.P.H., Gail Dawson, B.Pharm., Wilson Hu, M.D., M.B.A., Connie Leggio, B.Sc., Diane Washington, M.D., and Russell L. Basser, M.B., B.S., M.D., F.R.A.C.P.Thu, 17  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/25/2405?rss=1&ssource=collectionSearchRss&queryTerm=5We are now facing a pandemic caused by an epidemiologically distinct, novel virus, the 2009 pandemic influenza A (H1N1) virus (swine flu), against which few persons born since 1970 have...http://content.nejm.org/cgi/content/short/361/24/e112?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 10  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/24/e112?rss=1&ssource=collectionSearchRss&queryTerm=5With the 2009 H1N1 pandemic well under way, many clinicians are providing care to patients with influenza. Previously, although antiviral treatment was recommended,12 clinicians may not always have prescribed it...http://content.nejm.org/cgi/content/short/361/23/e110?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 03  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/23/e110?rss=1&ssource=collectionSearchRss&queryTerm=5To the Editor: Neuraminidase inhibitors (oseltamivir and zanamivir) are recommended for treatment of severe illness caused by the 2009 pandemic influenza A (H1N1) virus, and their use has also been...http://content.nejm.org/cgi/content/short/361/23/2296?rss=1&ssource=collectionSearchRss&queryTerm=5Mariana Baz, M.Sc., Yacine Abed, Ph.D., Jesse Papenburg, M.D., Xavier Bouhy, B.Sc., Marie-Ève Hamelin, Ph.D., and Guy Boivin, M.D.Thu, 03  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/23/2296?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old man presented with vegetating lesions on the right foot that had been slowly enlarging during the past several years. On physical examination, several nodular and verrucous lesions were...http://content.nejm.org/cgi/content/short/361/22/2165?rss=1&ssource=collectionSearchRss&queryTerm=5Alcides Troncoso, M.D., Ph.D. and Javier Bava, M.D., Ph.D.Thu, 26  Nov  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/22/2165?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Kuru is a devastating epidemic prion disease that affected a highly restricted geographic area of the Papua New Guinea highlands; at its peak, it predominantly affected adult women and...http://content.nejm.org/cgi/content/short/361/21/2056?rss=1&ssource=collectionSearchRss&queryTerm=5Simon Mead, M.R.C.P., Jerome Whitfield, M.A., Mark Poulter, B.Sc., Paresh Shah, Ph.D., James Uphill, B.Sc., Tracy Campbell, B.Sc., Huda Al-Dujaily, B.Sc., Holger Hummerich, Ph.D., Jon Beck, B.Sc., Charles A. Mein, Ph.D., Claudio Verzilli, Ph.D., John Whittaker, Ph.D., Michael P. Alpers, F.R.S., and John Collinge, F.R.S.Thu, 19  Nov  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/21/2056?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Recurrent sinopulmonary and cutaneous viral infections with elevated serum levels of IgE are features of some variants of combined immunodeficiency. The genetic causes of these variants are unknown.<br/><br/><em>Methods:</em> We...http://content.nejm.org/cgi/content/short/361/21/2046?rss=1&ssource=collectionSearchRss&queryTerm=5Qian Zhang, M.D., Jeremiah C. Davis, M.P.H., Ian T. Lamborn, B.S., Alexandra F. Freeman, M.D., Huie Jing, Ph.D., Amanda J. Favreau, B.S., Helen F. Matthews, B.S.N., Joie Davis, M.S.N., Maria L. Turner, M.D., Gulbu Uzel, M.D., Steven M. Holland, M.D., and Helen C. Su, M.D., Ph.D.Thu, 19  Nov  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/21/2046?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Peter P. Moschovis (Medicine and Pediatrics): A 60-year-old man with diabetes mellitus and a history of renal transplantation was admitted to this hospital because of mental-status changes, diarrhea, renal...http://content.nejm.org/cgi/content/short/361/20/1980?rss=1&ssource=collectionSearchRss&queryTerm=5Lindsey R. Baden, M.D., Subba R. Digumarthy, M.D., Alexander S.R. Guimaraes, M.D., Ph.D., and John A. Branda, M.D.Thu, 12  Nov  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/20/1980?rss=1&ssource=collectionSearchRss&queryTerm=5Approximately one third of children who have a urinary tract infection — the most frequent serious bacterial infection in young febrile children — have vesicoureteral reflux, a congenital condition in...http://content.nejm.org/cgi/content/short/361/18/1804?rss=1&ssource=collectionSearchRss&queryTerm=5Alejandro Hoberman, M.D., and Ron Keren, M.D., M.P.H.Thu, 29  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/18/1804?rss=1&ssource=collectionSearchRss&queryTerm=5We lead inextricably mycotic lives: yeasts leaven our bread, ferment our wine and beer, and inhabit our skins, mouths, and gastrointestinal tracts; however, not all is harmony. Hippocrates reported aphthous...http://content.nejm.org/cgi/content/short/361/18/1798?rss=1&ssource=collectionSearchRss&queryTerm=5Steven M. Holland, M.D., and Donald C. Vinh, M.D.Thu, 29  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/18/1798?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Robert W. McGarrah (Medicine): A 20-year-old man was admitted to this hospital because of sore throat, fever, and a diffuse rash.<br/><br/>The patient had been well until approximately 4 weeks...http://content.nejm.org/cgi/content/short/361/18/1787?rss=1&ssource=collectionSearchRss&queryTerm=5Charles R. Taylor, M.D., Rajesh T. Gandhi, M.D., Jason Handwerker, M.D., and Lyn M. Duncan, M.D.Thu, 29  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/18/1787?rss=1&ssource=collectionSearchRss&queryTerm=5Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis...http://content.nejm.org/cgi/content/short/361/18/1760?rss=1&ssource=collectionSearchRss&queryTerm=5Bart Ferwerda, Ph.D., Gerben Ferwerda, Ph.D., M.D., Theo S. Plantinga, M.S., Janet A. Willment, Ph.D., Annemiek B. van Spriel, Ph.D., Hanka Venselaar, M.S., Clara C. Elbers, Ph.D., Melissa D. Johnson, Ph.D., M.D., Alessandra Cambi, Ph.D., Cristal Huysamen, Ph.D., Liesbeth Jacobs, B.S., Trees Jansen, B.S., Karlijn Verheijen, B.S., Laury Masthoff, M.D., Servaas A. Morré, Ph.D., Gert Vriend, Ph.D., David L. Williams, Ph.D., M.D., John R. Perfect, Ph.D., M.D., Leo A.B. Joosten, Ph.D., Cisca Wijmenga, Ph.D., Jos W.M. van der Meer, Ph.D., M.D., Gosse J. Adema, Ph.D., Bart Jan Kullberg, Ph.D., M.D., Gordon D. Brown, Ph.D., and Mihai G. Netea, Ph.D., M.D.Thu, 29  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/18/1760?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Antibiotics are widely administered to children with the intention of preventing urinary tract infection, but adequately powered, placebo-controlled trials regarding efficacy are lacking. This study from four Australian centers...http://content.nejm.org/cgi/content/short/361/18/1748?rss=1&ssource=collectionSearchRss&queryTerm=5Jonathan C. Craig, M.B., Ch.B., Ph.D., Judy M. Simpson, Ph.D., Gabrielle J. Williams, Ph.D., M.P.H., Alison Lowe, B.Sc., Graham J. Reynolds, M.B., B.S., Steven J. McTaggart, M.B., B.S., Ph.D., Elisabeth M. Hodson, M.B., B.S., Jonathan R. Carapetis, M.B., B.S., Ph.D., Noel E. Cranswick, M.B., B.S., Grahame Smith, M.B., B.S., Les M. Irwig, M.B., B.Ch., Ph.D., Patrina H.Y. Caldwell, Ph.D., Sana Hamilton, M.P.H., and Leslie P. Roy, M.B., B.S., for the Prevention of Recurrent Urinary Tract Infection in Children with Vesicoureteric Reflux and Normal Renal Tracts (PRIVENT) InvestigatorsThu, 29  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/18/1748?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Chronic mucocutaneous candidiasis may be manifested as a primary immunodeficiency characterized by persistent or recurrent infections of the mucosa or the skin with candida species. Most cases are sporadic,...http://content.nejm.org/cgi/content/short/361/18/1727?rss=1&ssource=collectionSearchRss&queryTerm=5Erik-Oliver Glocker, M.D., Andre Hennigs, Mohammad Nabavi, M.D., Alejandro A. Schäffer, Ph.D., Cristina Woellner, M.Sc., Ulrich Salzer, M.D., Dietmar Pfeifer, Ph.D., Hendrik Veelken, M.D., Klaus Warnatz, M.D., Fariba Tahami, M.Sc., Sarah Jamal, M.Sc., Annabelle Manguiat, M.Sc., Nima Rezaei, M.D., Ali Akbar Amirzargar, M.D., Alessandro Plebani, M.D., Nicole Hannesschläger, B.Sc., Olaf Gross, Ph.D., Jürgen Ruland, M.D., and Bodo Grimbacher, M.D.Thu, 29  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/18/1727?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Claudius H.O. Conrad (Surgery): A 35-year-old woman was transferred to this hospital because of abdominal pain, fever, and hypotension.<br/><br/>Three days earlier, an elective cesarean section was performed at another...http://content.nejm.org/cgi/content/short/361/17/1689?rss=1&ssource=collectionSearchRss&queryTerm=5Marc A. de Moya, M.D., Marcela G. del Carmen, M.D., Rae M. Allain, M.D., Ronald E. Hirschberg, M.D., Jo-Anne O. Shepard, M.D., and Richard L. Kradin, M.D.Thu, 22  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/17/1689?rss=1&ssource=collectionSearchRss&queryTerm=5A 47-year-old man reports a 1-week history of diarrhea, with grossly bloody stools for the past 5 days. He reports no history of travel, contacts with sick persons, or underlying...http://content.nejm.org/cgi/content/short/361/16/1560?rss=1&ssource=collectionSearchRss&queryTerm=5Herbert L. DuPont, M.D.Thu, 15  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/16/1560?rss=1&ssource=collectionSearchRss&queryTerm=5A 65-year-old white man with a history of multiple myeloma presented with thick, leathery, gray skin of the torso and extremities. Panel A shows the left axilla. The patient reported...http://content.nejm.org/cgi/content/short/361/15/e29?rss=1&ssource=collectionSearchRss&queryTerm=5Pooja Khera, M.D. and Joseph C. English, M.D.Thu, 08  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/15/e29?rss=1&ssource=collectionSearchRss&queryTerm=5The prevalence of filarial infections in the tropics is second only to that of geohelminth (soil-transmitted helminth) infections. Filarial infections in humans include the various forms of lymphatic filariasis (Wuchereria...http://content.nejm.org/cgi/content/short/361/15/1502?rss=1&ssource=collectionSearchRss&queryTerm=5Achim Hoerauf, M.D.Thu, 08  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/15/1502?rss=1&ssource=collectionSearchRss&queryTerm=5A 58-year-old man presented with a 1-year history of dysuria. His medical history was notable for recurrent pyelonephritis on the right side. Evaluation at this time revealed staghorn calculus (Panel...http://content.nejm.org/cgi/content/short/361/15/1486?rss=1&ssource=collectionSearchRss&queryTerm=5Shanmugasundaram Rajaian, M.D. and Nitin Sudhakar Kekre, M.D.Thu, 08  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/15/1486?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Mansonella perstans infection is common in areas of Africa where Wuchereria bancrofti, a causative agent of lymphatic filariasis, is endemic. M. perstans is refractory to standard antifilarial therapies. The...http://content.nejm.org/cgi/content/short/361/15/1448?rss=1&ssource=collectionSearchRss&queryTerm=5Yaya I. Coulibaly, M.D., Benoit Dembele, M.D., Abdallah A. Diallo, D.E.A., Ettie M. Lipner, M.P.H., Salif S. Doumbia, Siaka Y. Coulibaly, M.D., Siaka Konate, M.D., Dapa A. Diallo, M.D., Daniel Yalcouye, Pharm.D., Joseph Kubofcik, B.S., Ogobara K. Doumbo, M.D., Abdel K. Traore, M.D., Adama D. Keita, M.D., Michael P. Fay, Ph.D., Sekou F. Traore, Ph.D., Thomas B. Nutman, M.D., and Amy D. Klion, M.D.Thu, 08  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/15/1448?rss=1&ssource=collectionSearchRss&queryTerm=5A 76-year-old native Dutch woman was admitted to our intensive care unit for hemodynamic monitoring after undergoing vulvectomy and inguinal lymph-node dissection for vulvar carcinoma. Preoperative evaluation had revealed a...http://content.nejm.org/cgi/content/short/361/14/1386?rss=1&ssource=collectionSearchRss&queryTerm=5R. Arthur Bouwman, M.D., Ph.D. and Rob J.M. Strack van Schijndel, M.D.Thu, 01  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/14/1386?rss=1&ssource=collectionSearchRss&queryTerm=5A 44-year-old man presented with a 7-day history of epistaxis on the left side. He reported that he had washed his face in a freshwater stream 7 days before the...http://content.nejm.org/cgi/content/short/361/9/e14?rss=1&ssource=collectionSearchRss&queryTerm=5Yueng-Hsiang Chu, M.D. and Jih-Chin Lee, M.D.Thu, 27  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/9/e14?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. David T. Ting (Medical Oncology): A 56-year-old woman was admitted to this hospital because of fever, rash, and lymphadenopathy.<br/><br/>She had been well until 11 weeks earlier when, while residing...http://content.nejm.org/cgi/content/short/361/9/900?rss=1&ssource=collectionSearchRss&queryTerm=5Jeremy S. Abramson, M.D., Subba Digumarthy, M.D., and Judith A. Ferry, M.D.Thu, 27  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/9/900?rss=1&ssource=collectionSearchRss&queryTerm=5The study of the relation between infectious diseases and national security is hardly a new endeavor. In this book, Andrew Price-Smith reminds us that Thucydides, in his 5th-century publication The...http://content.nejm.org/cgi/content/short/361/8/830?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 20  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/8/830?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. David M. Dudzinski (Medicine): Fever and abdominal pain and distention developed in a 34-year-old man with cystic fibrosis during an admission to this hospital for pulmonary care.<br/><br/>The patient was...http://content.nejm.org/cgi/content/short/361/8/807?rss=1&ssource=collectionSearchRss&queryTerm=5Steven D. Freedman, M.D., Ph.D., Raul N. Uppot, M.D., and Mari Mino-Kenudson, M.D.Thu, 20  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/8/807?rss=1&ssource=collectionSearchRss&queryTerm=5The numbers of primary total hip and total knee arthroplasties have been increasing over the past decade, with nearly 800,000 such procedures performed in the United States in 2006 (Figure...http://content.nejm.org/cgi/content/short/361/8/787?rss=1&ssource=collectionSearchRss&queryTerm=5Jose L. Del Pozo, M.D., Ph.D., and Robin Patel, M.D.Thu, 20  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/8/787?rss=1&ssource=collectionSearchRss&queryTerm=5A 34-year-old Brazilian man presented with a 24-year history of prominent, progressively dilating superficial veins. The veins of the lower limbs dilated first, gradually becoming discolored and indurated (Panel A)....http://content.nejm.org/cgi/content/short/361/6/e9?rss=1&ssource=collectionSearchRss&queryTerm=5André Rodrigues Durães, M.D. and Lilian Souza AraujoThu, 06  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/6/e9?rss=1&ssource=collectionSearchRss&queryTerm=5To the Editor: Artemisinin-based combination therapies have recently been introduced in virtually all countries in which malaria is endemic, thereby making such drugs the most essential class of antimalarial agents....http://content.nejm.org/cgi/content/short/361/5/540?rss=1&ssource=collectionSearchRss&queryTerm=5Harald Noedl, M.D., Ph.D., Duong Socheat, M.D., and Wichai Satimai, M.D.Thu, 30  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/5/540?rss=1&ssource=collectionSearchRss&queryTerm=5Platelets have long been known to interact cooperatively with erythrocytes in thrombogenesis, both generally and in patients with sickle cell disease.1 Recently, the molecular mechanisms by which neutrophils can bridge...http://content.nejm.org/cgi/content/short/361/5/526?rss=1&ssource=collectionSearchRss&queryTerm=5Doron C. Greenbaum, Ph.D., and Garret A. FitzGerald, M.D.Thu, 30  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/5/526?rss=1&ssource=collectionSearchRss&queryTerm=5Over the past 5 years, we have witnessed remarkable progress in malaria control. In Africa, the approach has been to “scale up for impact”1 by rapidly deploying insecticide-treated nets and...http://content.nejm.org/cgi/content/short/361/5/522?rss=1&ssource=collectionSearchRss&queryTerm=5Carlos C. Campbell, M.D., M.P.H.Thu, 30  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/5/522?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> An effective vaccine for malaria is urgently needed. Naturally acquired immunity to malaria develops slowly, and induction of protection in humans can be achieved artificially by the inoculation of...http://content.nejm.org/cgi/content/short/361/5/468?rss=1&ssource=collectionSearchRss&queryTerm=5Meta Roestenberg, M.D., Matthew McCall, M.D., Joost Hopman, M.D., Jorien Wiersma, Adrian J.F. Luty, Ph.D., Geert Jan van Gemert, B.Sc., Marga van de Vegte-Bolmer, B.Sc., Ben van Schaijk, M.Sc., Karina Teelen, Theo Arens, Lopke Spaarman, B.Sc., Quirijn de Mast, M.D., Will Roeffen, Ph.D., Georges Snounou, Ph.D., Laurent Rénia, Ph.D., Andre van der Ven, M.D., Cornelus C. Hermsen, Ph.D., and Robert Sauerwein, M.D.Thu, 30  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/5/468?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease. There are recent concerns that the efficacy of such therapies has declined...http://content.nejm.org/cgi/content/short/361/5/455?rss=1&ssource=collectionSearchRss&queryTerm=5Arjen M. Dondorp, M.D., François Nosten, M.D., Poravuth Yi, M.D., Debashish Das, M.D., Aung Phae Phyo, M.D., Joel Tarning, Ph.D., Khin Maung Lwin, M.D., Frederic Ariey, M.D., Warunee Hanpithakpong, Ph.D., Sue J. Lee, Ph.D., Pascal Ringwald, M.D., Kamolrat Silamut, Ph.D., Mallika Imwong, Ph.D., Kesinee Chotivanich, Ph.D., Pharath Lim, M.D., Trent Herdman, Ph.D., Sen Sam An, Shunmay Yeung, Ph.D., Pratap Singhasivanon, M.D., Nicholas P.J. Day, D.M., Niklas Lindegardh, Ph.D., Duong Socheat, M.D., and Nicholas J. White, F.R.S.Thu, 30  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/5/455?rss=1&ssource=collectionSearchRss&queryTerm=5The fascinating field of infectious diseases is evolving rapidly. The discovery of new pathogens, the reappearance of old ones, and the emergence of new information have made infectious diseases books...http://content.nejm.org/cgi/content/short/361/4/428?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 23  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/4/428?rss=1&ssource=collectionSearchRss&queryTerm=5Enteric fevers encompass typhoid fever caused by Salmonella enterica serotype Typhi (S. Typhi) and paratyphoid fever caused by serotype Paratyphi A or B (S. Paratyphi). These human-restricted pathogens are acquired...http://content.nejm.org/cgi/content/short/361/4/403?rss=1&ssource=collectionSearchRss&queryTerm=5Myron M. Levine, M.D., D.T.P.H.Thu, 23  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/4/403?rss=1&ssource=collectionSearchRss&queryTerm=5A 53-year-old woman was admitted to the hospital for evaluation of a 1-week history of lower abdominal pain and dysuria. She was afebrile. Plain abdominal radiography showed air throughout the...http://content.nejm.org/cgi/content/short/361/4/388?rss=1&ssource=collectionSearchRss&queryTerm=5Chih-Cheng Lu, M.D. and Tse-Chou Cheng, M.D.Thu, 23  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/4/388?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Typhoid fever remains an important cause of illness and death in the developing world. Uncertainties about the protective effect of Vi polysaccharide vaccine in children under the age of...http://content.nejm.org/cgi/content/short/361/4/335?rss=1&ssource=collectionSearchRss&queryTerm=5Dipika Sur, M.D., R. Leon Ochiai, M.H.S., Sujit K. Bhattacharya, M.D., Nirmal K. Ganguly, Ph.D., Mohammad Ali, Ph.D., Byomkesh Manna, Ph.D., Shanta Dutta, M.D., Ph.D., Allan Donner, Ph.D., Suman Kanungo, M.B., B.S., D.I.H., Jin Kyung Park, Ph.D., Mahesh K. Puri, M.Sc., Deok Ryun Kim, M.Sc., Dharitri Dutta, M.B., B.S., D.C.H., Barnali Bhaduri, M.Sc., Camilo J. Acosta, M.D., Ph.D., and John D. Clemens, M.D.Thu, 23  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/4/335?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Deborah L. Cummins (Dermatology): A 59-year-old man was seen by consultants in infectious disease and dermatology because of cutaneous and pulmonary lesions that developed after induction chemotherapy for acute...http://content.nejm.org/cgi/content/short/361/3/287?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas F. Patterson, M.D., Bonnie T. Mackool, M.D., Matthew D. Gilman, M.D., and Adriano Piris, M.D.Thu, 16  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/3/287?rss=1&ssource=collectionSearchRss&queryTerm=5In this issue of the Journal, Frank and colleagues present the case history and autopsy results of a widely publicized death in the summer of 2007 of a young woman...http://content.nejm.org/cgi/content/short/361/2/193?rss=1&ssource=collectionSearchRss&queryTerm=5Elizabeth L. Hohmann, M.D.Thu, 09  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/2/193?rss=1&ssource=collectionSearchRss&queryTerm=5In a world filled with pressing unmet medical needs, why would a physician want to protect against a disease that is rarely seen? Part of the answer can be deduced...http://content.nejm.org/cgi/content/short/361/2/191?rss=1&ssource=collectionSearchRss&queryTerm=5Gary J. Nabel, M.D., Ph.D.Thu, 09  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/2/191?rss=1&ssource=collectionSearchRss&queryTerm=5A 17-year-old girl presented to the emergency department with a black necrotic lesion on her left cheek and periorbital edema. She had been well until 15 days before presentation, when...http://content.nejm.org/cgi/content/short/361/2/178?rss=1&ssource=collectionSearchRss&queryTerm=5Mohsen Esfandbod, M.D. and Mahdi Malekpour, M.D.Thu, 09  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/2/178?rss=1&ssource=collectionSearchRss&queryTerm=5We present a case of disseminated histoplasmosis, complicated by retroperitoneal bleeding and leading to death, in a patient who was receiving systemic immunosuppressive therapy for rheumatoid arthritis and who was...http://content.nejm.org/cgi/content/short/361/2/161?rss=1&ssource=collectionSearchRss&queryTerm=5Karen M. Frank, M.D., Ph.D., D. Kyle Hogarth, M.D., Jonathan L. Miller, M.D., Ph.D., Saptarshi Mandal, M.B., B.S., Philip J. Mease, M.D., R. Jude Samulski, Ph.D., Glen A. Weisgerber, M.D., and John Hart, M.D.Thu, 09  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/2/161?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> From 2001 through March 2006, Planned Parenthood health centers throughout the United States provided medical abortion (abortion by means of medication) principally by a regimen of oral mifepristone followed...http://content.nejm.org/cgi/content/short/361/2/145?rss=1&ssource=collectionSearchRss&queryTerm=5Mary Fjerstad, N.P., M.H.S., James Trussell, Ph.D., Irving Sivin, M.A., E. Steve Lichtenberg, M.D., M.P.H., and Vanessa Cullins, M.D., M.P.H., M.B.A.Thu, 09  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/2/145?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Inhalational anthrax caused by Bacillus anthracis is associated with high mortality primarily due to toxin-mediated injury. Raxibacumab is a human IgG1λ monoclonal antibody directed against protective antigen, a component...http://content.nejm.org/cgi/content/short/361/2/135?rss=1&ssource=collectionSearchRss&queryTerm=5Thi-Sau Migone, Ph.D., G. Mani Subramanian, M.D., Ph.D., John Zhong, Ph.D., Letha M. Healey, M.D., Al Corey, B.S., Matt Devalaraja, Ph.D., Larry Lo, Ph.D., Stephen Ullrich, Ph.D., Janelle Zimmerman, B.S., Andrew Chen, Ph.D., Maggie Lewis, M.S., Gabriel Meister, Ph.D., Karen Gillum, D.V.M., Daniel Sanford, Ph.D., Jason Mott, D.V.M., Ph.D., and Sally D. Bolmer, Ph.D.Thu, 09  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/2/135?rss=1&ssource=collectionSearchRss&queryTerm=5The recent behavior of two infamous pathogens — methicillin-resistant Staphylococcus aureus (MRSA) and this winter's pre-swine edition of influenza virus — has proved an embarrassment to scientists everywhere. Both organisms...http://content.nejm.org/cgi/content/short/361/2/120?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 09  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/2/120?rss=1&ssource=collectionSearchRss&queryTerm=5Laboratory medicine has no more urgent role than in the diagnosis and management of infections in immunocompromised patients. For this vulnerable population, clinical algorithms are logically rooted in the need...http://content.nejm.org/cgi/content/short/361/1/101?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 02  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/1/101?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Group B streptococcal disease is one of the most common infections in the first week after birth. In 2002, national guidelines recommended universal late antenatal screening of pregnant women...http://content.nejm.org/cgi/content/short/360/25/2626?rss=1&ssource=collectionSearchRss&queryTerm=5Melissa K. Van Dyke, Ph.D., Christina R. Phares, Ph.D., Ruth Lynfield, M.D., Ann R. Thomas, M.D., Kathryn E. Arnold, M.D., Allen S. Craig, M.D., Janet Mohle-Boetani, M.D., Ken Gershman, M.D., William Schaffner, M.D., Susan Petit, M.P.H., Shelley M. Zansky, Ph.D., Craig A. Morin, M.P.H., Nancy L. Spina, M.P.H., Kathryn Wymore, M.P.H., Lee H. Harrison, M.D., Kathleen A. Shutt, M.S., Joseph Bareta, M.P.H., Sandra N. Bulens, M.P.H., Elizabeth R. Zell, M.Stat., Anne Schuchat, M.D., and Stephanie J. Schrag, D.Phil.Thu, 18  Jun  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/25/2626?rss=1&ssource=collectionSearchRss&queryTerm=5A 63-year-old woman presented with a 2-day history of fever, abdominal pain, and vomiting. There was no history of previous episodes. Physical examination revealed fever and moderate abdominal tenderness in...http://content.nejm.org/cgi/content/short/360/24/2563?rss=1&ssource=collectionSearchRss&queryTerm=5Ping-Hsien Chen, M.D. and Chiao-Hsiung Chuang, M.D.Thu, 11  Jun  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/24/2563?rss=1&ssource=collectionSearchRss&queryTerm=5In late April, we presented a case of a healthy black woman incidentally found to be infected with hepatitis C virus (HCV) in Clinical Decisions,1 an interactive feature designed to...http://content.nejm.org/cgi/content/short/360/23/e30?rss=1&ssource=collectionSearchRss&queryTerm=5Marissa B. Wilck, M.D., Mary Beth Hamel, M.D., and Lindsey R. Baden, M.D.Thu, 04  Jun  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/23/e30?rss=1&ssource=collectionSearchRss&queryTerm=5An 86-year-old man was hospitalized for repeated episodes of septic shock due to methicillin-resistant Staphylococcus aureus (MRSA) pneumonia; he ultimately died of pseudomonal sepsis and pneumonia. In 1948, the patient...http://content.nejm.org/cgi/content/short/360/23/e29?rss=1&ssource=collectionSearchRss&queryTerm=5Shimpei Gotoh, M.D. and Naohiko Chohnabayashi, M.D., Ph.D.Thu, 04  Jun  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/23/e29?rss=1&ssource=collectionSearchRss&queryTerm=5It is pointed out in the introduction to this fine textbook that in 1939, aspergillosis was described as “so rare as to be of little practical importance.” Much has changed...http://content.nejm.org/cgi/content/short/360/20/2147?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 14  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/20/2147?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Mathias Lichterfeld (Infectious Disease): A 25-year-old man was admitted to this hospital because of coma after cardiac arrest.<br/><br/>He had been well until 4 hours before admission, when he was...http://content.nejm.org/cgi/content/short/360/20/2118?rss=1&ssource=collectionSearchRss&queryTerm=5Camille N. Kotton, M.D., Nahel Elias, M.D., Francis L. Delmonico, M.D., and Richard L. Kradin, M.D.Thu, 14  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/20/2118?rss=1&ssource=collectionSearchRss&queryTerm=5A 68-year-old man reports changes in his left big toenail. It has been discolored distally for the past 2 years. It has become thickened and difficult to cut and is...http://content.nejm.org/cgi/content/short/360/20/2108?rss=1&ssource=collectionSearchRss&queryTerm=5David de Berker, M.R.C.P.Thu, 14  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/20/2108?rss=1&ssource=collectionSearchRss&queryTerm=5Vaccines are among the most effective prevention tools available to clinicians. However, the success of an immunization program depends on high rates of acceptance and coverage. There is evidence of...http://content.nejm.org/cgi/content/short/360/19/1981?rss=1&ssource=collectionSearchRss&queryTerm=5Saad B. Omer, M.B., B.S., Ph.D., M.P.H., Daniel A. Salmon, Ph.D., M.P.H., Walter A. Orenstein, M.D., M. Patricia deHart, Sc.D., and Neal Halsey, M.D.Thu, 07  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/19/1981?rss=1&ssource=collectionSearchRss&queryTerm=5Filamentous fungi (molds) are ancient lineages that have existed for approximately 1 billion years1 and thrive in soil and decomposing vegetation independent of an animal host. Thus, the evolution from...http://content.nejm.org/cgi/content/short/360/18/1870?rss=1&ssource=collectionSearchRss&queryTerm=5Brahm H. Segal, M.D.Thu, 30  Apr  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/18/1870?rss=1&ssource=collectionSearchRss&queryTerm=5A 54-year-old woman was admitted to the hospital because of respiratory failure, hypotension, and a cavitary lesion in the lung.<br/><br/>She had rheumatoid arthritis but had otherwise been well until approximately...http://content.nejm.org/cgi/content/short/360/17/1770?rss=1&ssource=collectionSearchRss&queryTerm=5Michael E. Weinblatt, M.D., Gerald F. Abbott, M.D., and Aashiyana F. Koreishi, M.D.Thu, 23  Apr  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/17/1770?rss=1&ssource=collectionSearchRss&queryTerm=5A 52-year-old woman from southern Tunisia presented with a 2-year history of an asymptomatic, thick, reddish plaque on her right ear. The lesion began as multiple erythematous papules that later...http://content.nejm.org/cgi/content/short/360/14/e20?rss=1&ssource=collectionSearchRss&queryTerm=5Taoufik Zaz, M.D. and Hamida Turki, M.D.Thu, 02  Apr  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/14/e20?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Naana Afua Jumah (Student, Harvard Medical School): A 23-year-old woman was seen in the gynecology clinic of this hospital because of a high-grade squamous intraepithelial lesion seen on pathological...http://content.nejm.org/cgi/content/short/360/13/1337?rss=1&ssource=collectionSearchRss&queryTerm=5Mark A. Goldstein, M.D., Annekathryn Goodman, M.D., Marcela G. del Carmen, M.D., M.P.H., and David C. Wilbur, M.D.Thu, 26  Mar  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/13/1337?rss=1&ssource=collectionSearchRss&queryTerm=5A 53-year-old intensive care nurse receiving monotherapy with efalizumab for psoriasis involving her arms, legs, and nails presented with a several-week history of slowly progressive green discoloration of both thumbnails,...http://content.nejm.org/cgi/content/short/360/11/1125?rss=1&ssource=collectionSearchRss&queryTerm=5Ulrich R. Hengge, M.D. and Virginia Bardeli, M.D.Thu, 12  Mar  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/11/1125?rss=1&ssource=collectionSearchRss&queryTerm=5In 2006, the results of pivotal clinical trials of two new rotavirus vaccines — RotaTeq (Merck) and Rotarix (GlaxoSmithKline) — were published, and high efficacy (85 to 98%) against severe...http://content.nejm.org/cgi/content/short/360/11/1063?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 12  Mar  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/11/1063?rss=1&ssource=collectionSearchRss&queryTerm=5Inexcusably, the completely preventable ancient scourge of cholera rages among poverty-stricken and displaced people today, with as many as one in five persons with severe illness dying for lack of...http://content.nejm.org/cgi/content/short/360/11/1060?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 12  Mar  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/11/1060?rss=1&ssource=collectionSearchRss&queryTerm=5Two years ago, a nationwide outbreak of Shiga toxin–producing Escherichia coli O157:H7 enteritis linked to consumption of contaminated spinach from one California supplier captured the attention of the national media...http://content.nejm.org/cgi/content/short/360/10/949?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 05  Mar  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/10/949?rss=1&ssource=collectionSearchRss&queryTerm=5We report on three cases of meningococcal disease caused by ciprofloxacin-resistant Neisseria meningitidis, one in North Dakota and two in Minnesota. The cases were caused by the same serogroup B...http://content.nejm.org/cgi/content/short/360/9/886?rss=1&ssource=collectionSearchRss&queryTerm=5Henry M. Wu, M.D., Brian H. Harcourt, Ph.D., Cynthia P. Hatcher, B.S., Stanley C. Wei, M.D., Ryan T. Novak, Ph.D., Xin Wang, Ph.D., Billie A. Juni, M.S., Anita Glennen, B.S., David J. Boxrud, M.S., Jean Rainbow, R.N., M.P.H., Susanna Schmink, B.S., Raydel D. Mair, B.S., M. Jordan Theodore, B.S., Molly A. Sander, M.P.H., Tracy K. Miller, M.P.H., Kirby Kruger, B.S., Amanda C. Cohn, M.D., Thomas A. Clark, M.D., M.P.H., Nancy E. Messonnier, M.D., Leonard W. Mayer, Ph.D., and Ruth Lynfield, M.D.Thu, 26  Feb  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/9/886?rss=1&ssource=collectionSearchRss&queryTerm=5A 22-year-old man presented with a 1-month history of severe pubic itch that was worst at night. He had had a new sexual partner 1 week before the onset of...http://content.nejm.org/cgi/content/short/360/8/e11?rss=1&ssource=collectionSearchRss&queryTerm=5Sung Bin Cho, M.D. and Hyung Su Kim, M.D.Thu, 19  Feb  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/8/e11?rss=1&ssource=collectionSearchRss&queryTerm=5Since it was first recognized that hepatitis B virus and HIV can be transmitted from donors to recipients by transfusion, physicians and the public alike have been focused on the...http://content.nejm.org/cgi/content/short/360/7/739?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 12  Feb  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/7/739?rss=1&ssource=collectionSearchRss&queryTerm=5The antimicrobial era began about 75 years ago. Although it is far from over, it is being increasingly challenged by the emergence of resistant microorganisms. Antimicrobial resistance is the inevitable...http://content.nejm.org/cgi/content/short/360/5/550?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 29  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/5/550?rss=1&ssource=collectionSearchRss&queryTerm=5In March 1942, a 33-year-old woman lay dying of streptococcal sepsis in a New Haven, Connecticut, hospital, and despite the best efforts of contemporary medical science, her doctors could not...http://content.nejm.org/cgi/content/short/360/5/439?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 29  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/5/439?rss=1&ssource=collectionSearchRss&queryTerm=5A 24-year-old man who had quadriplegia due to a traumatic spinal cord injury was found on routine surveillance cultures to have methicillin-resistant Staphylococcus aureus (MRSA) colonization of his anterior nares....http://content.nejm.org/cgi/content/short/360/3/e3?rss=1&ssource=collectionSearchRss&queryTerm=5Curtis J. Donskey, M.D. and Brittany C. Eckstein, B.S.Thu, 15  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/3/e3?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. William D. Binder (Emergency Services): A 25-year-old man was transferred to the emergency department of this hospital because of pain and swelling of the right hand and hypotension.<br/><br/>The patient...http://content.nejm.org/cgi/content/short/360/3/281?rss=1&ssource=collectionSearchRss&queryTerm=5Michael R. Filbin, M.D., David C. Ring, M.D., Ph.D., Michael R. Wessels, M.D., Laura L. Avery, M.D., and Richard L. Kradin, M.D.Thu, 15  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/3/281?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Invasive pneumococcal disease declined among children and adults after the introduction of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) in 2000, but its effect on pneumococcal meningitis is unclear.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/360/3/244?rss=1&ssource=collectionSearchRss&queryTerm=5Heather E. Hsu, M.P.H., Kathleen A. Shutt, M.S., Matthew R. Moore, M.D., M.P.H., Bernard W. Beall, Ph.D., Nancy M. Bennett, M.D., Allen S. Craig, M.D., Monica M. Farley, M.D., James H. Jorgensen, Ph.D., Catherine A. Lexau, Ph.D., M.P.H., Susan Petit, M.P.H., Arthur Reingold, M.D., William Schaffner, M.D., Ann Thomas, M.D., Cynthia G. Whitney, M.D., M.P.H., and Lee H. Harrison, M.D.Thu, 15  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/3/244?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Schistosoma japonicum causes an infection involving humans, livestock, and snails and is a significant cause of morbidity in China.<br/><br/><em>Methods:</em> We evaluated a comprehensive control strategy in two intervention villages...http://content.nejm.org/cgi/content/short/360/2/121?rss=1&ssource=collectionSearchRss&queryTerm=5Long-De Wang, M.D., Hong-Gen Chen, Ph.D., Jia-Gang Guo, Ph.D., Xiao-Jun Zeng, M.D., Xian-Lin Hong, Ji-Jie Xiong, Xiao-Hua Wu, M.Sc., Xian-Hong Wang, Ph.D., Li-Ying Wang, Gang Xia, M.Sc., Yang Hao, M.Sc., Daniel P. Chin, M.D., and Xiao-Nong Zhou, Ph.D.Thu, 08  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/2/121?rss=1&ssource=collectionSearchRss&queryTerm=5Schistosomiasis remains one of the world's most prevalent diseases. Despite more than a century of control efforts and the introduction of highly effective antischistosomal drug therapy in the 1980s, the...http://content.nejm.org/cgi/content/short/360/2/106?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 08  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/2/106?rss=1&ssource=collectionSearchRss&queryTerm=5A golden era followed Fleming's discovery of penicillin, during which many novel classes of antibacterial drugs were developed. Most of these antibiotics, such as streptomycin and tetracycline, are derivatives of...http://content.nejm.org/cgi/content/short/360/1/83?rss=1&ssource=collectionSearchRss&queryTerm=5Gordon Dougan, D.Phil.Thu, 01  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/1/83?rss=1&ssource=collectionSearchRss&queryTerm=5A 67-year-old man presented with a 3-month history of fatigue and fever. He had undergone heart transplantation 6 years earlier for idiopathic cardiomyopathy. He reported no weight loss, night sweats,...http://content.nejm.org/cgi/content/short/360/1/72?rss=1&ssource=collectionSearchRss&queryTerm=5Nasia Safdar, M.D., Cybele L. Abad, M.D., Shoba Narayan, M.D., Daniel R. Kaul, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 01  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/1/72?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Selective digestive tract decontamination (SDD) and selective oropharyngeal decontamination (SOD) are infection-prevention measures used in the treatment of some patients in intensive care, but reported effects on patient outcome...http://content.nejm.org/cgi/content/short/360/1/20?rss=1&ssource=collectionSearchRss&queryTerm=5A.M.G.A. de Smet, M.D., J.A.J.W. Kluytmans, M.D., Ph.D., B.S. Cooper, Ph.D., E.M. Mascini, M.D., Ph.D., R.F.J. Benus, M.D., T.S. van der Werf, M.D., Ph.D., J.G. van der Hoeven, M.D., Ph.D., P. Pickkers, M.D., Ph.D., D. Bogaers-Hofman, I.C.P., N.J.M. van der Meer, M.D., Ph.D., A.T. Bernards, M.D., Ph.D., E.J. Kuijper, M.D., Ph.D., J.C.A. Joore, M.D., M.A. Leverstein-van Hall, M.D., Ph.D., A.J.G.H. Bindels, M.D., Ph.D., A.R. Jansz, M.D., R.M.J. Wesselink, M.D., Ph.D., B.M. de Jongh, M.D., Ph.D., P.J.W. Dennesen, M.D., Ph.D., G.J. van Asselt, M.D., Ph.D., L.F. te Velde, M.D., I.H.M.E. Frenay, M.D., Ph.D., K. Kaasjager, M.D., Ph.D., F.H. Bosch, M.D., Ph.D., M. van Iterson, M.D., S.F.T. Thijsen, M.D., Ph.D., G.H. Kluge, M.D., Ph.D., W. Pauw, M.D., J.W. de Vries, M.D., Ph.D., J.A. Kaan, M.D., J.P. Arends, M.D., L.P.H.J. Aarts, M.D., Ph.D., P.D.J. Sturm, M.D., Ph.D., H.I.J. Harinck, M.D., Ph.D., A. Voss, M.D., Ph.D., E.V. Uijtendaal, Pharm.D., H.E.M. Blok, M.Sc., E.S. Thieme Groen, M.D., M.E. Pouw, M.D., C.J. Kalkman, M.D., Ph.D., and M.J.M. Bonten, M.D., Ph.D.Thu, 01  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/1/20?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Aaron Savar (Neuro-Ophthalmology): A 26-year-old man was seen in the Neuro-Ophthalmology Clinic of the Massachusetts Eye and Ear Infirmary (MEEI) because of blurred vision in the right eye.<br/><br/>Approximately 8...http://content.nejm.org/cgi/content/short/359/26/2825?rss=1&ssource=collectionSearchRss&queryTerm=5Dean M. Cestari, M.D., Ralph B. Metson, M.D., Mary E. Cunnane, M.D., and William C. Faquin, M.D., Ph.D.Thu, 25  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/26/2825?rss=1&ssource=collectionSearchRss&queryTerm=5A healthy 35-year-old man presented with small eggs and a brownish lesion on the medial edge of his right big toe (Panel A). Two weeks before presentation, he had returned...http://content.nejm.org/cgi/content/short/359/24/e30?rss=1&ssource=collectionSearchRss&queryTerm=5Michael Muehlstaedt, M.D.Thu, 11  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/24/e30?rss=1&ssource=collectionSearchRss&queryTerm=5To the Editor: Although artemisinins are potent and rapidly acting antimalarial drugs, their widespread use for treating patients with Plasmodium falciparum malaria raises the question of emerging drug resistance.12 Artemisinin...http://content.nejm.org/cgi/content/short/359/24/2619?rss=1&ssource=collectionSearchRss&queryTerm=5Harald Noedl, M.D., Ph.D., Youry Se, M.D., Kurt Schaecher, Ph.D., Bryan L. Smith, M.D., Duong Socheat, M.D., and Mark M. Fukuda, M.D.Thu, 11  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/24/2619?rss=1&ssource=collectionSearchRss&queryTerm=5Wellems and Miller1 wrote of two worlds of malaria: one, of the residents of rural tropical areas in which the disease is endemic, and the other, of travelers to those...http://content.nejm.org/cgi/content/short/359/24/2601?rss=1&ssource=collectionSearchRss&queryTerm=5J. Kevin Baird, Ph.D.Thu, 11  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/24/2601?rss=1&ssource=collectionSearchRss&queryTerm=5An effective human malaria vaccine has been sought for over 70 years, with little success.1 A successful malaria vaccine used in conjunction with other control interventions would help reduce and...http://content.nejm.org/cgi/content/short/359/24/2599?rss=1&ssource=collectionSearchRss&queryTerm=5William E. Collins, Ph.D., and John W. Barnwell, M.P.H., Ph.D.Thu, 11  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/24/2599?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea.<br/><br/><em>Methods:</em> Between April 2005 and July 2007, we conducted an...http://content.nejm.org/cgi/content/short/359/24/2545?rss=1&ssource=collectionSearchRss&queryTerm=5Harin A. Karunajeewa, M.B., B.S., Ivo Mueller, Ph.D., Michele Senn, M.D., Enmoore Lin, Ph.D., Irwin Law, M.B., B.S., P. Servina Gomorrai, Dip.Nurs., Olive Oa, H.E.O., Suzanne Griffin, Dip.Nurs., Kaye Kotab, Dip.Nurs., Penias Suano, B.Sc.Nurs., Nandao Tarongka, Alice Ura, Dulcie Lautu, B.Sc., Madhu Page-Sharp, Ph.D., Rina Wong, B.Sc., Sam Salman, Peter Siba, Ph.D., Kenneth F. Ilett, Ph.D., and Timothy M.E. Davis, D.Phil., M.B., B.S.Thu, 11  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/24/2545?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The RTS,S/AS malaria vaccine is being developed for delivery through the World Health Organization's Expanded Program on Immunization (EPI). We assessed the feasibility of integrating RTS,S/AS02D into a standard...http://content.nejm.org/cgi/content/short/359/24/2533?rss=1&ssource=collectionSearchRss&queryTerm=5Salim Abdulla, M.D., Ph.D., Rolf Oberholzer, M.D., Omar Juma, M.D., Sulende Kubhoja, M.D., M.M.E.D., Francisca Machera, A.M.O., Christopher Membi, A.D.M.L.S., Said Omari, D.M.L.T., Alwisa Urassa, B.P.A., Hassan Mshinda, Ph.D., Ajuza Jumanne, M.D., Nahya Salim, M.D., M.M.E.D., Mwanjaa Shomari, B.Sc., Thomas Aebi, M.D., David M. Schellenberg, M.D., Ph.D., Terrell Carter, M.H.S., Tonya Villafana, Ph.D., M.P.H., Marie-Ange Demoitié, M.Sc., Marie-Claude Dubois, M.Sc., Amanda Leach, M.R.C.P.C.H., Marc Lievens, M.Sc., Johan Vekemans, M.D., Ph.D., Joe Cohen, Ph.D., W. Ripley Ballou, M.D., and Marcel Tanner, Ph.D., M.P.H.Thu, 11  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/24/2533?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Plasmodium falciparum malaria is a pressing global health problem. A previous study of the malaria vaccine RTS,S (which targets the circumsporozoite protein), given with an adjuvant system (AS02A), showed...http://content.nejm.org/cgi/content/short/359/24/2521?rss=1&ssource=collectionSearchRss&queryTerm=5Philip Bejon, Ph.D., John Lusingu, Ph.D., Ally Olotu, M.B., Ch.B., Amanda Leach, M.R.C.P.C.H., Marc Lievens, M.Sc., Johan Vekemans, Ph.D., Salum Mshamu, M.D., Trudie Lang, Ph.D., Jayne Gould, Ph.D., Marie-Claude Dubois, M.Sc., Marie-Ange Demoitié, M.Sc., Jean-Francois Stallaert, B.Sc., Preeti Vansadia, M.H.S., Terrell Carter, M.H.S., Patricia Njuguna, M.D., Ken O. Awuondo, H.N.D., Anangisye Malabeja, M.D., Omar Abdul, M.D., Samwel Gesase, M.D., Neema Mturi, M.R.C.Paed., Chris J. Drakeley, Ph.D., Barbara Savarese, R.N., Tonya Villafana, Ph.D., W. Ripley Ballou, M.D., Joe Cohen, Ph.D., Eleanor M. Riley, Ph.D., Martha M. Lemnge, Ph.D., Kevin Marsh, F.R.C.P., and Lorenz von Seidlein, Ph.D.Thu, 11  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/24/2521?rss=1&ssource=collectionSearchRss&queryTerm=5A 25-year-old woman with a history of depression, mitral-valve prolapse, and migraine headaches presented to a hospital emergency department with a 3-day history of subjective fever, diffuse arthralgia, and severe...http://content.nejm.org/cgi/content/short/359/23/2478?rss=1&ssource=collectionSearchRss&queryTerm=5Michael P. Thomas, M.D., and Andrew Wang, M.D.Thu, 04  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/23/2478?rss=1&ssource=collectionSearchRss&queryTerm=5In the 1950s and 1960s, according to a theory known as the British hypothesis, repeated airway infection and hypersecretion of mucus were thought to be the causes of chronic obstructive...http://content.nejm.org/cgi/content/short/359/22/2355?rss=1&ssource=collectionSearchRss&queryTerm=5Sanjay Sethi, M.D., and Timothy F. Murphy, M.D.Thu, 27  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/22/2355?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Adam B. Cohen (Neurology): A 59-year-old man was admitted to the neurology service of this hospital because of chronic daily headache, fever, and myalgia.<br/><br/>Approximately 6 months earlier, the patient...http://content.nejm.org/cgi/content/short/359/21/2267?rss=1&ssource=collectionSearchRss&queryTerm=5Steven D. Brass, M.D., M.P.H., Marlene L. Durand, M.D.,John H. Stone, M.D., M.P.H., John W. Chen, M.D., Ph.D.,and James R. Stone, M.D., Ph.D.Thu, 20  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/21/2267?rss=1&ssource=collectionSearchRss&queryTerm=5A 49-year-old man presented to the emergency room with a 2-day history of decreased vision in his left eye. He described his vision as “looking through branches in a tree.”...http://content.nejm.org/cgi/content/short/359/20/e25?rss=1&ssource=collectionSearchRss&queryTerm=5Michael A. Albert, Jr., M.D. and Jill R. Wells, M.D.Thu, 13  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/20/e25?rss=1&ssource=collectionSearchRss&queryTerm=5To the Editor: In the United States, the dissemination of a major clone of community-associated methicillin-resistant Staphylococcus aureus (MRSA), designated USA300, and outbreaks of vancomycin-resistant Enterococcus faecalis (VREF) have been...http://content.nejm.org/cgi/content/short/359/20/2177?rss=1&ssource=collectionSearchRss&queryTerm=5Cesar A. Arias, M.D., Ph.D., Sandra Rincon, M.Sc., Shahreen Chowdhury, B.S., Ernesto Martínez, M.D., Wilfrido Coronell, M.D., Jinnethe Reyes, M.Sc., Sreedhar R. Nallapareddy, M.Sc., Ph.D., and Barbara E. Murray, M.D.Thu, 13  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/20/2177?rss=1&ssource=collectionSearchRss&queryTerm=5Did you know that corn originated from weedy teosinte? Or that long before he became the first president of Israel, Chaim Weizmann worked as a biotechnologist in England, where he...http://content.nejm.org/cgi/content/short/359/18/1970?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 30  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/18/1970?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Mary Pisculli (Infectious Disease): A 58-year-old woman was transferred to this hospital because of severe right-sided neck pain, fever, and abnormal findings on cervical magnetic resonance imaging (MRI).<br/><br/>Two to...http://content.nejm.org/cgi/content/short/359/18/1942?rss=1&ssource=collectionSearchRss&queryTerm=5Julie L. Gerberding, M.D., M.P.H., Javier M. Romero, M.D., and Mary Jane Ferraro, Ph.D., M.P.H.Thu, 30  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/18/1942?rss=1&ssource=collectionSearchRss&queryTerm=5In 1935, Hall and O'Toole first isolated a gram-positive, cytotoxin-producing anaerobic bacterium from the stool of healthy neonates.1 They named it Bacillus difficilis to reflect the difficulties they encountered in...http://content.nejm.org/cgi/content/short/359/18/1932?rss=1&ssource=collectionSearchRss&queryTerm=5Ciarán P. Kelly, M.D., and J. Thomas LaMont, M.D.Thu, 30  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/18/1932?rss=1&ssource=collectionSearchRss&queryTerm=5Allogeneic hematopoietic stem-cell transplantation is a potentially lifesaving cancer therapy that, at least temporarily, renders patients highly immunocompromised and vulnerable to infection. Aspergillus fumigatus, a common environmental fungus that causes...http://content.nejm.org/cgi/content/short/359/17/1836?rss=1&ssource=collectionSearchRss&queryTerm=5Eric G. Pamer, M.D.Thu, 23  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/17/1836?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Toll-like receptors (TLRs) are essential components of the immune response to fungal pathogens. We examined the role of TLR polymorphisms in conferring a risk of invasive aspergillosis among recipients...http://content.nejm.org/cgi/content/short/359/17/1766?rss=1&ssource=collectionSearchRss&queryTerm=5Pierre-Yves Bochud, M.D., Jason W. Chien, M.D., Kieren A. Marr, M.D., Wendy M. Leisenring, Sc.D., Arlo Upton, M.D., Marta Janer, Ph.D., Stephanie D. Rodrigues, Sarah Li, John A. Hansen, M.D., Lue Ping Zhao, Ph.D., Alan Aderem, Ph.D., and Michael Boeckh, M.D.Thu, 23  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/17/1766?rss=1&ssource=collectionSearchRss&queryTerm=5In early September, we presented a case of a college athlete with a skin and soft-tissue infection in Clinical Decisions,1 an interactive feature designed to assess how readers would manage...http://content.nejm.org/cgi/content/short/359/15/e20?rss=1&ssource=collectionSearchRss&queryTerm=5Sarah P. Hammond, M.D., and Lindsey R. Baden, M.D.Thu, 09  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/15/e20?rss=1&ssource=collectionSearchRss&queryTerm=5When a healthy volunteer coughs, he expels a turbulent jet of air with density changes that distort a projected schlieren light beam (Panel A). A velocity map early in the...http://content.nejm.org/cgi/content/short/359/15/e19?rss=1&ssource=collectionSearchRss&queryTerm=5Julian W. Tang, F.R.C.Path. and Gary S. Settles, Ph.D.Thu, 09  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/15/e19?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Young infants and pregnant women are at increased risk for serious consequences of influenza infection. Inactivated influenza vaccine is recommended for pregnant women but is not licensed for infants...http://content.nejm.org/cgi/content/short/359/15/1555?rss=1&ssource=collectionSearchRss&queryTerm=5K. Zaman, M.B., B.S., Ph.D., Eliza Roy, M.B., B.S., D.C.H.,Shams E. Arifeen, M.B., B.S., Dr.P.H., Mahbubur Rahman, M.B., B.S., Ph.D., Rubhana Raqib, Ph.D., Emily Wilson, M.H.S., Saad B. Omer, M.B., B.S., Ph.D., Nigar S. Shahid, M.B., B.S., M.P.H., Robert F. Breiman, M.D., and Mark C. Steinhoff, M.D.Thu, 09  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/15/1555?rss=1&ssource=collectionSearchRss&queryTerm=5To the Editor: Dengue, the most common vectorborne viral infection worldwide,1 is predominantly transmitted by the Aedes aegypti mosquito. We describe a well-documented cluster of blood transfusion–associated dengue infections in...http://content.nejm.org/cgi/content/short/359/14/1526?rss=1&ssource=collectionSearchRss&queryTerm=5Paul A. Tambyah, M.B., B.S., Evelyn S.C. Koay, F.R.C.Path., Michelle L.M. Poon, M.R.C.P., Raymond V.T.P. Lin, F.R.C.P.A., and Benjamin K.C. Ong, F.R.C.P.Thu, 02  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/14/1526?rss=1&ssource=collectionSearchRss&queryTerm=5A 58-year-old healthy man was evaluated for a toothache of 2 days' duration. He was treated with oral penicillin and an opiate analgesic and advised to have the affected teeth...http://content.nejm.org/cgi/content/short/359/14/1501?rss=1&ssource=collectionSearchRss&queryTerm=5Jon Heavey, M.D. and Naren Gupta, M.D., Ph.D.Thu, 02  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/14/1501?rss=1&ssource=collectionSearchRss&queryTerm=5A 46-year-old man with Raynaud's disease who emigrated from Cambodia 30 years ago presented with a 2-month history of myalgias, exertional dyspnea, and an elevated level of creatine kinase. An...http://content.nejm.org/cgi/content/short/359/11/e12?rss=1&ssource=collectionSearchRss&queryTerm=5Stephen R. Gorman, D.O., M.S. and Donald E. Craven, M.D.Thu, 11  Sep  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/11/e12?rss=1&ssource=collectionSearchRss&queryTerm=5A 20-year-old college basketball player presents to the emergency department with a 2-day history of a red, painful area on his right buttock. He reports that there was no specific...http://content.nejm.org/cgi/content/short/359/10/1063?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 04  Sep  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/10/1063?rss=1&ssource=collectionSearchRss&queryTerm=5A 30-year-old healthy woman presented with pruritic papules on both arms and breasts. Physical examination revealed multiple erythematous papules in a partially linear pattern. The patient had stayed in a...http://content.nejm.org/cgi/content/short/359/10/1047?rss=1&ssource=collectionSearchRss&queryTerm=5Armin Stucki, M.D. and Roger Ludwig, M.D.Thu, 04  Sep  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/10/1047?rss=1&ssource=collectionSearchRss&queryTerm=5A 64-year-old man was admitted to the hospital because of abdominal pain, nausea, and an elevated level of serum creatinine. The patient had been in his usual state of health...http://content.nejm.org/cgi/content/short/359/9/951?rss=1&ssource=collectionSearchRss&queryTerm=5Theodore I. Steinman, M.D., Anthony E. Samir, M.D., and Lynn D. Cornell, M.D.Thu, 28  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/9/951?rss=1&ssource=collectionSearchRss&queryTerm=5In the wake of Cyclone Nargis, which devastated the Myanmar delta in early May, and the seismic earthquake that shook China shortly thereafter, access to safe drinking water and proper...http://content.nejm.org/cgi/content/short/359/8/784?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 21  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/8/784?rss=1&ssource=collectionSearchRss&queryTerm=5The small intestine is a lush, dynamic organ with a big job to do. Its villi and microvilli provide a platform for nutrient absorption, but at the same time, the...http://content.nejm.org/cgi/content/short/359/7/756?rss=1&ssource=collectionSearchRss&queryTerm=5Maria T. Abreu, M.D.Thu, 14  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/7/756?rss=1&ssource=collectionSearchRss&queryTerm=5A 26-year-old man who smoked and had a long history of poorly controlled asthma and severe environmental allergies was admitted for an exacerbation of asthma. He reported no recent hospitalizations...http://content.nejm.org/cgi/content/short/359/6/e7?rss=1&ssource=collectionSearchRss&queryTerm=5Ting-hsu Chen, M.D. and Helen Hollingsworth, M.D.Thu, 07  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/6/e7?rss=1&ssource=collectionSearchRss&queryTerm=5A 64-year-old Filipino man presented to a Baltimore hospital with a 4-month history of worsening midback pain, progressive leg weakness, and intermittent bladder and bowel incontinence. He had no fever...http://content.nejm.org/cgi/content/short/359/6/628?rss=1&ssource=collectionSearchRss&queryTerm=5Oluwaseun O. Falade, M.D., M.P.H., Emmanuel S. Antonarakis, M.D., Daniel R. Kaul, M.D., Sanjay Saint, M.D., M.P.H., and Patrick A. Murphy, M.D.Thu, 07  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/6/628?rss=1&ssource=collectionSearchRss&queryTerm=5A family of three persons is planning a safari to southern Africa. The itinerary includes 3 days in Cape Town, South Africa, 3 days in Kruger National Park, South Africa,...http://content.nejm.org/cgi/content/short/359/6/603?rss=1&ssource=collectionSearchRss&queryTerm=5David O. Freedman, M.D.Thu, 07  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/6/603?rss=1&ssource=collectionSearchRss&queryTerm=5An 11-month-old boy was admitted to this hospital because of fevers and pulmonary infiltrates. One month before admission, a month after beginning a visit to India with his parents, daily...http://content.nejm.org/cgi/content/short/359/2/178?rss=1&ssource=collectionSearchRss&queryTerm=5Jason B. Harris, M.D., Ian C. Michelow, M.D., Sjirk J. Westra, M.D., and Richard L. Kradin, M.D.Thu, 10  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/2/178?rss=1&ssource=collectionSearchRss&queryTerm=5Infections caused by Staphylococcus aureus, particularly those that are resistant to methicillin and all available β-lactam antibiotics — the so-called methicillin-resistant S. aureus (MRSA) infections — have been declared a...http://content.nejm.org/cgi/content/short/359/1/85?rss=1&ssource=collectionSearchRss&queryTerm=5Robert S. Daum, M.D.Thu, 03  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/1/85?rss=1&ssource=collectionSearchRss&queryTerm=5A 72-year-old man presented with a 3-month history of watery diarrhea. This condition was associated with intermittent fevers, abdominal pain, and weight loss of 15 lb (6.8 kg). The patient...http://content.nejm.org/cgi/content/short/359/1/75?rss=1&ssource=collectionSearchRss&queryTerm=5Eddy Fan, M.D., Christine Soong, M.D., Kevin C. Kain, M.D., and Allan S. Detsky, M.D., Ph.D.Thu, 03  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/1/75?rss=1&ssource=collectionSearchRss&queryTerm=5A 68-year-old man was admitted to the hospital because of headache and loss of vision in the right eye. Orthotopic allogeneic liver transplantation had been performed 3 1/2 months earlier...http://content.nejm.org/cgi/content/short/358/24/2619?rss=1&ssource=collectionSearchRss&queryTerm=5Margaret Seton, M.D., Misha Pless, M.D., Jay A. Fishman, M.D., Paul A. Caruso, M.D., and E. Tessa Hedley-Whyte, M.D.Thu, 12  Jun  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/24/2619?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Widespread infections of avian species with avian influenza H5N1 virus and its limited spread to humans suggest that the virus has the potential to cause a human influenza pandemic....http://content.nejm.org/cgi/content/short/358/24/2573?rss=1&ssource=collectionSearchRss&queryTerm=5Hartmut J. Ehrlich, M.D., Markus Müller, M.D., Helen M.L. Oh, M.D., Paul A. Tambyah, M.B., B.S., Christian Joukhadar, M.D., Emanuele Montomoli, Ph.D., Dale Fisher, F.R.A.C.P., Greg Berezuk, M.S., Sandor Fritsch, Ph.D., Alexandra Löw-Baselli, Ph.D., Nina Vartian, Ph.D., Roman Bobrovsky, Ph.D., Borislava G. Pavlova, Ph.D., Eva Maria Pöllabauer, M.D., Otfried Kistner, Ph.D., and P. Noel Barrett, Ph.D., for the Baxter H5N1 Pandemic Influenza Vaccine Clinical Study TeamThu, 12  Jun  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/24/2573?rss=1&ssource=collectionSearchRss&queryTerm=5The quest for a fully immunogenic vaccine against influenza H5N1 viruses has gone on for more than 10 years, since this family of potentially pandemic viruses emerged as a cause...http://content.nejm.org/cgi/content/short/358/24/2540?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 12  Jun  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/24/2540?rss=1&ssource=collectionSearchRss&queryTerm=5A 19-year-old woman presented to the emergency department with a 10-day history of intermittent odynophagia, voice changes, and fever. Before her visit to the emergency department, she was treated with...http://content.nejm.org/cgi/content/short/358/23/e27?rss=1&ssource=collectionSearchRss&queryTerm=5James F. Fiechtl, M.D. and Lawrence B. Stack, M.D.Thu, 05  Jun  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/23/e27?rss=1&ssource=collectionSearchRss&queryTerm=5This past October, at a scientific conference in Seattle, Bill and Melinda Gates issued a challenge that rocked the international health community. The leaders of the world's richest charitable foundation...http://content.nejm.org/cgi/content/short/358/23/2425?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 05  Jun  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/23/2425?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old bisexual man presented with a few weeks' history of lethargy followed by the onset of a widespread nonpruritic rash that covered much of his body, including the palms...http://content.nejm.org/cgi/content/short/358/20/2160?rss=1&ssource=collectionSearchRss&queryTerm=5Ivan Tonna, M.R.C.P. and Robert B.S. Laing, M.D., F.R.C.P.E.Thu, 15  May  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/20/2160?rss=1&ssource=collectionSearchRss&queryTerm=5A 34-year-old man came to the emergency room with a 3-day history of fevers (peak temperature, 40°C), accompanied by shaking chills. Laboratory tests revealed a hemolytic anemia, with a hemoglobin...http://content.nejm.org/cgi/content/short/358/17/e19?rss=1&ssource=collectionSearchRss&queryTerm=5Kyle Noskoviak, M.D. and Elizabeth Broome, M.D.Thu, 24  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/17/e19?rss=1&ssource=collectionSearchRss&queryTerm=5Malaria, a tremendously successful pathogen that is responsible for more than 300 million cases and 1 million deaths annually,1 has had a large impact on the shape of the human...http://content.nejm.org/cgi/content/short/358/17/1855?rss=1&ssource=collectionSearchRss&queryTerm=5Johanna P. Daily, M.D., and Pardis Sabeti, M.D., Ph.D.Thu, 24  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/17/1855?rss=1&ssource=collectionSearchRss&queryTerm=5An otherwise healthy 30-year-old man had been ill for 2 days when he presented with a temperature of 39°C and reported passing dark urine (his case was noted in Bhatt...http://content.nejm.org/cgi/content/short/358/17/1837?rss=1&ssource=collectionSearchRss&queryTerm=5Martin Tombe, M.D.Thu, 24  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/17/1837?rss=1&ssource=collectionSearchRss&queryTerm=5A previously well, American-born 35-year-old man presents with a 5-day history of fever and progressive dyspnea and a 2-day history of jaundice. An evaluation 3 days before his presentation led...http://content.nejm.org/cgi/content/short/358/17/1829?rss=1&ssource=collectionSearchRss&queryTerm=5Philip J. Rosenthal, M.D.Thu, 24  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/17/1829?rss=1&ssource=collectionSearchRss&queryTerm=5Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and...http://content.nejm.org/cgi/content/short/358/17/1805?rss=1&ssource=collectionSearchRss&queryTerm=5Kodjo Ayi, Ph.D., Gundula Min-Oo, Ph.D., Lena Serghides, Ph.D., Maryanne Crockett, M.D., Melanie Kirby-Allen, M.D., Ian Quirt, M.D., Philippe Gros, Ph.D., and Kevin C. Kain, M.D.Thu, 24  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/17/1805?rss=1&ssource=collectionSearchRss&queryTerm=5Trachoma, a chronic bacterial keratoconjunctivitis, has always been inextricably linked with poverty. It would not even be mentioned in the curricula of many U.S. medical schools today if not for...http://content.nejm.org/cgi/content/short/358/17/1777?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 24  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/17/1777?rss=1&ssource=collectionSearchRss&queryTerm=5A 62-year-old man reported having had fatigue, fever, and cramping abdominal pain for 7 days. He also reported that he had recently eaten raw pond smelt (Hypomesus olidus). The results...http://content.nejm.org/cgi/content/short/358/16/e18?rss=1&ssource=collectionSearchRss&queryTerm=5Do Hyun Park, M.D., Ph.D. and Hyun-Young Son, M.D.Thu, 17  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/16/e18?rss=1&ssource=collectionSearchRss&queryTerm=5A 45-year-old man was admitted to this hospital for orthotopic liver transplantation. The patient had been well until the age of 18 years, when a diagnosis of non-A, non-B hepatitis...http://content.nejm.org/cgi/content/short/358/15/1604?rss=1&ssource=collectionSearchRss&queryTerm=5Jay A. Fishman, M.D., R. Gilberto Gonzalez, M.D., Ph.D., and John A. Branda, M.D.Thu, 10  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/15/1604?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The widespread use of a second dose of mumps vaccine among U.S. schoolchildren beginning in 1990 was followed by historically low reports of mumps cases. A 2010 elimination goal...http://content.nejm.org/cgi/content/short/358/15/1580?rss=1&ssource=collectionSearchRss&queryTerm=5Gustavo H. Dayan, M.D., M. Patricia Quinlisk, M.D., M.P.H., Amy A. Parker, M.S.N., M.P.H., Albert E. Barskey, M.P.H., Meghan L. Harris, M.P.H., Jennifer M. Hill Schwartz, M.P.H., Kae Hunt, B.A., Carol G. Finley, B.S., Dennis P. Leschinsky, B.S., Anne L. O'Keefe, M.D., M.P.H., Joshua Clayton, B.S., Lon K. Kightlinger, Ph.D., M.S.P.H., Eden G. Dietle, B.S., Jeffrey Berg, Cynthia L. Kenyon, M.P.H., Susan T. Goldstein, M.D., Shannon K. Stokley, M.P.H., Susan B. Redd, Paul A. Rota, Ph.D., Jennifer Rota, M.P.H., Daoling Bi, M.S., Sandra W. Roush, M.T., M.P.H., Carolyn B. Bridges, M.D., Tammy A. Santibanez, Ph.D., Umesh Parashar, M.B., B.S., M.P.H., William J. Bellini, Ph.D., and Jane F. Seward, M.B., B.S., M.P.H.Thu, 10  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/15/1580?rss=1&ssource=collectionSearchRss&queryTerm=5A 60-year-old woman presented to the outpatient clinic with vague abdominal discomfort that had developed over the previous several weeks. There was no abdominal tenderness. Laboratory evaluation was notable for...http://content.nejm.org/cgi/content/short/358/14/e16?rss=1&ssource=collectionSearchRss&queryTerm=5Myoung Kuk Jang, M.D. and Ki Sung Lee, M.D.Thu, 03  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/14/e16?rss=1&ssource=collectionSearchRss&queryTerm=5A 79-year-old man with a 5-month history of fatigue and 20-lb (9-kg) weight loss presented to his local physician. The patient also reported intermittent episodes of high temperature, night sweats,...http://content.nejm.org/cgi/content/short/358/14/1496?rss=1&ssource=collectionSearchRss&queryTerm=5Nasia Safdar, M.D., Cybele L. Abad, M.D., Daniel R. Kaul, M.D., David Jarrard, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 03  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/14/1496?rss=1&ssource=collectionSearchRss&queryTerm=5A 60-year-old man infected with the human immunodeficiency virus (HIV) (CD4 count of 450 per cubic millimeter and HIV viral load of <50 copies per milliliter) who had HIV-associated dementia...http://content.nejm.org/cgi/content/short/358/13/e14?rss=1&ssource=collectionSearchRss&queryTerm=5William J. Mason, M.D. and Hilary H. Nickols, M.D., Ph.D.Thu, 27  Mar  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/13/e14?rss=1&ssource=collectionSearchRss&queryTerm=5 08032027.xml 08032027.xml 08032027.xml 08032027.xml Acinetobacter is a gram-negative coccobacillus (Figure 1)12 that during the past three decades has emerged from an organism of questionable pathogenicity to an infectious agent...http://content.nejm.org/cgi/content/short/358/12/1271?rss=1&ssource=collectionSearchRss&queryTerm=5L. Silvia Munoz-Price, M.D., and Robert A. Weinstein, M.D.Thu, 20  Mar  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/12/1271?rss=1&ssource=collectionSearchRss&queryTerm=5Septic shock is one of the most challenging problems in critical care medicine. Shock due to sepsis accounts for many of the deaths in medical and surgical intensive care units.1234...http://content.nejm.org/cgi/content/short/358/9/954?rss=1&ssource=collectionSearchRss&queryTerm=5Joseph E. Parrillo, M.D.Thu, 28  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/9/954?rss=1&ssource=collectionSearchRss&queryTerm=5A 65-year-old woman with a 15-year history of diabetes presented with fever (temperature, 38.5°C), chills, malaise, and a rash on the medial surface of the right thigh, vulva, and lower...http://content.nejm.org/cgi/content/short/358/9/940?rss=1&ssource=collectionSearchRss&queryTerm=5Fone-Ching Hsiao, M.D. and Chang-Hsun Hsieh, M.D.Thu, 28  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/9/940?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized that low-dose vasopressin...http://content.nejm.org/cgi/content/short/358/9/877?rss=1&ssource=collectionSearchRss&queryTerm=5James A. Russell, M.D., Keith R. Walley, M.D., Joel Singer, Ph.D., Anthony C. Gordon, M.B., B.S., M.D., Paul C. Hébert, M.D., D. James Cooper, B.M., B.S., M.D., Cheryl L. Holmes, M.D., Sangeeta Mehta, M.D., John T. Granton, M.D., Michelle M. Storms, B.Sc.N., Deborah J. Cook, M.D., Jeffrey J. Presneill, M.B., B.S., Ph.D., and Dieter Ayers, M.Sc., for the VASST InvestigatorsThu, 28  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/9/877?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Nancy Cibotti-Granof (Medicine): A 46-year-old woman with end-stage renal disease was seen by a rheumatology consultant because of stiffness of her joints and skin.<br/><br/>The patient had been well except...http://content.nejm.org/cgi/content/short/358/8/827?rss=1&ssource=collectionSearchRss&queryTerm=5Jonathan Kay, M.D., Hasan Bazari, M.D., Laura L. Avery, M.D., and Aashiyana F. Koreishi, M.D.Thu, 21  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/8/827?rss=1&ssource=collectionSearchRss&queryTerm=5About 80,000 catheter-related bloodstream infections occur in U.S. intensive care units (ICUs) each year, causing as many as 28,000 deaths and costing the health care system as much as $2.3...http://content.nejm.org/cgi/content/short/358/8/768?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 21  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/8/768?rss=1&ssource=collectionSearchRss&queryTerm=5Acute lower respiratory tract infections are a persistent and pervasive public health problem. They cause a greater burden of disease worldwide than human immunodeficiency virus infection, malaria, cancer, or heart...http://content.nejm.org/cgi/content/short/358/7/716?rss=1&ssource=collectionSearchRss&queryTerm=5Joseph P. Mizgerd, Sc.D.Thu, 14  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/7/716?rss=1&ssource=collectionSearchRss&queryTerm=5Crouplike symptoms develop in a previously healthy 2-year-old girl at 11 p.m. She is seen in an emergency department 2 hours later with a barking cough and, when upset, inspiratory...http://content.nejm.org/cgi/content/short/358/4/384?rss=1&ssource=collectionSearchRss&queryTerm=5James D. Cherry, M.D., M.Sc.Thu, 24  Jan  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/4/384?rss=1&ssource=collectionSearchRss&queryTerm=5A 52-year-old man presented to his primary care physician with dyspnea and cough. For the past 15 years, he had recurrent episodes of cough that were relieved only by intermittent...http://content.nejm.org/cgi/content/short/358/1/70?rss=1&ssource=collectionSearchRss&queryTerm=5Michael E. Ezzie, M.D., William J. Janssen, M.D., James M. O'Brien, M.D., Charity C. Fox, M.D., and Marvin I. Schwarz, M.D.Thu, 03  Jan  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/1/70?rss=1&ssource=collectionSearchRss&queryTerm=5Increasingly potent immunosuppressive agents have dramatically reduced the incidence of rejection of transplanted organs while increasing patients' susceptibility to opportunistic infections and cancer.12 At the same time, patterns of opportunistic...http://content.nejm.org/cgi/content/short/357/25/2601?rss=1&ssource=collectionSearchRss&queryTerm=5Jay A. Fishman, M.D.Thu, 20  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/25/2601?rss=1&ssource=collectionSearchRss&queryTerm=5Death and long-term disabilities are common outcomes of acute bacterial meningitis, especially in developing countries, even when highly effective antibiotic therapy is given. Therefore, improvement in the outcomes of acute...http://content.nejm.org/cgi/content/short/357/24/2507?rss=1&ssource=collectionSearchRss&queryTerm=5Brian M. Greenwood, M.D.Thu, 13  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/24/2507?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In sub-Saharan Africa, bacterial meningitis is common and is associated with a high mortality. Adjuvant therapy with corticosteroids reduces mortality among adults in the developed world, but it has...http://content.nejm.org/cgi/content/short/357/24/2441?rss=1&ssource=collectionSearchRss&queryTerm=5Matthew Scarborough, M.R.C.P., Stephen B. Gordon, M.D., Christopher J.M. Whitty, F.R.C.P., Neil French, Ph.D., Yasin Njalale, Dip.Med.Sci., Alex Chitani, Dip.Med.Sci., Timothy E.A. Peto, Ph.D., David G. Lalloo, F.R.C.P., and Eduard E. Zijlstra, Ph.D.Thu, 13  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/24/2441?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> It is uncertain whether all adults with bacterial meningitis benefit from treatment with adjunctive dexamethasone.<br/><br/><em>Methods:</em> We conducted a randomized, double-blind, placebo-controlled trial of dexamethasone in 435 patients over the...http://content.nejm.org/cgi/content/short/357/24/2431?rss=1&ssource=collectionSearchRss&queryTerm=5Nguyen Thi Hoang Mai, M.D., Tran Thi Hong Chau, M.D., Guy Thwaites, M.D., Ly Van Chuong, M.D., Dinh Xuan Sinh, M.D., Ho Dang Trung Nghia, M.D., Phung Quoc Tuan, M.D., Nguyen Duy Phong, M.D., Nguyen Hoan Phu, M.D., To Song Diep, M.D., Nguyen van Vinh Chau, M.D., Nguyen Minh Duong, M.D., James Campbell, Constance Schultsz, M.D., Chris Parry, M.D., M. Estee Torok, M.D., Nicholas White, F.R.C.P., Nguyen Tran Chinh, M.D., Tran Tinh Hien, M.D., Kasia Stepniewska, Ph.D., and Jeremy J. Farrar, F.R.C.P.Thu, 13  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/24/2431?rss=1&ssource=collectionSearchRss&queryTerm=5A 24-year-old man presented with black discoloration and hairy appearance of his tongue, which he had had for 2 days, and a sore throat. He had been taking ciprofloxacin and...http://content.nejm.org/cgi/content/short/357/23/2388?rss=1&ssource=collectionSearchRss&queryTerm=5Asha Ramsakal, D.O., M.B.S. and Lovpreet Mangat, M.D.Thu, 06  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/23/2388?rss=1&ssource=collectionSearchRss&queryTerm=5In recent weeks, over-the-counter cough and cold medications for children have received unprecedented attention from regulators, physicians, the media, and parents. This scrutiny represents a long-overdue reassessment of products that...http://content.nejm.org/cgi/content/short/357/23/2321?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 06  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/23/2321?rss=1&ssource=collectionSearchRss&queryTerm=5An 81-year-old woman with rheumatoid arthritis, Sjögren's syndrome, and hypertension presented with swelling and pain in the area of the left heel, which had developed suddenly a week after a...http://content.nejm.org/cgi/content/short/357/20/2067?rss=1&ssource=collectionSearchRss&queryTerm=5Harsha Vyas, M.D. and Guha Krishnaswamy, M.D.Thu, 15  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/20/2067?rss=1&ssource=collectionSearchRss&queryTerm=5A 77-year-old right-handed man was admitted to the hospital because of the recent onset of pain in the ear, difficulty speaking, and altered mental status. The patient had been well...http://content.nejm.org/cgi/content/short/357/19/1957?rss=1&ssource=collectionSearchRss&queryTerm=5Martin A. Samuels, M.D., R. Gilberto Gonzalez, M.D., Ph.D., Arthur Y. Kim, M.D., and Anat Stemmer-Rachamimov, M.D.Thu, 08  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/19/1957?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Hepatitis A vaccine administered to persons after exposure to the hepatitis A virus has not been compared directly with immune globulin, which is known to be highly effective in...http://content.nejm.org/cgi/content/short/357/17/1685?rss=1&ssource=collectionSearchRss&queryTerm=5John C. Victor, Ph.D., M.P.H., Arnold S. Monto, M.D., Tatiyana Y. Surdina, M.D., Saida Z. Suleimenova, M.D., Gilberto Vaughan, Ph.D., Omana V. Nainan, Ph.D., Michael O. Favorov, M.D., Ph.D., Harold S. Margolis, M.D., and Beth P. Bell, M.D., M.P.H.Thu, 25  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/17/1685?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The hyper-IgE syndrome (or Job's syndrome) is a rare disorder of immunity and connective tissue characterized by dermatitis, boils, cyst-forming pneumonias, elevated serum IgE levels, retained primary dentition, and...http://content.nejm.org/cgi/content/short/357/16/1608?rss=1&ssource=collectionSearchRss&queryTerm=5Steven M. Holland, M.D., Frank R. DeLeo, Ph.D., Houda Z. Elloumi, Ph.D., Amy P. Hsu, B.A., Gulbu Uzel, M.D., Nina Brodsky, B.S., Alexandra F. Freeman, M.D., Andrew Demidowich, B.A., Joie Davis, A.P.R.N., Maria L. Turner, M.D., Victoria L. Anderson, C.R.N.P., Dirk N. Darnell, M.A., Pamela A. Welch, B.S.N., Douglas B. Kuhns, Ph.D., David M. Frucht, M.D., Harry L. Malech, M.D., John I. Gallin, M.D., Scott D. Kobayashi, Ph.D., Adeline R. Whitney, B.A., Jovanka M. Voyich, Ph.D., James M. Musser, M.D., Ph.D., Cristina Woellner, M.Sc., Alejandro A. Schäffer, Ph.D., Jennifer M. Puck, M.D., and Bodo Grimbacher, M.D.Thu, 18  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/16/1608?rss=1&ssource=collectionSearchRss&queryTerm=5In the first half of the past century, it was thought that asthma was precipitated or prolonged by infection and that infection with several bacteria, including Streptococcus pneumoniae and Haemophilus...http://content.nejm.org/cgi/content/short/357/15/1545?rss=1&ssource=collectionSearchRss&queryTerm=5Erika von Mutius, M.D., M.Sc.Thu, 11  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/15/1545?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Pathological features of the airway in young children with severe recurrent wheeze suggest an association between bacterial colonization and the initiating events of early asthma. We conducted a study...http://content.nejm.org/cgi/content/short/357/15/1487?rss=1&ssource=collectionSearchRss&queryTerm=5Hans Bisgaard, M.D., D.M.Sc., Mette Northman Hermansen, M.D., Frederik Buchvald, M.D., Ph.D., Lotte Loland, M.D., Ph.D., Liselotte Brydensholt Halkjaer, M.D., Ph.D., Klaus Bønnelykke, M.D., Martin Brasholt, M.D., Andreas Heltberg, M.D., Nadja Hawwa Vissing, M.D., Sannie Vester Thorsen, M.Sc., Malene Stage, M.Sc., and Christian Bressen Pipper, M.Sc., Ph.D.Thu, 11  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/15/1487?rss=1&ssource=collectionSearchRss&queryTerm=5Annual administration of inactivated influenza vaccine to older adults has long been recommended by public health authorities.1 The risks of influenza-related complications, hospitalizations, and deaths increase with age, as does...http://content.nejm.org/cgi/content/short/357/14/1439?rss=1&ssource=collectionSearchRss&queryTerm=5John D. Treanor, M.D.Thu, 04  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/14/1439?rss=1&ssource=collectionSearchRss&queryTerm=5A 73-year-old man presented to the emergency department with a 4-day history of nonproductive cough that worsened at night. He did not have fever, chills, headache, myalgias, rhinorrhea, nasal congestion,...http://content.nejm.org/cgi/content/short/357/14/1432?rss=1&ssource=collectionSearchRss&queryTerm=5Paul B. Cornia, M.D., Benjamin A. Lipsky, M.D., Sanjay Saint, M.D., M.P.H., and Ralph Gonzales, M.D., M.S.P.H.Thu, 04  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/14/1432?rss=1&ssource=collectionSearchRss&queryTerm=5 07100428.xml 07100428.xml 07100428.xml 07100428.xml Lyme disease, the most common tick-borne infection in the northern hemisphere, is a serious public health problem. In North America, it is caused exclusively by...http://content.nejm.org/cgi/content/short/357/14/1422?rss=1&ssource=collectionSearchRss&queryTerm=5Henry M. Feder, Jr., M.D., Barbara J.B. Johnson, Ph.D., Susan O'Connell, M.D., Eugene D. Shapiro, M.D., Allen C. Steere, M.D., Gary P. Wormser, M.D., and the Ad Hoc International Lyme Disease GroupThu, 04  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/14/1422?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Reliable estimates of the effectiveness of influenza vaccine among persons 65 years of age and older are important for informed vaccination policies and programs. Short-term studies may provide misleading...http://content.nejm.org/cgi/content/short/357/14/1373?rss=1&ssource=collectionSearchRss&queryTerm=5Kristin L. Nichol, M.D., M.P.H., M.B.A., James D. Nordin, M.D., M.P.H., David B. Nelson, Ph.D., John P. Mullooly, Ph.D., and Eelko Hak, Ph.D.Thu, 04  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/14/1373?rss=1&ssource=collectionSearchRss&queryTerm=5A 76-year-old male nursing home resident with dementia and end-stage renal disease who was undergoing hemodialysis was admitted to the hospital after a syncopal episode that occurred during dialysis. Torsades...http://content.nejm.org/cgi/content/short/357/13/e14?rss=1&ssource=collectionSearchRss&queryTerm=5Jooyun Lee, M.D.Thu, 27  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/13/e14?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Allison L. McDonough (Internal Medicine): A 51-year-old man with a history of gastric cancer was admitted to the hospital because of a new pulmonary lesion.<br/><br/>The patient had been in...http://content.nejm.org/cgi/content/short/357/12/1239?rss=1&ssource=collectionSearchRss&queryTerm=5Edward T. Ryan, M.D., Suzanne L. Aquino, M.D., and Richard L. Kradin, M.D.Thu, 20  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/12/1239?rss=1&ssource=collectionSearchRss&queryTerm=5A 70-year-old man with a history of heart disease, hyperlipidemia, and diabetes mellitus presented at the hospital with a 4-day history of increasing abdominal pain, nausea, and vomiting. The temperature...http://content.nejm.org/cgi/content/short/357/12/1238?rss=1&ssource=collectionSearchRss&queryTerm=5Yogesh Shrestha, M.D. and Steven Trottier, M.D.Thu, 20  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/12/1238?rss=1&ssource=collectionSearchRss&queryTerm=5Although typhoid fever, caused by infection with Salmonella enterica serovar Typhi (often called S. typhi), long ago ceased to be a public health problem in industrialized countries, it is still...http://content.nejm.org/cgi/content/short/357/11/1069?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 13  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/11/1069?rss=1&ssource=collectionSearchRss&queryTerm=5A 64-year-old man with a history of coronary artery disease and peripheral vascular disease was admitted to the hospital with a several-month history of fevers, chills, and fatigue. These symptoms...http://content.nejm.org/cgi/content/short/357/10/1029?rss=1&ssource=collectionSearchRss&queryTerm=5Christopher J. Graber, M.D., M.P.H., Adam S. Lauring, M.D., Ph.D., and Peter V. Chin-Hong, M.D.Thu, 06  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/10/1029?rss=1&ssource=collectionSearchRss&queryTerm=5A healthy 60-year-old woman presented with hematemesis and melena, which she had had for 1 day. Her physical examination was unremarkable, as were the results of routine blood tests. On...http://content.nejm.org/cgi/content/short/357/10/1028?rss=1&ssource=collectionSearchRss&queryTerm=5Wen-Shen Liao, M.D. and Ming Jong Bair, M.D.Thu, 06  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/10/1028?rss=1&ssource=collectionSearchRss&queryTerm=5The neglected tropical diseases are a group of 13 major disabling conditions that are among the most common chronic infections in the world's poorest people. A blueprint for the control...http://content.nejm.org/cgi/content/short/357/10/1018?rss=1&ssource=collectionSearchRss&queryTerm=5Peter J. Hotez, M.D., Ph.D., David H. Molyneux, Ph.D., D.Sc., Alan Fenwick, Ph.D., Jacob Kumaresan, M.B., B.S., Dr.P.H., Sonia Ehrlich Sachs, M.D., Jeffrey D. Sachs, Ph.D., and Lorenzo Savioli, M.D.Thu, 06  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/10/1018?rss=1&ssource=collectionSearchRss&queryTerm=5A 30-year-old primigravida was admitted to the hospital in active spontaneous labor at 39.7 weeks' gestation.<br/><br/>The patient had received prenatal care at this hospital since 11.1 weeks' gestation. She had...http://content.nejm.org/cgi/content/short/357/9/918?rss=1&ssource=collectionSearchRss&queryTerm=5Ronald S. Gibbs, M.D., and Drucilla J. Roberts, M.D.Thu, 30  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/9/918?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. James J. Tolle (Pulmonary and Critical Care Medicine): A 61-year-old man was admitted to this hospital because of recurrent fevers. He had been well until approximately 3.5 months earlier,...http://content.nejm.org/cgi/content/short/357/8/807?rss=1&ssource=collectionSearchRss&queryTerm=5Gregg S. Meyer, M.D., Charles A. Hales, M.D., Philip C. Amrein, M.D., Amita Sharma, M.D., and Richard L. Kradin, M.D.Thu, 23  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/8/807?rss=1&ssource=collectionSearchRss&queryTerm=5An enormous array of adaptive mechanisms on both sides of the host–microbial interface reflects a complex coevolution. Deciphering the cross-talk at this interface may yield new insights into its relevance...http://content.nejm.org/cgi/content/short/357/7/708?rss=1&ssource=collectionSearchRss&queryTerm=5Clara Abraham, M.D., and Judy H. Cho, M.D.Thu, 16  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/7/708?rss=1&ssource=collectionSearchRss&queryTerm=5The ultrasound system used by bats, dolphins, and whales has developed into a technology that has found numerous applications in diverse fields, including the biomedical domain, where it has been...http://content.nejm.org/cgi/content/short/357/7/705?rss=1&ssource=collectionSearchRss&queryTerm=5Francis A. Waldvogel, M.D.Thu, 16  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/7/705?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Culturing of samples of periprosthetic tissue is the standard method used for the microbiologic diagnosis of prosthetic-joint infection, but this method is neither sensitive nor specific. In prosthetic-joint infection,...http://content.nejm.org/cgi/content/short/357/7/654?rss=1&ssource=collectionSearchRss&queryTerm=5Andrej Trampuz, M.D., Kerryl E. Piper, M.S., Melissa J. Jacobson, A.S., Arlen D. Hanssen, M.D., Krishnan K. Unni, M.D., Douglas R. Osmon, M.D., Jayawant N. Mandrekar, Ph.D., Franklin R. Cockerill, M.D., James M. Steckelberg, M.D., James F. Greenleaf, Ph.D., and Robin Patel, M.D.Thu, 16  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/7/654?rss=1&ssource=collectionSearchRss&queryTerm=5A healthy 26-year-old driver had routine laboratory tests performed to renew his driver's license. Hematuria (3+) was incidentally noted. He reported having had no urinary tract symptoms. Abdominal radiography of...http://content.nejm.org/cgi/content/short/357/6/e7?rss=1&ssource=collectionSearchRss&queryTerm=5Yahya Daneshbod, M.D.Thu, 09  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/6/e7?rss=1&ssource=collectionSearchRss&queryTerm=5A 36-year-old pregnant woman at 21 weeks of gestation presented with a 4-week history of a dry, nonproductive cough. The patient said she had no fever, chills, dyspnea, chest pain,...http://content.nejm.org/cgi/content/short/357/5/489?rss=1&ssource=collectionSearchRss&queryTerm=5Wendy W. Yeh, M.D., Sanjay Saint, M.D., M.P.H., and Steven E. Weinberger, M.D.Thu, 02  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/5/489?rss=1&ssource=collectionSearchRss&queryTerm=5A 54-year-old woman presented with a sudden onset of fever (temperature, 39.3°C) and erythema on the right breast and right arm (Panel A) and on the right side of the...http://content.nejm.org/cgi/content/short/357/5/488?rss=1&ssource=collectionSearchRss&queryTerm=5Gheorghe Peltecu, M.D., Ph.D.Thu, 02  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/5/488?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Epidemiologic studies of the prevalence of rheumatic heart disease have used clinical screening with echocardiographic confirmation of suspected cases. We hypothesized that echocardiographic screening of all surveyed children would...http://content.nejm.org/cgi/content/short/357/5/470?rss=1&ssource=collectionSearchRss&queryTerm=5Eloi Marijon, M.D., Phalla Ou, M.D., David S. Celermajer, Ph.D., F.R.A.C.P., Beatriz Ferreira, M.D., Ph.D., Ana Olga Mocumbi, M.D., Dinesh Jani, M.D., Christophe Paquet, M.D., M.P.H., Sophie Jacob, Ph.D., Daniel Sidi, M.D., Ph.D., and Xavier Jouven, M.D., Ph.D.Thu, 02  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/5/470?rss=1&ssource=collectionSearchRss&queryTerm=5Only 30 or 40 years ago, rheumatic fever was a common topic in the Journal. A PubMed search for articles on rheumatic fever published between 1967 and 1976 returned 55...http://content.nejm.org/cgi/content/short/357/5/439?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 02  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/5/439?rss=1&ssource=collectionSearchRss&queryTerm=5The recent case of Atlanta attorney Andrew Speaker has focused attention on the role of compulsory isolation and quarantine in tuberculosis control. In May, after being diagnosed with a drug-resistant...http://content.nejm.org/cgi/content/short/357/5/433?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 02  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/5/433?rss=1&ssource=collectionSearchRss&queryTerm=5A 37-year-old man presents for the evaluation of localized swelling and tenderness of the left leg just below the knee. He suspects this lesion developed after a spider bite, although...http://content.nejm.org/cgi/content/short/357/4/380?rss=1&ssource=collectionSearchRss&queryTerm=5Robert S. Daum, M.D., C.M.Thu, 26  Jul  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/4/380?rss=1&ssource=collectionSearchRss&queryTerm=5A 57-year-old man who had end-stage renal disease was admitted to the hospital because of infection of a left-upper-extremity fistula. Vancomycin was started empirically, and blood cultures grew methicillin-resistant Staphylococcus...http://content.nejm.org/cgi/content/short/357/2/163?rss=1&ssource=collectionSearchRss&queryTerm=5Elizabeth H. Burgess, M.D. and Luis Fernando Mora Vieira, M.D.Thu, 12  Jul  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/2/163?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Surgeons in training are at high risk for needlestick injuries. The reporting of such injuries is a critical step in initiating early prophylaxis or treatment.<br/><br/><em>Methods:</em> We surveyed surgeons in...http://content.nejm.org/cgi/content/short/356/26/2693?rss=1&ssource=collectionSearchRss&queryTerm=5Martin A. Makary, M.D., M.P.H., Ali Al-Attar, M.D., Ph.D., Christine G. Holzmueller, B.A., J. Bryan Sexton, Ph.D., Dora Syin, B.S., Marta M. Gilson, Ph.D., Mark S. Sulkowski, M.D., and Peter J. Pronovost, M.D., Ph.D.Thu, 28  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/26/2693?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Maxwell T. Vergo (Department of Medicine): A 19-year-old woman was transferred to this hospital because of joint pain, fever, and hypotension.<br/><br/>The patient, a freshman student at a local university,...http://content.nejm.org/cgi/content/short/356/25/2631?rss=1&ssource=collectionSearchRss&queryTerm=5Benjamin T. Davis, M.D., and Mark S. Pasternack, M.D.Thu, 21  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/25/2631?rss=1&ssource=collectionSearchRss&queryTerm=5Entecavir, a drug approved by the Food and Drug Administration for the treatment of chronic hepatitis B virus (HBV) infection, is not believed to inhibit replication of human immunodeficiency virus...http://content.nejm.org/cgi/content/short/356/25/2614?rss=1&ssource=collectionSearchRss&queryTerm=5Moira A. McMahon, B.S., Benjamin L. Jilek, B.S., Timothy P. Brennan, M.S., Lin Shen, M.D., Yan Zhou, Ph.D., Megan Wind-Rotolo, Ph.D., Sifei Xing, B.S., Shridhar Bhat, Ph.D., Braden Hale, M.D., Robert Hegarty, M.S.N., Curtis R. Chong, M.Phil., Jun O. Liu, Ph.D., Robert F. Siliciano, M.D., Ph.D., and Chloe L. Thio, M.D.Thu, 21  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/25/2614?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Visceral leishmaniasis (kala-azar) affects large, rural, resource-poor populations in South Asia, Africa, and Brazil. Safe, effective, and affordable new therapies are needed. We conducted a randomized, controlled, phase 3...http://content.nejm.org/cgi/content/short/356/25/2571?rss=1&ssource=collectionSearchRss&queryTerm=5Shyam Sundar, M.D., T.K. Jha, M.D., Chandreshwar P. Thakur, M.D., Prabhat K. Sinha, M.D., and Sujit K. Bhattacharya, M.D.Thu, 21  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/25/2571?rss=1&ssource=collectionSearchRss&queryTerm=5It is hard to overstate the medical importance and burden of vector-transmitted infectious diseases. Whether the metric used is mortality (malaria, for example, kills 1 million to 2 million people...http://content.nejm.org/cgi/content/short/356/25/2567?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 21  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/25/2567?rss=1&ssource=collectionSearchRss&queryTerm=5Guinea worm disease, or dracunculiasis — Latin for “affliction with little dragons” — is a plague so ancient that it has been found in Egyptian mummies and has been proposed...http://content.nejm.org/cgi/content/short/356/25/2561?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 21  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/25/2561?rss=1&ssource=collectionSearchRss&queryTerm=5A 53-year-old man with crohn's disease, short-bowel syndrome that required total parenteral nutrition, a history of recurrent catheter infections, hypertension, chronic renal insufficiency, and mitral regurgitation presented with fevers of...http://content.nejm.org/cgi/content/short/356/24/e25?rss=1&ssource=collectionSearchRss&queryTerm=5Parul Bhargava, M.B., B.S. and Lorinda P. Longhi, B.S., M.T.Thu, 14  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/24/e25?rss=1&ssource=collectionSearchRss&queryTerm=5For three decades, antifungal chemotherapy was dominated by a single effective fungicidal agent: amphotericin B deoxycholate. However, concern about toxicity profoundly limited its use. The 1990s saw the introduction of...http://content.nejm.org/cgi/content/short/356/24/2525?rss=1&ssource=collectionSearchRss&queryTerm=5Jack D. Sobel, M.D., and Sanjay G. Revankar, M.D.Thu, 14  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/24/2525?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Invasive candida infections are a major cause of morbidity and mortality in preterm infants. We performed a multicenter, randomized, double-blind, placebo-controlled trial of fluconazole for the prevention of fungal...http://content.nejm.org/cgi/content/short/356/24/2483?rss=1&ssource=collectionSearchRss&queryTerm=5Paolo Manzoni, M.D., Ilaria Stolfi, M.D., Lorenza Pugni, M.D., Lidia Decembrino, M.D., Cristiana Magnani, M.D., Gennaro Vetrano, M.D., Elisabetta Tridapalli, M.D., Giuseppina Corona, M.D., Chiara Giovannozzi, M.D., Daniele Farina, M.D., Riccardo Arisio, M.D., Franco Merletti, M.D., Ph.D., Milena Maule, M.D., Fabio Mosca, M.D., Ph.D., Roberto Pedicino, M.D., Mauro Stronati, M.D., Michael Mostert, M.D., and Giovanna Gomirato, M.D., for the Italian Task Force for the Study and Prevention of Neonatal Fungal Infections and the Italian Society of NeonatologyThu, 14  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/24/2483?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Anidulafungin, a new echinocandin, has potent activity against candida species. We compared anidulafungin with fluconazole in a randomized, double-blind, noninferiority trial of treatment for invasive candidiasis.<br/><br/><em>Methods:</em> Adults with invasive...http://content.nejm.org/cgi/content/short/356/24/2472?rss=1&ssource=collectionSearchRss&queryTerm=5Annette C. Reboli, M.D., Coleman Rotstein, M.D., Peter G. Pappas, M.D., Stanley W. Chapman, M.D., Daniel H. Kett, M.D., Deepali Kumar, M.D., Robert Betts, M.D., Michele Wible, M.S., Beth P. Goldstein, Ph.D., Jennifer Schranz, M.D., David S. Krause, M.D., and Thomas J. Walsh, M.D., for the Anidulafungin Study GroupThu, 14  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/24/2472?rss=1&ssource=collectionSearchRss&queryTerm=5A 34-year-old black woman presented to a walk-in clinic with a 3-day history of malaise. Her colleagues had noticed yellowing of her eyes over the past few days. The patient...http://content.nejm.org/cgi/content/short/356/23/2407?rss=1&ssource=collectionSearchRss&queryTerm=5Clinton L. Greenstone, M.D., Sanjay Saint, M.D., M.P.H., and Richard H. Moseley, M.D.Thu, 07  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/23/2407?rss=1&ssource=collectionSearchRss&queryTerm=5Bartonella species cause serious human infections globally, including bacillary angiomatosis, Oroya fever, trench fever, and endocarditis. We describe a patient who had fever and splenomegaly after traveling to Peru and...http://content.nejm.org/cgi/content/short/356/23/2381?rss=1&ssource=collectionSearchRss&queryTerm=5Marina E. Eremeeva, M.D., Ph.D., Helen L. Gerns, B.A., Shari L. Lydy, Ph.D., Jeanna S. Goo, B.S., Edward T. Ryan, M.D., Smitha S. Mathew, B.S., Mary Jane Ferraro, Ph.D., Judith M. Holden, M.P.H., William L. Nicholson, Ph.D., Gregory A. Dasch, Ph.D., and Jane E. Koehler, M.D.Thu, 07  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/23/2381?rss=1&ssource=collectionSearchRss&queryTerm=5Careful microbiologic evaluation of patients with various illnesses has led to the discovery of many important pathogens in recent decades, including human immunodeficiency virus (HIV), legionella species, Borrelia burgdorferi (the...http://content.nejm.org/cgi/content/short/356/23/2346?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 07  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/23/2346?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Surajit Nundy (Department of Medicine): A 25-year-old woman was admitted to this hospital because of a 5-month history of relapsing fevers and a 3-day history of dyspnea. She had...http://content.nejm.org/cgi/content/short/356/22/2313?rss=1&ssource=collectionSearchRss&queryTerm=5Christopher P. Stowell, M.D., Ph.D., Jeffrey A. Gelfand, M.D., Jo-Anne O. Shepard, M.D., and Alexander Kratz, M.D., Ph.D.Thu, 31  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/22/2313?rss=1&ssource=collectionSearchRss&queryTerm=5A 20-year-old woman with asthma was taken to the emergency room of another hospital because of cardiorespiratory arrest. The patient had had severe asthma since childhood. She was born after...http://content.nejm.org/cgi/content/short/356/20/2083?rss=1&ssource=collectionSearchRss&queryTerm=5Michael E. Wechsler, M.D., M.M.Sc., Jo-Anne O. Shepard, M.D., and Eugene J. Mark, M.D.Thu, 17  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/20/2083?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old male physician was seen in August because of a 1-week history of fever and night sweats. The night sweats required at least one nightly change of his pajamas...http://content.nejm.org/cgi/content/short/356/18/1871?rss=1&ssource=collectionSearchRss&queryTerm=5Daniel R. Kaul, M.D., Mark B. Orringer, M.D., Sanjay Saint, M.D., M.P.H., and Stephen R. Jones, M.D.Thu, 03  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/18/1871?rss=1&ssource=collectionSearchRss&queryTerm=5A 20-year-old man, who had long-standing end-stage renal disease and was receiving peritoneal dialysis, presented with fever and abdominal pain. The patient began peritoneal dialysis at the age of 4...http://content.nejm.org/cgi/content/short/356/17/e16?rss=1&ssource=collectionSearchRss&queryTerm=5Phillip H. Kuo, M.D., Ph.D. and Myung Soo Shin, M.D., D.Sc.Thu, 26  Apr  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/17/e16?rss=1&ssource=collectionSearchRss&queryTerm=5Three years ago, the Food and Drug Administration (FDA) approved the drug Ketek (telithromycin), lauding it as the first of a new class of antimicrobial agents that circumvent antibiotic resistance....http://content.nejm.org/cgi/content/short/356/16/1601?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 19  Apr  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/16/1601?rss=1&ssource=collectionSearchRss&queryTerm=5A 59-year-old man was admitted to this hospital in late summer because of back pain, weakness in the right arm, and cranial-nerve palsies.<br/><br/>The patient was in his usual state of...http://content.nejm.org/cgi/content/short/356/15/1561?rss=1&ssource=collectionSearchRss&queryTerm=5David M. Greer, M.D., M.A., Pamela W. Schaefer, M.D., Scott R. Plotkin, M.D., Ph.D., Robert P. Hasserjian, M.D., and Allen C. Steere, M.D.Thu, 12  Apr  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/15/1561?rss=1&ssource=collectionSearchRss&queryTerm=5A 49-year-old man came to the clinic with a 1-week history of suprapubic pain and fever. On examination, he had a temperature of 38.1°C but appeared well. A urinalysis revealed...http://content.nejm.org/cgi/content/short/356/14/1456?rss=1&ssource=collectionSearchRss&queryTerm=5Brook Watts, M.D., Pushkar Argekar, M.D., Sanjay Saint, M.D., M.P.H., and Carol A. Kauffman, M.D.Thu, 05  Apr  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/14/1456?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Steven J. Russell (Medicine): A 48-year-old man was admitted to this hospital in the early spring because of a 20-hour history of chest pain. The pain was substernal and...http://content.nejm.org/cgi/content/short/356/11/1153?rss=1&ssource=collectionSearchRss&queryTerm=5Gregory D. Lewis, M.D., Charles B. Holmes, M.D., M.P.H., Godtfred Holmvang, M.D., and Joan R. Butterton, M.D.Thu, 15  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/11/1153?rss=1&ssource=collectionSearchRss&queryTerm=5A 79-year-old woman presented with a 1-month history of dyspnea and a cough productive of yellow sputum. She reported no chest pain, hemoptysis, night sweats, or fever. Three months earlier,...http://content.nejm.org/cgi/content/short/356/9/943?rss=1&ssource=collectionSearchRss&queryTerm=5Nasia Safdar, M.D., Daniel R. Kaul, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 01  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/9/943?rss=1&ssource=collectionSearchRss&queryTerm=5An afebrile 8-year-old Ethiopian girl presented with a limp. Two years earlier, she had had mild trauma followed by “bone infection” and had received short courses of oral antibiotics. Examination...http://content.nejm.org/cgi/content/short/356/8/e7?rss=1&ssource=collectionSearchRss&queryTerm=5Avigdor Hevroni, M.D. and Benjamin Z. Koplewitz, M.D.Thu, 22  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/8/e7?rss=1&ssource=collectionSearchRss&queryTerm=5In 2006, an outbreak of chikungunya fever — an arthralgic disease caused by a mosquito-borne alphavirus — swept over a number of islands in the Indian Ocean (the Comoros, Mauritius,...http://content.nejm.org/cgi/content/short/356/8/769?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 22  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/8/769?rss=1&ssource=collectionSearchRss&queryTerm=5Two quite different influenza vaccines are now licensed for use in the United States — a trivalent inactivated influenza vaccine that is administered intramuscularly and a live attenuated influenza vaccine...http://content.nejm.org/cgi/content/short/356/7/729?rss=1&ssource=collectionSearchRss&queryTerm=5Nancy J. Cox, Ph.D., and Carolyn Buxton Bridges, M.D.Thu, 15  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/7/729?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Julie E. Myers (Department of Medicine): A 53-year-old man with a prosthetic aortic valve was admitted to this hospital because of the recent onset of fatigue, dyspnea, weight loss,...http://content.nejm.org/cgi/content/short/356/7/715?rss=1&ssource=collectionSearchRss&queryTerm=5Didier Raoult, M.D., Suhny Abbara, M.D., Davinder S. Jassal, M.D., and Richard L. Kradin, M.D.Thu, 15  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/7/715?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Universal vaccination of children 6 to 59 months of age with trivalent inactivated influenza vaccine has recently been recommended by U.S. advisory bodies. To evaluate alternative vaccine approaches, we...http://content.nejm.org/cgi/content/short/356/7/685?rss=1&ssource=collectionSearchRss&queryTerm=5Robert B. Belshe, M.D., Kathryn M. Edwards, M.D., Timo Vesikari, M.D., Steven V. Black, M.D., Robert E. Walker, M.D., Micki Hultquist, M.S., George Kemble, Ph.D., and Edward M. Connor, M.D., for the CAIV-T Comparative Efficacy Study GroupThu, 15  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/7/685?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Treatment of acute Kawasaki disease with intravenous immune globulin and aspirin reduces the risk of coronary-artery abnormalities and systemic inflammation, but despite intravenous immune globulin therapy, coronary-artery abnormalities develop...http://content.nejm.org/cgi/content/short/356/7/663?rss=1&ssource=collectionSearchRss&queryTerm=5Jane W. Newburger, M.D., M.P.H., Lynn A. Sleeper, Sc.D., Brian W. McCrindle, M.D., M.P.H., L. LuAnn Minich, M.D., Welton Gersony, M.D., Victoria L. Vetter, M.D., Andrew M. Atz, M.D., Jennifer S. Li, M.D., Masato Takahashi, M.D., Annette L. Baker, M.S.N., P.N.P., Steven D. Colan, M.D., Paul D. Mitchell, M.S., Gloria L. Klein, M.S., R.D., and Robert P. Sundel, M.D., for the Pediatric Heart Network InvestigatorsThu, 15  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/7/663?rss=1&ssource=collectionSearchRss&queryTerm=5Two generations of clinicians and researchers have been stumped by the riddle of Kawasaki disease. How can an illness look like an infectious disease but not have a recoverable agent;...http://content.nejm.org/cgi/content/short/356/7/659?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 15  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/7/659?rss=1&ssource=collectionSearchRss&queryTerm=5A 19-year-old woman underwent five cycles of chemotherapy for acute myelomonocytic leukemia that had been diagnosed 7 months earlier. During the last cycle of chemotherapy, neutropenia developed, lasting 22 days,...http://content.nejm.org/cgi/content/short/356/4/e4?rss=1&ssource=collectionSearchRss&queryTerm=5Nermin Halkic, M.D. and Riadh Ksontini, M.D.Thu, 25  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/4/e4?rss=1&ssource=collectionSearchRss&queryTerm=5Invasive fungal diseases contribute substantially to death and illness associated with the prolonged, profound neutropenia resulting from intensive chemotherapy for hematologic cancers and from myeloablation for allogeneic hematopoietic stem-cell transplantation....http://content.nejm.org/cgi/content/short/356/4/409?rss=1&ssource=collectionSearchRss&queryTerm=5Ben E. De Pauw, M.D., and J. Peter Donnelly, Ph.D.Thu, 25  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/4/409?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Patients with neutropenia resulting from chemotherapy for acute myelogenous leukemia or the myelodysplastic syndrome are at high risk for difficult-to-treat and often fatal invasive fungal infections.<br/><br/><em>Methods:</em> In this randomized,...http://content.nejm.org/cgi/content/short/356/4/348?rss=1&ssource=collectionSearchRss&queryTerm=5Oliver A. Cornely, M.D., Johan Maertens, M.D., Drew J. Winston, M.D., John Perfect, M.D., Andrew J. Ullmann, M.D., Thomas J. Walsh, M.D., David Helfgott, M.D., Jerzy Holowiecki, M.D., Dick Stockelberg, M.D., Yeow-Tee Goh, M.D., Mario Petrini, M.D., Cathy Hardalo, M.D., Ramachandran Suresh, Ph.D., and David Angulo-Gonzalez, M.D.Thu, 25  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/4/348?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Invasive fungal infections are an important cause of morbidity and mortality after allogeneic hematopoietic stem-cell transplantation.<br/><br/><em>Methods:</em> In an international, randomized, double-blind trial, we compared oral posaconazole with oral fluconazole...http://content.nejm.org/cgi/content/short/356/4/335?rss=1&ssource=collectionSearchRss&queryTerm=5Andrew J. Ullmann, M.D., Jeffrey H. Lipton, M.D., David H. Vesole, M.D., Ph.D., Pranatharthi Chandrasekar, M.D., Amelia Langston, M.D., Stefano R. Tarantolo, M.D., Hildegard Greinix, M.D., Wellington Morais de Azevedo, M.D., Ph.D., Vijay Reddy, M.D., Navdeep Boparai, M.S., Lisa Pedicone, Ph.D., Hernando Patino, M.D., and Simon Durrant, M.D.Thu, 25  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/4/335?rss=1&ssource=collectionSearchRss&queryTerm=5In a ceremony held at the New York Public Library on June 26, 2006, Microsoft founder and global health philanthropist Bill Gates expressed his belief that “there is no reason...http://content.nejm.org/cgi/content/short/356/3/209?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 18  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/3/209?rss=1&ssource=collectionSearchRss&queryTerm=5November 2, 2006: the Boston Globe reports an outbreak of whooping cough affecting one patient and 15 staff members at Boston Children's Hospital; 60 other staff members have respiratory symptoms...http://content.nejm.org/cgi/content/short/356/2/110?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 11  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/2/110?rss=1&ssource=collectionSearchRss&queryTerm=5A 45-year-old woman from northern Ontario presented to her local hospital with a 2-year history of asymmetric migratory arthralgias involving the left knee, ankles, elbows, and fingers. She also had...http://content.nejm.org/cgi/content/short/356/1/68?rss=1&ssource=collectionSearchRss&queryTerm=5Jeremy Jones, M.D., Hillar Vellend, M.D., Allan S. Detsky, M.D., Ph.D., and Ophyr Mourad, M.D., M.Sc.Thu, 04  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/1/68?rss=1&ssource=collectionSearchRss&queryTerm=5The discovery of Whipple's disease and its causative bacterium, Tropheryma whipplei, is a prime example of how modern technologies have contributed to medical knowledge. Although Whipple's disease was first described...http://content.nejm.org/cgi/content/short/356/1/55?rss=1&ssource=collectionSearchRss&queryTerm=5Florence Fenollar, M.D., Ph.D., Xavier Puéchal, M.D., Ph.D., and Didier Raoult, M.D., Ph.D.Thu, 04  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/1/55?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> An estimated 1.4 million salmonella infections occur annually in the United States. The majority of these infections are foodborne, but many are acquired by contact with animals. In August...http://content.nejm.org/cgi/content/short/356/1/21?rss=1&ssource=collectionSearchRss&queryTerm=5Stephen J. Swanson, M.D., Cynthia Snider, M.H.S., Christopher R. Braden, M.D., David Boxrud, M.Sc., Arno Wünschmann, D.V.M., Jo Ann Rudroff, Jana Lockett, and Kirk E. Smith, D.V.M., Ph.D.Thu, 04  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/1/21?rss=1&ssource=collectionSearchRss&queryTerm=5Each year, 36 million patients are admitted to acute care hospitals in the United States, staying for 164 million days.1 Eleven percent (18 million days) of these hospitalizations are spent...http://content.nejm.org/cgi/content/short/355/26/2781?rss=1&ssource=collectionSearchRss&queryTerm=5Richard P. Wenzel, M.D., and Michael B. Edmond, M.D.Thu, 28  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/26/2781?rss=1&ssource=collectionSearchRss&queryTerm=5Humans have innate immunity against Trypanosoma brucei brucei that is known to involve apolipoprotein L-I (APOL1). Recently, a case of T. evansi infection in a human was identified in India....http://content.nejm.org/cgi/content/short/355/26/2752?rss=1&ssource=collectionSearchRss&queryTerm=5Benoit Vanhollebeke, Eng., Philippe Truc, Ph.D., Philippe Poelvoorde, M.Sc., Annette Pays, M.Sc., Prashant P. Joshi, M.D., Ravindra Katti, M.D., Jean G. Jannin, M.D., and Etienne Pays, Ph.D.Thu, 28  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/26/2752?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal.<br/><br/><em>Methods:</em> We conducted a collaborative cohort study predominantly in ICUs in Michigan. An evidence-based...http://content.nejm.org/cgi/content/short/355/26/2725?rss=1&ssource=collectionSearchRss&queryTerm=5Peter Pronovost, M.D., Ph.D., Dale Needham, M.D., Ph.D., Sean Berenholtz, M.D., David Sinopoli, M.P.H., M.B.A., Haitao Chu, M.D., Ph.D., Sara Cosgrove, M.D., Bryan Sexton, Ph.D., Robert Hyzy, M.D., Robert Welsh, M.D., Gary Roth, M.D., Joseph Bander, M.D., John Kepros, M.D., and Christine Goeschel, R.N., M.P.A.Thu, 28  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/26/2725?rss=1&ssource=collectionSearchRss&queryTerm=5A 21-year-old woman with human immunodeficiency virus infection and a CD4 count of 400 cells per cubic millimeter who was not receiving antiretroviral therapy presented with a 1-week history of...http://content.nejm.org/cgi/content/short/355/25/e27?rss=1&ssource=collectionSearchRss&queryTerm=5Ju-Yi Chen, M.D. and Yi-Heng Li, M.D., Ph.D.Thu, 21  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/25/e27?rss=1&ssource=collectionSearchRss&queryTerm=5In this issue of the Journal, Heyland et al., writing for the Canadian Critical Care Trials Group, report the results of a multicenter, randomized trial comparing the use of bronchoalveolar...http://content.nejm.org/cgi/content/short/355/25/2691?rss=1&ssource=collectionSearchRss&queryTerm=5Marin H. Kollef, M.D.Thu, 21  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/25/2691?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Sherry Chou (Neurology): A 24-year-old woman was transferred to this hospital because of seizures and a lesion in the brain.<br/><br/>A diagnosis of systemic lupus erythematosus (SLE) had been made...http://content.nejm.org/cgi/content/short/355/25/2678?rss=1&ssource=collectionSearchRss&queryTerm=5Jang-Ho J. Cha, M.D., Ph.D., Karen Furie, M.D., Jonathan Kay, M.D., Rochelle P. Walensky, M.D., M.P.H., Mark E. Mullins, M.D., Ph.D., and E. Tessa Hedley-Whyte, M.D.Thu, 21  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/25/2678?rss=1&ssource=collectionSearchRss&queryTerm=5A 32-year-old man infected with the human immunodeficiency virus (HIV) who had a CD4 count of 9 cells per cubic millimeter had a 9-month history of weight loss, with progressive...http://content.nejm.org/cgi/content/short/355/25/2677?rss=1&ssource=collectionSearchRss&queryTerm=5Gleusa Castro, M.D. and Roberto Martinez, M.D.Thu, 21  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/25/2677?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Critically ill patients who require mechanical ventilation are at risk for ventilator-associated pneumonia. Current data are conflicting as to the optimal diagnostic approach in patients who have suspected ventilator-associated...http://content.nejm.org/cgi/content/short/355/25/2619?rss=1&ssource=collectionSearchRss&queryTerm=5The Canadian Critical Care Trials GroupThu, 21  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/25/2619?rss=1&ssource=collectionSearchRss&queryTerm=5A 44-year-old woman with chronic hepatitis C has intermittent fatigue and persistent elevations in serum alanine aminotransferase levels. She has had hepatitis C for 10 years. The diagnosis was made...http://content.nejm.org/cgi/content/short/355/23/2444?rss=1&ssource=collectionSearchRss&queryTerm=5Jay H. Hoofnagle, M.D., and Leonard B. Seeff, M.D.Thu, 07  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/23/2444?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Antibiotic-associated hemorrhagic colitis is a distinct form of antibiotic-associated colitis in which Clostridium difficile is absent. Although the cause is not known, previous reports have suggested a role of...http://content.nejm.org/cgi/content/short/355/23/2418?rss=1&ssource=collectionSearchRss&queryTerm=5Christoph Högenauer, M.D., Cord Langner, M.D., Eckhard Beubler, Ph.D., Irmgard T. Lippe, Ph.D., Rudolf Schicho, Ph.D., Gregor Gorkiewicz, M.D., Robert Krause, M.D., Nikolas Gerstgrasser, M.D., Guenter J. Krejs, M.D., and Thomas A. Hinterleitner, M.D.Thu, 07  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/23/2418?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Since 2003, the widespread ongoing epizootic of avian influenza A (H5N1) among poultry and birds has resulted in human H5N1 cases in 10 countries. The first case of H5N1...http://content.nejm.org/cgi/content/short/355/21/2186?rss=1&ssource=collectionSearchRss&queryTerm=5I. Nyoman Kandun, M.D., M.P.H., Hariadi Wibisono, M.D., Ph.D., M.P.H., Endang R. Sedyaningsih, M.D., D.P.H., Yusharmen, M.D., Widarso Hadisoedarsuno, M.D., Wilfried Purba, D.V.M., M.P.H., Hari Santoso, M.Epid., Chita Septiawati, M.D., Erna Tresnaningsih, M.D., Ph.D., Bambang Heriyanto, M.Epid., Djoko Yuwono, M.S., Syahrial Harun, M.S., Santoso Soeroso, M.D., M.H.A., Sardikin Giriputra, M.D., M.H.A., Patrick J. Blair, Ph.D., Andrew Jeremijenko, M.B., B.S., M.H.A., Herman Kosasih, M.D., Shannon D. Putnam, Ph.D., Gina Samaan, M.App.Epid., Marlinggom Silitonga, M.D., M.Epid., K.H. Chan, Ph.D., Leo L.M. Poon, Ph.D., Wilina Lim, M.D., Alexander Klimov, Ph.D., D.Sc., Stephen Lindstrom, Ph.D., Yi Guan, M.D., Ph.D., Ruben Donis, Ph.D., Jacqueline Katz, Ph.D., Nancy Cox, Ph.D., Malik Peiris, D.Phil., M.D., and Timothy M. Uyeki, M.D., M.P.H.Thu, 23  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/21/2186?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> An outbreak of highly pathogenic avian influenza A (H5N1) that had previously been detected throughout Asia, with major economic and health repercussions, extended to eastern Turkey in late December...http://content.nejm.org/cgi/content/short/355/21/2179?rss=1&ssource=collectionSearchRss&queryTerm=5Ahmet Faik Oner, M.D., Ali Bay, M.D., Sukru Arslan, M.D., Hayrettin Akdeniz, M.D., Huseyin Avni Sahin, M.D., Yasar Cesur, M.D., Serdar Epcacan, M.D., Neziha Yilmaz, M.D., Ibrahim Deger, M.D., Baran Kizilyildiz, M.D., Hasan Karsen, M.D., and Mehmet Ceyhan, M.D.Thu, 23  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/21/2179?rss=1&ssource=collectionSearchRss&queryTerm=5There is no question that there will be another influenza pandemic someday. We simply don't know when it will occur or whether it will be caused by the H5N1 avian...http://content.nejm.org/cgi/content/short/355/21/2174?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 23  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/21/2174?rss=1&ssource=collectionSearchRss&queryTerm=5An 89-year-old woman presented with a nonhealing ulcer on her right leg. She was taking 100 mg of minocycline orally twice a day as suppressive therapy for a corynebacterium infection...http://content.nejm.org/cgi/content/short/355/20/e23?rss=1&ssource=collectionSearchRss&queryTerm=5Adrian N. Holm, M.D. and Wayne K. Nelson, M.D.Thu, 16  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/20/e23?rss=1&ssource=collectionSearchRss&queryTerm=5A 40-year-old man with no underlying lung disease has a 7-day history of mild shortness of breath with exertion, as well as cough that is now productive of purulent sputum....http://content.nejm.org/cgi/content/short/355/20/2125?rss=1&ssource=collectionSearchRss&queryTerm=5Richard P. Wenzel, M.D., and Alpha A. Fowler III, M.D.Thu, 16  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/20/2125?rss=1&ssource=collectionSearchRss&queryTerm=5Despite advances in medical knowledge, imaging techniques, and surgical interventions, spinal epidural abscess remains a challenging problem that often eludes diagnosis and receives suboptimal treatment. The incidence of this disease...http://content.nejm.org/cgi/content/short/355/19/2012?rss=1&ssource=collectionSearchRss&queryTerm=5Rabih O. Darouiche, M.D.Thu, 09  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/19/2012?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In 1993, Malawi became the first country in Africa to replace chloroquine with the combination of sulfadoxine and pyrimethamine for the treatment of malaria. At that time, the clinical...http://content.nejm.org/cgi/content/short/355/19/1959?rss=1&ssource=collectionSearchRss&queryTerm=5Miriam K. Laufer, M.D., Phillip C. Thesing, D.O., Nicole D. Eddington, M.S., Rhoda Masonga, Fraction K. Dzinjalamala, Ph.D., Shannon L. Takala, Ph.D., Terrie E. Taylor, D.O., and Christopher V. Plowe, M.D., M.P.H.Thu, 09  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/19/1959?rss=1&ssource=collectionSearchRss&queryTerm=5In the wealthier parts of the world, the death of a child from an infectious disease is a rare tragedy. In poor countries, it is commonplace. In rural sub-Saharan Africa,...http://content.nejm.org/cgi/content/short/355/19/1956?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 09  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/19/1956?rss=1&ssource=collectionSearchRss&queryTerm=5First it was hamburger, then municipal water, apple cider, swimming in the lake, the day-care center, the petting zoo . . . and now, spinach. Is nothing safe?<br/><br/>Between August 19...http://content.nejm.org/cgi/content/short/355/19/1952?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 09  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/19/1952?rss=1&ssource=collectionSearchRss&queryTerm=5A 21-year-old man presented to the emergency department after a 2-day history of increasing pain in the right lower quadrant. The pain was dull and nonradiating, was not exacerbated by...http://content.nejm.org/cgi/content/short/355/18/1913?rss=1&ssource=collectionSearchRss&queryTerm=5Kathryn B. Robertson, M.D., William J. Janssen, M.D., Sanjay Saint, M.D., M.P.H., and Steven E. Weinberger, M.D.Thu, 02  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/18/1913?rss=1&ssource=collectionSearchRss&queryTerm=5Pemphigus, which is caused by autoantibodies, and bullous impetigo (including its generalized form, the staphylococcal scalded-skin syndrome), which is caused by Staphylococcus aureus, are seemingly unrelated diseases. However, 200 years...http://content.nejm.org/cgi/content/short/355/17/1800?rss=1&ssource=collectionSearchRss&queryTerm=5John R. Stanley, M.D., and Masayuki Amagai, M.D., Ph.D.Thu, 26  Oct  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/17/1800?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Christine M. Cserti: A 3-year-old girl was admitted to this hospital because of fever and parasites in the peripheral blood.<br/><br/>Three weeks earlier, the patient and her 5-year-old brother and...http://content.nejm.org/cgi/content/short/355/16/1715?rss=1&ssource=collectionSearchRss&queryTerm=5Iain P. Fraser, M.B., Ch.B., D.Phil., Christine M. Cserti, M.D., and Walter H. Dzik, M.D.Thu, 19  Oct  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/16/1715?rss=1&ssource=collectionSearchRss&queryTerm=5A better understanding of the inflammatory, procoagulant, and immunosuppressive aspects of sepsis has contributed to rational therapeutic plans from which several important themes emerge.1 First, rapid diagnosis (within the first...http://content.nejm.org/cgi/content/short/355/16/1699?rss=1&ssource=collectionSearchRss&queryTerm=5James A. Russell, M.D.Thu, 19  Oct  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/16/1699?rss=1&ssource=collectionSearchRss&queryTerm=5Urinary urgency and fever developed in a 55-year-old, bedridden woman with multiple sclerosis, a long-term indwelling Foley catheter, and multiple prior urinary tract infections. The patient had recently been transferred...http://content.nejm.org/cgi/content/short/355/14/1487?rss=1&ssource=collectionSearchRss&queryTerm=5Robert M. Kalus, M.D., Kaveh G. Shojania, M.D., John K. Amory, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 05  Oct  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/14/1487?rss=1&ssource=collectionSearchRss&queryTerm=5A previously healthy 18-year-old college freshman presented to an emergency department with acute onset of fever and headache. He was listless and in distress. His temperature was 40.0°C, his pulse...http://content.nejm.org/cgi/content/short/355/14/1466?rss=1&ssource=collectionSearchRss&queryTerm=5Pierce Gardner, M.D.Thu, 05  Oct  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/14/1466?rss=1&ssource=collectionSearchRss&queryTerm=5...http://content.nejm.org/cgi/content/short/355/13/e12?rss=1&ssource=collectionSearchRss&queryTerm=5Miles S. Ellenby, M.D., Ken Tegtmeyer, M.D., Susanna Lai, M.P.H., and Dana A.V. Braner, M.D.Thu, 28  Sep  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/13/e12?rss=1&ssource=collectionSearchRss&queryTerm=5In 2002, as mosquitoes carried West Nile virus across the United States, infecting 4200 people, 23 confirmed cases of transfusion-transmitted infection and 7 related deaths were reported.1 This was a...http://content.nejm.org/cgi/content/short/355/13/1303?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 28  Sep  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/13/1303?rss=1&ssource=collectionSearchRss&queryTerm=5A 24-year-old sexually active woman presents with a 3-day history of vaginal pruritus and increased vaginal discharge. One year before presentation, she had the same symptoms, which resolved with use...http://content.nejm.org/cgi/content/short/355/12/1244?rss=1&ssource=collectionSearchRss&queryTerm=5Linda O. Eckert, M.D.Thu, 21  Sep  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/12/1244?rss=1&ssource=collectionSearchRss&queryTerm=5Vaccines that are composed of inactivated bacterial toxins work well for diseases such as diphtheria and tetanus, in which a single secreted toxin is the primary mediator of disease. Pathogens...http://content.nejm.org/cgi/content/short/355/11/1171?rss=1&ssource=collectionSearchRss&queryTerm=5Timothy L. Yahr, Ph.D.Thu, 14  Sep  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/11/1171?rss=1&ssource=collectionSearchRss&queryTerm=5A 62-year-old man was admitted to the intensive care unit (ICU) with severe community-acquired pneumonia. On the sixth hospital day, he remained intubated and was receiving broad-spectrum antibiotics for his...http://content.nejm.org/cgi/content/short/355/11/1154?rss=1&ssource=collectionSearchRss&queryTerm=5John E. Bennett, M.D.Thu, 14  Sep  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/11/1154?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Melissa Sue Lee (Pediatrics): A 17-year-old boy was admitted to this hospital because of fever and nodules in the liver and spleen. The patient had been well until two...http://content.nejm.org/cgi/content/short/355/9/941?rss=1&ssource=collectionSearchRss&queryTerm=5Stephen I. Pelton, M.D., John Y. Kim, M.D., and Richard L. Kradin, M.D.Thu, 31  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/9/941?rss=1&ssource=collectionSearchRss&queryTerm=5A 25-year-old man was admitted for pain and distention of the abdomen. He had a three-day history of dizziness, fatigue, myalgia, and mild fever. On physical examination, he was in...http://content.nejm.org/cgi/content/short/355/9/940?rss=1&ssource=collectionSearchRss&queryTerm=5Antoine Ghossain, M.D.Thu, 31  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/9/940?rss=1&ssource=collectionSearchRss&queryTerm=5The second half of 2005 saw one of the largest outbreaks of Japanese encephalitis that has occurred in northern India in recent years. Cases were first reported in the state...http://content.nejm.org/cgi/content/short/355/9/869?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 31  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/9/869?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Chagas' disease is an important health problem in Latin America, and cardiac involvement is associated with substantial morbidity and mortality. We developed a model to predict the risk of...http://content.nejm.org/cgi/content/short/355/8/799?rss=1&ssource=collectionSearchRss&queryTerm=5Anis Rassi, Jr., M.D., Ph.D., Anis Rassi, M.D., William C. Little, M.D., Sérgio S. Xavier, M.D., Ph.D., Sérgio G. Rassi, M.D., Alexandre G. Rassi, M.D., Gustavo G. Rassi, M.D., Alejandro Hasslocher-Moreno, M.D., Andrea S. Sousa, M.D., Ph.D., and Maurício I. Scanavacca, M.D., Ph.D.Thu, 24  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/8/799?rss=1&ssource=collectionSearchRss&queryTerm=5Nearly 100 years since its discovery by the Brazilian physician Carlos Chagas, the protozoan parasite Trypanosoma cruzi remains perhaps the most common cause of myocarditis worldwide. The lethality of Chagas'...http://content.nejm.org/cgi/content/short/355/8/760?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 24  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/8/760?rss=1&ssource=collectionSearchRss&queryTerm=5A 14-year-old female refugee from Cameroon was admitted to our clinic for a medical checkup two weeks after arriving in Germany. Her medical history was notable only for multiple episodes...http://content.nejm.org/cgi/content/short/355/7/e6?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas Weitzel, M.D. and Tomas Jelinek, M.D.Thu, 17  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/7/e6?rss=1&ssource=collectionSearchRss&queryTerm=5The decline in the development of new antibiotics, the recognition that partial vancomycin resistance may result in some vancomycin treatment failures among methicillin-resistant Staphylococcus aureus (MRSA) infections, and the emergence...http://content.nejm.org/cgi/content/short/355/7/724?rss=1&ssource=collectionSearchRss&queryTerm=5M. Lindsay Grayson, M.D.Thu, 17  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/7/724?rss=1&ssource=collectionSearchRss&queryTerm=5A 25-year-old bodybuilder was hospitalized with a painful left upper arm five days after injecting 1.5 ml of a steroid preparation into the medial aspect of his left biceps brachii...http://content.nejm.org/cgi/content/short/355/7/713?rss=1&ssource=collectionSearchRss&queryTerm=5Oliver P. Gautschi, M.D. and René Zellweger, M.D.Thu, 17  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/7/713?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA.<br/><br/><em>Methods:</em> We enrolled adult patients with acute, purulent skin and...http://content.nejm.org/cgi/content/short/355/7/666?rss=1&ssource=collectionSearchRss&queryTerm=5Gregory J. Moran, M.D., Anusha Krishnadasan, Ph.D., Rachel J. Gorwitz, M.D., M.P.H., Gregory E. Fosheim, M.P.H., Linda K. McDougal, M.S., Roberta B. Carey, Ph.D., and David A. Talan, M.D., for the ncy ID Net Study GroupThu, 17  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/7/666?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed.<br/><br/><em>Methods:</em> We randomly assigned 124 patients with S. aureus bacteremia with or without endocarditis to receive 6 mg of daptomycin...http://content.nejm.org/cgi/content/short/355/7/653?rss=1&ssource=collectionSearchRss&queryTerm=5Vance G. Fowler, Jr., M.D., M.H.S., Helen W. Boucher, M.D., G. Ralph Corey, M.D., Elias Abrutyn, M.D., Adolf W. Karchmer, M.D., Mark E. Rupp, M.D., Donald P. Levine, M.D., Henry F. Chambers, M.D., Francis P. Tally, M.D., Gloria A. Vigliani, M.D., Christopher H. Cabell, M.D., M.H.S., Arthur Stanley Link, M.D., Ignace DeMeyer, M.D., Scott G. Filler, M.D., Marcus Zervos, M.D., Paul Cook, M.D., Jeffrey Parsonnet, M.D., Jack M. Bernstein, M.D., Connie Savor Price, M.D., Graeme N. Forrest, M.D., Gerd Fätkenheuer, M.D., Marcelo Gareca, M.D., Susan J. Rehm, M.D., Hans Reinhardt Brodt, M.D., Alan Tice, M.D., and Sara E. Cosgrove, M.D., for the Endocarditis and Bacteremia Study GroupThu, 17  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/7/653?rss=1&ssource=collectionSearchRss&queryTerm=5Deaths from cholera are again making news, this time in Angola. According to the World Health Organization (WHO), Angola had reported 46,758 cases of cholera, including 1893 deaths, as of...http://content.nejm.org/cgi/content/short/355/7/649?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 17  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/7/649?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Measles was declared eliminated from the United States in 2000 but remains endemic worldwide. In 2005, a 17-year-old unvaccinated girl who was incubating measles returned from Romania, creating the...http://content.nejm.org/cgi/content/short/355/5/447?rss=1&ssource=collectionSearchRss&queryTerm=5Amy A. Parker, M.S.N., M.P.H., Wayne Staggs, M.S., Gustavo H. Dayan, M.D., Ismael R. Ortega-Sánchez, Ph.D., Paul A. Rota, Ph.D., Luis Lowe, M.S., Patricia Boardman, B.S., R.N., Robert Teclaw, D.V.M., Ph.D., Charlene Graves, M.D., and Charles W. LeBaron, M.D.Thu, 03  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/5/447?rss=1&ssource=collectionSearchRss&queryTerm=5The control and virtual elimination of measles in the United States is a public health success that has provided a model for immunization programs in other parts of the developed...http://content.nejm.org/cgi/content/short/355/5/440?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 03  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/5/440?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Tick-borne relapsing fever (TBRF) is an acute febrile illness. In Israel, TBRF is caused by Borrelia persica and is transmitted by Ornithodoros tholozani ticks. We examined the safety and...http://content.nejm.org/cgi/content/short/355/2/148?rss=1&ssource=collectionSearchRss&queryTerm=5Tal Hasin, M.D., Nadav Davidovitch, M.D., Ph.D., Regev Cohen, M.D., Tsachi Dagan, M.D., Ayal Romem, M.D., Nadav Orr, Ph.D., Eyal Klement, D.V.M., Nir Lubezky, M.D., Raid Kayouf, R.N., M.Sc., Tamar Sela, B.Sc., Nathan Keller, M.D., Ph.D., Estela Derazne, M.Sc., Tamar Halperin, Ph.D., Miri Yavzori, M.Sc., Itamar Grotto, M.D., M.P.H., and Dani Cohen, Ph.D.Thu, 13  Jul  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/2/148?rss=1&ssource=collectionSearchRss&queryTerm=5A new mother sits by her tiny, premature baby in a neonatal intensive care unit. She watches as a physician touches the baby without first washing his hands or using...http://content.nejm.org/cgi/content/short/355/2/121?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 13  Jul  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/2/121?rss=1&ssource=collectionSearchRss&queryTerm=5Influenza is an uncontrolled epidemic disease that occurs every winter. Epidemics, which vary in severity, are measured by excess mortality, but influenza is always the leading cause of acute respiratory...http://content.nejm.org/cgi/content/short/355/1/79?rss=1&ssource=collectionSearchRss&queryTerm=5W. Paul Glezen, M.D.Thu, 06  Jul  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/1/79?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The disease burden of influenza infection among children is not well established. We conducted a population-based surveillance of medical visits associated with laboratory-confirmed influenza.<br/><br/><em>Methods:</em> Eligible children were younger than...http://content.nejm.org/cgi/content/short/355/1/31?rss=1&ssource=collectionSearchRss&queryTerm=5Katherine A. Poehling, M.D., M.P.H., Kathryn M. Edwards, M.D., Geoffrey A. Weinberg, M.D., Peter Szilagyi, M.D., M.P.H., Mary Allen Staat, M.D., M.P.H., Marika K. Iwane, Ph.D., M.P.H., Carolyn B. Bridges, M.D., Carlos G. Grijalva, M.D., M.P.H.,Yuwei Zhu, M.D., David I. Bernstein, M.D., Guillermo Herrera, M.D., M.B.A., Dean Erdman, Ph.D., Caroline B. Hall, M.D., Ranee Seither, M.P.H., and Marie R. Griffin, M.D., M.P.H., for the New Vaccine Surveillance NetworkThu, 06  Jul  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/1/31?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Alec D. Weisberg (Medicine): An 84-year-old man was transferred to this hospital because of staphylococcal bacteremia and renal failure. Two weeks before admission, fever, chills, nausea, vomiting, shortness of...http://content.nejm.org/cgi/content/short/354/26/2803?rss=1&ssource=collectionSearchRss&queryTerm=5Mark D. Denton, M.D., Ph.D., Subba R. Digumarthy, M.D., Sarah Chua, M.D., and Robert B. Colvin, M.D.Thu, 29  Jun  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/26/2803?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old man presented with a two-day history of headache, fever, and generalized weakness. He had received a cadaveric kidney transplant five years earlier. His medications included 5 mg of...http://content.nejm.org/cgi/content/short/354/26/2802?rss=1&ssource=collectionSearchRss&queryTerm=5Megdad Zaatreh, M.D. and Wael Alabulkarim, M.D.Thu, 29  Jun  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/26/2802?rss=1&ssource=collectionSearchRss&queryTerm=5A 26-year-old woman with a summer home on Long Island, New York, had a low-grade fever, malaise, arthralgias, headache, and neck pain one week after removing a tick from her...http://content.nejm.org/cgi/content/short/354/26/2794?rss=1&ssource=collectionSearchRss&queryTerm=5Gary P. Wormser, M.D.Thu, 29  Jun  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/26/2794?rss=1&ssource=collectionSearchRss&queryTerm=5Since September 11, 2001, the threat of bioterrorism has caused Congress and the President to dramatically increase research funding for countermeasures, including funding for new biosecurity laboratories. The new kind...http://content.nejm.org/cgi/content/short/354/25/2715?rss=1&ssource=collectionSearchRss&queryTerm=5George J. Annas, J.D., M.P.H.Thu, 22  Jun  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/25/2715?rss=1&ssource=collectionSearchRss&queryTerm=5At first glance, the report by Saha et al.1 in this issue of the Journal demonstrates the important finding that a single dose of azithromycin is effective in the treatment...http://content.nejm.org/cgi/content/short/354/23/2500?rss=1&ssource=collectionSearchRss&queryTerm=5Richard L. Guerrant, M.D.Thu, 08  Jun  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/23/2500?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Single-dose azithromycin is effective in the treatment of severe cholera in children, but its effectiveness in adults has not been evaluated.<br/><br/><em>Methods:</em> We conducted a double-blind, randomized trial comparing the...http://content.nejm.org/cgi/content/short/354/23/2452?rss=1&ssource=collectionSearchRss&queryTerm=5Debasish Saha, M.B., B.S., Mohammad M. Karim, M.B., B.S., Wasif A. Khan, M.B., B.S., Sabeena Ahmed, M.Sc., Mohammed A. Salam, M.B., B.S., and Michael L. Bennish, M.D.Thu, 08  Jun  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/23/2452?rss=1&ssource=collectionSearchRss&queryTerm=5A 71-year-old retired schoolteacher from rural Ohio presented to his local hospital with a two-week history of malaise, fever, anorexia, chills, and sweats. He had not had a cough or...http://content.nejm.org/cgi/content/short/354/18/1937?rss=1&ssource=collectionSearchRss&queryTerm=5Maria-Fernanda Bonilla, M.D., Daniel R. Kaul, M.D., Sanjay Saint, M.D., M.P.H., Carlos M. Isada, M.D., and Daniel J. Brotman, M.D.Thu, 04  May  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/18/1937?rss=1&ssource=collectionSearchRss&queryTerm=5An otherwise healthy, 7 1/2-year-old girl had a two-week history of a swelling behind her left ear. She had no systemic illness and noted no improvement with a course of...http://content.nejm.org/cgi/content/short/354/17/e17?rss=1&ssource=collectionSearchRss&queryTerm=5Tal Eidlitz-Markus, M.D. and Avraham Zeharia, M.D.Thu, 27  Apr  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/17/e17?rss=1&ssource=collectionSearchRss&queryTerm=5The reverse-transcriptase inhibitor lamivudine (Zeffix, GlaxoSmithKline) is often used to treat chronic infection with hepatitis B virus (HBV) until resistance develops. Treatment may then be switched to the reverse-transcriptase inhibitor...http://content.nejm.org/cgi/content/short/354/17/1807?rss=1&ssource=collectionSearchRss&queryTerm=5Oliver Schildgen, Ph.D., Hueseyin Sirma, M.D., Anneke Funk, Ph.D., Cynthia Olotu, M.S., Ulrike C. Wend, Heinz Hartmann, M.D., Martin Helm, Jürgen K. Rockstroh, M.D., Wulf R. Willems, M.D., Hans Will, Ph.D., and Wolfram H. Gerlich, Ph.D.Thu, 27  Apr  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/17/1807?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Malabsorption of thyroxine has been described in patients treated with drugs that modify an acidic environment. We determined whether there is an increased need for thyroxine in patients with...http://content.nejm.org/cgi/content/short/354/17/1787?rss=1&ssource=collectionSearchRss&queryTerm=5Marco Centanni, M.D., Lucilla Gargano, M.D., Gianluca Canettieri, M.D., Nicola Viceconti, M.D., Antonella Franchi, M.D., Gianfranco Delle Fave, M.D., and Bruno Annibale, M.D.Thu, 27  Apr  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/17/1787?rss=1&ssource=collectionSearchRss&queryTerm=5A 46-year-old woman and her husband had their sleep disturbed by pruritus, waking up to find similar, itchy papular lesions over their finger webs (Panel A), axillae, groins, and buttocks....http://content.nejm.org/cgi/content/short/354/16/1728?rss=1&ssource=collectionSearchRss&queryTerm=5Tak K. Kong, F.R.C.P. and Wing K. To, F.R.C.P.A.Thu, 20  Apr  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/16/1728?rss=1&ssource=collectionSearchRss&queryTerm=5A 30-year-old man notes diffuse, intense itching. He reports that his girlfriend has the same itching. Examination of the skin reveals interdigital lesions, with small papules, vesicles, and excoriations on...http://content.nejm.org/cgi/content/short/354/16/1718?rss=1&ssource=collectionSearchRss&queryTerm=5Olivier Chosidow, M.D., Ph.D.Thu, 20  Apr  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/16/1718?rss=1&ssource=collectionSearchRss&queryTerm=5A nationwide vaccination program may have direct or indirect health effects that may be anticipated or unanticipated; although these effects are, of course, intended to be beneficial, some potentially adverse...http://content.nejm.org/cgi/content/short/354/14/1522?rss=1&ssource=collectionSearchRss&queryTerm=5Daniel M. Musher, M.D.Thu, 06  Apr  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/14/1522?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Five of seven serotypes in the pneumococcal conjugate vaccine, introduced for infants in the United States in 2000, are responsible for most penicillin-resistant infections. We examined the effect of...http://content.nejm.org/cgi/content/short/354/14/1455?rss=1&ssource=collectionSearchRss&queryTerm=5Moe H. Kyaw, Ph.D., M.P.H., Ruth Lynfield, M.D., William Schaffner, M.D., Allen S. Craig, M.D., James Hadler, M.D., M.P.H., Arthur Reingold, M.D., Ann R. Thomas, M.D., M.P.H., Lee H. Harrison, M.D., Nancy M. Bennett, M.D., Monica M. Farley, M.D., Richard R. Facklam, Ph.D., James H. Jorgensen, Ph.D., John Besser, M.S., Elizabeth R. Zell, M.Stat., Anne Schuchat, M.D., and Cynthia G. Whitney, M.D., M.P.H., for Active Bacterial Core Surveillance of the Emerging Infections Program NetworkThu, 06  Apr  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/14/1455?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old man presented with intermittent, crampy pain in the right lower quadrant of the abdomen. The pain had started two days after his return from a two-week trip to...http://content.nejm.org/cgi/content/short/354/13/e12?rss=1&ssource=collectionSearchRss&queryTerm=5Michael D. Brown, M.D.Thu, 30  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/13/e12?rss=1&ssource=collectionSearchRss&queryTerm=5Bacteria of the genus rickettsia cause life-threatening rickettsioses such as Rocky Mountain spotted fever, typhus fever, Mediterranean spotted fever, and murine typhus. The clinical manifestations of these types of rickettsioses...http://content.nejm.org/cgi/content/short/354/13/1418?rss=1&ssource=collectionSearchRss&queryTerm=5David H. Walker, M.D.Thu, 30  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/13/1418?rss=1&ssource=collectionSearchRss&queryTerm=5The medical community and the public have been buffeted by a steady stream of news linking the use of widely prescribed medications with serious health risks. The latest in this...http://content.nejm.org/cgi/content/short/354/13/1413?rss=1&ssource=collectionSearchRss&queryTerm=5Jerry H. Gurwitz, M.D.Thu, 30  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/13/1413?rss=1&ssource=collectionSearchRss&queryTerm=5Avian influenza A (H5N1) virus poses an important pandemic threat. A study by the Congressional Budget Office estimates that the consequences of a severe pandemic could, in the United States,...http://content.nejm.org/cgi/content/short/354/13/1411?rss=1&ssource=collectionSearchRss&queryTerm=5Gregory A. Poland, M.D.Thu, 30  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/13/1411?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Gatifloxacin has been associated with both hypoglycemia and hyperglycemia. We examined dysglycemia-related health outcomes associated with various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66...http://content.nejm.org/cgi/content/short/354/13/1352?rss=1&ssource=collectionSearchRss&queryTerm=5Laura Y. Park-Wyllie, Pharm.D., David N. Juurlink, M.D., Ph.D., Alexander Kopp, B.A., Baiju R. Shah, M.D., Ph.D., Therese A. Stukel, Ph.D., Carmine Stumpo, Pharm.D., Linda Dresser, Pharm.D., Donald E. Low, M.D., and Muhammad M. Mamdani, Pharm.D., M.P.H.Thu, 30  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/13/1352?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Influenza A (H5N1) viruses could cause a severe worldwide epidemic, with high attack rates, large numbers of deaths and hospitalizations, and wide disruption. Effective vaccines against these viruses in...http://content.nejm.org/cgi/content/short/354/13/1343?rss=1&ssource=collectionSearchRss&queryTerm=5John J. Treanor, M.D., James D. Campbell, M.D., Kenneth M. Zangwill, M.D., Thomas Rowe, M.S., and Mark Wolff, Ph.D.Thu, 30  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/13/1343?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Amanda F. Peppercorn (Infectious Diseases): A 35-year-old woman was admitted to this hospital because of recurrent abdominal pain in the right upper quadrant. One year earlier, abdominal pain developed...http://content.nejm.org/cgi/content/short/354/12/1295?rss=1&ssource=collectionSearchRss&queryTerm=5Rocío M. Hurtado, M.D., Dushyant V. Sahani, M.D., and Richard L. Kradin, M.D.Thu, 23  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/12/1295?rss=1&ssource=collectionSearchRss&queryTerm=5A 47-year-old man was transferred to the emergency department of this hospital at 10 a.m. on a day in early June because of altered mental status and acute renal failure....http://content.nejm.org/cgi/content/short/354/10/1065?rss=1&ssource=collectionSearchRss&queryTerm=5J. Kimo Takayesu, M.D., M.Sc., Hasan Bazari, M.D., and Michael Linshaw, M.D.Thu, 09  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/10/1065?rss=1&ssource=collectionSearchRss&queryTerm=5A 31-year-old woman, 33 weeks pregnant, presented with a fever (40°C) and chills 2 months after returning from a trip to Brazil. A mixed infection of Plasmodium malariae and P....http://content.nejm.org/cgi/content/short/354/10/1064?rss=1&ssource=collectionSearchRss&queryTerm=5Rebekah Karplus, M.D. and Stephanie P. Johnston, M.S.Thu, 09  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/10/1064?rss=1&ssource=collectionSearchRss&queryTerm=5A 16-year-old, previously healthy boy came to the hospital with a history of fever for several days, nonproductive cough, and coryza. On examination he appeared to be acutely ill; his...http://content.nejm.org/cgi/content/short/354/7/740?rss=1&ssource=collectionSearchRss&queryTerm=5Lawrence M. Tierney, Jr., M.D. and Kevin C. Wang, M.D., Ph.D.Thu, 16  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/7/740?rss=1&ssource=collectionSearchRss&queryTerm=5A woman with stage T3N0 anal carcinoma was treated with radiotherapy and concurrent chemotherapy with fluorouracil and mitomycin. The total dose of radiotherapy was 5940 cGy, with the high-dose area...http://content.nejm.org/cgi/content/short/354/6/622?rss=1&ssource=collectionSearchRss&queryTerm=5Song K. Kang, M.D.Thu, 09  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/6/622?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old woman presents to the hospital with cellulitis. She reports a history of urticaria 30 years earlier associated with taking penicillin for a respiratory tract infection. Should cephalosporins be...http://content.nejm.org/cgi/content/short/354/6/601?rss=1&ssource=collectionSearchRss&queryTerm=5Rebecca S. Gruchalla, M.D., Ph.D., and Munir Pirmohamed, Ph.D., F.R.C.P.Thu, 09  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/6/601?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> We created the orphan drug Human Botulism Immune Globulin Intravenous (Human) (BIG-IV), which neutralizes botulinum toxin, and evaluated its safety and efficacy in treating infant botulism, the intestinal-toxemia form...http://content.nejm.org/cgi/content/short/354/5/462?rss=1&ssource=collectionSearchRss&queryTerm=5Stephen S. Arnon, M.D., Robert Schechter, M.D., Susan E. Maslanka, Ph.D., Nicholas P. Jewell, Ph.D., and Charles L. Hatheway, Ph.D.Thu, 02  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/5/462?rss=1&ssource=collectionSearchRss&queryTerm=5A 63-year-old woman was admitted to the hospital for evaluation of a pancreatic mass.<br/><br/>Four months before admission, the patient noticed dysuria and dark urine. The results of urinalysis showed 3+...http://content.nejm.org/cgi/content/short/354/4/398?rss=1&ssource=collectionSearchRss&queryTerm=5Robert H. Schapiro, M.D., Michael M. Maher, M.D., and Joseph Misdraji, M.D.Thu, 26  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/4/398?rss=1&ssource=collectionSearchRss&queryTerm=5The antibiotics currently used in clinical practice are either bacteriostatic (that is, they inhibit bacterial growth) or bacteriocidal (that is, they kill bacteria). These antibiotics work by inhibiting bacterial processes...http://content.nejm.org/cgi/content/short/354/3/296?rss=1&ssource=collectionSearchRss&queryTerm=5Matthew K. Waldor, M.D., Ph.D.Thu, 19  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/3/296?rss=1&ssource=collectionSearchRss&queryTerm=5A 31-year-old man with the acquired immunodeficiency syndrome (AIDS) was evaluated at the infectious disease clinic of this hospital because of rectal pain and a mucopurulent rectal discharge.<br/><br/>Four days before...http://content.nejm.org/cgi/content/short/354/3/284?rss=1&ssource=collectionSearchRss&queryTerm=5Benjamin T. Davis, M.D., Michael Thiim, M.D., and Lawrence R. Zukerberg, M.D.Thu, 19  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/3/284?rss=1&ssource=collectionSearchRss&queryTerm=5In 2001, my research team was visiting a farming community in northwestern Nigeria, where word quickly spread to neighboring villages that foreign doctors were examining the mouths of sick children....http://content.nejm.org/cgi/content/short/354/3/221?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 19  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/3/221?rss=1&ssource=collectionSearchRss&queryTerm=5A 64-year-old man with emphysema who had received a double-lung allograft six months previously was admitted to the hospital because of cough, hemoptysis, and abdominal pain.<br/><br/>Three days before admission, abdominal...http://content.nejm.org/cgi/content/short/354/2/180?rss=1&ssource=collectionSearchRss&queryTerm=5Robert H. Rubin, M.D., Matthew D. Gilman, M.D., and Richard L. Kradin, M.D.Thu, 12  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/2/180?rss=1&ssource=collectionSearchRss&queryTerm=5A 37-year-old woman from Illinois with a history of an idiopathic T-cell deficiency (CD4 cell count, 249 cells per cubic millimeter, and negative for infection with the human immunodeficiency virus),...http://content.nejm.org/cgi/content/short/354/2/179?rss=1&ssource=collectionSearchRss&queryTerm=5Jeremy Topin, M.D. and Gökhan M. Mutlu, M.D.Thu, 12  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/2/179?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Approximately 8 percent of travelers to the developing world require medical care during or after travel. Current understanding of morbidity profiles among ill returned travelers is based on limited...http://content.nejm.org/cgi/content/short/354/2/119?rss=1&ssource=collectionSearchRss&queryTerm=5David O. Freedman, M.D., Leisa H. Weld, Ph.D., Phyllis E. Kozarsky, M.D., Tamara Fisk, M.D., Rachel Robins, M.D., Frank von Sonnenburg, M.D., Jay S. Keystone, M.D., Prativa Pandey, M.D., and Martin S. Cetron, M.D., for the GeoSentinel Surveillance NetworkThu, 12  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/2/119?rss=1&ssource=collectionSearchRss&queryTerm=5In 2004, 763 million people crossed international borders, reflecting an increase of 73 percent over the course of 15 years.1 International travel has rebounded since the attacks of September 11,...http://content.nejm.org/cgi/content/short/354/2/115?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 12  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/2/115?rss=1&ssource=collectionSearchRss&queryTerm=5The United States has become preoccupied with the threat of bioterrorism — the potential for the poisoning of the milk supply with botulinum toxin, the hypothetical dissemination of smallpox by...http://content.nejm.org/cgi/content/short/354/2/113?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 12  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/2/113?rss=1&ssource=collectionSearchRss&queryTerm=5Research conducted at biosafety level 4, popularly known as the hot zone, continues to be both revered and feared. Biosafety level 4 laboratories are the places to study dangerous and...http://content.nejm.org/cgi/content/short/354/2/109?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 12  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/2/109?rss=1&ssource=collectionSearchRss&queryTerm=5Bacterial meningitis is a medical, neurologic, and sometimes neurosurgical emergency that requires a multidisciplinary approach. Bacterial meningitis has an annual incidence of 4 to 6 cases per 100,000 adults (defined...http://content.nejm.org/cgi/content/short/354/1/44?rss=1&ssource=collectionSearchRss&queryTerm=5Diederik van de Beek, M.D., Ph.D., Jan de Gans, M.D., Ph.D., Allan R. Tunkel, M.D., Ph.D., and Eelco F.M. Wijdicks, M.D., Ph.D.Thu, 05  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/1/44?rss=1&ssource=collectionSearchRss&queryTerm=5A healthy 43-year-old Nigerian man living in the United States noticed something wiggling in his right eye while he was driving. He went to his optometrist, who saw an opaque,...http://content.nejm.org/cgi/content/short/353/25/e22?rss=1&ssource=collectionSearchRss&queryTerm=5Amita Gupta, M.D. and Sanjay Kedhar, M.D.Thu, 22  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/25/e22?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Jennifer Phillips (Internal Medicine): A 63-year-old woman was seen by infectious-disease specialists at this hospital because of a positive serologic test for syphilis and persistent peripheral-blood eosinophilia.<br/><br/>The patient was...http://content.nejm.org/cgi/content/short/353/25/2697?rss=1&ssource=collectionSearchRss&queryTerm=5Edward T. Ryan, M.D., Donna Felsenstein, M.D., Suzanne L. Aquino, M.D., John A. Branda, M.D., and John G. Morgan, M.B.Thu, 22  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/25/2697?rss=1&ssource=collectionSearchRss&queryTerm=5Recent experience with influenza, the severe acute respiratory syndrome (also known as SARS), avian influenza, and community-acquired methicillin-resistant Staphylococcus aureus has demonstrated how old pathogens can emerge with increased virulence...http://content.nejm.org/cgi/content/short/353/23/2503?rss=1&ssource=collectionSearchRss&queryTerm=5John G. Bartlett, M.D., and Trish M. Perl, M.D.Thu, 08  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/23/2503?rss=1&ssource=collectionSearchRss&queryTerm=5A 75-year-old man with peripheral vascular disease, chronic obstructive pulmonary disease, and diabetes mellitus presented with gangrene of the right fourth toe and underwent tarsal–metatarsal amputation to manage the progression...http://content.nejm.org/cgi/content/short/353/23/2491?rss=1&ssource=collectionSearchRss&queryTerm=5Paul L. Wolf, M.D. and Armen Kasyan, M.D.Thu, 08  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/23/2491?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile–associated diarrhea.<br/><br/><em>Methods:</em> In 2004 we conducted a prospective study at 12 Quebec...http://content.nejm.org/cgi/content/short/353/23/2442?rss=1&ssource=collectionSearchRss&queryTerm=5Vivian G. Loo, M.D., Louise Poirier, M.D., Mark A. Miller, M.D., Matthew Oughton, M.D., Michael D. Libman, M.D., Sophie Michaud, M.D., M.P.H., Anne-Marie Bourgault, M.D., Tuyen Nguyen, M.D., Charles Frenette, M.D., Mirabelle Kelly, M.D., Anne Vibien, M.D., Paul Brassard, M.D., Susan Fenn, M.L.T., Ken Dewar, Ph.D., Thomas J. Hudson, M.D., Ruth Horn, M.D., Pierre René, M.D., Yury Monczak, Ph.D., and André Dascal, M.D.Thu, 08  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/23/2442?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Recent reports suggest that the rate and severity of Clostridium difficile–associated disease in the United States are increasing and that the increase may be associated with the emergence of...http://content.nejm.org/cgi/content/short/353/23/2433?rss=1&ssource=collectionSearchRss&queryTerm=5L. Clifford McDonald, M.D., George E. Killgore, Dr.P.H., Angela Thompson, M.M.Sc., Robert C. Owens, Jr., Pharm.D., Sophia V. Kazakova, M.D., M.P.H., Ph.D., Susan P. Sambol, M.T., Stuart Johnson, M.D., and Dale N. Gerding, M.D.Thu, 08  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/23/2433?rss=1&ssource=collectionSearchRss&queryTerm=5On a hot and steamy summer day in Berlin — August 4, 1890, to be precise — the 10th International Medical Congress opened with a flair and fanfare that few...http://content.nejm.org/cgi/content/short/353/23/2426?rss=1&ssource=collectionSearchRss&queryTerm=5Howard Markel, M.D., Ph.D.Thu, 08  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/23/2426?rss=1&ssource=collectionSearchRss&queryTerm=5“During my wandering through medicine, I encountered sites where gold was lying around. It needs a lot of serendipity to distinguish gold from ignobility; this however is not a particular...http://content.nejm.org/cgi/content/short/353/23/2423?rss=1&ssource=collectionSearchRss&queryTerm=5Stefan H.E. Kaufmann, Ph.D.Thu, 08  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/23/2423?rss=1&ssource=collectionSearchRss&queryTerm=5In 2002, Barry Marshall — the cowinner with Robin Warren of this year's Nobel Prize in Physiology or Medicine for their discovery of Helicobacter pylori — edited a book entitled...http://content.nejm.org/cgi/content/short/353/23/2421?rss=1&ssource=collectionSearchRss&queryTerm=5Julie Parsonnet, M.D.Thu, 08  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/23/2421?rss=1&ssource=collectionSearchRss&queryTerm=5Endometritis and toxic shock syndrome associated with Clostridium sordellii have previously been reported after childbirth and, in one case, after medical abortion. We describe four deaths due to endometritis and...http://content.nejm.org/cgi/content/short/353/22/2352?rss=1&ssource=collectionSearchRss&queryTerm=5Marc Fischer, M.D., M.P.H., Julu Bhatnagar, Ph.D., Jeannette Guarner, M.D., Sarah Reagan, M.P.H., Jill K. Hacker, Ph.D., Sharon H. Van Meter, M.D., Vadims Poukens, M.D., David B. Whiteman, M.D., Anthony Iton, M.D., J.D., M.P.H., Michele Cheung, M.D., M.P.H., David E. Dassey, M.D., M.P.H., Wun-Ju Shieh, M.D., Ph.D., and Sherif R. Zaki, M.D., Ph.D.Thu, 01  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/22/2352?rss=1&ssource=collectionSearchRss&queryTerm=5The Population Council submitted a new drug application to the Food and Drug Administration (FDA) on March 14, 1996, for the progesterone antagonist mifepristone (also known as RU 486) to...http://content.nejm.org/cgi/content/short/353/22/2317?rss=1&ssource=collectionSearchRss&queryTerm=5Michael F. Greene, M.D.Thu, 01  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/22/2317?rss=1&ssource=collectionSearchRss&queryTerm=5All technological advancements — from knives and forks to airplanes and rockets — have been exploited for destructive ends. Inherent in every scientific discovery is the “dual use” dilemma: the...http://content.nejm.org/cgi/content/short/353/21/2214?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 24  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/21/2214?rss=1&ssource=collectionSearchRss&queryTerm=5Even as they have advanced our understanding and treatment of disease, the achievements of modern biomedical research have also increased people's ability to misuse discoveries in ways that could threaten...http://content.nejm.org/cgi/content/short/353/21/2212?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 24  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/21/2212?rss=1&ssource=collectionSearchRss&queryTerm=5A 64-year-old man with a history of colonic resection for adenocarcinoma six years earlier presented with weakness and abdominal discomfort of six months' duration. Computed tomography of the abdomen with...http://content.nejm.org/cgi/content/short/353/18/e16?rss=1&ssource=collectionSearchRss&queryTerm=5Mustafa Saad, M.D. and Jonathan Moorman, M.D., Ph.D.Thu, 03  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/18/e16?rss=1&ssource=collectionSearchRss&queryTerm=5Illicit drug use is a worldwide health problem. Annually, Approximately 5 percent of the global population, or 200 million people, use illicit drugs.1 In a U.S. survey, 19.5 million people...http://content.nejm.org/cgi/content/short/353/18/1945?rss=1&ssource=collectionSearchRss&queryTerm=5Rachel J. Gordon, M.D., M.P.H., and Franklin D. Lowy, M.D.Thu, 03  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/18/1945?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Bacterial vaginosis affects millions of women and is associated with several serious health conditions. The cause of bacterial vaginosis remains poorly understood despite numerous studies based on cultures. Bacteria...http://content.nejm.org/cgi/content/short/353/18/1899?rss=1&ssource=collectionSearchRss&queryTerm=5David N. Fredricks, M.D., Tina L. Fiedler, B.S., and Jeanne M. Marrazzo, M.D., M.P.H.Thu, 03  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/18/1899?rss=1&ssource=collectionSearchRss&queryTerm=5From the time that Robert Koch prepared stained smears of biologic samples from humans, scientists have been engaged in describing the microbiologic flora of the human vagina. In 1882, Döderlein...http://content.nejm.org/cgi/content/short/353/18/1886?rss=1&ssource=collectionSearchRss&queryTerm=5Sharon L. Hillier, Ph.D.Thu, 03  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/18/1886?rss=1&ssource=collectionSearchRss&queryTerm=5Sometime within the next two years, clinical researchers are expected to begin inoculating at least 2000 African infants in the largest trial ever undertaken of an experimental vaccine for malaria....http://content.nejm.org/cgi/content/short/353/18/1877?rss=1&ssource=collectionSearchRss&queryTerm=5Susan Okie, M.D.Thu, 03  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/18/1877?rss=1&ssource=collectionSearchRss&queryTerm=5A 62-year-old man reported acute left retro-orbital pain of one week's duration. Physical examination revealed no abnormalities. Three days later, double vision developed, and the next day a rash appeared...http://content.nejm.org/cgi/content/short/353/16/e14?rss=1&ssource=collectionSearchRss&queryTerm=5Edward Jude, M.D., M.R.C.P. and Amiya Chakraborty, M.R.C.P.Thu, 20  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/16/e14?rss=1&ssource=collectionSearchRss&queryTerm=5A 52-year-old man from southern Louisiana with a history of nonalcoholic steatohepatitis presented to the emergency room with a report of severe bilateral lower-leg pain and swelling. He had ingested...http://content.nejm.org/cgi/content/short/353/15/1604?rss=1&ssource=collectionSearchRss&queryTerm=5Lara M. Falcon, M.D. and Lan Pham, M.D.Thu, 13  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/15/1604?rss=1&ssource=collectionSearchRss&queryTerm=5Never before Hurricane Katrina has a disaster caused such a massive displacement of a U.S. population. Never before has the country seen so vividly the exposure and vulnerability of displaced...http://content.nejm.org/cgi/content/short/353/15/1544?rss=1&ssource=collectionSearchRss&queryTerm=5P. Gregg Greenough, M.D., M.P.H., and Thomas D. Kirsch, M.D., M.P.H.Thu, 13  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/15/1544?rss=1&ssource=collectionSearchRss&queryTerm=5“What can I do to help?” The voice was clear and assertive, almost authoritative, and it captured my attention immediately. I looked up from the chaotic mosaic of maps, lists,...http://content.nejm.org/cgi/content/short/353/15/1541?rss=1&ssource=collectionSearchRss&queryTerm=5Hilarie H. Cranmer, M.D., M.P.H.Thu, 13  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/15/1541?rss=1&ssource=collectionSearchRss&queryTerm=5A 50-year-old man presented to the clinic with fever, chills, and generalized weakness that he had had for three weeks. He also noticed pain and swelling in his right hand...http://content.nejm.org/cgi/content/short/353/14/1503?rss=1&ssource=collectionSearchRss&queryTerm=5Amr H. Sawalha, M.D., Sanjay Saint, M.D., M.P.H., Robert W. Ike, M.D., and Michael S. Bronze, M.D.Thu, 06  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/14/1503?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Vibrio parahaemolyticus, the leading cause of seafood-associated gastroenteritis in the United States, typically is associated with the consumption of raw oysters gathered from warm-water estuaries. We describe a recognized...http://content.nejm.org/cgi/content/short/353/14/1463?rss=1&ssource=collectionSearchRss&queryTerm=5Joseph B. McLaughlin, M.D., M.P.H., Angelo DePaola, Ph.D., Cheryl A. Bopp, M.S., Karen A. Martinek, R.N., M.P.H., Nancy P. Napolilli, B.S., Christine G. Allison, B.S., Shelley L. Murray, B.S., Eric C. Thompson, B.S., Michele M. Bird, M.S., and John P. Middaugh, M.D.Thu, 06  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/14/1463?rss=1&ssource=collectionSearchRss&queryTerm=5Sepsis, severe sepsis, and septic shock represent a spectrum of increasingly severe diseases that result from serious infection and the body's response to microbiologic invasion. Population data suggest that 750,000...http://content.nejm.org/cgi/content/short/353/13/1398?rss=1&ssource=collectionSearchRss&queryTerm=5Joseph E. Parrillo, M.D.Thu, 29  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/13/1398?rss=1&ssource=collectionSearchRss&queryTerm=5A 56-year-old man was referred to the transplantation infectious-disease clinic because of a low-grade fever and left axillary lymphadenopathy.<br/><br/>The patient had received a cadaveric kidney transplant five years earlier for...http://content.nejm.org/cgi/content/short/353/13/1387?rss=1&ssource=collectionSearchRss&queryTerm=5Jane E. Koehler, M.D., and Lyn M. Duncan, M.D.Thu, 29  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/13/1387?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In November 2001, the Food and Drug Administration (FDA) approved drotrecogin alfa (activated) (DrotAA) for adults who had severe sepsis and a high risk of death. The FDA required...http://content.nejm.org/cgi/content/short/353/13/1332?rss=1&ssource=collectionSearchRss&queryTerm=5Edward Abraham, M.D., Pierre-François Laterre, M.D., Rekha Garg, M.D., Howard Levy, M.D., Ph.D., Deepak Talwar, M.D., Benjamin L. Trzaskoma, M.S., Bruno François, M.D., Jeffrey S. Guy, M.D., Martina Brückmann, M.D., Álvaro Rea-Neto, M.D., Rolf Rossaint, M.D., Dominique Perrotin, M.D., Armin Sablotzki, M.D., Ph.D., Nancy Arkins, R.N., Barbara G. Utterback, M.S., M.B.A., and William L. Macias, M.D., for the Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study GroupThu, 29  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/13/1332?rss=1&ssource=collectionSearchRss&queryTerm=5The demonstration in Tanzania of equivalent efficacy of azithromycin and penicillin G benzathine for treating early syphilis and presumed early latent syphilis (rapid plasma reagin titer, ≥1:8) represents a potentially...http://content.nejm.org/cgi/content/short/353/12/1291?rss=1&ssource=collectionSearchRss&queryTerm=5King K. Holmes, M.D., Ph.D.Thu, 22  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/12/1291?rss=1&ssource=collectionSearchRss&queryTerm=5Staphylococcus aureus has increasingly been recognized as a cause of severe invasive illness. We describe three children who died at our institution after rapidly progressive clinical deterioration from this infection,...http://content.nejm.org/cgi/content/short/353/12/1245?rss=1&ssource=collectionSearchRss&queryTerm=5Patricia V. Adem, M.D., Christopher P. Montgomery, M.D., Aliya N. Husain, M.D., Tracy K. Koogler, M.D., Valerie Arangelovich, M.D., Michel Humilier, M.D., Susan Boyle-Vavra, Ph.D., and Robert S. Daum, M.D.Thu, 22  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/12/1245?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Pilot studies suggest that a single, 2-g oral dose of azithromycin may be an alternative to a 2.4-MU intramuscular dose of penicillin G benzathine in the prevention and treatment...http://content.nejm.org/cgi/content/short/353/12/1236?rss=1&ssource=collectionSearchRss&queryTerm=5Gabriele Riedner, M.D., Ph.D., Mary Rusizoka, Dipl.Med., Jim Todd, M.Sc., Leonard Maboko, M.D., Michael Hoelscher, M.D., Donan Mmbando, M.D., Eleuter Samky, M.D., Eligius Lyamuya, Ph.D., David Mabey, M.D., Ph.D., Heiner Grosskurth, M.D., Ph.D., and Richard Hayes, D.Sc.Thu, 22  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/12/1236?rss=1&ssource=collectionSearchRss&queryTerm=5A male infant was born at a gestational age of 26 weeks and weighed 830 g. He required intubation and was transferred to the neonatal intensive care unit. His treatment...http://content.nejm.org/cgi/content/short/353/10/e9?rss=1&ssource=collectionSearchRss&queryTerm=5Erez Nadir, M.D. and Miriam Kaufshtein, M.Sc.Thu, 08  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/10/e9?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The role of prophylactic antibacterial agents after chemotherapy remains controversial.<br/><br/><em>Methods:</em> We conducted a randomized, double-blind, placebo-controlled trial in patients who were receiving cyclic chemotherapy for solid tumors or lymphoma...http://content.nejm.org/cgi/content/short/353/10/988?rss=1&ssource=collectionSearchRss&queryTerm=5Michael Cullen, M.D., Neil Steven, Ph.D., Lucinda Billingham, Ph.D., Claire Gaunt, B.Sc., Mark Hastings, M.D., Peter Simmonds, M.D., Nicholas Stuart, M.D., Daniel Rea, Ph.D., Mark Bower, Ph.D., Indrajit Fernando, M.D., Robert Huddart, Ph.D., Simon Gollins, D.Phil., and Andrew Stanley, M.R.Pharm.S., for the Simple Investigation in Neutropenic Individuals of the Frequency of Infection after Chemotherapy +/– Antibiotic in a Number of Tumours (SIGNIFICANT) Trial GroupThu, 08  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/10/988?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The prophylactic use of fluoroquinolones in patients with cancer and neutropenia is controversial and is not a recommended intervention.<br/><br/><em>Methods:</em> We randomly assigned 760 consecutive adult patients with cancer in...http://content.nejm.org/cgi/content/short/353/10/977?rss=1&ssource=collectionSearchRss&queryTerm=5Giampaolo Bucaneve, M.D., Alessandra Micozzi, M.D., Francesco Menichetti, M.D., Pietro Martino, M.D., M. Stella Dionisi, M.D., Giovanni Martinelli, M.D., Bernardino Allione, M.D., Domenico D'Antonio, M.D., Maurizio Buelli, M.D., A. Maria Nosari, M.D., Daniela Cilloni, M.D., Eliana Zuffa, M.D., Renato Cantaffa, M.D., Giorgina Specchia, M.D., Sergio Amadori, M.D., Francesco Fabbiano, M.D., Giorgio Lambertenghi Deliliers, M.D., Francesco Lauria, M.D., Robin Foà, M.D., and Albano Del Favero, M.D., for the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Infection ProgramThu, 08  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/10/977?rss=1&ssource=collectionSearchRss&queryTerm=5Improved management of infectious complications of cancer has contributed substantially to the success of care over the past several decades. In the 1960s it became clear that neutropenia was highly...http://content.nejm.org/cgi/content/short/353/10/1052?rss=1&ssource=collectionSearchRss&queryTerm=5Lindsey R. Baden, M.D.Thu, 08  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/10/1052?rss=1&ssource=collectionSearchRss&queryTerm=5A 43-year-old man was admitted with a relapse of acute myelomonocytic leukemia eight months after having undergone autologous hematopoietic stem-cell transplantation. Fever (temperature, >39°C) developed within one day of the...http://content.nejm.org/cgi/content/short/353/8/e7?rss=1&ssource=collectionSearchRss&queryTerm=5Francisco J. Ortuño, M.D., Ph.D. and Inmaculada Heras, M.D.Thu, 25  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/8/e7?rss=1&ssource=collectionSearchRss&queryTerm=5A 40-year-old man was admitted to this hospital because of persistent fever, night sweats, anorexia, and weight loss.<br/><br/>The patient had been in excellent health until eight and a half weeks...http://content.nejm.org/cgi/content/short/353/7/713?rss=1&ssource=collectionSearchRss&queryTerm=5Dennis L. Kasper, M.D., Dushyant Sahani, M.D., and Joseph Misdraji, M.D.Thu, 18  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/7/713?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Rocky Mountain spotted fever is a life-threatening, tick-borne disease caused by Rickettsia rickettsii. This disease is rarely reported in Arizona, and the principal vectors, Dermacentor species ticks, are uncommon...http://content.nejm.org/cgi/content/short/353/6/587?rss=1&ssource=collectionSearchRss&queryTerm=5Linda J. Demma, Ph.D., Marc S. Traeger, M.D., William L. Nicholson, Ph.D., Christopher D. Paddock, M.D., Dianna M. Blau, D.V.M., Ph.D., Marina E. Eremeeva, M.D., Ph.D., Gregory A. Dasch, Ph.D., Michael L. Levin, Ph.D., Joseph Singleton, Jr., B.S., Sherif R. Zaki, M.D., Ph.D., James E. Cheek, M.D., David L. Swerdlow, M.D., and Jennifer H. McQuiston, D.V.M.Thu, 11  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/6/587?rss=1&ssource=collectionSearchRss&queryTerm=5The explosive growth of emerging infections during the past 20 years has made it difficult to issue a call to arms about any pathogen with ecologic and epidemiologic features that...http://content.nejm.org/cgi/content/short/353/6/551?rss=1&ssource=collectionSearchRss&queryTerm=5J. Stephen Dumler, M.D., and David H. Walker, M.D.Thu, 11  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/6/551?rss=1&ssource=collectionSearchRss&queryTerm=5A 40-year-old, previously healthy man presented with a four-day history of pain in the left upper quadrant of the abdomen, accompanied by fatigue, fever, sweating, and sore throat. Physical examination...http://content.nejm.org/cgi/content/short/353/5/508?rss=1&ssource=collectionSearchRss&queryTerm=5Karen M. Kim, M.D. and Richard I. Kopelman, M.D.Thu, 04  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/5/508?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Echinacea has been widely used as an herbal remedy for the common cold, but efficacy studies have produced conflicting results, and there are a variety of echinacea products on...http://content.nejm.org/cgi/content/short/353/4/341?rss=1&ssource=collectionSearchRss&queryTerm=5Ronald B. Turner, M.D., Rudolf Bauer, Ph.D., Karin Woelkart, Thomas C. Hulsey, D.Sc., and J. David Gangemi, Ph.D.Thu, 28  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/4/341?rss=1&ssource=collectionSearchRss&queryTerm=5Tales of malaria abound among travelers to Africa, and this account is typical. Someone who is far away from reliable health care is suddenly flattened by heat and a raging...http://content.nejm.org/cgi/content/short/353/4/335?rss=1&ssource=collectionSearchRss&queryTerm=5Alan Magill, M.D., and Claire Panosian, M.D.Thu, 28  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/4/335?rss=1&ssource=collectionSearchRss&queryTerm=5An infant in rural Africa has fever. Acetaminophen does not work. The fever spikes, and the father makes his way to the local kiosk and buys malaria medicine — chloroquine...http://content.nejm.org/cgi/content/short/353/4/333?rss=1&ssource=collectionSearchRss&queryTerm=5Kenneth J. Arrow, Ph.D., Hellen Gelband, M.H.S., and Dean T. Jamison, Ph.D.Thu, 28  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/4/333?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Sherry Chou (Neurology): An 81-year-old man was admitted to the Massachusetts General Hospital in September because of fever, chills, productive cough, and diffuse weakness.<br/><br/>Two weeks before admission, a cough...http://content.nejm.org/cgi/content/short/353/3/287?rss=1&ssource=collectionSearchRss&queryTerm=5Harry Hollander, M.D., Pamela W. Schaefer, M.D., and E. Tessa Hedley-Whyte, M.D.Thu, 21  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/3/287?rss=1&ssource=collectionSearchRss&queryTerm=5A healthy 42-year-old man presented with a broad eroded, ulcerated lesion on the left foot, which had developed over the previous month. His new job required that he wear boots,...http://content.nejm.org/cgi/content/short/353/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas P. Habif, M.D.Thu, 14  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=5An 18-year-old man presented with symptoms that evolved over the course of three days and included fever, radicular back pain, vertigo, ataxia, headache, and left-sided hemiparesis. He reported that he...http://content.nejm.org/cgi/content/short/353/2/188?rss=1&ssource=collectionSearchRss&queryTerm=5Pasiri Sithinamsuwan, M.D. and Parnsiri Chairangsaris, M.D.Thu, 14  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/2/188?rss=1&ssource=collectionSearchRss&queryTerm=5A 35-year-old man was brought to the hospital after sustaining injuries associated with the tsunami in Southeast Asia on December 26, 2004. The patient had inhaled seawater when he nearly...http://content.nejm.org/cgi/content/short/352/25/e23?rss=1&ssource=collectionSearchRss&queryTerm=5Kamonporn Limchawalit, M.D. and Chirotchana Suchato, M.D.Thu, 23  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/25/e23?rss=1&ssource=collectionSearchRss&queryTerm=5Editor's note: After the earthquake and tsunami in the Indian Ocean on December 26, 2004, the Massachusetts General Hospital formed a clinical-response team to work with Project HOPE (Health Opportunities...http://content.nejm.org/cgi/content/short/352/25/2628?rss=1&ssource=collectionSearchRss&queryTerm=5Ann Y. Kao, M.D., Rus Munandar, M.D., Stephen L. Ferrara, M.D., Lt. Comdr., David M. Systrom, M.D., Robert L. Sheridan, M.D., Sydney S. Cash, M.D., Ph.D., and Edward T. Ryan, M.D.Thu, 23  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/25/2628?rss=1&ssource=collectionSearchRss&queryTerm=5A five-year-old girl received the diagnosis of respiratory papillomatosis after an episode of respiratory distress in which the collapse of the right lung required intubation. During bronchoscopy, a single laryngeal...http://content.nejm.org/cgi/content/short/352/24/e22?rss=1&ssource=collectionSearchRss&queryTerm=5Daniel Glikman, M.D. and Fuad M. Baroody, M.D.Thu, 16  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/24/e22?rss=1&ssource=collectionSearchRss&queryTerm=5Worldwide, some 55,000 people die every year from rabies, mostly in Asian and African countries where canine rabies is endemic. Children are frequently the victims of rabies. In the United...http://content.nejm.org/cgi/content/short/352/24/2549?rss=1&ssource=collectionSearchRss&queryTerm=5Alan C. Jackson, M.D.Thu, 16  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/24/2549?rss=1&ssource=collectionSearchRss&queryTerm=5We report the survival of a 15-year-old girl in whom clinical rabies developed one month after she was bitten by a bat. Treatment included induction of coma while a native...http://content.nejm.org/cgi/content/short/352/24/2508?rss=1&ssource=collectionSearchRss&queryTerm=5Rodney E. Willoughby, Jr., M.D., Kelly S. Tieves, D.O., George M. Hoffman, M.D., Nancy S. Ghanayem, M.D., Catherine M. Amlie-Lefond, M.D., Michael J. Schwabe, M.D., Michael J. Chusid, M.D., and Charles E. Rupprecht, V.M.D., Ph.D.Thu, 16  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/24/2508?rss=1&ssource=collectionSearchRss&queryTerm=5A 65-year-old man presented with skin lesions on his chest and left arm and shoulder six weeks after returning from a vacation in Belize at the beach and in the...http://content.nejm.org/cgi/content/short/352/23/e21?rss=1&ssource=collectionSearchRss&queryTerm=5Francisco M. Marty, M.D. and Kristen R. Whiteside, B.S.Thu, 09  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/23/e21?rss=1&ssource=collectionSearchRss&queryTerm=5A 20-year-old man who had immigrated to the United States from Mexico three months earlier presented to the emergency department, reporting that he had had weight loss and pain in...http://content.nejm.org/cgi/content/short/352/22/2338?rss=1&ssource=collectionSearchRss&queryTerm=5Shelby Dames, M.D., Claude Tonnerre, M.D., Sanjay Saint, M.D., M.P.H., and Stephen R. Jones, M.D.Thu, 02  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/22/2338?rss=1&ssource=collectionSearchRss&queryTerm=5At an office visit in June 2004, a 49-year-old man reported fatigue, arthralgia, and headache, along with a two-day history of chest pain. The patient had hypercholesterolemia, for which he...http://content.nejm.org/cgi/content/short/352/22/2337?rss=1&ssource=collectionSearchRss&queryTerm=5Ralph Rosenberg, M.D.Thu, 02  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/22/2337?rss=1&ssource=collectionSearchRss&queryTerm=5Brucellosis, like tuberculosis, is a chronic granulomatous infection caused by intracellular bacteria and requires combined, protracted antibiotic treatment. The disease causes much clinical morbidity as well as a considerable loss...http://content.nejm.org/cgi/content/short/352/22/2325?rss=1&ssource=collectionSearchRss&queryTerm=5Georgios Pappas, M.D., Nikolaos Akritidis, M.D., Mile Bosilkovski, M.D., and Epameinondas Tsianos, M.D.Thu, 02  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/22/2325?rss=1&ssource=collectionSearchRss&queryTerm=5A 33-year-old woman who had had Crohn's disease for many years reported the development of dull pain in the left lower back, which was associated with sporadic episodes of fever...http://content.nejm.org/cgi/content/short/352/21/2222?rss=1&ssource=collectionSearchRss&queryTerm=5Philippe de Saussure, M.D. and Claudio Soravia, M.D.Thu, 26  May  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/21/2222?rss=1&ssource=collectionSearchRss&queryTerm=5On March 21, 2005, the Centers for Disease Control and Prevention (CDC) in Atlanta confirmed the presence of Marburg virus in 9 of 12 patient samples of tissue and blood...http://content.nejm.org/cgi/content/short/352/21/2155?rss=1&ssource=collectionSearchRss&queryTerm=5Nestor Ndayimirije, M.D., and Mary Kay Kindhauser, M.A.Thu, 26  May  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/21/2155?rss=1&ssource=collectionSearchRss&queryTerm=5A 67-year-old man was admitted to the hospital with a 12-year history of swelling of his left leg. He had emigrated to the United Kingdom from Jamaica at the age...http://content.nejm.org/cgi/content/short/352/20/e19?rss=1&ssource=collectionSearchRss&queryTerm=5Michael Brown, M.R.C.P., Ph.D. and Geoffrey Pasvol, F.R.C.P., D.Phil.Thu, 19  May  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/20/e19?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The risk of invasive pneumococcal disease among persons with asthma is unknown.<br/><br/><em>Methods:</em> We conducted a nested case–control study to examine the association between asthma and invasive pneumococcal disease. The...http://content.nejm.org/cgi/content/short/352/20/2082?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas R. Talbot, M.D., M.P.H., Tina V. Hartert, M.D., M.P.H., Ed Mitchel, M.S., Natasha B. Halasa, M.D., M.P.H., Patrick G. Arbogast, Ph.D., Katherine A. Poehling, M.D., M.P.H., William Schaffner, M.D., Allen S. Craig, M.D., and Marie R. Griffin, M.D., M.P.H.Thu, 19  May  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/20/2082?rss=1&ssource=collectionSearchRss&queryTerm=5A 38-year-old man was admitted to this hospital because of blurred vision and fever.<br/><br/>The patient had ulcerative colitis but had been well while receiving treatment with mercaptopurine and balsalazide until...http://content.nejm.org/cgi/content/short/352/19/2003?rss=1&ssource=collectionSearchRss&queryTerm=5Sekar Kathiresan, M.D., Peter B. Kelsey, M.D., Allen C. Steere, M.D., C. Stephen Foster, M.D., Marcio S. Curvelo, M.D., and James R. Stone, M.D., Ph.D.Thu, 12  May  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/19/2003?rss=1&ssource=collectionSearchRss&queryTerm=5A 17-year-old boy presented to his primary care physician, reporting four days of low back pain, a temperature as high as 40°C, headache, diffuse myalgias, and vomiting. The patient had...http://content.nejm.org/cgi/content/short/352/18/1914?rss=1&ssource=collectionSearchRss&queryTerm=5Daniel R. Kaul, M.D., Scott A. Flanders, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 05  May  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/18/1914?rss=1&ssource=collectionSearchRss&queryTerm=5It is ironic that respiratory syncytial virus (RSV) infection in adults, though recognized for several decades, has been overlooked, at least in part, because of the importance of RSV in...http://content.nejm.org/cgi/content/short/352/17/1810?rss=1&ssource=collectionSearchRss&queryTerm=5Sanjay Sethi, M.D., and Timothy F. Murphy, M.D.Thu, 28  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/17/1810?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Respiratory syncytial virus (RSV) is an increasingly recognized cause of illness in adults. Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help...http://content.nejm.org/cgi/content/short/352/17/1749?rss=1&ssource=collectionSearchRss&queryTerm=5Ann R. Falsey, M.D., Patricia A. Hennessey, R.N., Maria A. Formica, M.S., Christopher Cox, Ph.D., and Edward E. Walsh, M.D.Thu, 28  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/17/1749?rss=1&ssource=collectionSearchRss&queryTerm=5A 23-year-old woman with a one-week history of swelling and pain in her right third finger (Panel A, arrow) was seen by an orthopedist, who prescribed cephalexin and indomethacin for...http://content.nejm.org/cgi/content/short/352/16/e15?rss=1&ssource=collectionSearchRss&queryTerm=5Stephan Russ, M.D. and Keith Wrenn, M.D.Thu, 21  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/16/e15?rss=1&ssource=collectionSearchRss&queryTerm=5Two large, high-quality, and convincingly negative clinical trials for the secondary prevention of coronary heart disease,12 published in this issue of the Journal, raise questions as to whether we are...http://content.nejm.org/cgi/content/short/352/16/1706?rss=1&ssource=collectionSearchRss&queryTerm=5Jeffrey L. Anderson, M.D.Thu, 21  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/16/1706?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Chlamydia pneumoniae has been found within atherosclerotic plaques, and elevated titers of antibody to this organism have been linked to a higher risk of coronary events. Pilot studies have...http://content.nejm.org/cgi/content/short/352/16/1646?rss=1&ssource=collectionSearchRss&queryTerm=5Christopher P. Cannon, M.D., Eugene Braunwald, M.D., Carolyn H. McCabe, B.S., J. Thomas Grayston, M.D., Brent Muhlestein, M.D., Robert P. Giugliano, M.D., Richard Cairns, M.Sc., and Allan M. Skene, Ph.D., for the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 InvestigatorsThu, 21  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/16/1646?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Epidemiologic, laboratory, animal, and clinical studies suggest that there is an association between Chlamydia pneumoniae infection and atherogenesis. We evaluated the efficacy of one year of azithromycin treatment for...http://content.nejm.org/cgi/content/short/352/16/1637?rss=1&ssource=collectionSearchRss&queryTerm=5J. Thomas Grayston, M.D., Richard A. Kronmal, Ph.D., Lisa A. Jackson, M.D., Alfred F. Parisi, M.D., Joseph B. Muhlestein, M.D., Jerome D. Cohen, M.D., William J. Rogers, M.D., John R. Crouse, M.D., Sandra L. Borrowdale, M.S., Eleanor Schron, M.S., and Charles Knirsch, M.D., for the ACES InvestigatorsThu, 21  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/16/1637?rss=1&ssource=collectionSearchRss&queryTerm=5Malaria is a disease with far-reaching effects: 40 percent of the world's population is at risk for malarial infection, approximately 300 million to 400 million cases occur annually, and each...http://content.nejm.org/cgi/content/short/352/15/1600?rss=1&ssource=collectionSearchRss&queryTerm=5Ute Frevert, D.V.M., Ph.D., and Elizabeth Nardin, Ph.D.Thu, 14  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/15/1600?rss=1&ssource=collectionSearchRss&queryTerm=5The opening of the Panama Canal in 1914 initiated an era in which efforts to control malaria were aimed at the anopheline mosquito. The World Health Organization's Global Malaria Eradication...http://content.nejm.org/cgi/content/short/352/15/1565?rss=1&ssource=collectionSearchRss&queryTerm=5J. Kevin Baird, Ph.D.Thu, 14  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/15/1565?rss=1&ssource=collectionSearchRss&queryTerm=5Laypeople and health care professionals alike recognize Staphylococcus aureus as an important cause of disease and understand that antibiotic-resistant strains pose a threat to the community. Before the availability of...http://content.nejm.org/cgi/content/short/352/14/1485?rss=1&ssource=collectionSearchRss&queryTerm=5Henry F. Chambers, M.D.Thu, 07  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/14/1485?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Necrotizing fasciitis is a life-threatening infection requiring urgent surgical and medical therapy. Staphylococcus aureus has been a very uncommon cause of necrotizing fasciitis, but we have recently noted an...http://content.nejm.org/cgi/content/short/352/14/1445?rss=1&ssource=collectionSearchRss&queryTerm=5Loren G. Miller, M.D., M.P.H., Francoise Perdreau-Remington, Ph.D., Gunter Rieg, M.D., Sheherbano Mehdi, M.D., Josh Perlroth, M.D., Arnold S. Bayer, M.D., Angela W. Tang, M.D., Tieu O. Phung, M.D., and Brad Spellberg, M.D.Thu, 07  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/14/1445?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. The national burden and clinical effect of this novel presentation of MRSA...http://content.nejm.org/cgi/content/short/352/14/1436?rss=1&ssource=collectionSearchRss&queryTerm=5Scott K. Fridkin, M.D., Jeffrey C. Hageman, M.H.S., Melissa Morrison, M.P.H., Laurie Thomson Sanza, R.N., Kathryn Como-Sabetti, M.P.H., John A. Jernigan, M.D., Kathleen Harriman, Ph.D., Lee H. Harrison, M.D., Ruth Lynfield, M.D., and Monica M. Farley, M.D., for the Active Bacterial Core Surveillance Program of the Emerging Infections Program NetworkThu, 07  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/14/1436?rss=1&ssource=collectionSearchRss&queryTerm=5A 57-year-old woman with hypertension and chronic renal insufficiency who had refused dialysis for two years was found in respiratory distress after one week of upper respiratory symptoms due to...http://content.nejm.org/cgi/content/short/352/13/e13?rss=1&ssource=collectionSearchRss&queryTerm=5Stephen R. Walsh, M.D.C.M. and Nereida A. Parada, M.D.Thu, 31  Mar  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/13/e13?rss=1&ssource=collectionSearchRss&queryTerm=5A 67-year-old man was transferred to this hospital with acute respiratory failure.<br/><br/>Four days before admission, the patient had visited his primary care physician because of a three-month history of chest...http://content.nejm.org/cgi/content/short/352/12/1238?rss=1&ssource=collectionSearchRss&queryTerm=5David M. Systrom, M.D., and Conrad Wittram, M.B., Ch.B.Thu, 24  Mar  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/12/1238?rss=1&ssource=collectionSearchRss&queryTerm=5Six weeks ago, a 45-year-old woman noticed a scratchy feeling in her throat that has now progressed to more than 20 episodes of severe, spasmodic coughing per day. Her coughing...http://content.nejm.org/cgi/content/short/352/12/1215?rss=1&ssource=collectionSearchRss&queryTerm=5Erik L. Hewlett, M.D., and Kathryn M. Edwards, M.D.Thu, 24  Mar  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/12/1215?rss=1&ssource=collectionSearchRss&queryTerm=5A 26-year-old man presented to the emergency department with a two-day history of a sore throat. He was unable to eat solids because of pain and swelling but was tolerating...http://content.nejm.org/cgi/content/short/352/11/e10?rss=1&ssource=collectionSearchRss&queryTerm=5Shilpa Nimishikavi, M.D. and Latha Stead, M.D.Thu, 17  Mar  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/11/e10?rss=1&ssource=collectionSearchRss&queryTerm=5It is paradoxical that Hippocrates established in ancient times the clinical importance of pleural infections, yet only a few high-quality trials have studied this common condition during the intervening 2400...http://content.nejm.org/cgi/content/short/352/9/926?rss=1&ssource=collectionSearchRss&queryTerm=5John E. Heffner, M.D.Thu, 03  Mar  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/9/926?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid collections. This use is based on small trials that did not have the statistical power to evaluate accurately...http://content.nejm.org/cgi/content/short/352/9/865?rss=1&ssource=collectionSearchRss&queryTerm=5Nicholas A. Maskell, M.R.C.P., Christopher W.H. Davies, M.D., Andrew J. Nunn, M.Sc., Emma L. Hedley, Fergus V. Gleeson, F.R.C.P., Robert Miller, F.R.C.P., Rhian Gabe, M.Phil., Glyn L. Rees, Timothy E.A. Peto, F.R.C.P., Mark A. Woodhead, F.R.C.P., Donald J. Lane, F.R.C.P., Janet H. Darbyshire, M.B., Ch.B., and Robert J.O. Davies, D.M., for the First Multicenter Intrapleural Sepsis Trial (MIST1) GroupThu, 03  Mar  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/9/865?rss=1&ssource=collectionSearchRss&queryTerm=5Proper clinical and public health treatment of patients with gonorrhea or chlamydial infection must include the treatment of their sexual partners. Such partners are often asymptomatic and, unless treated, will...http://content.nejm.org/cgi/content/short/352/7/720?rss=1&ssource=collectionSearchRss&queryTerm=5Emily J. Erbelding, M.D., M.P.H., and Jonathan M. Zenilman, M.D.Thu, 17  Feb  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/7/720?rss=1&ssource=collectionSearchRss&queryTerm=5Dr. Daniel Egan (Emergency Medicine, Massachusetts General Hospital and Brigham and Women's Hospital): A 53-year-old man came to the emergency department because of symptoms of depression.<br/><br/>The patient had been in...http://content.nejm.org/cgi/content/short/352/7/709?rss=1&ssource=collectionSearchRss&queryTerm=5Paul D. Biddinger, M.D., Eric M. Isselbacher, M.D., Dali Fan, M.D., Ph.D., and Jo-Anne O. Shepard, M.D.Thu, 17  Feb  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/7/709?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Many sex partners of persons with gonorrhea or chlamydial infections are not treated, which leads to frequent reinfections and further transmission.<br/><br/><em>Methods:</em> We randomly assigned women and heterosexual men with...http://content.nejm.org/cgi/content/short/352/7/676?rss=1&ssource=collectionSearchRss&queryTerm=5Matthew R. Golden, M.D., M.P.H., William L.H. Whittington, A.B., H. Hunter Handsfield, M.D., James P. Hughes, Ph.D., Walter E. Stamm, M.D., Matthew Hogben, Ph.D., Agnes Clark, B.S., Cheryl Malinski, B.S., Jennifer R.L. Helmers, B.S., Katherine K. Thomas, M.S., and King K. Holmes, M.D., Ph.D.Thu, 17  Feb  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/7/676?rss=1&ssource=collectionSearchRss&queryTerm=5A 35-year-old man presented to the emergency department of this hospital because of nasal congestion, swelling, and pain in his right nostril.<br/><br/>He had been in his usual state of health...http://content.nejm.org/cgi/content/short/352/6/609?rss=1&ssource=collectionSearchRss&queryTerm=5Peter F. Weller, M.D., Marlene L. Durand, M.D., and Ben Z. Pilch, M.D.Thu, 10  Feb  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/6/609?rss=1&ssource=collectionSearchRss&queryTerm=5A 63-year-old woman was admitted to the hospital with vomiting and abdominal pain. Approximately one year earlier, she had undergone a papillotomy and laparoscopic cholecystectomy for biliary colic. Laboratory examination...http://content.nejm.org/cgi/content/short/352/5/e4?rss=1&ssource=collectionSearchRss&queryTerm=5Betram G. Esser-Köchling, M.D. and Friedrich W. Hirsch, M.D.Thu, 03  Feb  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/5/e4?rss=1&ssource=collectionSearchRss&queryTerm=5A 20-year-old man was transferred to an academic medical center in Salt Lake City for further evaluation of diarrhea, abdominal pain, and fever. Two months before admission, he presented to...http://content.nejm.org/cgi/content/short/352/5/489?rss=1&ssource=collectionSearchRss&queryTerm=5Christopher J. Goulet, M.D., Richard H. Moseley, M.D., Claude Tonnerre, M.D., Iqbal S. Sandhu, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 03  Feb  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/5/489?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of infections outside of health care settings. We investigated an outbreak of abscesses due to MRSA among members of a professional...http://content.nejm.org/cgi/content/short/352/5/468?rss=1&ssource=collectionSearchRss&queryTerm=5Sophia V. Kazakova, M.D., M.P.H., Ph.D., Jeffrey C. Hageman, M.H.S., Matthew Matava, M.D., Arjun Srinivasan, M.D., Larry Phelan, B.S., B.A., Bernard Garfinkel, M.D., Thomas Boo, M.D., Sigrid McAllister, B.S., M.T.(A.S.C.P.), Jim Anderson, B.S., A.T.C., Bette Jensen, M.M.Sc., Doug Dodson, B.S., David Lonsway, M.M.Sc., Linda K. McDougal, M.S., Matthew Arduino, Dr.P.H., Victoria J. Fraser, M.D., George Killgore, Dr.P.H., Fred C. Tenover, Ph.D., Sara Cody, M.D., and Daniel B. Jernigan, M.D., M.P.H.Thu, 03  Feb  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/5/468?rss=1&ssource=collectionSearchRss&queryTerm=5The β-lactamases are the major defense of gram-negative bacteria against β-lactam antibiotics. β-Lactamases can be broadly divided into enzymes with a serine residue at the active site, similar to bacterial...http://content.nejm.org/cgi/content/short/352/4/380?rss=1&ssource=collectionSearchRss&queryTerm=5George A. Jacoby, M.D., and Luisa Silvia Munoz-Price, M.D.Thu, 27  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/4/380?rss=1&ssource=collectionSearchRss&queryTerm=5A 23-year-old woman who had emigrated from Cameroon two years previously was admitted because of bilateral breast lumps. Her history was unremarkable. On physical examination, several nonpainful, mobile, firm lumps...http://content.nejm.org/cgi/content/short/352/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=5Hatem Alkadhi, M.D. and Elisabeth Garzoli, M.D.Thu, 13  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=5Malaria currently kills up to 3 million people per year worldwide, most of them children in sub-Saharan Africa.1 Yet the disease is utterly treatable and highly preventable. Now, the international...http://content.nejm.org/cgi/content/short/352/2/115?rss=1&ssource=collectionSearchRss&queryTerm=5Jeffrey D. Sachs, Ph.D.Thu, 13  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/2/115?rss=1&ssource=collectionSearchRss&queryTerm=5For the past 25 years, since the United Nations Children's Fund (UNICEF) has been publishing estimates of mortality among children worldwide, the international medical community has been aware of the...http://content.nejm.org/cgi/content/short/352/1/75?rss=1&ssource=collectionSearchRss&queryTerm=5E. Kim Mulholland, M.D., and Richard A. Adegbola, Ph.D.Thu, 06  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/1/75?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> There are few epidemiologic data on invasive bacterial infections among children in sub-Saharan Africa. We studied every acute pediatric admission to a rural district hospital in Kenya to examine...http://content.nejm.org/cgi/content/short/352/1/39?rss=1&ssource=collectionSearchRss&queryTerm=5James A. Berkley, M.D., Brett S. Lowe, M.Phil., Isaiah Mwangi, M.B., B.Ch., Thomas Williams, Ph.D., Evasius Bauni, M.Sc., Saleem Mwarumba, H.N.D., Caroline Ngetsa, H.N.D., Mary P.E. Slack, F.R.C.Path., Sally Njenga, H.N.D., C. Anthony Hart, F.R.C.Path., Kathryn Maitland, Ph.D., Mike English, M.D., Kevin Marsh, F.R.C.P., and J. Anthony G. Scott, M.R.C.P.Thu, 06  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/1/39?rss=1&ssource=collectionSearchRss&queryTerm=5The oral cavity is a complex environment composed of tissues with different origins, structures, and functions. Moreover, a myriad of commensal bacteria, fungi, and viruses populate the mucosa, connective tissue,...http://content.nejm.org/cgi/content/short/351/25/2649?rss=1&ssource=collectionSearchRss&queryTerm=5Adi A. Garfunkel, D.M.D.Thu, 16  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/25/2649?rss=1&ssource=collectionSearchRss&queryTerm=5A previously healthy, 37-year-old woman presented to the emergency department obtunded and hypotensive. The previous night, a cough and sore throat had developed, and the patient had awoken with a...http://content.nejm.org/cgi/content/short/351/25/2636?rss=1&ssource=collectionSearchRss&queryTerm=5Christine L. Hann, M.D., Ph.D. and Eric P. Schmidt, M.D.Thu, 16  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/25/2636?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> There is evidence that chronic inflammation may promote atherosclerotic disease. We tested the hypothesis that acute infection and vaccination increase the short-term risk of vascular events.<br/><br/><em>Methods:</em> We undertook within-person...http://content.nejm.org/cgi/content/short/351/25/2611?rss=1&ssource=collectionSearchRss&queryTerm=5Liam Smeeth, Ph.D., Sara L. Thomas, Ph.D., Andrew J. Hall, Ph.D., Richard Hubbard, D.M., Paddy Farrington, Ph.D., and Patrick Vallance, M.D.Thu, 16  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/25/2611?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment. We tested the ability of palifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal...http://content.nejm.org/cgi/content/short/351/25/2590?rss=1&ssource=collectionSearchRss&queryTerm=5Ricardo Spielberger, M.D., Patrick Stiff, M.D., William Bensinger, M.D., Teresa Gentile, M.D., Ph.D., Daniel Weisdorf, M.D., Tarun Kewalramani, M.D., Thomas Shea, M.D., Saul Yanovich, M.D., Keith Hansen, M.D., Stephen Noga, M.D., Ph.D., John McCarty, M.D., C. Frederick LeMaistre, M.D., Eric C. Sung, D.D.S., Bruce R. Blazar, M.D., Dieter Elhardt, Ph.D., Mon-Gy Chen, M.S., and Christos Emmanouilides, M.D.Thu, 16  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/25/2590?rss=1&ssource=collectionSearchRss&queryTerm=5In our ever-shrinking world, widespread media coverage of infections, ranging from the severe acute respiratory syndrome (also known as SARS) and influenza in Asia to acute gastroenteritis on cruise ships...http://content.nejm.org/cgi/content/short/351/23/2417?rss=1&ssource=collectionSearchRss&queryTerm=5Daniel M. Musher, M.D., and Benjamin L. Musher, M.D.Thu, 02  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/23/2417?rss=1&ssource=collectionSearchRss&queryTerm=5The current shortfall in anticipated doses of vaccine for the upcoming influenza season1 makes the reports by Belshe et al.2 and Kenney et al.3 in this issue of the Journal...http://content.nejm.org/cgi/content/short/351/22/2330?rss=1&ssource=collectionSearchRss&queryTerm=5John R. La Montagne, Ph.D., and Anthony S. Fauci, M.D.Thu, 25  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/22/2330?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The loss of half the U.S. supply of influenza vaccine due to contamination has created a critical shortage. Dose-sparing strategies that use intradermal delivery of vaccines may be one...http://content.nejm.org/cgi/content/short/351/22/2295?rss=1&ssource=collectionSearchRss&queryTerm=5Richard T. Kenney, M.D., Sarah A. Frech, D.V.M., Larry R. Muenz, Ph.D., Christina P. Villar, M.P.H., and Gregory M. Glenn, M.D.Thu, 25  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/22/2295?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> If found to be safe and immunogenic, reduced doses of influenza vaccine given by the intradermal route could increase the number of available doses of vaccine.<br/><br/><em>Methods:</em> In an open-label...http://content.nejm.org/cgi/content/short/351/22/2286?rss=1&ssource=collectionSearchRss&queryTerm=5Robert B. Belshe, M.D., Frances K. Newman, M.S., Joan Cannon, R.N., Carol Duane, R.N., Ph.D., John Treanor, M.D., Christian Van Hoecke, M.D., Barbara J. Howe, M.D., and Gary Dubin, M.D.Thu, 25  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/22/2286?rss=1&ssource=collectionSearchRss&queryTerm=5A 29-year-old soldier had a two-day history of headache and fever. He reported having had an intermittent, clear nasal discharge from the left nostril since his involvement in a minor...http://content.nejm.org/cgi/content/short/351/21/e19?rss=1&ssource=collectionSearchRss&queryTerm=5Gregory Youngnam Chang, M.D.Thu, 18  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/21/e19?rss=1&ssource=collectionSearchRss&queryTerm=5Despite long-standing efforts to control it, trachoma remains the leading cause of preventable blindness in the world. According to the most recent estimates, some 84 million people have active trachoma...http://content.nejm.org/cgi/content/short/351/19/2004?rss=1&ssource=collectionSearchRss&queryTerm=5Silvio P. Mariotti, M.D.Thu, 04  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/19/2004?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> 04110433.xml Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is an important cause of blindness. Current recommended dosing intervals for mass azithromycin treatment for trachoma are based on...http://content.nejm.org/cgi/content/short/351/19/1962?rss=1&ssource=collectionSearchRss&queryTerm=5Anthony W. Solomon, M.B., B.S., Ph.D., Martin J. Holland, Ph.D., Neal D.E. Alexander, Ph.D., Patrick A. Massae, D.C.E.H., Aura Aguirre, Ph.D., Angels Natividad-Sancho, M.Sc., Sandra Molina, M.Sc., Salesia Safari, M.D., John F. Shao, M.D., Ph.D., Paul Courtright, Dr.P.H., Rosanna W. Peeling, Ph.D., Sheila K. West, Ph.D., Robin L. Bailey, F.R.C.P., Ph.D., Allen Foster, F.R.C.S., F.R.C.Ophth., and David C.W. Mabey, D.M., F.R.C.P.Thu, 04  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/19/1962?rss=1&ssource=collectionSearchRss&queryTerm=5Two thirds of the global population is at risk for malaria. However, about 90 percent of deaths from this disease occur in sub-Saharan Africa, where 1.5 million to 2.5 million...http://content.nejm.org/cgi/content/short/351/18/1901?rss=1&ssource=collectionSearchRss&queryTerm=5Kenneth D. Vernick, Ph.D., and Andrew P. Waters, Ph.D.Thu, 28  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/18/1901?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> We conducted a nationwide study in the Netherlands to determine clinical features and prognostic factors in adults with community-acquired acute bacterial meningitis.<br/><br/><em>Methods:</em> From October 1998 to April 2002, all...http://content.nejm.org/cgi/content/short/351/18/1849?rss=1&ssource=collectionSearchRss&queryTerm=5Diederik van de Beek, M.D., Ph.D., Jan de Gans, M.D., Ph.D., Lodewijk Spanjaard, M.D., Ph.D., Martijn Weisfelt, M.D., Johannes B. Reitsma, M.D., Ph.D., and Marinus Vermeulen, M.D., Ph.D.Thu, 28  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/18/1849?rss=1&ssource=collectionSearchRss&queryTerm=5The history of community-acquired bacterial meningitis arguably represents the best example of the salutary effect of the introduction of antimicrobial agents. Before the use of specific antiserums, the outlook for...http://content.nejm.org/cgi/content/short/351/18/1826?rss=1&ssource=collectionSearchRss&queryTerm=5Morton N. Swartz, M.D.Thu, 28  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/18/1826?rss=1&ssource=collectionSearchRss&queryTerm=5A 73-year-old man with a history of colon cancer presented to the emergency department with a three-day history of pain in the right hip, without a history of trauma. He...http://content.nejm.org/cgi/content/short/351/17/e15?rss=1&ssource=collectionSearchRss&queryTerm=5Rafael Arteta-Bulos, M.D. and Syed Mustafa Karim, M.D.Thu, 21  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/17/e15?rss=1&ssource=collectionSearchRss&queryTerm=5Just when scientists thought they had figured out the fundamental mechanisms through which gene expression is regulated, studies of the nematode Caenorhabditis elegans1 revealed the existence of a pathway, now...http://content.nejm.org/cgi/content/short/351/17/1772?rss=1&ssource=collectionSearchRss&queryTerm=5Mario Stevenson, Ph.D.Thu, 21  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/17/1772?rss=1&ssource=collectionSearchRss&queryTerm=5A 61-year-old man presented with a reddish brown rash in his groin; he had had the rash for more than 30 years and described it as mildly pruritic. After the...http://content.nejm.org/cgi/content/short/351/16/1666?rss=1&ssource=collectionSearchRss&queryTerm=5Scott D. Miller, M.D. and Kathleen David-Bajar, M.D.Thu, 14  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/16/1666?rss=1&ssource=collectionSearchRss&queryTerm=5Prosthetic-joint replacement is used increasingly to alleviate pain and to improve mobility. Infections associated with prosthetic joints cause significant morbidity and account for a substantial proportion of health care expenditures.12...http://content.nejm.org/cgi/content/short/351/16/1645?rss=1&ssource=collectionSearchRss&queryTerm=5Werner Zimmerli, M.D., Andrej Trampuz, M.D., and Peter E. Ochsner, M.D.Thu, 14  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/16/1645?rss=1&ssource=collectionSearchRss&queryTerm=5Empirical antibacterial therapy for fever and neutropenia has dramatically improved outcomes in a large number of patients, making it possible for many to undergo successful antineoplastic therapy. Because the diagnosis...http://content.nejm.org/cgi/content/short/351/14/1445?rss=1&ssource=collectionSearchRss&queryTerm=5Jean Klastersky, M.D., Ph.D.Thu, 30  Sep  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/14/1445?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Patients with persistent fever and neutropenia often receive empirical therapy with conventional or liposomal amphotericin B for the prevention and early treatment of invasive fungal infections. Caspofungin, a member...http://content.nejm.org/cgi/content/short/351/14/1391?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas J. Walsh, M.D., Hedy Teppler, M.D., Gerald R. Donowitz, M.D., Johan A. Maertens, M.D., Lindsey R. Baden, M.D., Anna Dmoszynska, M.D., Ph.D., Oliver A. Cornely, M.D., Michael R. Bourque, M.S., Robert J. Lupinacci, M.S., Carole A. Sable, M.D., and Ben E. dePauw, M.D., Ph.D.Thu, 30  Sep  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/14/1391?rss=1&ssource=collectionSearchRss&queryTerm=5During the past 12 months, poliovirus has been spreading to states in Nigeria that were previously free of poliomyelitis. Moreover, global surveillance for acute flaccid paralysis1 — involving the genomic...http://content.nejm.org/cgi/content/short/351/13/1275?rss=1&ssource=collectionSearchRss&queryTerm=5David L. Heymann, M.D., and R. Bruce Aylward, M.D.Thu, 23  Sep  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/13/1275?rss=1&ssource=collectionSearchRss&queryTerm=5 Dr. Claudia U. Chae: A 75-year-old woman was admitted to the hospital because of chest pain. One week before admission she had had an illness characterized by fever, headache,...http://content.nejm.org/cgi/content/short/351/12/1240?rss=1&ssource=collectionSearchRss&queryTerm=5Adolf W. Karchmer, M.D., David F. Torchiana, M.D., Claudia U. Chae, M.D., M.P.H., Nadeem A. Afridi, M.D., and Stuart L. Houser, M.D.Thu, 16  Sep  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/12/1240?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Available treatments for hepatitis B e antigen (HBeAg)–negative chronic hepatitis B are associated with poor sustained responses. As a result, nucleoside and nucleotide analogues are typically continued indefinitely, a...http://content.nejm.org/cgi/content/short/351/12/1206?rss=1&ssource=collectionSearchRss&queryTerm=5Patrick Marcellin, M.D., George K.K. Lau, M.D., Ferruccio Bonino, M.D., Patrizia Farci, M.D., Stephanos Hadziyannis, M.D., Rui Jin, M.D., Zhi-Meng Lu, M.D., Teerha Piratvisuth, M.D., Georgios Germanidis, M.D., Cihan Yurdaydin, M.D., Moises Diago, M.D., Selim Gurel, M.D., Ming-Yang Lai, M.D., Peter Button, M.Sc., and Nigel Pluck, M.D., for the Peginterferon Alfa-2a HBeAg-Negative Chronic Hepatitis B Study GroupThu, 16  Sep  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/12/1206?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Oral erythromycin prolongs cardiac repolarization and is associated with case reports of torsades de pointes. Because erythromycin is extensively metabolized by cytochrome P-450 3A (CYP3A) isozymes, commonly used medications...http://content.nejm.org/cgi/content/short/351/11/1089?rss=1&ssource=collectionSearchRss&queryTerm=5Wayne A. Ray, Ph.D., Katherine T. Murray, M.D., Sarah Meredith, M.B., B.S., Sukumar Suguna Narasimhulu, M.B., B.S., M.P.H., Kathi Hall, M.S., and C. Michael Stein, M.B., Ch.B.Thu, 09  Sep  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/11/1089?rss=1&ssource=collectionSearchRss&queryTerm=5A healthy 60-year-old woman presented with a painful left hand. She noted that she had pulled a splinter from her left thumb while on vacation three months previously. She reported...http://content.nejm.org/cgi/content/short/351/9/911?rss=1&ssource=collectionSearchRss&queryTerm=5Roxann Powers, M.D. and Melanie Fisher, M.D.Thu, 26  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/9/911?rss=1&ssource=collectionSearchRss&queryTerm=5A 43-year-old man has a two-week history of nasal congestion, postnasal drip, and fatigue. He has used an over-the-counter nasal decongestant and acetaminophen, without relief. During the past few days,...http://content.nejm.org/cgi/content/short/351/9/902?rss=1&ssource=collectionSearchRss&queryTerm=5Jay F. Piccirillo, M.D.Thu, 26  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/9/902?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> No safe and convenient regimen has proved to be effective for the management of recurrent vulvovaginal candidiasis.<br/><br/><em>Methods:</em> After inducing clinical remission with open-label fluconazole given in three 150-mg doses...http://content.nejm.org/cgi/content/short/351/9/876?rss=1&ssource=collectionSearchRss&queryTerm=5Jack D. Sobel, M.D., Harold C. Wiesenfeld, M.D., Mark Martens, M.D., Penny Danna, M.D., Thomas M. Hooton, M.D., Anne Rompalo, M.D., Malcolm Sperling, M.D., Charles Livengood III, M.D., Benson Horowitz, M.D., James Von Thron, M.D., Libby Edwards, M.D., Helene Panzer, Ph.D., and Teng-Chiao Chu, Ph.D.Thu, 26  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/9/876?rss=1&ssource=collectionSearchRss&queryTerm=5Vulvovaginal symptoms are common, and they represent one of the most frequent reasons for visits to physicians by women in all age groups. Vulvovaginitis is rarely life-threatening, and it is...http://content.nejm.org/cgi/content/short/351/9/851?rss=1&ssource=collectionSearchRss&queryTerm=5David A. Eschenbach, M.D.Thu, 26  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/9/851?rss=1&ssource=collectionSearchRss&queryTerm=5Hookworm infection in humans is caused by an infection with the helminth nematode parasites Necator americanus and Ancylostoma duodenale and is transmitted through contact with contaminated soil. It is one...http://content.nejm.org/cgi/content/short/351/8/799?rss=1&ssource=collectionSearchRss&queryTerm=5Peter J. Hotez, M.D., Ph.D., Simon Brooker, D.Phil., Jeffrey M. Bethony, Ph.D., Maria Elena Bottazzi, Ph.D., Alex Loukas, Ph.D., and Shuhua Xiao, M.D.Thu, 19  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/8/799?rss=1&ssource=collectionSearchRss&queryTerm=5In 1941, Skinner and Keefer vividly chronicled an astonishing 82 percent mortality among 122 consecutive patients who had been treated for Staphylococcus aureus bacteremia in the preantibiotic era.1 Of the...http://content.nejm.org/cgi/content/short/351/6/523?rss=1&ssource=collectionSearchRss&queryTerm=5Richard P. Wenzel, M.D.Thu, 05  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/6/523?rss=1&ssource=collectionSearchRss&queryTerm=5A 45-year-old man was admitted to the hospital because of a fever (temperature, 40°C), myalgia, and headache. He did not have diarrhea. On examination, he had bilateral proptosis with chemosis...http://content.nejm.org/cgi/content/short/351/5/487?rss=1&ssource=collectionSearchRss&queryTerm=5Leonardo M. Astudillo, M.D. and Philippe M. Arlet, M.D.Thu, 29  Jul  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/5/487?rss=1&ssource=collectionSearchRss&queryTerm=5A 44-year-old woman presented with a 10-month history of intermittent discomfort in the right upper abdomen. On physical examination, a mass filling the epigastrium and the right subcostal region was...http://content.nejm.org/cgi/content/short/351/4/e3?rss=1&ssource=collectionSearchRss&queryTerm=5Nermin Halkic, M.D. and Michel Gillet, M.D.Thu, 22  Jul  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/4/e3?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Vestibular neuritis is the second most common cause of peripheral vestibular vertigo. Its assumed cause is a reactivation of herpes simplex virus type 1 infection. Therefore, corticosteroids, antiviral agents,...http://content.nejm.org/cgi/content/short/351/4/354?rss=1&ssource=collectionSearchRss&queryTerm=5Michael Strupp, M.D., Vera Carina Zingler, M.D., Viktor Arbusow, M.D., Daniel Niklas, Klaus Peter Maag, M.D., Ph.D., Marianne Dieterich, M.D., Sandra Bense, M.D., Diethilde Theil, D.V.M., Klaus Jahn, M.D., and Thomas Brandt, M.D.Thu, 22  Jul  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/4/354?rss=1&ssource=collectionSearchRss&queryTerm=5Acute renal failure occurs in approximately 19 percent of patients with moderate sepsis, 23 percent with severe sepsis, and 51 percent with septic shock when blood cultures are positive (Table...http://content.nejm.org/cgi/content/short/351/2/159?rss=1&ssource=collectionSearchRss&queryTerm=5Robert W. Schrier, M.D., and Wei Wang, M.D.Thu, 08  Jul  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/2/159?rss=1&ssource=collectionSearchRss&queryTerm=5For decades, syphilis infection has been treated with penicillin, and Treponema pallidum has not developed resistance to penicillin. 04070830.xml 04070830.xml In many countries, the recommended treatment for early syphilis is...http://content.nejm.org/cgi/content/short/351/2/154?rss=1&ssource=collectionSearchRss&queryTerm=5Sheila A. Lukehart, Ph.D., Charmie Godornes, B.S., Barbara J. Molini, M.S., Patricia Sonnett, B.S., Susan Hopkins, M.D., Fiona Mulcahy, M.D., Joseph Engelman, M.D., Samuel J. Mitchell, M.D., Ph.D., Anne M. Rompalo, M.D., Christina M. Marra, M.D., and Jeffrey D. Klausner, M.D., M.P.H.Thu, 08  Jul  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/2/154?rss=1&ssource=collectionSearchRss&queryTerm=5Syphilis. The name of this widespread and ancient disease is familiar to health care providers worldwide. This name recognition, however, belies the complexity of the disease, as well as the...http://content.nejm.org/cgi/content/short/351/2/122?rss=1&ssource=collectionSearchRss&queryTerm=5Edward W. Hook III, M.D., and Rosanna W. Peeling, Ph.D.Thu, 08  Jul  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/2/122?rss=1&ssource=collectionSearchRss&queryTerm=5Microsporidia are obligate intracellular eukaryotes that have emerged as a cause of chronic diarrheal syndromes in patients with human immunodeficiency virus (HIV) infection.1 Most cases have been caused by Enterocytozoon...http://content.nejm.org/cgi/content/short/351/1/42?rss=1&ssource=collectionSearchRss&queryTerm=5Christina M. Coyle, M.D., Louis M. Weiss, M.D., M.P.H., Luther V. Rhodes III, M.D., Ann Cali, Ph.D., Peter M. Takvorian, Ph.D., Daniel F. Brown, M.D., Govinda S. Visvesvara, Ph.D., Lihua Xiao, D.V.M., Ph.D., Jaan Naktin, M.D., Eric Young, M.D., Marcelo Gareca, M.D., Georgia Colasante, M.S., and Murray Wittner, M.D., Ph.D.Thu, 01  Jul  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/1/42?rss=1&ssource=collectionSearchRss&queryTerm=5A 12-year-old boy with acute myelogenous leukemia that had been diagnosed two months earlier presented to a hospital with fever and leg pain. He had received intravenous cytarabine two weeks...http://content.nejm.org/cgi/content/short/350/25/2603?rss=1&ssource=collectionSearchRss&queryTerm=5Stephen M. Schexnayder, M.D. and Sarah G. Klein, M.D.Thu, 17  Jun  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/25/2603?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Allografts are commonly used in orthopedic reconstructive surgery. In 2001, approximately 875,000 musculoskeletal allografts were distributed by U.S. tissue banks. After the death from Clostridium sordellii sepsis of a...http://content.nejm.org/cgi/content/short/350/25/2564?rss=1&ssource=collectionSearchRss&queryTerm=5Marion A. Kainer, M.B., B.S., M.P.H., Jeanne V. Linden, M.D., M.P.H., David N. Whaley, Harvey T. Holmes, Ph.D., William R. Jarvis, M.D., Daniel B. Jernigan, M.D., M.P.H., and Lennox K. Archibald, M.B., B.S.Thu, 17  Jun  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/25/2564?rss=1&ssource=collectionSearchRss&queryTerm=5The 2003 Institute of Medicine report Microbial Threats to Health: Emergence, Detection, and Response lists “advances in medical technologies, such as blood transfusions and organ transplants,” as one reason for...http://content.nejm.org/cgi/content/short/350/25/2544?rss=1&ssource=collectionSearchRss&queryTerm=5Robin Patel, M.D, and Andrej Trampuz, M.D.Thu, 17  Jun  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/25/2544?rss=1&ssource=collectionSearchRss&queryTerm=5A 74-year-old man was brought to the emergency department after being found confused and incapacitated at home. The patient lived in a residential hotel and had previously been healthy and...http://content.nejm.org/cgi/content/short/350/23/2399?rss=1&ssource=collectionSearchRss&queryTerm=5Ashish K. Jha, M.D., Kaveh G. Shojania, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 03  Jun  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/23/2399?rss=1&ssource=collectionSearchRss&queryTerm=5In terms of sheer drama, the emergence of the severe acute respiratory syndrome (SARS) rivaled the most exotic Michael Crichton thriller. A novel viral strain spread in “wet markets” from...http://content.nejm.org/cgi/content/short/350/23/2332?rss=1&ssource=collectionSearchRss&queryTerm=5Robert A. Weinstein, M.D.Thu, 03  Jun  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/23/2332?rss=1&ssource=collectionSearchRss&queryTerm=5A 68-year-old woman with diabetes mellitus that was treated with insulin was hospitalized because of abdominal pain and vomiting. She had been treated empirically for a urinary tract infection with...http://content.nejm.org/cgi/content/short/350/22/2280?rss=1&ssource=collectionSearchRss&queryTerm=5Keyvan Ravakhah, M.D., M.B.A. and Ramona Simionescu, M.D.Thu, 27  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/22/2280?rss=1&ssource=collectionSearchRss&queryTerm=5On September 30, 2003, Boston University and the University of Texas at Galveston were each awarded $120 million by the National Institute of Allergy and Infectious Diseases to build a...http://content.nejm.org/cgi/content/short/350/21/2121?rss=1&ssource=collectionSearchRss&queryTerm=5Louise Richardson, Ph.D.Thu, 20  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/21/2121?rss=1&ssource=collectionSearchRss&queryTerm=5The attacks on the World Trade Center and the Pentagon on September 11, 2001, and the deliberate release of anthrax spores that occurred soon thereafter starkly revealed our vulnerability to...http://content.nejm.org/cgi/content/short/350/21/2119?rss=1&ssource=collectionSearchRss&queryTerm=5Rona Hirschberg, Ph.D., John La Montagne, Ph.D., and Anthony S. Fauci, M.D.Thu, 20  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/21/2119?rss=1&ssource=collectionSearchRss&queryTerm=5Streptococcus pyogenes, also known as group A streptococcus, is the cause of purulent pharyngitis and pyoderma, occasionally complicated by scarlet fever, rheumatic fever, and glomerulonephritis — a scenario familiar to...http://content.nejm.org/cgi/content/short/350/20/2093?rss=1&ssource=collectionSearchRss&queryTerm=5Eric J. Brown, M.D.Thu, 13  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/20/2093?rss=1&ssource=collectionSearchRss&queryTerm=5Because of my extensive training — four years of medical school, three years of pediatric residency, a two-year fellowship in pediatric infectious diseases — and because of my years of...http://content.nejm.org/cgi/content/short/350/20/2023?rss=1&ssource=collectionSearchRss&queryTerm=5Perri Klass, M.D.Thu, 13  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/20/2023?rss=1&ssource=collectionSearchRss&queryTerm=5A 26-year-old woman with end-stage renal disease from primary membranoproliferative glomerulonephritis presented with a two-week history of intermittent fever, with temperatures as high as 39°C. She had received her second...http://content.nejm.org/cgi/content/short/350/19/1990?rss=1&ssource=collectionSearchRss&queryTerm=5Uptal D. Patel, M.D., Harry Hollander, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 06  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/19/1990?rss=1&ssource=collectionSearchRss&queryTerm=5A 47-year-old man was admitted to the intensive care unit with respiratory failure complicating pneumonia due to legionella infection. Mechanical ventilation with positive end-expiratory pressure was initiated. Radiographs of the...http://content.nejm.org/cgi/content/short/350/18/e16?rss=1&ssource=collectionSearchRss&queryTerm=5Jolanda H.M. van Steijn, M.D. and Peter H.J. van der Voort, M.D., Ph.D.Thu, 29  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/18/e16?rss=1&ssource=collectionSearchRss&queryTerm=5A 64-year-old Korean woman had a four-week history of dull pain in the lower abdomen that was worse on movement; she had no gastrointestinal or urogenital symptoms. The previous year,...http://content.nejm.org/cgi/content/short/350/17/1763?rss=1&ssource=collectionSearchRss&queryTerm=5Rodney C. Studd, M.B., Ch.B. and Peter J. Stewart, F.R.A.C.S.Thu, 22  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/17/1763?rss=1&ssource=collectionSearchRss&queryTerm=5What does it mean to describe an infection as having airborne transmission, and what are the clinical implications? There is a fitting symmetry between the report by Yu et al....http://content.nejm.org/cgi/content/short/350/17/1710?rss=1&ssource=collectionSearchRss&queryTerm=5Chad J. Roy, M.S.P.H., Ph.D., and Donald K. Milton, M.D., Dr.P.H.Thu, 22  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/17/1710?rss=1&ssource=collectionSearchRss&queryTerm=5A 35-year-old woman presented with a three-day history of sore throat, painful swelling of the neck, fever, rigor, hemoptysis, and dyspnea. Examination revealed pustular exudates on the right tonsil and...http://content.nejm.org/cgi/content/short/350/16/e14?rss=1&ssource=collectionSearchRss&queryTerm=5Clinton Lai, M.B., Ch.B., M.R.C.P. and Dharshan R. Vummidi, M.R.C.P.Thu, 15  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/16/e14?rss=1&ssource=collectionSearchRss&queryTerm=5A 68-year-old man originally from the Philippines presented with a three-month history of increasing dyspnea on exertion and orthopnea. He also reported an unintentional weight loss of 7 kg (15...http://content.nejm.org/cgi/content/short/350/14/1443?rss=1&ssource=collectionSearchRss&queryTerm=5Paul B. Cornia, M.D., Benjamin A. Lipsky, M.D., Gurpreet Dhaliwal, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 01  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/14/1443?rss=1&ssource=collectionSearchRss&queryTerm=5A 23-year-old Peace Corps volunteer lived in a traditional mud hut with a thatched roof in a rural savannah village in Gambia. Several painless ulcers developed on his lower legs...http://content.nejm.org/cgi/content/short/350/14/1442?rss=1&ssource=collectionSearchRss&queryTerm=5Stephen Morris-Jones, M.R.C.P. and Martin Weber, M.D.Thu, 01  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/14/1442?rss=1&ssource=collectionSearchRss&queryTerm=5About half of the 2 million cases of nosocomial infection that occur each year in the United States are associated with indwelling devices. Although less common than infections related to...http://content.nejm.org/cgi/content/short/350/14/1422?rss=1&ssource=collectionSearchRss&queryTerm=5Rabih O. Darouiche, M.D.Thu, 01  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/14/1422?rss=1&ssource=collectionSearchRss&queryTerm=5 Dr. Bimalangshu R. Dey: A 58-year-old man with a large sacral ulcer was admitted to the hospital for chemotherapy to treat acute myeloid leukemia.<br/><br/>The patient had had recurrent infections...http://content.nejm.org/cgi/content/short/350/13/1339?rss=1&ssource=collectionSearchRss&queryTerm=5Jay A. Fishman, M.D., Bimalangshu R. Dey, M.D., and Robert P. Hasserjian, M.D.Thu, 25  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/13/1339?rss=1&ssource=collectionSearchRss&queryTerm=5One afternoon last December, I took a tour of my hospital with Deborah Yokoe, an infectious-disease specialist, and Susan Marino, a medical technologist by training. They work in our infection-control...http://content.nejm.org/cgi/content/short/350/13/1283?rss=1&ssource=collectionSearchRss&queryTerm=5Atul Gawande, M.D., M.P.H.Thu, 25  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/13/1283?rss=1&ssource=collectionSearchRss&queryTerm=5On first setting foot on the moon, Neil Armstrong famously proclaimed that he had taken “One small step for man, one giant leap for mankind.” With minor adjustments, he could...http://content.nejm.org/cgi/content/short/350/12/1171?rss=1&ssource=collectionSearchRss&queryTerm=5Mark S. Klempner, M.D., and Daniel S. Shapiro, M.D.Thu, 18  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/12/1171?rss=1&ssource=collectionSearchRss&queryTerm=5A 28-year-old man was admitted to the hospital because of abdominal pain and fever.<br/><br/>The patient had been well until 10 days earlier, when mild epigastric pain developed. Two days before...http://content.nejm.org/cgi/content/short/350/11/1131?rss=1&ssource=collectionSearchRss&queryTerm=5William R. Brugge, M.D., Peter R. Mueller, M.D., and Joseph Misdraji, M.D.Thu, 11  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/11/1131?rss=1&ssource=collectionSearchRss&queryTerm=5March 14, 2004, marks the 150th anniversary of the birth of Paul Ehrlich, one of the generation of pioneers who, during the 50 years that led up to World War...http://content.nejm.org/cgi/content/short/350/11/1079?rss=1&ssource=collectionSearchRss&queryTerm=5Robert S. Schwartz, M.D.Thu, 11  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/11/1079?rss=1&ssource=collectionSearchRss&queryTerm=5A 29-year-old man infected with the human immunodeficiency virus (HIV) presented with right-sided abdominal pain and diarrhea. His CD4 cell count was 24 per cubic millimeter, and his HIV viral...http://content.nejm.org/cgi/content/short/350/10/e9?rss=1&ssource=collectionSearchRss&queryTerm=5Faheem Younus, M.D. and Roy T. Steigbigel, M.D.Thu, 04  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/10/e9?rss=1&ssource=collectionSearchRss&queryTerm=5A previously healthy 16-year-old girl presented to her physician because of a two-day history of sore throat, fatigue, fever, headache, and vomiting; she had not had rhinorrhea or a cough....http://content.nejm.org/cgi/content/short/350/10/1037?rss=1&ssource=collectionSearchRss&queryTerm=5Sandra J. Bliss, M.D., Scott A. Flanders, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 04  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/10/1037?rss=1&ssource=collectionSearchRss&queryTerm=5A small, raised, erythematous lesion developed on the dorsum of the hand of a 35-year-old man who worked in a pet shop. Over a period of three months, there was...http://content.nejm.org/cgi/content/short/350/9/e8?rss=1&ssource=collectionSearchRss&queryTerm=5Chau Nguyen, M.D.Thu, 26  Feb  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/9/e8?rss=1&ssource=collectionSearchRss&queryTerm=5An otherwise healthy 40-year-old man felt feverish and noted pain and redness over the dorsum of his foot. Tender edema and erythema extended up the pretibial area. Fissures were present...http://content.nejm.org/cgi/content/short/350/9/904?rss=1&ssource=collectionSearchRss&queryTerm=5Morton N. Swartz, M.D.Thu, 26  Feb  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/9/904?rss=1&ssource=collectionSearchRss&queryTerm=5A 60-year-old woman with a history of radiologically confirmed seronegative rheumatoid arthritis presented to the emergency department with a 10-day history of worsening dyspnea on exertion, nonproductive cough, and subjective...http://content.nejm.org/cgi/content/short/350/6/599?rss=1&ssource=collectionSearchRss&queryTerm=5Anthony A. Hilliard, M.D., Steven E. Weinberger, M.D., Lawrence M. Tierney, Jr., M.D., David E. Midthun, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 05  Feb  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/6/599?rss=1&ssource=collectionSearchRss&queryTerm=5On December 9, 2003, a nonambulatory (“downer”) dairy cow was slaughtered in Washington State, and because the animal's condition was attributed to complications from calving, the animal was judged to...http://content.nejm.org/cgi/content/short/350/6/539?rss=1&ssource=collectionSearchRss&queryTerm=5Christl A. Donnelly, Sc.D.Thu, 05  Feb  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/6/539?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The diagnosis and treatment of bacterial pneumonia in patients who are receiving mechanical ventilation remain a difficult challenge. The triggering receptor expressed on myeloid cells (TREM-1) is a member...http://content.nejm.org/cgi/content/short/350/5/451?rss=1&ssource=collectionSearchRss&queryTerm=5Sébastien Gibot, M.D., Aurélie Cravoisy, M.D., Bruno Levy, M.D., Ph.D., Marie-Christine Bene, M.D., Ph.D., Gilbert Faure, M.D., Ph.D., and Pierre-Edouard Bollaert, M.D., Ph.D.Thu, 29  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/5/451?rss=1&ssource=collectionSearchRss&queryTerm=5The food in the United States is among the safest in the world, but recent outbreaks of hepatitis A remind us that foodborne illness remains an important public health concern....http://content.nejm.org/cgi/content/short/350/5/437?rss=1&ssource=collectionSearchRss&queryTerm=5David W.K. Acheson, M.D., and Anthony E. Fiore, M.D., M.P.H.Thu, 29  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/5/437?rss=1&ssource=collectionSearchRss&queryTerm=5The establishment of an appropriate diagnosis of ventilator-associated pneumonia is one of the most crucial and difficult issues in the care of critically ill patients. Established clinical criteria alone, such...http://content.nejm.org/cgi/content/short/350/5/433?rss=1&ssource=collectionSearchRss&queryTerm=5Antoni Torres, M.D., and Santiago Ewig, M.D.Thu, 29  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/5/433?rss=1&ssource=collectionSearchRss&queryTerm=5Taenia solium causes two different diseases. When the adult cestode infests the human intestine, taeniasis develops; it is generally asymptomatic, but the host becomes a continuous source of taenia eggs,...http://content.nejm.org/cgi/content/short/350/3/280?rss=1&ssource=collectionSearchRss&queryTerm=5Julio Sotelo, M.D.Thu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/280?rss=1&ssource=collectionSearchRss&queryTerm=5A 15-year-old Peruvian girl who lived in the Andes mountains had a three-month history of headache, nausea, vomiting, and visual obscuration and a one-month history of incoherent speech, confusion, and...http://content.nejm.org/cgi/content/short/350/3/266?rss=1&ssource=collectionSearchRss&queryTerm=5Howard W. Sander, M.D. and Conrado Castro, M.D.Thu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/266?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Neurocysticercosis is the main cause of adult-onset seizures in the developing world. Whether therapy with antiparasitic agents results in improved seizure control has been questioned because of the lack...http://content.nejm.org/cgi/content/short/350/3/249?rss=1&ssource=collectionSearchRss&queryTerm=5Héctor H. Garcia, M.D., Ph.D., E. Javier Pretell, M.D., Robert H. Gilman, M.D., S. Manuel Martinez, M.D., Lawrence H. Moulton, Ph.D., Oscar H. Del Brutto, M.D., Genaro Herrera, M.D., Carlton A.W. Evans, M.D., Ph.D., and Armando E. Gonzalez, D.V.M., Ph.D., for the Cysticercosis Working Group in PeruThu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/249?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Immunoproliferative small intestinal disease (also known as alpha chain disease) is a form of lymphoma that arises in small intestinal mucosa-associated lymphoid tissue (MALT) and is associated with the...http://content.nejm.org/cgi/content/short/350/3/239?rss=1&ssource=collectionSearchRss&queryTerm=5Marc Lecuit, M.D., Ph.D., Eric Abachin, Ph.D., Antoine Martin, M.D., Claire Poyart, M.D., Ph.D., Philippe Pochart, Ph.D., Felipe Suarez, M.D., Djaouida Bengoufa, M.D., Ph.D., Jean Feuillard, M.D., Ph.D., Anne Lavergne, M.D., Jeffrey I. Gordon, M.D., Patrick Berche, M.D., Ph.D., Loïc Guillevin, M.D., and Olivier Lortholary, M.D., Ph.D.Thu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/239?rss=1&ssource=collectionSearchRss&queryTerm=5It may come as a surprise that a lowly tapeworm is responsible for as many as 10 percent of cases in which a patient presents with seizures to an emergency...http://content.nejm.org/cgi/content/short/350/3/215?rss=1&ssource=collectionSearchRss&queryTerm=5James H. Maguire, M.D.Thu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/215?rss=1&ssource=collectionSearchRss&queryTerm=5Fifty years ago, the idea that infectious agents caused lymphoma would have seemed heretical. Although viruses were known to cause tumors in animals, they were not considered a cause of...http://content.nejm.org/cgi/content/short/350/3/213?rss=1&ssource=collectionSearchRss&queryTerm=5Julie Parsonnet, M.D., and Peter G. Isaacson, F.R.C.Path.Thu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/213?rss=1&ssource=collectionSearchRss&queryTerm=5A 14-year-old girl presented with worsening headaches, unilateral decreased visual acuity (20/20 in the right eye and 5/200 in the left eye), and ocular pain in the left eye. The...http://content.nejm.org/cgi/content/short/350/2/e1?rss=1&ssource=collectionSearchRss&queryTerm=5Arnd M. Herz, M.D. and J. Michael Lahey, M.D.Thu, 08  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/2/e1?rss=1&ssource=collectionSearchRss&queryTerm=5Idiopathic pulmonary fibrosis, defined pathologically as usual interstitial pneumonia, is a fatal disease that occurs most commonly among persons who are 60 years of age or older and in otherwise...http://content.nejm.org/cgi/content/short/350/2/181?rss=1&ssource=collectionSearchRss&queryTerm=5Alvin S. Teirstein, M.D.Thu, 08  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/2/181?rss=1&ssource=collectionSearchRss&queryTerm=5A 49-year-old left-handed woman was evaluated in the neurology clinic because of painful asymmetric neuropathy.<br/><br/>The patient had been well until several years earlier, when numbness developed in the right hand....http://content.nejm.org/cgi/content/short/350/2/166?rss=1&ssource=collectionSearchRss&queryTerm=5David A. Chad, M.D., and E. Tessa Hedley-Whyte, M.D.Thu, 08  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/2/166?rss=1&ssource=collectionSearchRss&queryTerm=5An otherwise healthy 23-year-old man presents after the acute onset of watery diarrhea that has persisted for two days. He reports associated nausea and cramping but no emesis and is...http://content.nejm.org/cgi/content/short/350/1/38?rss=1&ssource=collectionSearchRss&queryTerm=5Nathan M. Thielman, M.D., M.P.H., and Richard L. Guerrant, M.D.Thu, 01  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/1/38?rss=1&ssource=collectionSearchRss&queryTerm=5A 19-year-old woman visits her primary care provider for counseling about contraception. She became sexually active one year previously and has had a new sexual partner for the past three...http://content.nejm.org/cgi/content/short/349/25/2424?rss=1&ssource=collectionSearchRss&queryTerm=5Jeffrey F. Peipert, M.D., M.P.H.Thu, 18  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/25/2424?rss=1&ssource=collectionSearchRss&queryTerm=5A 12-year-old girl was admitted to the hospital because of fever, vomiting, and an abrupt onset of unresponsiveness.<br/><br/>She had been well until one week earlier, when a cough, sore throat,...http://content.nejm.org/cgi/content/short/349/24/2341?rss=1&ssource=collectionSearchRss&queryTerm=5H. Shaw Warren, Jr., M.D., R. Gilberto Gonzalez, M.D., and Di Tian, M.D., Ph.D.Thu, 11  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/24/2341?rss=1&ssource=collectionSearchRss&queryTerm=5The failure to achieve a rapid and reliable means of diagnosing most infectious diseases remains a frustrating testimony to the diversity of pathogens and the complexity of human–microbe interactions. With...http://content.nejm.org/cgi/content/short/349/22/2162?rss=1&ssource=collectionSearchRss&queryTerm=5David A. Relman, M.D.Thu, 27  Nov  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/22/2162?rss=1&ssource=collectionSearchRss&queryTerm=5A 62-year-old woman presented to her local emergency department because of pain in the epigastrium and right upper quadrant. The pain had begun insidiously five days earlier and was constant,...http://content.nejm.org/cgi/content/short/349/19/1848?rss=1&ssource=collectionSearchRss&queryTerm=5Sandra J. Bliss, M.D., Richard H. Moseley, M.D., John Del Valle, M.D., and Sanjay Saint, M.D., M.P.H.Thu, 06  Nov  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/19/1848?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics.<br/><br/><em>Methods:</em> We conducted a retrospective cohort study using the General Practice Research Database in...http://content.nejm.org/cgi/content/short/349/17/1628?rss=1&ssource=collectionSearchRss&queryTerm=5Brian L. Strom, M.D., M.P.H., Rita Schinnar, M.P.A., Andrea J. Apter, M.D., David J. Margolis, M.D., Ph.D., Ebbing Lautenbach, M.D., M.P.H., M.S.C.E., Sean Hennessy, Pharm.D., Ph.D., Warren B. Bilker, Ph.D., and Dan Pettitt, D.V.M.Thu, 23  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/17/1628?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Most antimalarial agents used by travelers act on the parasite's blood stage and therefore do not prevent late-onset illness, particularly that due to species that cause relapsing malaria. We...http://content.nejm.org/cgi/content/short/349/16/1510?rss=1&ssource=collectionSearchRss&queryTerm=5Eli Schwartz, M.D., Monica Parise, M.D., Phyllis Kozarsky, M.D., and Martin Cetron, M.D.Thu, 16  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/16/1510?rss=1&ssource=collectionSearchRss&queryTerm=5Cases of malaria acquired by international travelers from industrialized countries probably number 25,000 annually; of these, about 10,000 are reported, and 150 are fatal. These numbers are growing because of...http://content.nejm.org/cgi/content/short/349/16/1496?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas E. Wellems, M.D., Ph.D., and Louis H. Miller, M.D.Thu, 16  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/16/1496?rss=1&ssource=collectionSearchRss&queryTerm=5A 26-year-old U.S. soldier was referred to our institution with a two-week history of unexplained fever and weight loss. The physical examination was unremarkable. Laboratory examination revealed anemia, leukopenia, mild...http://content.nejm.org/cgi/content/short/349/14/e13?rss=1&ssource=collectionSearchRss&queryTerm=5Matthew W. Pantsari, M.D. and Teresa A. Coleman, M.D.Thu, 02  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/14/e13?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Acute respiratory tract infections caused by Streptococcus pneumoniae are a leading cause of morbidity and mortality in young children. We evaluated the efficacy of a 9-valent pneumococcal conjugate vaccine...http://content.nejm.org/cgi/content/short/349/14/1341?rss=1&ssource=collectionSearchRss&queryTerm=5Keith P. Klugman, M.B., B.Ch., Ph.D., Shabir A. Madhi, M.B., B.Ch., Robin E. Huebner, Ph.D., Robert Kohberger, Ph.D., Nontombi Mbelle, M.B., B.Ch., M.Med., and Nathaniel Pierce, M.D., for the Vaccine Trialists GroupThu, 02  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/14/1341?rss=1&ssource=collectionSearchRss&queryTerm=5Despite the fact that a licensed pneumococcal capsular polysaccharide vaccine has been available for more than 30 years, Streptococcus pneumoniae continues to sicken and kill children and adults throughout the...http://content.nejm.org/cgi/content/short/349/14/1312?rss=1&ssource=collectionSearchRss&queryTerm=5Kathryn M. Edwards, M.D., and Marie R. Griffin, M.D., M.P.H.Thu, 02  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/14/1312?rss=1&ssource=collectionSearchRss&queryTerm=5A 60-year-old man was evaluated in the clinic in mid-June because of fever, rigors, and sweats.<br/><br/>The patient had been well until 10 days earlier, when anorexia, a sore throat, diffuse...http://content.nejm.org/cgi/content/short/349/12/1168?rss=1&ssource=collectionSearchRss&queryTerm=5Joshua D. Gutman, M.D., Camille N. Kotton, M.D., and Alexander Kratz, M.D., Ph.D.Thu, 18  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/12/1168?rss=1&ssource=collectionSearchRss&queryTerm=5A newborn boy was admitted to a special-care nursery because of petechiae and thrombocytopenia.<br/><br/>The boy had been delivered at this hospital at 39 weeks' gestation to a 32-year-old woman who...http://content.nejm.org/cgi/content/short/349/7/691?rss=1&ssource=collectionSearchRss&queryTerm=5John F. Modlin, M.D., P. Ellen Grant, M.D., Robert S. Makar, M.D., Ph.D., Drucilla J. Roberts, M.D., and Kalpathy S. Krishnamoorthy, M.D., M.B., B.S.Thu, 14  Aug  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/7/691?rss=1&ssource=collectionSearchRss&queryTerm=5An 86-year-old man presented with abdominal discomfort and fever. His medical history was notable for long-standing hypertension, mild chronic renal insufficiency, coronary-artery bypass surgery, and abdominal-aortic-aneurysm repair seven years earlier,...http://content.nejm.org/cgi/content/short/349/6/597?rss=1&ssource=collectionSearchRss&queryTerm=5Sigall Kassutto, M.D., and Marshall A. Wolf, M.D.Thu, 07  Aug  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/6/597?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In June 2002, the Food and Drug Administration received reports of bacterial meningitis in patients with cochlear implants for treatment of hearing loss. Implants that included a positioner (a...http://content.nejm.org/cgi/content/short/349/5/435?rss=1&ssource=collectionSearchRss&queryTerm=5Jennita Reefhuis, Ph.D., Margaret A. Honein, Ph.D., Cynthia G. Whitney, M.D., Shadi Chamany, M.D., Eric A. Mann, M.D., Ph.D., Krista R. Biernath, M.D., Karen Broder, M.D., Susan Manning, M.D., Swati Avashia, M.D., Marcia Victor, M.P.H., Pamela Costa, M.A., Owen Devine, Ph.D., Ann Graham, C.R.N.A., M.P.H., and Coleen Boyle, Ph.D.Thu, 31  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/5/435?rss=1&ssource=collectionSearchRss&queryTerm=5Currently, a cochlear implant is the standard treatment for people whose hearing ability is so poor that well-fit hearing aids fail to permit effective oral communication. The implant is a...http://content.nejm.org/cgi/content/short/349/5/421?rss=1&ssource=collectionSearchRss&queryTerm=5George A. Gates, M.D., and Richard T. Miyamoto, M.D.Thu, 31  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/5/421?rss=1&ssource=collectionSearchRss&queryTerm=5A 22-year-old man was examined in the clinic because of fever, chills, and thrombocytopenia.<br/><br/>Five months earlier, the patient, who was late in planning a six-week trip to South America, had...http://content.nejm.org/cgi/content/short/349/3/287?rss=1&ssource=collectionSearchRss&queryTerm=5Johanna P. Daily, M.D., and Mary Ann Waldron, M.T.(A.S.C.P.)Thu, 17  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/3/287?rss=1&ssource=collectionSearchRss&queryTerm=5A 28-year-old woman telephones her physician to report dysuria and urinary urgency during the preceding three days. She has had several previous urinary tract infections, including three during the past...http://content.nejm.org/cgi/content/short/349/3/259?rss=1&ssource=collectionSearchRss&queryTerm=5Stephan D. Fihn, M.D., M.P.H.Thu, 17  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/3/259?rss=1&ssource=collectionSearchRss&queryTerm=5A 76-year-old woman with a history of diabetes mellitus and myocardial infarction presented with abdominal pain. A plain radiograph (Panel A) showed an air and soft-tissue doughnut sign in the...http://content.nejm.org/cgi/content/short/349/3/258?rss=1&ssource=collectionSearchRss&queryTerm=5Satoshi Asada, M.D. and Tatsuya Kawasaki, M.D.Thu, 17  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/3/258?rss=1&ssource=collectionSearchRss&queryTerm=5A 77-year-old man with diabetes presented with a four-day history of fever and worsening left-sided neck and shoulder pain accompanied by numbness and paresthesias in the fingers of the hand...http://content.nejm.org/cgi/content/short/348/25/2525?rss=1&ssource=collectionSearchRss&queryTerm=5Michelle V. Lee, M.D. and Anthony Minotti, M.D.Thu, 19  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/25/2525?rss=1&ssource=collectionSearchRss&queryTerm=5In this issue of the Journal, Gallin and colleagues1 report the results of a clinical trial of itraconazole for the prevention of severe fungal infection in children and adults with...http://content.nejm.org/cgi/content/short/348/24/2455?rss=1&ssource=collectionSearchRss&queryTerm=5Stephen W. Lagakos, Ph.D.Thu, 12  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/24/2455?rss=1&ssource=collectionSearchRss&queryTerm=5The number of cases of Lyme disease reported in the United States has increased from 491 cases in 1982,1 the first year of national surveillance, to 17,029 in 2001,2 despite...http://content.nejm.org/cgi/content/short/348/24/2424?rss=1&ssource=collectionSearchRss&queryTerm=5Edward B. Hayes, M.D., and Joseph Piesman, D.Sc.Thu, 12  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/24/2424?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Chronic granulomatous disease is a rare disorder in which the phagocytes fail to produce hydrogen peroxide. The patients are predisposed to bacterial and fungal infections. Prophylactic antibiotics and interferon...http://content.nejm.org/cgi/content/short/348/24/2416?rss=1&ssource=collectionSearchRss&queryTerm=5John I. Gallin, M.D., David W. Alling, M.D., Harry L. Malech, M.D., Robert Wesley, Ph.D., Deloris Koziol, Ph.D., Beatriz Marciano, M.D., Eli M. Eisenstein, M.D., Maria L. Turner, M.D., Ellen S. DeCarlo, R.N., Judith M. Starling, R.Ph., and Steven M. Holland, M.D.Thu, 12  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/24/2416?rss=1&ssource=collectionSearchRss&queryTerm=5As private citizens and as public health professionals, we are enthralled by the new, the unknown, and the catastrophic. This is especially true for epidemics that appear suddenly, spread rapidly,...http://content.nejm.org/cgi/content/short/348/22/2173?rss=1&ssource=collectionSearchRss&queryTerm=5Dale L. Morse, M.D.Thu, 29  May  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/22/2173?rss=1&ssource=collectionSearchRss&queryTerm=5A 58-year-old, right-handed woman was admitted to the hospital because of left hemiparesis.<br/><br/>The patient had been well until five days earlier, when a right frontal headache developed, with radiation to...http://content.nejm.org/cgi/content/short/348/21/2125?rss=1&ssource=collectionSearchRss&queryTerm=5Robert M. Friedlander, M.D., R. Gilberto Gonzalez, M.D., Nadeem A. Afridi, M.D., and Rolf Pfannl, M.D.Thu, 22  May  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/21/2125?rss=1&ssource=collectionSearchRss&queryTerm=5A 73-year-old woman was transferred to this hospital because of worsening pneumonia, increasing hypoxia, and azotemia.<br/><br/>She had been well until 17 days before admission, when nonbloody diarrhea and fatigue began....http://content.nejm.org/cgi/content/short/348/19/1902?rss=1&ssource=collectionSearchRss&queryTerm=5Aaron B. Waxman, M.D., Ph.D., Jo-Anne O. Shepard, M.D., and Eugene J. Mark, M.D.Thu, 08  May  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/19/1902?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Streptococcus pneumoniae is the chief cause of pneumonia in older adults, but it remains unclear whether use of the pneumococcal polysaccharide vaccine alters the overall risk of community-acquired pneumonia....http://content.nejm.org/cgi/content/short/348/18/1747?rss=1&ssource=collectionSearchRss&queryTerm=5Lisa A. Jackson, M.D., M.P.H., Kathleen M. Neuzil, M.D., M.P.H., Onchee Yu, M.S., Patti Benson, M.P.H., William E. Barlow, Ph.D., Annette L. Adams, M.P.H., Christi A. Hanson, B.A., Lisa D. Mahoney, M.P.H., David K. Shay, M.D., M.P.H., and William W. Thompson, Ph.D., for the Vaccine Safety DatalinkThu, 01  May  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/18/1747?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In early 2000, a protein–polysaccharide conjugate vaccine targeting seven pneumococcal serotypes was licensed in the United States for use in young children.<br/><br/><em>Methods:</em> We examined population-based data from the Active...http://content.nejm.org/cgi/content/short/348/18/1737?rss=1&ssource=collectionSearchRss&queryTerm=5Cynthia G. Whitney, M.D., M.P.H., Monica M. Farley, M.D., James Hadler, M.D., M.P.H., Lee H. Harrison, M.D., Nancy M. Bennett, M.D., Ruth Lynfield, M.D., Arthur Reingold, M.D., Paul R. Cieslak, M.D., Tamara Pilishvili, M.P.H., Delois Jackson, M.S.A., Richard R. Facklam, Ph.D., James H. Jorgensen, Ph.D., and Anne Schuchat, M.D., for the Active Bacterial Core Surveillance of the Emerging Infections Program NetworkThu, 01  May  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/18/1737?rss=1&ssource=collectionSearchRss&queryTerm=5Diarrheal diseases continue to be major causes of morbidity and mortality in children in developing countries. For example, in Bangladesh 1 in 30 children dies of diarrhea or dysentery by...http://content.nejm.org/cgi/content/short/348/16/1565?rss=1&ssource=collectionSearchRss&queryTerm=5Rashidul Haque, M.B., Ph.D., Christopher D. Huston, M.D., Molly Hughes, M.D., Ph.D., Eric Houpt, M.D., and William A. Petri, Jr., M.D., Ph.D.Thu, 17  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/16/1565?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Sepsis represents a substantial health care burden, and there is limited epidemiologic information about the demography of sepsis or about the temporal changes in its incidence and outcome. We...http://content.nejm.org/cgi/content/short/348/16/1546?rss=1&ssource=collectionSearchRss&queryTerm=5Greg S. Martin, M.D., David M. Mannino, M.D., Stephanie Eaton, M.D., and Marc Moss, M.D.Thu, 17  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/16/1546?rss=1&ssource=collectionSearchRss&queryTerm=5Until recently, vancomycin was the only uniformly effective treatment for staphylococcal infections. In 1997, the first clinical isolate of Staphylococcus aureus with reduced susceptibility to vancomycin was reported,1 and as...http://content.nejm.org/cgi/content/short/348/14/1342?rss=1&ssource=collectionSearchRss&queryTerm=5Soju Chang, M.D., M.P.H., Dawn M. Sievert, M.S., Jeffrey C. Hageman, M.H.S., Matthew L. Boulton, M.D., Fred C. Tenover, Ph.D., M.P.H., Frances Pouch Downes, Dr.P.H., Sandip Shah, M.S., James T. Rudrik, Ph.D., Guy R. Pupp, D.P.M., William J. Brown, Ph.D., Denise Cardo, M.D., and Scott K. Fridkin, M.D., for the Vancomycin-Resistant Investigative TeamThu, 03  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/14/1342?rss=1&ssource=collectionSearchRss&queryTerm=5“How contagious is it?” is a question regularly asked by family, friends, and colleagues, as well as school administrators and news reporters. The purpose of this article is to analyze...http://content.nejm.org/cgi/content/short/348/13/1256?rss=1&ssource=collectionSearchRss&queryTerm=5Daniel M. Musher, M.D.Thu, 27  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/13/1256?rss=1&ssource=collectionSearchRss&queryTerm=5In the United States, physicians insert more than 5 million central venous catheters every year.1 Central venous catheters allow measurement of hemodynamic variables that cannot be measured accurately by noninvasive...http://content.nejm.org/cgi/content/short/348/12/1123?rss=1&ssource=collectionSearchRss&queryTerm=5David C. McGee, M.D., and Michael K. Gould, M.D.Thu, 20  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/12/1123?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In February 2002, clinicians at the Dartmouth College Health Service recognized an outbreak of conjunctivitis; cultures of conjunctival swabs implicated Streptococcus pneumoniae. An investigation was begun to determine the...http://content.nejm.org/cgi/content/short/348/12/1112?rss=1&ssource=collectionSearchRss&queryTerm=5Michael Martin, M.D., M.P.H., John H. Turco, M.D., Michael E. Zegans, M.D., Richard R. Facklam, Ph.D., Samir Sodha, M.D., M.P.H., John A. Elliott, Ph.D., John H. Pryor, M.A., Bernard Beall, Ph.D., Dean D. Erdman, Dr.P.H., Yolanda Y. Baumgartner, M.B.A., Paul A. Sanchez, M.D., Joseph D. Schwartzman, M.D., José Montero, M.D., Anne Schuchat, M.D., and Cynthia G. Whitney, M.D., M.P.H.Thu, 20  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/12/1112?rss=1&ssource=collectionSearchRss&queryTerm=5“What the detective story is about,” said the great British mystery writer P.D. James in a 1986 interview, “is not murder but the restoration of order.” The same might be...http://content.nejm.org/cgi/content/short/348/12/1079?rss=1&ssource=collectionSearchRss&queryTerm=5Abigail Zuger, M.D.Thu, 20  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/12/1079?rss=1&ssource=collectionSearchRss&queryTerm=5A 43-year-old man was admitted to the hospital because of fever and rapid deterioration of vision in the left eye.<br/><br/>The patient had been well until six weeks earlier, when fevers,...http://content.nejm.org/cgi/content/short/348/9/834?rss=1&ssource=collectionSearchRss&queryTerm=5Robert H. Rubin, M.D., Mary Etta King, M.D., and Eugene J. Mark, M.D.Thu, 27  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/9/834?rss=1&ssource=collectionSearchRss&queryTerm=5Fever and neutropenia developed in a 14-year-old girl after she received intensive chemotherapy for her third relapse of pre–B-cell acute lymphocytic leukemia, including intrathecal therapy with methotrexate, cytarabine, and prednisone....http://content.nejm.org/cgi/content/short/348/8/720?rss=1&ssource=collectionSearchRss&queryTerm=5Miriam van Buiren, M.D. and Markus Uhl, M.D.Thu, 20  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/8/720?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Olfactory cortexes and the olfactory tracts are involved in sporadic Creutzfeldt–Jakob disease. We examined peripheral regions of the olfactory sensory pathway, including the olfactory mucosa, to assess whether pathologic...http://content.nejm.org/cgi/content/short/348/8/711?rss=1&ssource=collectionSearchRss&queryTerm=5Gianluigi Zanusso, M.D., Ph.D., Sergio Ferrari, M.D., Franco Cardone, Ph.D., Paolo Zampieri, M.D., Matteo Gelati, Ph.D., Michele Fiorini, Ph.D., Alessia Farinazzo, Ph.D., Marina Gardiman, M.D., Tiziana Cavallaro, M.D., Marina Bentivoglio, M.D., Pier Giorgio Righetti, Ph.D., Maurizio Pocchiari, M.D., Nicola Rizzuto, M.D., and Salvatore Monaco, M.D.Thu, 20  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/8/711?rss=1&ssource=collectionSearchRss&queryTerm=5Creutzfeldt–Jakob disease is an unusual neurologic disorder, with a prevalence of approximately 1 case per million population, which is about 1/10,000 that of Alzheimer's disease. Creutzfeldt–Jakob disease has captured widespread...http://content.nejm.org/cgi/content/short/348/8/681?rss=1&ssource=collectionSearchRss&queryTerm=5Kenneth L. Tyler, M.D.Thu, 20  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/8/681?rss=1&ssource=collectionSearchRss&queryTerm=5Nosocomial, or hospital-acquired, infections (more appropriately called health care–associated infections) are today by far the most common complications affecting hospitalized patients. Indeed, the Harvard Medical Practice Study II found that...http://content.nejm.org/cgi/content/short/348/7/651?rss=1&ssource=collectionSearchRss&queryTerm=5John P. Burke, M.D.Thu, 13  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/7/651?rss=1&ssource=collectionSearchRss&queryTerm=5A 32-year-old Kenyan woman presented in Boston with a three-month history of cough that was initially productive of thick, gray sputum that had gradually become blood-tinged. She had low-grade fevers....http://content.nejm.org/cgi/content/short/348/6/528?rss=1&ssource=collectionSearchRss&queryTerm=5Diana M. Brainard, M.D. and Edward T. Ryan, M.D., D.T.M.&H.Thu, 06  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/6/528?rss=1&ssource=collectionSearchRss&queryTerm=5It is now clear that virtually all squamous-cell cervical carcinomas contain one of 18 types of human papillomavirus (HPV) DNA, as shown definitively in the article by Muñoz et al....http://content.nejm.org/cgi/content/short/348/6/489?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas C. Wright, Jr., M.D., and Mark Schiffman, M.D.Thu, 06  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/6/489?rss=1&ssource=collectionSearchRss&queryTerm=5A 42-year-old woman was admitted to the hospital because of a productive cough, chills, and fever.<br/><br/>The patient had been well until seven months earlier, when an intermittent, generally nonproductive cough...http://content.nejm.org/cgi/content/short/348/5/447?rss=1&ssource=collectionSearchRss&queryTerm=5Lindsey R. Baden, M.D., and Danielle D. Elliott, M.D.Thu, 30  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/5/447?rss=1&ssource=collectionSearchRss&queryTerm=5The main clinical features of the Wiskott–Aldrich syndrome, an X-linked immunodeficiency, are thrombocytopenia with small platelets, eczema, susceptibility to opportunistic and pyogenic infections, and B-cell lymphomas associated with Epstein–Barr virus....http://content.nejm.org/cgi/content/short/348/4/350?rss=1&ssource=collectionSearchRss&queryTerm=5Scott B. Snapper, M.D., Ph.D., and Fred S. Rosen, M.D.Thu, 23  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/4/350?rss=1&ssource=collectionSearchRss&queryTerm=5A 36-year-old, right-handed man was admitted to the hospital because of seizures and severe hypertension.<br/><br/>The patient had an 18-year history of intravenous drug abuse, including abuse of heroin and cocaine...http://content.nejm.org/cgi/content/short/348/4/333?rss=1&ssource=collectionSearchRss&queryTerm=5Jonathan S. Coblyn, M.D., and Robert T. McCluskey, M.D.Thu, 23  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/4/333?rss=1&ssource=collectionSearchRss&queryTerm=5The question of whether to obtain imaging studies after a urinary tract infection in a child is a challenging one. The potential long-term morbidity associated with repeated bouts of pyelonephritis...http://content.nejm.org/cgi/content/short/348/3/251?rss=1&ssource=collectionSearchRss&queryTerm=5F. Bruder Stapleton, M.D.Thu, 16  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/3/251?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Endoscopes, including bronchoscopes, are the medical devices most frequently associated with outbreaks of nosocomial infections. We investigated an outbreak of Pseudomonas aeruginosa infections after bronchoscopic procedures.<br/><br/><em>Methods:</em> Microbiologic results were...http://content.nejm.org/cgi/content/short/348/3/221?rss=1&ssource=collectionSearchRss&queryTerm=5Arjun Srinivasan, M.D., Linda L. Wolfenden, M.D., Xiaoyan Song, M.D., Karen Mackie, R.N., Theresa L. Hartsell, M.D., Ph.D., Heather D. Jones, M.D., Gregory B. Diette, M.D., M.H.S., Jonathan B. Orens, M.D., Rex C. Yung, M.D., Tracy L. Ross, B.S., William Merz, Ph.D., Paul J. Scheel, M.D., Edward F. Haponik, M.D., and Trish M. Perl, M.D.Thu, 16  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/3/221?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Several outbreaks and pseudo-outbreaks of Pseudomonas aeruginosa and Serratia marcescens infections associated with bronchoscopy have been reported. We conducted an investigation of P. aeruginosa and S. marcescens isolates related...http://content.nejm.org/cgi/content/short/348/3/214?rss=1&ssource=collectionSearchRss&queryTerm=5David L. Kirschke, M.D., Timothy F. Jones, M.D., Allen S. Craig, M.D., Patricia S. Chu, M.D., Glenda G. Mayernick, R.N., Jayesh A. Patel, M.D., and William Schaffner, M.D.Thu, 16  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/3/214?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Guidelines from the American Academy of Pediatrics recommend obtaining a voiding cystourethrogram and a renal ultrasonogram for young children after a first urinary tract infection; renal scanning with technetium-99m–labeled...http://content.nejm.org/cgi/content/short/348/3/195?rss=1&ssource=collectionSearchRss&queryTerm=5Alejandro Hoberman, M.D., Martin Charron, M.D., Robert W. Hickey, M.D., Marc Baskin, M.D., Diana H. Kearney, R.N., and Ellen R. Wald, M.D.Thu, 16  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/3/195?rss=1&ssource=collectionSearchRss&queryTerm=5In the sepsis syndrome, a “cytokine storm” unleashes numerous inflammatory mediators that contribute to multiple-organ dysfunction and, frequently, to death. During the past decade, research on how the innate immune...http://content.nejm.org/cgi/content/short/348/2/167?rss=1&ssource=collectionSearchRss&queryTerm=5Craig Gerard, Ph.D., M.D.Thu, 09  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/2/167?rss=1&ssource=collectionSearchRss&queryTerm=5A 43-year-old man was admitted to the hospital because of fever, night sweats, weight loss, and headache.<br/><br/>The patient had reportedly been well until 15 days earlier, when fever developed. A...http://content.nejm.org/cgi/content/short/348/2/151?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 09  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/2/151?rss=1&ssource=collectionSearchRss&queryTerm=5Sepsis is the leading cause of death in critically ill patients in the United States. Sepsis develops in 750,000 people annually, and more than 210,000 of them die.12 After numerous...http://content.nejm.org/cgi/content/short/348/2/138?rss=1&ssource=collectionSearchRss&queryTerm=5Richard S. Hotchkiss, M.D., and Irene E. Karl, Ph.D.Thu, 09  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/2/138?rss=1&ssource=collectionSearchRss&queryTerm=5Candida species are now the fourth leading cause of nosocomial bloodstream infection in the United States, exceeded in some series only by Staphylococcus aureus, coagulase-negative staphylococcus, and enterococcus species.12 Wey...http://content.nejm.org/cgi/content/short/347/25/2070?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 19  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/25/2070?rss=1&ssource=collectionSearchRss&queryTerm=5A 65-year-old man with hypertension and degenerative joint disease presents to the emergency department with a three-day history of a productive cough and fever. He has a temperature of 38.3°C...http://content.nejm.org/cgi/content/short/347/25/2039?rss=1&ssource=collectionSearchRss&queryTerm=5Ethan A. Halm, M.D., M.P.H., and Alvin S. Teirstein, M.D.Thu, 19  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/25/2039?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. Headache and aphasia suddenly developed in a 49-year-old man. He had a history of aortic valvotomy for severe congenital aortic stenosis 30 years previously, and severe aortic stenosis...http://content.nejm.org/cgi/content/short/347/25/2030?rss=1&ssource=collectionSearchRss&queryTerm=5Joshua Lynfield, M.D. and Peter Kim Nelson, M.D.Thu, 19  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/25/2030?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind trial to compare caspofungin with amphotericin B deoxycholate for the primary treatment of invasive...http://content.nejm.org/cgi/content/short/347/25/2020?rss=1&ssource=collectionSearchRss&queryTerm=5Jorge Mora-Duarte, M.D., Robert Betts, M.D., Coleman Rotstein, M.D., Arnaldo Lopes Colombo, M.D., Luis Thompson-Moya, M.D., Juanita Smietana, B.S., Robert Lupinacci, M.S., Carole Sable, M.D., Nicholas Kartsonis, M.D., and John Perfect, M.D., for the Caspofungin Invasive Candidiasis Study GroupThu, 19  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/25/2020?rss=1&ssource=collectionSearchRss&queryTerm=5It was 1993 when the International Task Force for Disease Eradication identified lymphatic filariasis as one of only six diseases meeting the criteria for being eradicable or potentially eradicable.1 Since...http://content.nejm.org/cgi/content/short/347/23/1885?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 05  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/23/1885?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The global initiative to eradicate bancroftian filariasis currently relies on mass treatment with four to six annual doses of antifilarial drugs. The goal is to reduce the reservoir of...http://content.nejm.org/cgi/content/short/347/23/1841?rss=1&ssource=collectionSearchRss&queryTerm=5Moses J. Bockarie, Ph.D., Daniel J. Tisch, M.P.H., Will Kastens, B.Sc., Neal D.E. Alexander, Ph.D., Zachary Dimber, Florence Bockarie, Ervin Ibam, Michael P. Alpers, M.D., and James W. Kazura, M.D.Thu, 05  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/23/1841?rss=1&ssource=collectionSearchRss&queryTerm=5Visceral leishmaniasis is a well-recognized disseminated protozoal infection in both children and adults, but it has long been shrouded in mysterious-sounding names such as Dumdum fever and kala-azar (Hindi for...http://content.nejm.org/cgi/content/short/347/22/1793?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 28  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/22/1793?rss=1&ssource=collectionSearchRss&queryTerm=5Typhoid fever is a systemic infection with the bacterium Salmonella enterica serotype typhi. This highly adapted, human-specific pathogen has evolved remarkable mechanisms for persistence in its host that help to...http://content.nejm.org/cgi/content/short/347/22/1770?rss=1&ssource=collectionSearchRss&queryTerm=5Christopher M. Parry, M.B., Tran Tinh Hien, M.D., Gordon Dougan, Ph.D., Nicholas J. White, M.D., D.Sc., and Jeremy J. Farrar, M.B., D.Phil.Thu, 28  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/22/1770?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> There are 500,000 cases per year of visceral leishmaniasis, which occurs primarily in the Indian subcontinent. Almost all untreated patients die, and all the effective agents have been parenteral....http://content.nejm.org/cgi/content/short/347/22/1739?rss=1&ssource=collectionSearchRss&queryTerm=5Shyam Sundar, M.D., T.K. Jha, M.D., C.P. Thakur, M.D., Juergen Engel, Ph.D., Herbert Sindermann, Ph.D., Christina Fischer, Klaus Junge, Ph.D., Anthony Bryceson, M.D., and Jonathan Berman, M.D., Ph.D.Thu, 28  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/22/1739?rss=1&ssource=collectionSearchRss&queryTerm=5Encouraging results are reported in this issue of the Journal for an oral drug for use in the battle against visceral leishmaniasis in India (pages 1739–1746). Given the hurdles that...http://content.nejm.org/cgi/content/short/347/22/1737?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 28  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/22/1737?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A 26-year-old man presented with a four-month history of whitish oral lesions and pain on swallowing (Panels A and B). The patient had noticed lesions on the glans...http://content.nejm.org/cgi/content/short/347/21/1677?rss=1&ssource=collectionSearchRss&queryTerm=5Anja Ulmer, M.D. and Gerhard Fierlbeck, M.D.Thu, 21  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/21/1677?rss=1&ssource=collectionSearchRss&queryTerm=5The application of quantitative bacteriology to urine cultures almost five decades ago led to prospective scientific investigations of the epidemiology, pathogenesis, diagnosis, treatment, and prevention of urinary tract infections.1 Numerous...http://content.nejm.org/cgi/content/short/347/20/1617?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 14  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/20/1617?rss=1&ssource=collectionSearchRss&queryTerm=5In 1988, a landmark study was reported on the use of adjunctive treatment with dexamethasone in infants and children who had bacterial meningitis.1 The rationale for this study was based...http://content.nejm.org/cgi/content/short/347/20/1613?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 14  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/20/1613?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Asymptomatic bacteriuria is common among women with diabetes, and the treatment of such infections has been recommended to prevent complications related to symptomatic urinary tract infection.<br/><br/><em>Methods:</em> We enrolled women...http://content.nejm.org/cgi/content/short/347/20/1576?rss=1&ssource=collectionSearchRss&queryTerm=5Godfrey K.M. Harding, M.D., George G. Zhanel, Ph.D., Lindsay E. Nicolle, M.D., and Mary Cheang, M.Math.(Stat.), for the Manitoba Diabetes Urinary Tract Infection Study GroupThu, 14  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/20/1576?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Mortality and morbidity rates are high among adults with acute bacterial meningitis, especially those with pneumococcal meningitis. In studies of bacterial meningitis in animals, adjuvant treatment with corticosteroids has...http://content.nejm.org/cgi/content/short/347/20/1549?rss=1&ssource=collectionSearchRss&queryTerm=5Jan de Gans, Ph.D., and Diederik van de Beek, M.D., for the European Dexamethasone in Adulthood Bacterial Meningitis Study InvestigatorsThu, 14  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/20/1549?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old right-handed man was admitted to the hospital because of difficulty with his handwriting and motor problems in his right leg.<br/><br/>The patient, who was a teacher, had been well...http://content.nejm.org/cgi/content/short/347/18/1433?rss=1&ssource=collectionSearchRss&queryTerm=5Paula Ravin and E. Tessa Hedley-WhyteThu, 31  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/18/1433?rss=1&ssource=collectionSearchRss&queryTerm=5Microbes surround us. However, most of the time we are unaware of them. Our epithelial surfaces, which provide the physical barrier separating us from the environment, are usually free of...http://content.nejm.org/cgi/content/short/347/15/1199?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 10  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/15/1199?rss=1&ssource=collectionSearchRss&queryTerm=5Since the first culture of Helicobacter pylori 20 years ago, the diagnosis and treatment of upper gastroduodenal disease have changed dramatically. Peptic ulcer disease is now approached as an infectious...http://content.nejm.org/cgi/content/short/347/15/1175?rss=1&ssource=collectionSearchRss&queryTerm=5Sebastian Suerbaum, M.D., and Pierre Michetti, M.D.Thu, 10  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/15/1175?rss=1&ssource=collectionSearchRss&queryTerm=5An otherwise healthy 17-month-old boy had a cold accompanied by two days of rhinorrhea, cough, and fever (temperature of up to 38.8°C [102°F]). On day 5 he became fussy and...http://content.nejm.org/cgi/content/short/347/15/1169?rss=1&ssource=collectionSearchRss&queryTerm=5J. Owen Hendley, M.D.Thu, 10  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/15/1169?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and β-defensins. In normal skin these peptides are negligible, but they accumulate in skin affected...http://content.nejm.org/cgi/content/short/347/15/1151?rss=1&ssource=collectionSearchRss&queryTerm=5Peck Y. Ong, M.D., Takaaki Ohtake, M.D., Ph.D., Corinne Brandt, B.S., Ian Strickland, Ph.D., Mark Boguniewicz, M.D., Tomas Ganz, M.D., Ph.D., Richard L. Gallo, M.D., Ph.D., and Donald Y.M. Leung, M.D., Ph.D.Thu, 10  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/15/1151?rss=1&ssource=collectionSearchRss&queryTerm=5The use of susceptibility testing to identify appropriate antimicrobial agents has long been an important element of the practice of infectious-disease medicine. In most clinical settings, the finding that a...http://content.nejm.org/cgi/content/short/347/14/1110?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 03  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/14/1110?rss=1&ssource=collectionSearchRss&queryTerm=5Platelet transfusions carry a serious risk of bacterial sepsis. Platelets are stored at room temperature for no longer than 120 hours (five days), and a single bacterium of the type...http://content.nejm.org/cgi/content/short/347/14/1075?rss=1&ssource=collectionSearchRss&queryTerm=5Mehrdad Jafari, M.D., Ph.D., Jean Forsberg, M.D., Ronald O. Gilcher, M.D., James W. Smith, M.D., Ph.D., James M. Crutcher, M.D., M.P.H., Michael McDermott, B.S., Brent R. Brown, M.D., and James N. George, M.D.Thu, 03  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/14/1075?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Recombinant human activated protein C was shown in the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study to reduce mortality among patients with severe sepsis....http://content.nejm.org/cgi/content/short/347/13/993?rss=1&ssource=collectionSearchRss&queryTerm=5Braden J. Manns, M.D., Helen Lee, M.A., Christopher James Doig, M.D., David Johnson, M.D., and Cam Donaldson, Ph.D.Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/993?rss=1&ssource=collectionSearchRss&queryTerm=5Sepsis, a leading cause of death in the United States, is now viewed physiologically as a proinflammatory and procoagulant response to invading pathogens. There are three recognized stages in the...http://content.nejm.org/cgi/content/short/347/13/966?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/966?rss=1&ssource=collectionSearchRss&queryTerm=5In 2001, the Food and Drug Administration (FDA) evaluated an application for the use of drotrecogin alfa (activated), or recombinant human activated protein C (Xigris, Eli Lilly), in patients with...http://content.nejm.org/cgi/content/short/347/13/1030?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/1030?rss=1&ssource=collectionSearchRss&queryTerm=5A new hypothesis with implications for the treatment of sepsis has recently been tested — the hypothesis that part of the pathophysiology of sepsis is caused by unrestricted or inappropriate...http://content.nejm.org/cgi/content/short/347/13/1027?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/1027?rss=1&ssource=collectionSearchRss&queryTerm=5In contrast to the situation of patients receiving maintenance dialysis, in which information from large, standardized data bases may give us insight into potential management strategies, when it comes to...http://content.nejm.org/cgi/content/short/347/12/933?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 19  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/12/933?rss=1&ssource=collectionSearchRss&queryTerm=5Infectious agents can induce autoimmune diseases in several experimental settings, some of which have clinical counterparts. A variety of mechanisms have been invoked to explain these observations, including molecular mimicry...http://content.nejm.org/cgi/content/short/347/12/911?rss=1&ssource=collectionSearchRss&queryTerm=5Jean-François Bach, M.D., D.Sc.Thu, 19  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/12/911?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In some parts of the world, peritoneal dialysis is widely used for renal replacement in acute renal failure. In resource-rich countries, it has been supplanted in recent years by...http://content.nejm.org/cgi/content/short/347/12/895?rss=1&ssource=collectionSearchRss&queryTerm=5Nguyen Hoan Phu, M.D., Tran Tinh Hien, M.D., Nguyen Thi Hoang Mai, M.D., Tran Thi Hong Chau, M.D., Ly Van Chuong, M.D., Pham Phu Loc, M.D., Christopher Winearls, D.Phil., M.B., Jeremy Farrar, M.B., D.Phil., Nicholas White, M.D., D.Sc., and Nicholas Day, B.M., B.Ch.Thu, 19  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/12/895?rss=1&ssource=collectionSearchRss&queryTerm=5A 35-year-old woman was admitted to the hospital because of pain and swelling of the right thigh.<br/><br/>The patient had been in excellent health until the morning before admission, when she...http://content.nejm.org/cgi/content/short/347/11/831?rss=1&ssource=collectionSearchRss&queryTerm=5Deborah J. Hoadley and Eugene J. MarkThu, 12  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/11/831?rss=1&ssource=collectionSearchRss&queryTerm=5The use of anthrax as a biologic weapon in 2001 and concern about the health effects of exposure to particles and gases at the World Trade Center site (discussed by...http://content.nejm.org/cgi/content/short/347/11/824?rss=1&ssource=collectionSearchRss&queryTerm=5John Martyny, Ph.D., Craig S. Glazer, M.D., and Lee S. Newman, M.D.Thu, 12  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/11/824?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A 21-year-old, previously healthy man with excellent dentition presented with a two-week history of high-grade fever, chills, and malaise. On the fourth hospital day, an early decrescendo diastolic...http://content.nejm.org/cgi/content/short/347/11/816?rss=1&ssource=collectionSearchRss&queryTerm=5J.H. Marc Groeneveld, M.D. and Julien B.C.M. Puylaert, M.D., Ph.D.Thu, 12  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/11/816?rss=1&ssource=collectionSearchRss&queryTerm=5A 42-year-old man with a recent history of insomnia and problems concentrating during the day presented to the hospital with emotional distress and an inability to cope. He denied any...http://content.nejm.org/cgi/content/short/347/10/749?rss=1&ssource=collectionSearchRss&queryTerm=5Demetrios J. Sahlas, M.D., J. Dick MacLean, M.D., John Janevski, M.D., and Allan S. Detsky, M.D., Ph.D.Thu, 05  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/10/749?rss=1&ssource=collectionSearchRss&queryTerm=5Nineteen years ago, the first report of two outbreaks of hemorrhagic colitis linked with Escherichia coli O157:H7 infection was published in the Journal.1 Both outbreaks were associated with hamburger consumption,...http://content.nejm.org/cgi/content/short/347/8/608?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 22  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/8/608?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Outbreaks of Escherichia coli O157:H7 infections have involved direct transmission from animals and their environment to humans. We describe an outbreak among visitors to a Pennsylvania dairy and petting...http://content.nejm.org/cgi/content/short/347/8/555?rss=1&ssource=collectionSearchRss&queryTerm=5John A. Crump, M.B., Ch.B., D.T.M.&H., Alana C. Sulka, M.P.H., Adam J. Langer, D.V.M., Chad Schaben, M.P.H., Anita S. Crielly, M.S., Robert Gage, M.S.P.H., Michael Baysinger, B.S., Maria Moll, M.D., Gisela Withers, M.S., Denise M. Toney, Ph.D., Susan B. Hunter, M.S., R. Michael Hoekstra, Ph.D., Stephanie K. Wong, D.V.M., M.P.H., Patricia M. Griffin, M.D., and Thomas J. Van Gilder, M.D., M.P.H.Thu, 22  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/8/555?rss=1&ssource=collectionSearchRss&queryTerm=5Patients with chronic obstructive pulmonary disease have exacerbations characterized by increased dyspnea, accompanied by increases in coughing, sputum production and purulence, and wheezing. Although most of these episodes are self-limited,...http://content.nejm.org/cgi/content/short/347/7/526?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 15  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/7/526?rss=1&ssource=collectionSearchRss&queryTerm=5A 46-year-old woman was admitted to the hospital because of extensive pulmonary infiltrates.<br/><br/>The patient had felt well until several weeks before admission, when she began to have abdominal swelling and...http://content.nejm.org/cgi/content/short/347/7/517?rss=1&ssource=collectionSearchRss&queryTerm=5Katherine McGowan and Eugene J. MarkThu, 15  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/7/517?rss=1&ssource=collectionSearchRss&queryTerm=5Between 20 and 70 percent of the 50 million people who travel from the industrialized world to the developing world each year report some illness associated with their travel.12 Although...http://content.nejm.org/cgi/content/short/347/7/505?rss=1&ssource=collectionSearchRss&queryTerm=5Edward T. Ryan, M.D., Mary E. Wilson, M.D., and Kevin C. Kain, M.D.Thu, 15  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/7/505?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A 48-year-old man with diabetes mellitus underwent pancreas–kidney transplantation for end-stage renal disease. One month later, he was treated for rejection, and computed tomography of the chest showed...http://content.nejm.org/cgi/content/short/347/7/497?rss=1&ssource=collectionSearchRss&queryTerm=5Rick M. Fairhurst, M.D. and David A. Pegues, M.D.Thu, 15  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/7/497?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The role of bacterial pathogens in acute exacerbations of chronic obstructive pulmonary disease is controversial. 02081525.XML In older studies, the rates of isolation of bacterial pathogens from sputum were...http://content.nejm.org/cgi/content/short/347/7/465?rss=1&ssource=collectionSearchRss&queryTerm=5Sanjay Sethi, M.D., Nancy Evans, R.N., Brydon J.B. Grant, M.D., and Timothy F. Murphy, M.D.Thu, 15  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/7/465?rss=1&ssource=collectionSearchRss&queryTerm=5A 48-year-old man was admitted to the Ambulatory Disease Service of the Massachusetts Eye and Ear Infirmary because of severe chronic oral lesions.<br/><br/>For several years, the patient had taken ibuprofen...http://content.nejm.org/cgi/content/short/347/6/430?rss=1&ssource=collectionSearchRss&queryTerm=5George T. Gallagher and Stephen LyleThu, 08  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/6/430?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Voriconazole is a broad-spectrum triazole that is active against aspergillus species. 02080826.xml We conducted a randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/347/6/408?rss=1&ssource=collectionSearchRss&queryTerm=5Raoul Herbrecht, M.D., David W. Denning, F.R.C.P., Thomas F. Patterson, M.D., John E. Bennett, M.D., Reginald E. Greene, M.D., Jörg-W. Oestmann, M.D., Winfried V. Kern, M.D., Kieren A. Marr, M.D., Patricia Ribaud, M.D., Olivier Lortholary, M.D., Ph.D., Richard Sylvester, Sc.D., Robert H. Rubin, M.D., John R. Wingard, M.D., Paul Stark, M.D., Christine Durand, M.D., Denis Caillot, M.D., Eckhard Thiel, M.D., Pranatharthi H. Chandrasekar, M.D., Michael R. Hodges, M.D., Haran T. Schlamm, M.D., Peter F. Troke, Ph.D., and Ben de Pauw, M.D., for the Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillus Study GroupThu, 08  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/6/408?rss=1&ssource=collectionSearchRss&queryTerm=5The highest annual death rate before the sixth decade of life occurs during the first year of life.1 Most deaths during the first year occur during the perinatal period, particularly...http://content.nejm.org/cgi/content/short/347/4/280?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 25  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/4/280?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> It is uncertain whether the rates and causes of early-onset sepsis (that occurring within 72 hours after birth) among very-low-birth-weight infants have changed in recent years, since antibiotics have...http://content.nejm.org/cgi/content/short/347/4/240?rss=1&ssource=collectionSearchRss&queryTerm=5Barbara J. Stoll, M.D., Nellie Hansen, M.P.H., Avroy A. Fanaroff, M.D., Linda L. Wright, M.D., Waldemar A. Carlo, M.D., Richard A. Ehrenkranz, M.D., James A. Lemons, M.D., Edward F. Donovan, M.D., Ann R. Stark, M.D., Jon E. Tyson, M.D., M.P.H., William Oh, M.D., Charles R. Bauer, M.D., Sheldon B. Korones, M.D., Seetha Shankaran, M.D., Abbot R. Laptook, M.D., David K. Stevenson, M.D., Lu-Ann Papile, M.D., and W. Kenneth Poole, Ph.D.Thu, 25  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/4/240?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> 02072522.xml Guidelines issued in 1996 in the United States recommend either screening of pregnant women for group B streptococcal colonization by means of cultures (screening approach) or assessing clinical...http://content.nejm.org/cgi/content/short/347/4/233?rss=1&ssource=collectionSearchRss&queryTerm=5Stephanie J. Schrag, D.Phil., Elizabeth R. Zell, M.Stat., Ruth Lynfield, M.D., Aaron Roome, Ph.D., Kathryn E. Arnold, M.D., Allen S. Craig, M.D., Lee H. Harrison, M.D., Arthur Reingold, M.D., Karen Stefonek, R.N., M.P.H., Glenda Smith, B.S., Melanie Gamble, M.P.H., and Anne Schuchat, M.D., for the Active Bacterial Core Surveillance TeamThu, 25  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/4/233?rss=1&ssource=collectionSearchRss&queryTerm=5A 37-year-old man was admitted to the hospital because of three weeks of intermittent fever and abdominal and back pain.<br/><br/>The patient had been well until about seven months earlier, one...http://content.nejm.org/cgi/content/short/347/3/200?rss=1&ssource=collectionSearchRss&queryTerm=5James T. Noble and Eugene J. MarkThu, 18  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/3/200?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The ability to mount a prominent inflammatory response to bacterial pathogens confers an advantage in innate immune defense but may signal an increased risk of atherosclerosis. We determined whether...http://content.nejm.org/cgi/content/short/347/3/185?rss=1&ssource=collectionSearchRss&queryTerm=5Stefan Kiechl, M.D., Eva Lorenz, Ph.D., Markus Reindl, Ph.D., Christian J. Wiedermann, M.D., Friedrich Oberhollenzer, M.D., Enzo Bonora, M.D., Johann Willeit, M.D., and David A. Schwartz, M.D.Thu, 18  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/3/185?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A 23-year-old man with sickle cell disease was admitted after reporting fever and chills. He had emigrated from West Africa three months earlier. His temperature was 38.2°C, and...http://content.nejm.org/cgi/content/short/347/1/e1?rss=1&ssource=collectionSearchRss&queryTerm=5Fouad N. Boctor, M.D., Ph.D. and Joan Uehlinger, M.D.Thu, 04  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/1/e1?rss=1&ssource=collectionSearchRss&queryTerm=5Concern about mosquitoes, ticks, and the pathogens that they transmit grows annually in temperate parts of the world with the leafing of the trees. The arrival of West Nile virus...http://content.nejm.org/cgi/content/short/347/1/2?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 04  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/1/2?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The worldwide threat of arthropod-transmitted diseases, with their associated morbidity and mortality, underscores the need for effective insect repellents. Multiple chemical, botanical, and “alternative” repellent products are marketed to...http://content.nejm.org/cgi/content/short/347/1/13?rss=1&ssource=collectionSearchRss&queryTerm=5Mark S. Fradin, M.D., and John F. Day, Ph.D.Thu, 04  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/1/13?rss=1&ssource=collectionSearchRss&queryTerm=5Bacteria indigenous to the human body are numerous and varied and dwell in multiple niches in skin and on mucosal surfaces; many niches are persistently colonized by one or more...http://content.nejm.org/cgi/content/short/346/26/2083?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 27  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/26/2083?rss=1&ssource=collectionSearchRss&queryTerm=5A 37-year-old man was admitted to the Tropical and Geographic Medicine Center of this hospital because of fever and an inflamed foot.<br/><br/>The patient had been in vigorous health three months...http://content.nejm.org/cgi/content/short/346/26/2069?rss=1&ssource=collectionSearchRss&queryTerm=5Anne C. Moore, M.D., Ph.D., Edward T. Ryan, M.D., and Mary Ann Waldron, B.S.M.T. (ASCP)Thu, 27  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/26/2069?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The role of gastric acid suppression in preventing the recurrence of ulcer complications after the eradication of Helicobacter pylori infection in patients taking long-term low-dose aspirin is uncertain.<br/><br/><em>Methods:</em> We...http://content.nejm.org/cgi/content/short/346/26/2033?rss=1&ssource=collectionSearchRss&queryTerm=5Kam Chuen Lai, M.R.C.P., Shiu Kum Lam, M.D., Kent Man Chu, F.R.C.S., Benjamin C.Y. Wong, M.D., Wai Mo Hui, M.D., Wayne H.C. Hu, M.R.C.P., George K.K. Lau, M.D., Wai Man Wong, M.R.C.P., Man Fung Yuen, M.R.C.P., Annie O.O. Chan, M.R.C.P., Ching Lung Lai, M.D., and John Wong, F.R.A.C.S.Thu, 27  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/26/2033?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Intestinal microsporidiosis due to Enterocytozoon bieneusi is a cause of chronic diarrhea, malabsorption, and wasting in immunocompromised patients. Currently, there is no effective treatment.<br/><br/><em>Methods:</em> We conducted a randomized, double-blind,...http://content.nejm.org/cgi/content/short/346/25/1963?rss=1&ssource=collectionSearchRss&queryTerm=5Jean-Michel Molina, M.D., Muriel Tourneur, M.D., Claudine Sarfati, M.D., Sylvie Chevret, M.D., Amaury de Gouvello, M.D., Jean-Gérard Gobert, M.D., Suna Balkan, M.D., and Francis Derouin, M.D., for the Agence Nationale de Recherches sur le SIDA 090 Study GroupThu, 20  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/25/1963?rss=1&ssource=collectionSearchRss&queryTerm=5Infections at surgical sites remain an important cause of illness and death and substantially increase health care costs.1 Prevention is thus important not only for the safety of patients, but...http://content.nejm.org/cgi/content/short/346/24/1905?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 13  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/24/1905?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Patients with nasal carriage of Staphylococcus aureus have an increased risk of surgical-site infections caused by that organism. Treatment with mupirocin ointment can reduce the rate of nasal carriage...http://content.nejm.org/cgi/content/short/346/24/1871?rss=1&ssource=collectionSearchRss&queryTerm=5Trish M. Perl, M.D., Joseph J. Cullen, M.D., Richard P. Wenzel, M.D., M. Bridget Zimmerman, Ph.D., Michael A. Pfaller, M.D., Deborah Sheppard, Jennifer Twombley, R.N., Pamela P. French, M.D., M.P.H., Loreen A. Herwaldt, M.D., and the Mupirocin and the Risk of Study TeamThu, 13  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/24/1871?rss=1&ssource=collectionSearchRss&queryTerm=5A 59-year-old banker was referred for the evaluation of fevers that had started three weeks earlier, shortly after his arrival in western Texas on business. The fevers were associated with...http://content.nejm.org/cgi/content/short/346/23/1813?rss=1&ssource=collectionSearchRss&queryTerm=5Ashish K. Jha, M.D., Harold R. Collard, M.D., and Lawrence M. Tierney, M.D.Thu, 06  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/23/1813?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A 43-year-old woman had sudden visual loss in her left eye. Syphilis had been detected serologically four years before, but she did not complete a course of medical...http://content.nejm.org/cgi/content/short/346/23/1799?rss=1&ssource=collectionSearchRss&queryTerm=5Rita Dinis da Gama, M.D. and Manuela Cidade, M.D.Thu, 06  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/23/1799?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Identification of infants with Treponema pallidum infection of the central nervous system remains challenging.<br/><br/><em>Methods:</em> We used rabbit-infectivity testing of the cerebrospinal fluid to detect T. pallidum infection of the...http://content.nejm.org/cgi/content/short/346/23/1792?rss=1&ssource=collectionSearchRss&queryTerm=5Ian C. Michelow, M.B., B.Ch., D.T.M.&H., George D. Wendel, Jr., M.D., Michael V. Norgard, Ph.D., Fiker Zeray, R.N., N. Kristine Leos, B.S., Rajiha Alsaadi, M.S., and Pablo J. Sánchez, M.D.Thu, 06  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/23/1792?rss=1&ssource=collectionSearchRss&queryTerm=5A 55-year-old man was admitted to the hospital because of second-degree atrioventricular block.<br/><br/>The patient had been considered well until the day of admission, when a scheduled transurethral resection of the...http://content.nejm.org/cgi/content/short/346/22/1732?rss=1&ssource=collectionSearchRss&queryTerm=5Roger J. Hajjar and Richard L. KradinThu, 30  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/22/1732?rss=1&ssource=collectionSearchRss&queryTerm=5Cryptosporidiosis is caused by cryptosporidium, a parasite classified as an emerging pathogen by the Centers for Disease Control and Prevention (CDC).1 The organism infects the gastrointestinal epithelium to produce a...http://content.nejm.org/cgi/content/short/346/22/1723?rss=1&ssource=collectionSearchRss&queryTerm=5Xian-Ming Chen, M.D., Janet S. Keithly, Ph.D., Carlos V. Paya, M.D., Ph.D., and Nicholas F. LaRusso, M.D.Thu, 30  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/22/1723?rss=1&ssource=collectionSearchRss&queryTerm=5An eight-year-old girl is sent home after the school nurse detects head lice. She will not be permitted to return to school until the absence of infestation is documented. What...http://content.nejm.org/cgi/content/short/346/21/1645?rss=1&ssource=collectionSearchRss&queryTerm=5Richard J. Roberts, M.B., B.S., D.C.H., M.P.H.Thu, 23  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/21/1645?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> From June 30, 1998, through March 21, 1999, several patients in the surgical intensive care unit of a hospital acquired Serratia marcescens bacteremia. We investigated this outbreak.<br/><br/><em>Methods:</em> A case...http://content.nejm.org/cgi/content/short/346/20/1529?rss=1&ssource=collectionSearchRss&queryTerm=5Belinda E. Ostrowsky, M.D., M.P.H., Cynthia Whitener, M.D., Helen K. Bredenberg, M.D., Loretta A. Carson, M.S., Stacey Holt, B.S., Lori Hutwagner, M.S., Matthew J. Arduino, Dr.P.H., and William R. Jarvis, M.D.Thu, 16  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/20/1529?rss=1&ssource=collectionSearchRss&queryTerm=5A 51-year-old woman was admitted to the hospital because of recurrent hemoptysis.<br/><br/>The patient had been well until 18 months earlier, when she awoke from sleep with fluid in her mouth...http://content.nejm.org/cgi/content/short/346/19/1475?rss=1&ssource=collectionSearchRss&queryTerm=5Jennifer S. Daly and Eugene J. MarkThu, 09  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/19/1475?rss=1&ssource=collectionSearchRss&queryTerm=5A 59-year-old women presented with fever, abdominal pain, and hematuria. Two years earlier, systemic lupus erythematosus had been diagnosed after the development of a malar rash, arthritis, and nephritis. Three...http://content.nejm.org/cgi/content/short/346/18/1394?rss=1&ssource=collectionSearchRss&queryTerm=5Jessica E. Haberer, M.D., Joachim H. Ix, M.D., and Lawrence M. Tierney, Jr., M.D.Thu, 02  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/18/1394?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. An 81-year-old woman was admitted with weight loss (18 kg in 27 months), hemoptysis, and tubular and diffuse granular shadows on her chest radiograph (Panel A). Physical examination...http://content.nejm.org/cgi/content/short/346/18/1372?rss=1&ssource=collectionSearchRss&queryTerm=5Takae Ebihara, M.D., Ph.D. and Hidetada Sasaki, M.D., Ph.D.Thu, 02  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/18/1372?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In September 2000, a physician in northern California described four patients with persistent, culture-negative boils on the lower extremities. The patients had received pedicures at the same nail salon....http://content.nejm.org/cgi/content/short/346/18/1366?rss=1&ssource=collectionSearchRss&queryTerm=5Kevin L. Winthrop, M.D., Marcy Abrams, R.N., Mitchell Yakrus, M.S., M.P.H., Ira Schwartz, R.N., M.P.H., Janet Ely, B.A., Duncan Gillies, B.A., and Duc J. Vugia, M.D., M.P.H.Thu, 02  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/18/1366?rss=1&ssource=collectionSearchRss&queryTerm=5Too often antibiotics, remarkable therapies that can cure deadly and disabling infections, are used to satisfy patients' needs rather than out of clinical necessity. This practice translates into the excessive...http://content.nejm.org/cgi/content/short/346/16/1243?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 18  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/16/1243?rss=1&ssource=collectionSearchRss&queryTerm=5A 50-year-old man was admitted to the Tropical and Geographic Medicine Center of this hospital because of eosinophilia and fluctuating hepatic lesions.<br/><br/>The patient had been well until 10 months earlier,...http://content.nejm.org/cgi/content/short/346/16/1232?rss=1&ssource=collectionSearchRss&queryTerm=5J. Dick MacLean and Fiona M. Graeme-CookThu, 18  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/16/1232?rss=1&ssource=collectionSearchRss&queryTerm=5In 1851, Theodor Bilharz described a parasitic infection (bilharzia) that would later be termed schistosomiasis. Currently, 200 million people in 74 countries have this disease; 120 million of them have...http://content.nejm.org/cgi/content/short/346/16/1212?rss=1&ssource=collectionSearchRss&queryTerm=5Allen G.P. Ross, Ph.D., Paul B. Bartley, M.B., B.S., Adrian C. Sleigh, M.B., B.S., M.D., G. Richard Olds, M.D., Yuesheng Li, M.D., Ph.D., Gail M. Williams, Ph.D., and Donald P. McManus, Ph.D., D.Sc.Thu, 18  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/16/1212?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Resistance to erythromycin has been very uncommon among group A streptococci in the United States.<br/><br/><em>Methods:</em> As part of a longitudinal study, we obtained surveillance throat cultures twice monthly and...http://content.nejm.org/cgi/content/short/346/16/1200?rss=1&ssource=collectionSearchRss&queryTerm=5Judith M. Martin, M.D., Michael Green, M.D., M.P.H., Karen A. Barbadora, M.T.(A.S.C.P.), and Ellen R. Wald, M.D.Thu, 18  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/16/1200?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> It is uncertain whether male circumcision reduces the risks of penile human papillomavirus (HPV) infection in the man and of cervical cancer in his female partner.<br/><br/><em>Methods:</em> We pooled data...http://content.nejm.org/cgi/content/short/346/15/1105?rss=1&ssource=collectionSearchRss&queryTerm=5Xavier Castellsagué, M.D., F. Xavier Bosch, M.D., Nubia Muñoz, M.D., Chris J.L.M. Meijer, Ph.D., Keerti V. Shah, Dr.P.H., Silvia de Sanjosé, M.D., José Eluf-Neto, M.D., Corazon A. Ngelangel, M.D., Saibua Chichareon, M.D., Jennifer S. Smith, Ph.D., Rolando Herrero, M.D., Victor Moreno, M.D., and Silvia Franceschi, M.D., for the International Agency for Research on Cancer Multicenter Cervical Cancer Study GroupThu, 11  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/15/1105?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A 42-year-old man had a two-month history of low-grade fever, a 14-kg (30-lb) weight loss, night sweats, and pain and swelling of the right arm and thigh, with...http://content.nejm.org/cgi/content/short/346/14/1060?rss=1&ssource=collectionSearchRss&queryTerm=5Maqsood A. Bhatti, M.D. and Maria Teresa A. Seville, M.D.Thu, 04  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/14/1060?rss=1&ssource=collectionSearchRss&queryTerm=5An 80-year-old woman was admitted to the hospital because of sudden unilateral blindness.<br/><br/>The patient had a long history of medical problems. These included hypertension; mitral and tricuspid regurgitation, which had...http://content.nejm.org/cgi/content/short/346/12/924?rss=1&ssource=collectionSearchRss&queryTerm=5Don C. Bienfang and Diane KarlukThu, 21  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/12/924?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Whereas certain oral antifungal azoles are well documented to have activity against leishmania, data on the efficacy of fluconazole for leishmaniasis are limited. We conducted a controlled trial in...http://content.nejm.org/cgi/content/short/346/12/891?rss=1&ssource=collectionSearchRss&queryTerm=5Abdulrahman A. Alrajhi, M.D., M.P.H., Elfaki A. Ibrahim, Ph.D., Edward B. De Vol, Ph.D., Mohammad Khairat, M.D., Rajab M. Faris, M.D., and James H. Maguire, M.D., M.P.H.Thu, 21  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/12/891?rss=1&ssource=collectionSearchRss&queryTerm=5A 54-year-old man of Guyanese origin with human immunodeficiency virus (HIV) infection was hospitalized in Toronto with a one-week history of low-grade fever (temperature, <38°C). He had had a temperature...http://content.nejm.org/cgi/content/short/346/10/764?rss=1&ssource=collectionSearchRss&queryTerm=5Kevin C. Katz, M.D., Sharon L. Walmsley, M.D., Anne G. McLeod, M.D., Jay S. Keystone, M.D., and Allan S. Detsky, M.D., Ph.D.Thu, 07  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/10/764?rss=1&ssource=collectionSearchRss&queryTerm=5The emergence of Streptococcus pneumoniae that is resistant to the β-lactam and macrolide antimicrobial drugs has aroused concern about the use of these agents for the empirical treatment of community-acquired...http://content.nejm.org/cgi/content/short/346/10/747?rss=1&ssource=collectionSearchRss&queryTerm=5Ross Davidson, Ph.D., Rodrigo Cavalcanti, M.D., James L. Brunton, M.D., Darrin J. Bast, Ph.D., Joyce C.S. de Azavedo, Ph.D., Pamela Kibsey, M.D., Christine Fleming, M.L.T., and Donald E. Low, M.D.Thu, 07  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/10/747?rss=1&ssource=collectionSearchRss&queryTerm=5The battle with pneumococcus over the past century is reminiscent of the Hundred Years' War, the struggle between England and France that was interrupted by truces and stalemates. Streptococcus pneumoniae...http://content.nejm.org/cgi/content/short/346/10/722?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 07  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/10/722?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. Examination of a 74-year-old man with a one-year history of mild, stable angina revealed a murmur consistent with the presence of aortic regurgitation. Echocardiography demonstrated severe aortic regurgitation...http://content.nejm.org/cgi/content/short/346/9/676?rss=1&ssource=collectionSearchRss&queryTerm=5Peter J. Pugh, M.B., B.S. and Ever D. Grech, M.D.Thu, 28  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/9/676?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Outbreaks of eosinophilic meningitis caused by the roundworm Angiostrongylus cantonensis are rarely reported, even in regions of endemic infection such as Southeast Asia and the Pacific Basin. We report...http://content.nejm.org/cgi/content/short/346/9/668?rss=1&ssource=collectionSearchRss&queryTerm=5Trevor J. Slom, M.D., Margaret M. Cortese, M.D., Susan I. Gerber, M.D., Roderick C. Jones, M.P.H., Timothy H. Holtz, M.D., M.P.H., Adriana S. Lopez, M.H.S., Carlos H. Zambrano, M.D., Robert L. Sufit, M.D., Yuwaporn Sakolvaree, M.Sc., Wanpen Chaicumpa, Ph.D., Barbara L. Herwaldt, M.D., M.P.H., and Stuart Johnson, M.D., D.T.M.&H.Thu, 28  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/9/668?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In patients with decreased resistance to infection, Staphylococcus aureus is a major cause of bacteremia and its complications. The capsular polysaccharides are essential for the pathogenesis of and immunity...http://content.nejm.org/cgi/content/short/346/7/491?rss=1&ssource=collectionSearchRss&queryTerm=5Henry Shinefield, M.D., Steven Black, M.D., Ali Fattom, Ph.D., Gary Horwith, M.D., Scott Rasgon, M.D., Juan Ordonez, M.D., Hock Yeoh, M.D., David Law, M.D., John B. Robbins, M.D., Rachel Schneerson, M.D., Larry Muenz, Ph.D., Steve Fuller, Ph.D., Joanie Johnson, R.N., Bruce Fireman, M.A., Harry Alcorn, Pharm.D., and Robert Naso, Ph.D.Thu, 14  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/7/491?rss=1&ssource=collectionSearchRss&queryTerm=5Community-acquired pneumonia is a common and potentially serious infection that afflicts children throughout the world; it is fundamentally different in children and in adults. The annual incidence of pneumonia in...http://content.nejm.org/cgi/content/short/346/6/429?rss=1&ssource=collectionSearchRss&queryTerm=5Kenneth McIntosh, M.D.Thu, 07  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/6/429?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Salmonella enterica serotype choleraesuis is a cause of serious systemic infections. Because fluoroquinolones are the drug of choice for the treatment of severe salmonella infections, the emergence and dissemination...http://content.nejm.org/cgi/content/short/346/6/413?rss=1&ssource=collectionSearchRss&queryTerm=5Cheng-Hsun Chiu, M.D., Ph.D., Tsu-Lan Wu, M.S., Lin-Hui Su, M.S., Chishih Chu, Ph.D., Ju-Hsin Chia, M.S., An-Jing Kuo, M.S., Maw-Sheng Chien, Ph.D., and Tzou-Yien Lin, M.D.Thu, 07  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/6/413?rss=1&ssource=collectionSearchRss&queryTerm=5A 53-year-old woman reports severe watery diarrhea with cramps. She is in her 7th day of a 10-day course of cefixime, prescribed for bronchitis. How should she be evaluated and...http://content.nejm.org/cgi/content/short/346/5/334?rss=1&ssource=collectionSearchRss&queryTerm=5John G. Bartlett, M.D.Thu, 31  Jan  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/5/334?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A 62-year-old man presented with abdominal pain and a sigmoid-colostomy output of more than 1 liter of stool per day while receiving cefazolin for aspiration pneumonia. The colostomy...http://content.nejm.org/cgi/content/short/346/5/333?rss=1&ssource=collectionSearchRss&queryTerm=5George Triadafilopoulos, M.D.Thu, 31  Jan  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/5/333?rss=1&ssource=collectionSearchRss&queryTerm=5The risk of fungal infections increases greatly in patients with profound and protracted neutropenia. Because of the insensitivity of diagnostic methods and the poor outcomes associated with established infections, empirical...http://content.nejm.org/cgi/content/short/346/4/278?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 24  Jan  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/4/278?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Patients with neutropenia and persistent fever are often treated empirically with amphotericin B or liposomal amphotericin B to prevent invasive fungal infections. Antifungal triazoles offer a potentially safer and...http://content.nejm.org/cgi/content/short/346/4/225?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas J. Walsh, M.D., Peter Pappas, M.D., Drew J. Winston, M.D., Hillard M. Lazarus, M.D., Finn Petersen, M.D., John Raffalli, M.D., Saul Yanovich, M.D., Patrick Stiff, M.D., Richard Greenberg, M.D., Gerald Donowitz, M.D., Mindy Schuster, M.D., Annette Reboli, M.D., John Wingard, M.D., Carola Arndt, M.D., John Reinhardt, M.D., Susan Hadley, M.D., Robert Finberg, M.D., Michél Laverdière, M.D., John Perfect, M.D., Gary Garber, M.D., Giuseppe Fioritoni, M.D., Eli Anaissie, M.D., and Jeanette Lee, Ph.D., for the National Institute of Allergy and Infectious Diseases Mycoses Study GroupThu, 24  Jan  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/4/225?rss=1&ssource=collectionSearchRss&queryTerm=5Organ transplantation and major cancer chemotherapy are often associated with prolonged neutropenia (defined as less than 500 polymorphonuclear neutrophils per cubic millimeter), alterations in phagocyte function and lymphopenia due to...http://content.nejm.org/cgi/content/short/346/4/222?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 24  Jan  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/4/222?rss=1&ssource=collectionSearchRss&queryTerm=5A 24-year-old woman was admitted to the Travel and Tropical Medicine Center at this hospital because of edema and intermittent paresthesias of the right leg.<br/><br/>The patient was a volunteer with...http://content.nejm.org/cgi/content/short/346/2/115?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas B. Nutman, M.D., and Richard L. Kradin, M.D.Thu, 10  Jan  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/2/115?rss=1&ssource=collectionSearchRss&queryTerm=5The term “hemolytic–uremic syndrome” was coined by Gasser et al. in 19551 to describe a devastating illness consisting of acute renal failure accompanied by nonimmune hemolytic anemia and thrombocytopenia. Although...http://content.nejm.org/cgi/content/short/346/1/58?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 03  Jan  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/1/58?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The hemolytic–uremic syndrome is a thrombotic complication of Escherichia coli O157:H7 infection. It is not known whether the coagulation abnormalities precede, and potentially cause, this disorder.<br/><br/><em>Methods:</em> In 53 children...http://content.nejm.org/cgi/content/short/346/1/23?rss=1&ssource=collectionSearchRss&queryTerm=5Wayne L. Chandler, M.D., Srdjan Jelacic, B.S., Daniel R. Boster, B.S., Marcia A. Ciol, Ph.D., Glyn D. Williams, M.B., Ch.B., Sandra L. Watkins, M.D., Takashi Igarashi, M.D., Ph.D., and Phillip I. Tarr, M.D.Thu, 03  Jan  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/1/23?rss=1&ssource=collectionSearchRss&queryTerm=5An eight-year-old boy was admitted to the Massachusetts Eye and Ear Infirmary because of fever, headache, vertigo, and vomiting.<br/><br/>The child had been well until two days before admission, when he...http://content.nejm.org/cgi/content/short/345/26/1901?rss=1&ssource=collectionSearchRss&queryTerm=5Cliff A. Megerian and Tessa A. HadlockThu, 27  Dec  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/26/1901?rss=1&ssource=collectionSearchRss&queryTerm=5Meningitis remains a formidable foe because it often progresses rapidly and causes substantial morbidity and mortality.123 The rational management of meningitis has generally included a lumbar puncture to substantiate the...http://content.nejm.org/cgi/content/short/345/24/1768?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 13  Dec  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/24/1768?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In adults with suspected meningitis clinicians routinely order computed tomography (CT) of the head before performing a lumbar puncture.<br/><br/><em>Methods:</em> We prospectively studied 301 adults with suspected meningitis to determine...http://content.nejm.org/cgi/content/short/345/24/1727?rss=1&ssource=collectionSearchRss&queryTerm=5Rodrigo Hasbun, M.D., James Abrahams, M.D., James Jekel, M.D., and Vincent J. Quagliarello, M.D.Thu, 13  Dec  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/24/1727?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Invasive fungal infection is associated with substantial morbidity and mortality in preterm infants. We evaluated the efficacy of prophylactic fluconazole in preventing fungal colonization and invasive infection in extremely-low-birth-weight...http://content.nejm.org/cgi/content/short/345/23/1660?rss=1&ssource=collectionSearchRss&queryTerm=5David Kaufman, M.D., Robert Boyle, M.D., Kevin C. Hazen, Ph.D., James T. Patrie, M.S., Melinda Robinson, R.N., and Leigh Goodman Donowitz, M.D.Thu, 06  Dec  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/23/1660?rss=1&ssource=collectionSearchRss&queryTerm=5Tularemia, which is caused by the gram-negative bacillus Francisella tularensis, is now a rare infection in the United States. The peak incidence was in 1939, when about 2300 cases were...http://content.nejm.org/cgi/content/short/345/22/1637?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1637?rss=1&ssource=collectionSearchRss&queryTerm=5A 76-year-old man was admitted to the hospital because of atrial fibrillation and increasing dyspnea.<br/><br/>The patient had been well until three weeks earlier, during an unseasonably warm period in late...http://content.nejm.org/cgi/content/short/345/22/1627?rss=1&ssource=collectionSearchRss&queryTerm=5Sigal Yawetz, M.D., and Eugene J. Mark, M.D.Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1627?rss=1&ssource=collectionSearchRss&queryTerm=5The events that began this September, which have been described repeatedly in the media, have heightened awareness of and concern about anthrax. The initial reports documented 12 cases of clinical...http://content.nejm.org/cgi/content/short/345/22/1621?rss=1&ssource=collectionSearchRss&queryTerm=5Morton N. Swartz, M.D.Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1621?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A seven-month-old male infant was hospitalized with a two-day history of swelling of the left arm and a weeping lesion at the left elbow (Panel A). The patient...http://content.nejm.org/cgi/content/short/345/22/1611?rss=1&ssource=collectionSearchRss&queryTerm=5Kevin Joseph Roche, M.D., Mary Wu Chang, M.D., and Herbert Lazarus, M.D.Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1611?rss=1&ssource=collectionSearchRss&queryTerm=5Since the mid-1990s, Bacillus anthracis, the causative agent of anthrax, has been postulated to be a likely agent of biological warfare or terrorism because of its physical properties and its...http://content.nejm.org/cgi/content/short/345/22/1607?rss=1&ssource=collectionSearchRss&queryTerm=5Larry M. Bush, M.D., Barry H. Abrams, M.D., Anne Beall, B.S., M.T., and Caroline C. Johnson, M.D.Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1607?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> In the summer of 2000, an outbreak of primary pneumonic tularemia occurred on Martha's Vineyard, Massachusetts. The only previously reported outbreak of pneumonic tularemia in the United States also...http://content.nejm.org/cgi/content/short/345/22/1601?rss=1&ssource=collectionSearchRss&queryTerm=5Katherine A. Feldman, D.V.M., M.P.H., Russell E. Enscore, M.S., Sarah L. Lathrop, D.V.M., Ph.D., Bela T. Matyas, M.D., M.P.H., Michael McGuill, D.V.M., M.P.H., Martin E. Schriefer, Ph.D., Donna Stiles-Enos, R.N., David T. Dennis, M.D., M.P.H., Lyle R. Petersen, M.D., M.P.H., and Edward B. Hayes, M.D.Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1601?rss=1&ssource=collectionSearchRss&queryTerm=5A 57-year-old man was admitted to the hospital, for the sixth time, in January because of fever and cough.<br/><br/>The patient had a 25-year history of seronegative rheumatoid arthritis and a...http://content.nejm.org/cgi/content/short/345/21/1558?rss=1&ssource=collectionSearchRss&queryTerm=5Raphael Dolin and Eugene J. MarkThu, 22  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/21/1558?rss=1&ssource=collectionSearchRss&queryTerm=5A 54-year-old woman was admitted to the hospital with fever of unknown origin of one year's duration.<br/><br/>The patient was confined to a bed because of multiple sclerosis of 20 years'...http://content.nejm.org/cgi/content/short/345/19/1409?rss=1&ssource=collectionSearchRss&queryTerm=5Joseph O. Jacobson and Laurence de LevalThu, 08  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/19/1409?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen...http://content.nejm.org/cgi/content/short/345/19/1368?rss=1&ssource=collectionSearchRss&queryTerm=5Emanuel Rivers, M.D., M.P.H., Bryant Nguyen, M.D., Suzanne Havstad, M.A., Julie Ressler, B.S., Alexandria Muzzin, B.S., Bernhard Knoblich, M.D., Edward Peterson, Ph.D., and Michael Tomlanovich, M.D., for the Early Goal-Directed Therapy Collaborative GroupThu, 08  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/19/1368?rss=1&ssource=collectionSearchRss&queryTerm=5Infective endocarditis, a microbial infection of the endocardial surface of the heart, has been classified as “acute” or “subacute–chronic” on the basis of the tempo and severity of the clinical...http://content.nejm.org/cgi/content/short/345/18/1318?rss=1&ssource=collectionSearchRss&queryTerm=5Eleftherios Mylonakis, M.D., and Stephen B. Calderwood, M.D.Thu, 01  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/18/1318?rss=1&ssource=collectionSearchRss&queryTerm=5A 33-year-old man was admitted to the hospital because of leg numbness and back pain.<br/><br/>The patient had been well until six weeks before admission, when pruritus developed on his upper...http://content.nejm.org/cgi/content/short/345/17/1263?rss=1&ssource=collectionSearchRss&queryTerm=5C. Fordham von Reyn, M.D., and Eugene J. Mark, M.D.Thu, 25  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/17/1263?rss=1&ssource=collectionSearchRss&queryTerm=5The genomic sequences of more than 30 bacterial species, including virtually all important human pathogens, have been deciphered. The pneumococcus, discovered in 1880 virtually simultaneously by Pasteur in France and...http://content.nejm.org/cgi/content/short/345/16/1206?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 18  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/16/1206?rss=1&ssource=collectionSearchRss&queryTerm=5Antimicrobials have been used in food animals in North America and Europe for nearly half a century. Among the most common are drugs that are either identical to or related...http://content.nejm.org/cgi/content/short/345/16/1202?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 18  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/16/1202?rss=1&ssource=collectionSearchRss&queryTerm=5Otitis media in children leads to more than 20 million visits to physicians annually in the United States.123 By three years of age, 80 percent of all children in the...http://content.nejm.org/cgi/content/short/345/16/1177?rss=1&ssource=collectionSearchRss&queryTerm=5G. Scott Giebink, M.D.Thu, 18  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/16/1177?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Antibiotic-resistant enterococci are often present in retail meats, but it is unclear whether the ingestion of these contaminants leads to sustained intestinal carriage.<br/><br/><em>Methods:</em> We conducted a randomized, double-blind study...http://content.nejm.org/cgi/content/short/345/16/1161?rss=1&ssource=collectionSearchRss&queryTerm=5Thomas Lund Sørensen, M.D., Marianne Blom, M.Sc., Dominique L. Monnet, Ph.D., Niels Frimodt-Møller, M.D., D.M.Sc., Rikke Lykke Poulsen, Ph.D., and Frank Espersen, M.D., D.M.Sc.Thu, 18  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/16/1161?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The combination of the streptogramins quinupristin and dalfopristin was approved in the United States in late 1999 for the treatment of vancomycin-resistant Enterococcus faecium infections. Since 1974, another streptogramin,...http://content.nejm.org/cgi/content/short/345/16/1155?rss=1&ssource=collectionSearchRss&queryTerm=5L. Clifford McDonald, M.D., Shannon Rossiter, M.P.H., Constance Mackinson, M.T., Yong Yu Wang, M.D., M.P.H., Susan Johnson, M.T., Maureen Sullivan, M.P.H., Robert Sokolow, M.B.A., Emilio DeBess, D.V.M., M.P.V.M., Laura Gilbert, M.P.H., James A. Benson, M.T., Bertha Hill, and Frederick J. Angulo, D.V.M., Ph.D.Thu, 18  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/16/1155?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Salmonella is a leading cause of food-borne illness. The emergence of antimicrobial-resistant salmonella is associated with the use of antibiotics in animals raised for food; resistant bacteria can be...http://content.nejm.org/cgi/content/short/345/16/1147?rss=1&ssource=collectionSearchRss&queryTerm=5David G. White, Ph.D., Shaohua Zhao, D.V.M., Ph.D., Robert Sudler, M.S., Sherry Ayers, Sharon Friedman, B.A., Sheng Chen, D.V.M., Patrick F. McDermott, Ph.D., Shawn McDermott, B.S., David D. Wagner, Ph.D., and Jianghong Meng, D.V.M., Ph.D.Thu, 18  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/16/1147?rss=1&ssource=collectionSearchRss&queryTerm=5Community-acquired urinary tract infections occur mostly in women, are generally caused by Escherichia coli, and are among the most common bacterial infections. For the past two decades, trimethoprim–sulfamethoxazole or trimethoprim...http://content.nejm.org/cgi/content/short/345/14/1055?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 04  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/14/1055?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> The management of urinary tract infections is complicated by the increasing prevalence of antibiotic-resistant strains of Escherichia coli. We studied the clonal composition of E. coli isolates that were...http://content.nejm.org/cgi/content/short/345/14/1007?rss=1&ssource=collectionSearchRss&queryTerm=5Amee R. Manges, M.P.H., James R. Johnson, M.D., Betsy Foxman, Ph.D., Timothy T. O'Bryan, Kathleen E. Fullerton, M.P.H., and Lee W. Riley, M.D.Thu, 04  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/14/1007?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Infection with the larval form of the pork tapeworm, Taenia solium, can lead to the development of cysts in the brain. Surgical removal of cysts has been the accepted...http://content.nejm.org/cgi/content/short/345/12/879?rss=1&ssource=collectionSearchRss&queryTerm=5Jefferson V. Proaño, M.D., Ignacio Madrazo, M.D., D.Sc., Francisco Avelar, M.D., Blas López-Félix, M.D., Genaro Díaz, M.D., and Israel Grijalva, M.D., D.Sc.Thu, 20  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/12/879?rss=1&ssource=collectionSearchRss&queryTerm=5Worldwide, gastric cancer is the second most frequent cancer and the second leading cause of death from cancer. Since the discovery of Helicobacter pylori in 1982 by Marshall and Warren,...http://content.nejm.org/cgi/content/short/345/11/829?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 13  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/11/829?rss=1&ssource=collectionSearchRss&queryTerm=5A 44-year-old woman was admitted to this hospital because of abdominal pain, chills, fever, and jaundice.<br/><br/>The patient, a native of southern China, had been treated for intrahepatic stones by lithotripsy...http://content.nejm.org/cgi/content/short/345/11/817?rss=1&ssource=collectionSearchRss&queryTerm=5Raymond T. Chung, M.D., and Eric C. Sheffer, M.D>Thu, 13  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/11/817?rss=1&ssource=collectionSearchRss&queryTerm=5Cephalosporin antibiotics are widely prescribed for common infections such as bronchitis, otitis media, pneumonia, and cellulitis. They are also administered as first-line prophylaxis for many types of surgical procedures. A...http://content.nejm.org/cgi/content/short/345/11/804?rss=1&ssource=collectionSearchRss&queryTerm=5Pramod S. Kelkar, M.D., and James T.-C. Li, M.D., Ph.D.Thu, 13  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/11/804?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain.<br/><br/><em>Methods:</em> We prospectively studied 1526 Japanese...http://content.nejm.org/cgi/content/short/345/11/784?rss=1&ssource=collectionSearchRss&queryTerm=5Naomi Uemura, M.D., Shiro Okamoto, M.D., Soichiro Yamamoto, M.D., Nobutoshi Matsumura, M.D., Shuji Yamaguchi, M.D., Michio Yamakido, M.D., Kiyomi Taniyama, M.D., Naomi Sasaki, M.D., and Ronald J. Schlemper, M.D.Thu, 13  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/11/784?rss=1&ssource=collectionSearchRss&queryTerm=5Figure 1. A 60-year-old woman with a history of metastatic neuroendocrine tumor presented with rapidly progressive swelling of the left side of the face. She was dehydrated and acutely ill,...http://content.nejm.org/cgi/content/short/345/9/662?rss=1&ssource=collectionSearchRss&queryTerm=5Scott D. Lunin, M.D. and Stephan Moll, M.D.Thu, 30  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/9/662?rss=1&ssource=collectionSearchRss&queryTerm=5The first report of a health care worker infected with the human immunodeficiency virus (HIV) by a needle stick, published in the medical literature in 1984,1 launched a new era...http://content.nejm.org/cgi/content/short/345/7/538?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 16  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/7/538?rss=1&ssource=collectionSearchRss&queryTerm=5A 71-year-old man was admitted to the hospital because of diarrhea and abdominal pain.<br/><br/>The patient had a history of polycystic renal disease with hypertension and end-stage renal failure, for which...http://content.nejm.org/cgi/content/short/345/7/526?rss=1&ssource=collectionSearchRss&queryTerm=5Nezam H. Afdhal, M.D., and Rhonda K. Yantiss, M.D.Thu, 16  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/7/526?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Infection with Trichomonas vaginalis during pregnancy has been associated with preterm delivery. It is uncertain whether treatment of asymptomatic trichomoniasis in pregnant women reduces the occurrence of preterm delivery.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/345/7/487?rss=1&ssource=collectionSearchRss&queryTerm=5Mark A. Klebanoff, M.D., M.P.H., J. Christopher Carey, M.D., John C. Hauth, M.D., Sharon L. Hillier, Ph.D., Robert P. Nugent, Ph.D., M.P.H., Elizabeth A. Thom, Ph.D., J.M. Ernest, M.D., R. Phillip Heine, M.D., Ronald J. Wapner, M.D., Wayne Trout, M.D., Atef Moawad, M.D., Menachem Miodovnik, M.D., Baha M. Sibai, M.D., J. Peter Van Dorsten, M.D., Mitchell P. Dombrowski, M.D., Mary J. O'Sullivan, M.D., Michael Varner, M.D., Oded Langer, M.D., Donald McNellis, M.D., James M. Roberts, M.D., Kenneth J. Leveno, M.D., and the National Institute of Child Health and Human Development Network of Maternal–Fetal Medicine UnitsThu, 16  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/7/487?rss=1&ssource=collectionSearchRss&queryTerm=5A 46-year-old woman was admitted to the hospital because of recurrent hemoptysis.<br/><br/>Eight months earlier, a cough, nonpleuritic left-sided chest pain, and fatigue had developed, with minor episodes of hemoptysis. A...http://content.nejm.org/cgi/content/short/345/6/443?rss=1&ssource=collectionSearchRss&queryTerm=5John F. Beamis, M.D., and Eugene J. Mark, M.D.Thu, 09  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/6/443?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Impairment of the protein C anticoagulation pathway is critical to the thrombosis associated with sepsis and to the development of purpura fulminans in meningococcemia. We studied the expression of...http://content.nejm.org/cgi/content/short/345/6/408?rss=1&ssource=collectionSearchRss&queryTerm=5Saul N. Faust, M.R.C.P., Michael Levin, F.R.C.P., Ph.D., Odile B. Harrison, B.Sc., Robert D. Goldin, F.R.C.Path., Marion S. Lockhart, B.Sc., Sheila Kondaveeti, Ph.D., Zoltan Laszik, M.D., Charles T. Esmon, Ph.D., and Robert S. Heyderman, M.R.C.P., Ph.D.Thu, 09  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/6/408?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> Between March and May 1998, there was an outbreak of a clinically distinct skin eruption on the soles of the feet of children who used a community wading pool.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/345/5/335?rss=1&ssource=collectionSearchRss&queryTerm=5Loretta Fiorillo, M.D., Marc Zucker, M.D., Douglas Sawyer, M.D., and Andrew N. Lin, M.D.Thu, 02  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/5/335?rss=1&ssource=collectionSearchRss&queryTerm=5Glanders is a zoonotic disease of horses and related equids that was eliminated from the United States in 1934. The etiologic agent, Burkholderia mallei, has occasionally caused severe infection in...http://content.nejm.org/cgi/content/short/345/4/287?rss=1&ssource=collectionSearchRss&queryTerm=5Thu, 26  Jul  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/4/287?rss=1&ssource=collectionSearchRss&queryTerm=5Infection with Burkholderia mallei (formerly Pseudomonas mallei) can cause a subcutaneous infection known as farcy or can disseminate to cause the condition known as glanders. In humans, acute infection with...http://content.nejm.org/cgi/content/short/345/4/256?rss=1&ssource=collectionSearchRss&queryTerm=5Arjun Srinivasan, M.D., Carl N. Kraus, M.D., David DeShazer, Ph.D., Patrice M. Becker, M.D., James D. Dick, Ph.D., Lisa Spacek, M.D., John G. Bartlett, M.D., W. Russell Byrne, M.D., and David L. Thomas, M.D.Thu, 26  Jul  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/4/256?rss=1&ssource=collectionSearchRss&queryTerm=5A 25-year-old woman was admitted to the hospital because of persistent fever.<br/><br/>The patient was a resident of the Philippines who had flown to the United States 11 days before admission...http://content.nejm.org/cgi/content/short/345/3/201?rss=1&ssource=collectionSearchRss&queryTerm=5Eric J. Rubin, M.D., Ph.D., and Fiona M. Graeme-Cook, M.B.B.C.Thu, 19  Jul  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/3/201?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> It is controversial whether prolonged antibiotic treatment is effective for patients in whom symptoms persist after the recommended antibiotic treatment for acute Lyme disease.<br/><br/><em>Methods:</em> We conducted two randomized trials:...http://content.nejm.org/cgi/content/short/345/2/85?rss=1&ssource=collectionSearchRss&queryTerm=5Mark S. Klempner, M.D., Linden T. Hu, M.D., Janine Evans, M.D., Christopher H. Schmid, Ph.D., Gary M. Johnson, Richard P. Trevino, B.S., DeLona Norton, M.P.H., Lois Levy, M.S.W., Diane Wall, R.N., John McCall, Mark Kosinski, M.A., and Arthur Weinstein, M.D.Thu, 12  Jul  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/2/85?rss=1&ssource=collectionSearchRss&queryTerm=5<em>Background:</em> It is unclear