http://content.nejm.org/ The New England Journal of Medicine (NEJM) RSS feed — collection updates for Seizures. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. http://content.nejm.org/icons/nejm_name_220.gifhttp://content.nejm.org/The New England Journal of Medicine is owned, published, and copyrighted © 2010 Massachusetts Medical Society. All rights reserved.en-usDr. Bronwen C. Carroll (Pediatrics): A 9-month-old boy was admitted to this hospital because of a generalized seizure and a bulging fontanelle.<br/><br/>The patient was reportedly well until 3 days before...http://content.nejm.org/cgi/content/short/360/4/398?rss=1&ssource=collectionSearchRss&queryTerm=42Michael F. Holick, M.D., Ph.D., Ruth Lim, M.D., and Anand S. Dighe, M.D., Ph.D.Thu, 22  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/4/398?rss=1&ssource=collectionSearchRss&queryTerm=42A 30-year-old man presented with multiple asymptomatic, firm, polypoid, erythematous nodules on the upper and lower gingivae, which had developed during the previous 10 years. The patient had spastic quadriparesis...http://content.nejm.org/cgi/content/short/360/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=42Dong-Soo Yu, M.D. and Young-Bok Lee, M.D.Thu, 08  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=42Dr. Ronan Walsh (Department of Neurology, Brigham and Women's Hospital): A 61-year-old left-handed woman was admitted to the neurology service of this hospital because of a seizure and altered mental...http://content.nejm.org/cgi/content/short/353/21/2271?rss=1&ssource=collectionSearchRss&queryTerm=42Bradford C. Dickerson, M.D., David Holtzman, M.D., Ph.D., P. Ellen Grant, M.D., and Di Tian, M.D., Ph.D.Thu, 24  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/21/2271?rss=1&ssource=collectionSearchRss&queryTerm=42A 20-year-old man who had immigrated to the United States from Mexico three months earlier presented to the emergency department, reporting that he had had weight loss and pain in...http://content.nejm.org/cgi/content/short/352/22/2338?rss=1&ssource=collectionSearchRss&queryTerm=42Shelby Dames, M.D., Claude Tonnerre, M.D., Sanjay Saint, M.D., M.P.H., and Stephen R. Jones, M.D.Thu, 02  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/22/2338?rss=1&ssource=collectionSearchRss&queryTerm=42A 22-year-old woman with a history of a seizure disorder presented to the emergency department after having a rash for three days and a fever for one day. The rash...http://content.nejm.org/cgi/content/short/352/16/1696?rss=1&ssource=collectionSearchRss&queryTerm=42Jordan D. Fein, M.D. and Kendal L. Hamann, M.D.Thu, 21  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/16/1696?rss=1&ssource=collectionSearchRss&queryTerm=42Ten years ago, the story I was hearing did not ring any bells. It went like this. During recent months, an engineer in his 40s had been having episodes of...http://content.nejm.org/cgi/content/short/352/2/119?rss=1&ssource=collectionSearchRss&queryTerm=42Adam Zeman, D.M.Thu, 13  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/2/119?rss=1&ssource=collectionSearchRss&queryTerm=42A five-month-old girl was admitted to the hospital because of uncontrollable seizures. Her father had shaken her vigorously, allegedly in an attempt to rescue her from a choking spell. A...http://content.nejm.org/cgi/content/short/351/2/170?rss=1&ssource=collectionSearchRss&queryTerm=42Camille Hylton, M.D. and Morton F. Goldberg, M.D.Thu, 08  Jul  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/2/170?rss=1&ssource=collectionSearchRss&queryTerm=42Taenia solium causes two different diseases. When the adult cestode infests the human intestine, taeniasis develops; it is generally asymptomatic, but the host becomes a continuous source of taenia eggs,...http://content.nejm.org/cgi/content/short/350/3/280?rss=1&ssource=collectionSearchRss&queryTerm=42Julio Sotelo, M.D.Thu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/280?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> Neurocysticercosis is the main cause of adult-onset seizures in the developing world. Whether therapy with antiparasitic agents results in improved seizure control has been questioned because of the lack...http://content.nejm.org/cgi/content/short/350/3/249?rss=1&ssource=collectionSearchRss&queryTerm=42Héctor H. Garcia, M.D., Ph.D., E. Javier Pretell, M.D., Robert H. Gilman, M.D., S. Manuel Martinez, M.D., Lawrence H. Moulton, Ph.D., Oscar H. Del Brutto, M.D., Genaro Herrera, M.D., Carlton A.W. Evans, M.D., Ph.D., and Armando E. Gonzalez, D.V.M., Ph.D., for the Cysticercosis Working Group in PeruThu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/249?rss=1&ssource=collectionSearchRss&queryTerm=42It may come as a surprise that a lowly tapeworm is responsible for as many as 10 percent of cases in which a patient presents with seizures to an emergency...http://content.nejm.org/cgi/content/short/350/3/215?rss=1&ssource=collectionSearchRss&queryTerm=42James H. Maguire, M.D.Thu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/215?rss=1&ssource=collectionSearchRss&queryTerm=42Epilepsy is one of the most common neurologic problems worldwide. Approximately 2 million persons in the United States have epilepsy, and 3 percent of persons in the general population will...http://content.nejm.org/cgi/content/short/349/13/1257?rss=1&ssource=collectionSearchRss&queryTerm=42Bernard S. Chang, M.D., and Daniel H. Lowenstein, M.D.Thu, 25  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/13/1257?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> One third of patients with epilepsy have drug-resistant epilepsy, which is associated with an increased risk of death and debilitating psychosocial consequences. Because this form is resistant to multiple...http://content.nejm.org/cgi/content/short/348/15/1442?rss=1&ssource=collectionSearchRss&queryTerm=42Asra Siddiqui, M.R.C.P., Reinhold Kerb, Ph.D., Michael E. Weale, Ph.D., Ulrich Brinkmann, Ph.D., Alice Smith, B.Sc., David B. Goldstein, Ph.D., Nicholas W. Wood, F.R.C.P., Ph.D., and Sanjay M. Sisodiya, M.R.C.P., Ph.D.Thu, 10  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/15/1442?rss=1&ssource=collectionSearchRss&queryTerm=42Objective Magnesium sulfate may prevent eclampsia by reducing cerebral vasoconstriction and ischemia. Nimodipine is a calcium-channel blocker with specific cerebral vasodilator activity. Our objective was to determine whether nimodipine is...http://content.nejm.org/cgi/content/short/348/4/304?rss=1&ssource=collectionSearchRss&queryTerm=42Michael A. Belfort, M.D., Ph.D., John Anthony, M.B.Ch.B., George R. Saade, M.D., and John C. Allen, Jr., M.S., for the Nimodipine Study GroupThu, 23  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/4/304?rss=1&ssource=collectionSearchRss&queryTerm=42For centuries, practitioners of midwifery have feared the occurrence of convulsions during pregnancy because they carried a particularly grave prognosis for both mother and fetus. In 17th-century Paris, eclampsia was...http://content.nejm.org/cgi/content/short/348/4/275?rss=1&ssource=collectionSearchRss&queryTerm=42Michael F. Greene, M.D.Thu, 23  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/4/275?rss=1&ssource=collectionSearchRss&queryTerm=42A 5 1/2-year-old boy was admitted for video electroencephalographic monitoring to investigate his seizures.<br/><br/>The boy had been born to a 21-year-old woman by spontaneous vaginal delivery after an uncomplicated, full-term,...http://content.nejm.org/cgi/content/short/347/9/672?rss=1&ssource=collectionSearchRss&queryTerm=42Robert S. Rust and Diane KarlukThu, 29  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/9/672?rss=1&ssource=collectionSearchRss&queryTerm=42Status epilepticus is a series of successive grand mal seizures lasting minutes or even hours, without the recovery of normal consciousness. The resulting metabolic derangement of cells, depletion of the...http://content.nejm.org/cgi/content/short/345/9/689?rss=1&ssource=collectionSearchRss&queryTerm=42Thu, 30  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/9/689?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> It is uncertain whether the administration of benzodiazepines by paramedics is an effective and safe treatment for out-of-hospital status epilepticus.<br/><br/><em>Methods:</em> We conducted a randomized, double-blind trial to evaluate intravenous...http://content.nejm.org/cgi/content/short/345/9/631?rss=1&ssource=collectionSearchRss&queryTerm=42Brian K. Alldredge, Pharm.D., Alan M. Gelb, M.D., S. Marshal Isaacs, M.D., Megan D. Corry, E.M.T.-P., M.A., Faith Allen, M.D., SueKay Ulrich, R.N., M.S., Mildred D. Gottwald, Pharm.D., Nelda O'Neil, R.N., M.S.N., John M. Neuhaus, Ph.D., Mark R. Segal, Ph.D., and Daniel H. Lowenstein, M.D.Thu, 30  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/9/631?rss=1&ssource=collectionSearchRss&queryTerm=42This week the Journal's table of contents lists one title that is on our Web site but does not appear in the print version. The Journal's first Web-only Image in...http://content.nejm.org/cgi/content/short/345/5/365?rss=1&ssource=collectionSearchRss&queryTerm=42Thu, 02  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/5/365?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> Randomized trials of surgery for epilepsy have not been conducted, because of the difficulties involved in designing and implementing feasible studies. The lack of data supporting the therapeutic usefulness...http://content.nejm.org/cgi/content/short/345/5/311?rss=1&ssource=collectionSearchRss&queryTerm=42Samuel Wiebe, M.D., Warren T. Blume, M.D., John P. Girvin, M.D., Ph.D., and Michael Eliasziw, Ph.D., for the Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study GroupThu, 02  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/5/311?rss=1&ssource=collectionSearchRss&queryTerm=42A 31-year-old man was admitted to the hospital because of an apparent seizure and radiologic evidence of a cerebral lesion.<br/><br/>The patient had been in excellent health until five days earlier,...http://content.nejm.org/cgi/content/short/345/2/126?rss=1&ssource=collectionSearchRss&queryTerm=42Allan H. Ropper, M.D., and Anat Stemmer-Rachamimov, M.D.Thu, 12  Jul  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/2/126?rss=1&ssource=collectionSearchRss&queryTerm=42Approximately 2 million persons in the United States have epilepsy,12 making the prevalence of this disorder similar to that of type 1 diabetes mellitus.3 Each year, 100,000 new cases of...http://content.nejm.org/cgi/content/short/344/15/1145?rss=1&ssource=collectionSearchRss&queryTerm=42Thomas R. Browne, M.D., and Gregory L. Holmes, M.D.Thu, 12  Apr  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/15/1145?rss=1&ssource=collectionSearchRss&queryTerm=42Figure 1. A 17-year-old boy had generalized tonic–clonic seizures for four years. When the seizures began, a computed tomographic scan of his brain and an electroencephalogram were normal. Treatment with...http://content.nejm.org/cgi/content/short/342/5/325?rss=1&ssource=collectionSearchRss&queryTerm=42Sanjay Sharma, M.D., D.M. and S.K. Dasroy, B.D.S.Thu, 03  Feb  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/5/325?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> More than 30 percent of patients with epilepsy have inadequate control of seizures with drug therapy, but why this happens and whether it can be predicted are unknown. We...http://content.nejm.org/cgi/content/short/342/5/314?rss=1&ssource=collectionSearchRss&queryTerm=42Patrick Kwan, M.D., and Martin J. Brodie, M.D.Thu, 03  Feb  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/5/314?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> Seizures occur in 1 to 2 percent of neonates admitted to an intensive care unit. The treatment is usually with either phenobarbital or phenytoin, but the efficacy of the...http://content.nejm.org/cgi/content/short/341/7/485?rss=1&ssource=collectionSearchRss&queryTerm=42Michael J. Painter, M.D., Mark S. Scher, M.D., Aryeh D. Stein, Ph.D., Stacey Armatti, M.A., Zhiming Wang, Ph.D., Joseph C. Gardiner, Ph.D., Nigel Paneth, M.D., Beth Minnigh, Ph.D., and John Alvin, Ph.D.Thu, 12  Aug  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/7/485?rss=1&ssource=collectionSearchRss&queryTerm=42In the United States, epilepsy affects approximately 0.6 percent of the population (1.6 million persons) and has a lifetime prevalence of approximately 3 percent (and will thus affect 7.2 million...http://content.nejm.org/cgi/content/short/340/20/1565?rss=1&ssource=collectionSearchRss&queryTerm=42Orrin Devinsky, M.D.Thu, 20  May  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/20/1565?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> and <em>Methods:</em> Alcohol abuse is one of the most common causes of seizures in adults. In a randomized, double-blind study, we compared lorazepam with placebo for the prevention of...http://content.nejm.org/cgi/content/short/340/12/915?rss=1&ssource=collectionSearchRss&queryTerm=42Gail D'Onofrio, M.D., Niels K. Rathlev, M.D., Andrew S. Ulrich, M.D., Susan S. Fish, Pharm.D., M.P.H., and Eric S. Freedland, M.D.Thu, 25  Mar  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/12/915?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> and <em>Methods:</em> Although generalized convulsive status epilepticus is a life-threatening emergency, the best initial drug treatment is uncertain. We conducted a five-year randomized, double-blind, multicenter trial of four intravenous...http://content.nejm.org/cgi/content/short/339/12/792?rss=1&ssource=collectionSearchRss&queryTerm=42David M. Treiman, M.D., Patti D. Meyers, M.P.A., Nancy Y. Walton, Ph.D., Joseph F. Collins, Sc.D., Cindy Colling, R.Ph., M.S., A. James Rowan, M.D., Adrian Handforth, M.D., Edward Faught, M.D., Vincent P. Calabrese, M.D., Basim M. Uthman, M.D., R. Eugene Ramsay, M.D., and Meenal B. Mamdani, M.D., Pratap Yagnik, M.D., John C. Jones, M.D., Elizabeth Barry, M.D., Jane G. Boggs, M.D., Andres M. Kanner, M.D., for the Veterans Affairs Status Epilepticus Cooperative Study GroupThu, 17  Sep  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/12/792?rss=1&ssource=collectionSearchRss&queryTerm=42Three articles in this and the June 11 issue of the Journal give us an opportunity to reexamine issues that are critical to how we perceive and respond to seizures...http://content.nejm.org/cgi/content/short/338/26/1916?rss=1&ssource=collectionSearchRss&queryTerm=42Thu, 25  Jun  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/26/1916?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> Acute repetitive seizures are readily recognizable episodes involving increased seizure frequency. Urgent treatment is often required. Rectal diazepam gel is a promising therapy.<br/><br/><em>Methods:</em> We conducted a randomized, double-blind, parallel-group,...http://content.nejm.org/cgi/content/short/338/26/1869?rss=1&ssource=collectionSearchRss&queryTerm=42Fritz E. Dreifuss, M.D., N. Paul Rosman, M.D., James C. Cloyd, Pharm.D., John M. Pellock, M.D., Ruben I. Kuzniecky, M.D., Warren D. Lo, M.D., Fumisuke Matsuo, M.D., Gregory B. Sharp, M.D., Joan A. Conry, M.D., Donna C. Bergen, M.D., and Walter E. Bell, Ph.D.Thu, 25  Jun  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/26/1869?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> Hospital-based studies have reported that children with febrile convulsions have subsequent mental retardation and behavior problems. In contrast, population-based studies have reported a better outcome.<br/><br/><em>Methods:</em> We identified 398 children...http://content.nejm.org/cgi/content/short/338/24/1723?rss=1&ssource=collectionSearchRss&queryTerm=42Christopher M. Verity, F.R.C.P.C.H., Rosemary Greenwood, M.Sc., and Jean Golding, Ph.D.Thu, 11  Jun  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/24/1723?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> The long-term prognosis of seizures that begin in childhood is uncertain.<br/><br/><em>Methods:</em> We prospectively studied 245 children from the catchment area of Turku University Hospital in Turku, Finland, who had...http://content.nejm.org/cgi/content/short/338/24/1715?rss=1&ssource=collectionSearchRss&queryTerm=42Matti Sillanpää, M.D., Ph.D., Merja Jalava, M.D., Ph.D., Olli Kaleva, B.Sc., and Shlomo Shinnar, M.D., Ph.D.Thu, 11  Jun  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/24/1715?rss=1&ssource=collectionSearchRss&queryTerm=42A patient in status epilepticus has continuous or rapidly repeating seizures. Although the danger of this pattern of seizure activity has been recognized since antiquity, our understanding of the pathophysiology...http://content.nejm.org/cgi/content/short/338/14/970?rss=1&ssource=collectionSearchRss&queryTerm=42Daniel H. Lowenstein, M.D., and Brian K. Alldredge, Pharm.D.Thu, 02  Apr  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/14/970?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> Patients with a single unprovoked seizure have about a 35 percent risk of recurrence in the subsequent five years. We studied the risk of recurrence after two unprovoked seizures.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/338/7/429?rss=1&ssource=collectionSearchRss&queryTerm=42W. Allen Hauser, M.D., Stephen S. Rich, Ph.D., Ju R.-J. Lee, Ph.D., John F. Annegers, Ph.D., and V. Elving Anderson, Ph.D.Thu, 12  Feb  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/7/429?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> The risk of seizures is increased after traumatic brain injury, but the extent and duration of the increase in risk are unknown. The purpose of this study was to...http://content.nejm.org/cgi/content/short/338/1/20?rss=1&ssource=collectionSearchRss&queryTerm=42John F. Annegers, Ph.D., W. Allen Hauser, M.D., Sharon P. Coan, M.S., and Walter A. Rocca, M.D., M.P.H.Thu, 01  Jan  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/1/20?rss=1&ssource=collectionSearchRss&queryTerm=42<em>Background:</em> The Lennox–Gastaut syndrome, a severe form of epilepsy that usually begins in early childhood, is difficult to treat. Dose-related drug toxicity is common.<br/><br/><em>Methods:</em> We conducted a double-blind, placebo-controlled trial...http://content.nejm.org/cgi/content/short/337/25/1807?rss=1&ssource=collectionSearchRss&queryTerm=42Jacques Motte, M.D., Edwin Trevathan, M.D., M.P.H., Jan F.V. Arvidsson, M.D., Manuel Nieto Barrera, M.D., E. Lynette Mullens, M.D., Penelope Manasco, M.D., and the Lamictal Lennox–Gastaut Study GroupThu, 18  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/25/1807?rss=1&ssource=collectionSearchRss&queryTerm=42In the past two years, three new antiepileptic drugs — gabapentin, lamotrigine, and felbamate — have been approved for use in the United States. They are the first such drugs...http://content.nejm.org/cgi/content/short/334/24/1583?rss=1&ssource=collectionSearchRss&queryTerm=42Marc A. Dichter, M.D., Ph.D., and Martin J. Brodie, M.D.Thu, 13  Jun  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/24/1583?rss=1&ssource=collectionSearchRss&queryTerm=42Of the approximately 2 million Americans with a diagnosis of epilepsy who are treated with antiepileptic drugs, 20 percent continue to have seizures1; this group of patients accounts for over...http://content.nejm.org/cgi/content/short/334/10/647?rss=1&ssource=collectionSearchRss&queryTerm=42Jerome Engel, Jr., M.D., Ph.D.Thu, 07  Mar  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/10/647?rss=1&ssource=collectionSearchRss&queryTerm=42At a conservative estimate, 50 million people worldwide have epilepsy. The annual incidence ranges from 20 to 70 cases per 100,0001 and the point prevalence is 0.4 to 0.8 percent.2...http://content.nejm.org/cgi/content/short/334/3/168?rss=1&ssource=collectionSearchRss&queryTerm=42Martin J. Brodie, M.D., and Marc A. Dichter, M.D.Thu, 18  Jan  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/3/168?rss=1&ssource=collectionSearchRss&queryTerm=42