http://content.nejm.org/ The New England Journal of Medicine (NEJM) RSS feed — collection updates for Osteoporosis/Bone Disease. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. http://content.nejm.org/icons/nejm_name_220.gifhttp://content.nejm.org/The New England Journal of Medicine is owned, published, and copyrighted © 2010 Massachusetts Medical Society. All rights reserved.en-usTo the Editor: In 1990, Brasington described “Nintendinitis”1 in a patient with pain over the extensor tendon of her thumb after 5 hours of playing a Nintendo video game. Nintendo...http://content.nejm.org/cgi/content/short/362/5/473?rss=1&ssource=collectionSearchRss&queryTerm=35Karen A. Eley, M.R.C.S.(Ed)Thu, 04  Feb  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/5/473?rss=1&ssource=collectionSearchRss&queryTerm=35In this issue of the Journal, Smits et al.1 describe how they identified the cause of a rare human skeletal dysplasia, achondrogenesis type 1A. In so doing, they have provided...http://content.nejm.org/cgi/content/short/362/3/266?rss=1&ssource=collectionSearchRss&queryTerm=35Hudson H. Freeze, Ph.D.Thu, 21  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/3/266?rss=1&ssource=collectionSearchRss&queryTerm=35A 47-year-old woman of Italian descent with a history of transfusion-dependent β-thalassemia intermedia presented to the emergency department with dyspnea that had worsened during the previous several days. The physical...http://content.nejm.org/cgi/content/short/362/3/253?rss=1&ssource=collectionSearchRss&queryTerm=35Edward Smitaman, M.D. and Ami N. Rubinowitz, M.D.Thu, 21  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/3/253?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Establishing the genetic basis of phenotypes such as skeletal dysplasia in model organisms can provide insights into biologic processes and their role in human disease.<br/><br/><em>Methods:</em> We screened mutagenized mice...http://content.nejm.org/cgi/content/short/362/3/206?rss=1&ssource=collectionSearchRss&queryTerm=35Patrick Smits, Ph.D., Andrew D. Bolton, B.S., Vincent Funari, Ph.D., Minh Hong, Ph.D., Eric D. Boyden, Ph.D., Lei Lu, Ph.D., Danielle K. Manning, Ph.D., Noelle D. Dwyer, Ph.D., Jennifer L. Moran, Ph.D., Mary Prysak, B.S., Barry Merriman, Ph.D., Stanley F. Nelson, M.D., Luisa Bonafé, M.D., Ph.D., Andrea Superti-Furga, M.D., Shiro Ikegawa, M.D., Ph.D., Deborah Krakow, M.D., Daniel H. Cohn, Ph.D., Tom Kirchhausen, Ph.D., Matthew L. Warman, M.D., and David R. Beier, M.D., Ph.D.Thu, 21  Jan  2010 00:00:00 -05:00http://content.nejm.org/cgi/content/short/362/3/206?rss=1&ssource=collectionSearchRss&queryTerm=35A 67-year-old woman who had a history of breast cancer and who had undergone chemoradiotherapy 10 years earlier underwent routine follow-up chest radiography. The images revealed right axillary surgical clips...http://content.nejm.org/cgi/content/short/361/26/2557?rss=1&ssource=collectionSearchRss&queryTerm=35Jonathan H. Chung, M.D. and Sudhakar N. Pipavath, M.D.Thu, 24  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/26/2557?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. David T. Ting (Medical Oncology): A 23-year-old man was transferred to this hospital because of cough, hoarseness, fever, and abnormalities on chest imaging.<br/><br/>The patient had been well until 1...http://content.nejm.org/cgi/content/short/361/21/2080?rss=1&ssource=collectionSearchRss&queryTerm=35Edwin Choy, M.D., Ph.D., Subba R. Digumarthy, M.D., and Stephanie A. Koplin, M.D.Thu, 19  Nov  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/21/2080?rss=1&ssource=collectionSearchRss&queryTerm=35Autoantibodies against osteoprotegerin, which block the inhibitory effect of osteoprotegerin on signaling by the receptor activator of nuclear factor (NF)-κB (RANK), were identified in a man with celiac disease who...http://content.nejm.org/cgi/content/short/361/15/1459?rss=1&ssource=collectionSearchRss&queryTerm=35Philip L. Riches, M.R.C.P., Euan McRorie, F.R.C.P., William D. Fraser, Ph.D., F.R.C.Path., Catherine Determann, B.Med.Sci., Rob van't Hof, Ph.D., and Stuart H. Ralston, M.D.Thu, 08  Oct  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/15/1459?rss=1&ssource=collectionSearchRss&queryTerm=35More than a decade ago, receptor activator of nuclear factor-κB ligand (RANKL) was identified as the key molecule mediating osteoclast development, activity, and survival.1 Since osteoporosis results, in part, from...http://content.nejm.org/cgi/content/short/361/8/818?rss=1&ssource=collectionSearchRss&queryTerm=35Sundeep Khosla, M.D.Thu, 20  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/8/818?rss=1&ssource=collectionSearchRss&queryTerm=35The numbers of primary total hip and total knee arthroplasties have been increasing over the past decade, with nearly 800,000 such procedures performed in the United States in 2006 (Figure...http://content.nejm.org/cgi/content/short/361/8/787?rss=1&ssource=collectionSearchRss&queryTerm=35Jose L. Del Pozo, M.D., Ph.D., and Robin Patel, M.D.Thu, 20  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/8/787?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL) that blocks its binding to RANK, inhibiting the development and activity of osteoclasts,...http://content.nejm.org/cgi/content/short/361/8/756?rss=1&ssource=collectionSearchRss&queryTerm=35Steven R. Cummings, M.D., Javier San Martin, M.D., Michael R. McClung, M.D., Ethel S. Siris, M.D., Richard Eastell, M.D., Ian R. Reid, M.D., Pierre Delmas, M.D., Ph.D., Holly B. Zoog, Ph.D., Matt Austin, M.S., Andrea Wang, M.A., Stepan Kutilek, M.D., Silvano Adami, M.D., Ph.D., Jose Zanchetta, M.D., Cesar Libanati, M.D., Suresh Siddhanti, Ph.D., and Claus Christiansen, M.D., for the FREEDOM TrialThu, 20  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/8/756?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Androgen-deprivation therapy is well-established for treating prostate cancer but is associated with bone loss and an increased risk of fracture. We investigated the effects of denosumab, a fully human...http://content.nejm.org/cgi/content/short/361/8/745?rss=1&ssource=collectionSearchRss&queryTerm=35Matthew R. Smith, M.D., Ph.D., Blair Egerdie, M.D., Narciso Hernández Toriz, M.D., Robert Feldman, M.D., Teuvo L.J. Tammela, M.D., Fred Saad, M.D., Jiri Heracek, M.D., Ph.D., Maciej Szwedowski, M.D., Chunlei Ke, Ph.D., Amy Kupic, M.A., Benjamin Z. Leder, M.D., and Carsten Goessl, M.D., for the Denosumab HALT Prostate Cancer Study GroupThu, 20  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/8/745?rss=1&ssource=collectionSearchRss&queryTerm=35To the Editor: A magnitude 8.0 earthquake hit the densely populated region of Sichuan, China, on May 12, 2008, causing an estimated 374,643 injuries. By July 23, 2008, a total...http://content.nejm.org/cgi/content/short/361/6/636?rss=1&ssource=collectionSearchRss&queryTerm=35Zhi-hui Dong, M.D., Zhi-gang Yang, M.D., Ph.D., Tian-wu Chen, M.D., Yuan-chun Feng, M.D., Qi-ling Wang, M.D., and Zhi-gang Chu, M.D.Thu, 06  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/6/636?rss=1&ssource=collectionSearchRss&queryTerm=35Worldwide there are approximately 1.4 million persons with vertebral compression fractures.1 In the United States, there are approximately 750,000; only one third receive treatment.2 Prevalence estimates are imprecise because of...http://content.nejm.org/cgi/content/short/361/6/619?rss=1&ssource=collectionSearchRss&queryTerm=35James N. Weinstein, D.O., M.S.Thu, 06  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/6/619?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Vertebroplasty is commonly used to treat painful, osteoporotic vertebral compression fractures.<br/><br/><em>Methods:</em> In this multicenter trial, we randomly assigned 131 patients who had one to three painful osteoporotic vertebral compression...http://content.nejm.org/cgi/content/short/361/6/569?rss=1&ssource=collectionSearchRss&queryTerm=35David F. Kallmes, M.D., Bryan A. Comstock, M.S., Patrick J. Heagerty, Ph.D., Judith A. Turner, Ph.D., David J. Wilson, F.R.C.R., Terry H. Diamond, F.R.A.C.P., Richard Edwards, F.R.C.R., Leigh A. Gray, M.S., Lydia Stout, B.S., Sara Owen, M.Sc., William Hollingworth, Ph.D., Basavaraj Ghdoke, M.D., Deborah J. Annesley-Williams, F.R.C.R., Stuart H. Ralston, F.R.C.P., and Jeffrey G. Jarvik, M.D., M.P.H.Thu, 06  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/6/569?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Vertebroplasty has become a common treatment for painful osteoporotic vertebral fractures, but there is limited evidence to support its use.<br/><br/><em>Methods:</em> We performed a multicenter, randomized, double-blind, placebo-controlled trial in...http://content.nejm.org/cgi/content/short/361/6/557?rss=1&ssource=collectionSearchRss&queryTerm=35Rachelle Buchbinder, Ph.D., Richard H. Osborne, Ph.D., Peter R. Ebeling, M.D., John D. Wark, Ph.D., Peter Mitchell, M.Med., Chris Wriedt, M.B., B.S., Stephen Graves, D. Phil., Margaret P. Staples, Ph.D., and Bridie Murphy, B.Sc.Thu, 06  Aug  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/6/557?rss=1&ssource=collectionSearchRss&queryTerm=35A 31-year-old man presented to the emergency department with pain in the left shoulder. He had tripped over the shoulder strap of his backpack earlier in the day and noted...http://content.nejm.org/cgi/content/short/361/1/74?rss=1&ssource=collectionSearchRss&queryTerm=35Asaf Bitton, M.D., Maria Yialamas, M.D., Bruce D. Levy, M.D., Joel T. Katz, M.D., and Joseph Loscalzo, M.D., Ph.D.Thu, 02  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/1/74?rss=1&ssource=collectionSearchRss&queryTerm=35A 65-year-old woman with osteoarthritis of her right knee is referred by her primary care physician for orthopedic consultation. She is healthy except for some well-controlled hypertension. She is 5...http://content.nejm.org/cgi/content/short/360/17/1749?rss=1&ssource=collectionSearchRss&queryTerm=35Seth S. Leopold, M.D.Thu, 23  Apr  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/17/1749?rss=1&ssource=collectionSearchRss&queryTerm=35A 51-year-old woman with a history of hypertension and depression reported progressively worsening pain in the left thigh over a period of several months, which had made her unable to...http://content.nejm.org/cgi/content/short/360/14/1446?rss=1&ssource=collectionSearchRss&queryTerm=35Brendan M. Reilly, M.D., Peter D. Hart, M.D., Susana Mascarell, M.D., and Hemant Chatrath, M.D.Thu, 02  Apr  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/14/1446?rss=1&ssource=collectionSearchRss&queryTerm=35In a recent article, Yadav et al.1 elucidated the regulation of gut-produced serotonin by low-density lipoprotein receptor–related protein 5 (Lrp5) and the deleterious effect of serotonin on bone mass. This...http://content.nejm.org/cgi/content/short/360/10/957?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 05  Mar  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/10/957?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. Bronwen C. Carroll (Pediatrics): A 9-month-old boy was admitted to this hospital because of a generalized seizure and a bulging fontanelle.<br/><br/>The patient was reportedly well until 3 days before...http://content.nejm.org/cgi/content/short/360/4/398?rss=1&ssource=collectionSearchRss&queryTerm=35Michael F. Holick, M.D., Ph.D., Ruth Lim, M.D., and Anand S. Dighe, M.D., Ph.D.Thu, 22  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/4/398?rss=1&ssource=collectionSearchRss&queryTerm=35To the Editor: Between the time of the initial marketing of alendronate in October 1995 through mid-May 2008, the Food and Drug Administration (FDA) received reports of 23 patients in...http://content.nejm.org/cgi/content/short/360/1/89?rss=1&ssource=collectionSearchRss&queryTerm=35Diane K. Wysowski, Ph.D.Thu, 01  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/1/89?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoclasts are multinucleated cells responsible for the resorption of bone matrix. During the development and growth of a human, they ensure proper contouring of the bones and extension of the...http://content.nejm.org/cgi/content/short/360/1/80?rss=1&ssource=collectionSearchRss&queryTerm=35Julie Glowacki, Ph.D.Thu, 01  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/1/80?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Bisphosphonates decrease bone resorption and are commonly used to treat or prevent osteoporosis. However, the effect of bisphosphonates on their target cells remains enigmatic, since in patients benefiting from...http://content.nejm.org/cgi/content/short/360/1/53?rss=1&ssource=collectionSearchRss&queryTerm=35Robert S. Weinstein, M.D., Paula K. Roberson, Ph.D., and Stavros C. Manolagas, M.D., Ph.D.Thu, 01  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/1/53?rss=1&ssource=collectionSearchRss&queryTerm=35An 87-year-old man tripped and fell; subsequently, persistent pain developed in the left hip. A radiograph of the left hip 2 weeks after the fall revealed diffuse osteopenia with no...http://content.nejm.org/cgi/content/short/359/26/e33?rss=1&ssource=collectionSearchRss&queryTerm=35Emily N. Vinson, M.D.Thu, 25  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/26/e33?rss=1&ssource=collectionSearchRss&queryTerm=35A 12-year-old girl with an unremarkable history was evaluated for a nodule of the lateral nail fold on the right hallux that had been present for 3 months (Panel A)....http://content.nejm.org/cgi/content/short/359/25/e31?rss=1&ssource=collectionSearchRss&queryTerm=35Alexandre Campanelli, M.D. and Luca Borradori, M.D.Thu, 18  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/25/e31?rss=1&ssource=collectionSearchRss&queryTerm=35The temporomandibular joint (TMJ) may be affected by inflammatory, traumatic, infectious, congenital, developmental, and neoplastic diseases, as seen in other joints. However, the most common affliction of the TMJ and...http://content.nejm.org/cgi/content/short/359/25/2693?rss=1&ssource=collectionSearchRss&queryTerm=35Steven J. Scrivani, D.D.S., D.Med.Sc., David A. Keith, B.D.S., D.M.D., and Leonard B. Kaban, D.M.D., M.D.Thu, 18  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/25/2693?rss=1&ssource=collectionSearchRss&queryTerm=35A 58-year-old woman presented with a cavitating left breast lesion and increasing pain in the left arm. For over a year she had noticed an enlarging breast mass but did...http://content.nejm.org/cgi/content/short/359/24/2586?rss=1&ssource=collectionSearchRss&queryTerm=35Ashok Malani, M.D. and Rony M. Abou-Jawde, M.D.Thu, 11  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/24/2586?rss=1&ssource=collectionSearchRss&queryTerm=35To the Editor: There have been few reports of osteosarcoma after allogeneic bone marrow transplantation.1 We report the development of osteosarcoma in a recipient 17 years after stem-cell transplantation.<br/><br/>A 23-month-old...http://content.nejm.org/cgi/content/short/359/23/2502?rss=1&ssource=collectionSearchRss&queryTerm=35Massimo Berger, M.D., Michela Muraro, M.D., Franca Fagioli, M.D., and Stefano Ferrari, M.D.Thu, 04  Dec  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/23/2502?rss=1&ssource=collectionSearchRss&queryTerm=35A 17-year-old boy was seen at this hospital because of a pituitary tumor and radiologic evidence of bony abnormalities in the skull. The patient was well until approximately 12 years...http://content.nejm.org/cgi/content/short/359/22/2367?rss=1&ssource=collectionSearchRss&queryTerm=35Edward R. Smith, M.D., Jay Loeffler, M.D., Madhusmita Misra, M.D., Stuart R. Pomerantz, M.D., Anat Stemmer-Rachamimov, M.D., and Miriam D. Post, M.D.Thu, 27  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/22/2367?rss=1&ssource=collectionSearchRss&queryTerm=35A 40-year-old man presented with a 3-day history of increasing abdominal pain. On physical examination, rebound tenderness was present, and both hip joints were fixed in flexion state with no...http://content.nejm.org/cgi/content/short/359/19/2034?rss=1&ssource=collectionSearchRss&queryTerm=35Kyung-Su Park, M.D. and Young-Seok Cho, M.D.Thu, 06  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/19/2034?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. Mary Pisculli (Infectious Disease): A 58-year-old woman was transferred to this hospital because of severe right-sided neck pain, fever, and abnormal findings on cervical magnetic resonance imaging (MRI).<br/><br/>Two to...http://content.nejm.org/cgi/content/short/359/18/1942?rss=1&ssource=collectionSearchRss&queryTerm=35Julie L. Gerberding, M.D., M.P.H., Javier M. Romero, M.D., and Mary Jane Ferraro, Ph.D., M.P.H.Thu, 30  Oct  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/18/1942?rss=1&ssource=collectionSearchRss&queryTerm=35To the Editor: Bisphosphonates are being used increasingly for the prevention and treatment of osteoporosis, hypercalcemia of malignant disease, and other disorders of bone metabolism. Known ocular complications of bisphosphonates...http://content.nejm.org/cgi/content/short/359/13/1410?rss=1&ssource=collectionSearchRss&queryTerm=35Neil S. Sharma, M.B., B.S., M.P.H., Ju-Lee Ooi, M.B., B.S., M.P.H., Katherine Masselos, M.B., B.S., Michael J. Hooper, M.D., and Ian C. Francis, M.B., B.S., Ph.D.Thu, 25  Sep  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/13/1410?rss=1&ssource=collectionSearchRss&queryTerm=35Orthopedic surgeons perform arthroscopic surgery in many joints of the extremities, most commonly the knee. Two or three incisions are routinely made, each measuring approximately 7 mm. The knee is...http://content.nejm.org/cgi/content/short/359/11/1169?rss=1&ssource=collectionSearchRss&queryTerm=35Robert G. Marx, M.D.Thu, 11  Sep  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/11/1169?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> The efficacy of arthroscopic surgery for the treatment of osteoarthritis of the knee is unknown.<br/><br/><em>Methods:</em> We conducted a single-center, randomized, controlled trial of arthroscopic surgery in patients with moderate-to-severe...http://content.nejm.org/cgi/content/short/359/11/1097?rss=1&ssource=collectionSearchRss&queryTerm=35Alexandra Kirkley, M.D., Trevor B. Birmingham, Ph.D., Robert B. Litchfield, M.D., J. Robert Giffin, M.D., Kevin R. Willits, M.D., Cindy J. Wong, M.Sc., Brian G. Feagan, M.D., Allan Donner, Ph.D., Sharon H. Griffin, C.S.S., Linda M. D'Ascanio, B.Sc.N., Janet E. Pope, M.D., and Peter J. Fowler, M.D.Thu, 11  Sep  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/11/1097?rss=1&ssource=collectionSearchRss&queryTerm=35Since the mean life expectancy at menopause is 32.7 years, women spend more than one third of their lives in the estrogen-deficient postmenopausal state.1 Of the majority of menopausal women...http://content.nejm.org/cgi/content/short/359/7/753?rss=1&ssource=collectionSearchRss&queryTerm=35Ghada El-Hajj Fuleihan, M.D., M.P.H.Thu, 14  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/7/753?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. Flavia V. Castelino (Rheumatology, Allergy, and Immunology): A 43-year-old man was seen in the neuro-oncology clinic of this hospital because of fatigue and lesions in the pituitary and cerebellum...http://content.nejm.org/cgi/content/short/359/7/736?rss=1&ssource=collectionSearchRss&queryTerm=35John A. Mills, M.D., R. Gilberto Gonzalez, M.D., Ph.D., and Ronald Jaffe, M.D.Thu, 14  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/7/736?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Tibolone has estrogenic, progestogenic, and androgenic effects. Although tibolone prevents bone loss, its effects on fractures, breast cancer, and cardiovascular disease are uncertain.<br/><br/><em>Methods:</em> In this randomized study, we assigned...http://content.nejm.org/cgi/content/short/359/7/697?rss=1&ssource=collectionSearchRss&queryTerm=35Steven R. Cummings, M.D., Bruce Ettinger, M.D., Pierre D. Delmas, M.D., Ph.D., Peter Kenemans, M.D., Ph.D., Victoria Stathopoulos, Ph.D., Pierre Verweij, Ph.D., Mirjam Mol-Arts, M.D., Lenus Kloosterboer, Ph.D., Lori Mosca, M.D., Ph.D., M.P.H., Claus Christiansen, M.D., John Bilezikian, M.D., Eduardo Mario Kerzberg, M.D., Susan Johnson, M.D., Jose Zanchetta, M.D., Diederich E. Grobbee, M.D., Ph.D., Wilfried Seifert, Ph.D., and Richard Eastell, M.D., for the LIFT Trial InvestigatorsThu, 14  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/7/697?rss=1&ssource=collectionSearchRss&queryTerm=35A 64-year-old Filipino man presented to a Baltimore hospital with a 4-month history of worsening midback pain, progressive leg weakness, and intermittent bladder and bowel incontinence. He had no fever...http://content.nejm.org/cgi/content/short/359/6/628?rss=1&ssource=collectionSearchRss&queryTerm=35Oluwaseun O. Falade, M.D., M.P.H., Emmanuel S. Antonarakis, M.D., Daniel R. Kaul, M.D., Sanjay Saint, M.D., M.P.H., and Patrick A. Murphy, M.D.Thu, 07  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/6/628?rss=1&ssource=collectionSearchRss&queryTerm=35An otherwise healthy and functional 35-year-old man had an undisplaced fracture of the right fifth metacarpal neck after a fall. He presented 21 months later with pain, extensive swelling (Panels...http://content.nejm.org/cgi/content/short/359/5/508?rss=1&ssource=collectionSearchRss&queryTerm=35Oliver Guttmann, M.B., B.S. and Victoria Wykes, M.B., B.S., Ph.D.Thu, 31  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/5/508?rss=1&ssource=collectionSearchRss&queryTerm=35A 26-year-old man was admitted to this hospital because of back pain and a mass in the lung. He had been well until 17 days before admission, when he bent...http://content.nejm.org/cgi/content/short/359/4/405?rss=1&ssource=collectionSearchRss&queryTerm=35Lecia V. Sequist, M.D., M.P.H., Jeffrey E. Settleman, Ph.D., Jeanne B. Ackman, M.D., and A. John Iafrate, M.D., Ph.D.Thu, 24  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/4/405?rss=1&ssource=collectionSearchRss&queryTerm=35A 66-year-old man had progressive reduction of global spine movement for more than two decades that eventually resulted in complete spinal immobility. Extensive calcification of the intervertebral ligaments, bilateral ossification...http://content.nejm.org/cgi/content/short/359/4/404?rss=1&ssource=collectionSearchRss&queryTerm=35Jon K.C. Yoong, M.R.C.P.Thu, 24  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/4/404?rss=1&ssource=collectionSearchRss&queryTerm=35A 20-year-old man who had had idiopathic end-stage renal failure since he was 12 years of age and who was undergoing dialysis once weekly (with stable serum electrolyte, blood urea...http://content.nejm.org/cgi/content/short/359/1/74?rss=1&ssource=collectionSearchRss&queryTerm=35Yahya Daneshbod, M.D.Thu, 03  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/1/74?rss=1&ssource=collectionSearchRss&queryTerm=35A long latency period between an environmental trigger and the onset of subsequent disease is widely recognized in the etiology of certain cancers, yet this phenomenon is not generally considered...http://content.nejm.org/cgi/content/short/359/1/61?rss=1&ssource=collectionSearchRss&queryTerm=35Peter D. Gluckman, M.D., D.Sc., Mark A. Hanson, D.Phil., Cyrus Cooper, M.D., and Kent L. Thornburg, Ph.D.Thu, 03  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/1/61?rss=1&ssource=collectionSearchRss&queryTerm=35The first edition of Osteoporosis appeared in 1996 and was followed by the second edition in 2001. The third edition of this multiauthored book keeps up remarkably well with the...http://content.nejm.org/cgi/content/short/359/1/104?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 03  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/1/104?rss=1&ssource=collectionSearchRss&queryTerm=35A 71-year-old woman received a diagnosis of systemic sclerosis more than 30 years ago when she presented with Raynaud's phenomenon and cutaneous sclerosis. At that time she did not require...http://content.nejm.org/cgi/content/short/358/26/2812?rss=1&ssource=collectionSearchRss&queryTerm=35Leonardo Astudillo, M.D. and Elisabeth Arlet-Suau, M.D.Thu, 26  Jun  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/26/2812?rss=1&ssource=collectionSearchRss&queryTerm=35An 89-year-old woman was admitted to the hospital with hypercapnic respiratory failure. She had a long history of osteoporosis. Bone densitometry revealed a T score for the lumbar spine of...http://content.nejm.org/cgi/content/short/358/24/e28?rss=1&ssource=collectionSearchRss&queryTerm=35Boris Blechacz, M.D. and Ognjen Gajic, M.D.Thu, 12  Jun  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/24/e28?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoporosis is a common skeletal disorder characterized by compromised bone strength and increased bone fragility, affecting up to 40% of postmenopausal women and 15% of men.1 Its clinical significance lies...http://content.nejm.org/cgi/content/short/358/22/2403?rss=1&ssource=collectionSearchRss&queryTerm=35Joel N. Hirschhorn, M.D., Ph.D., and Luigi Gennari, M.D., Ph.D.Thu, 29  May  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/22/2403?rss=1&ssource=collectionSearchRss&queryTerm=35An 86-year-old woman with severe symptomatic aortic stenosis was referred for routine preoperative cardiac catheterization. During the procedure, pronounced tortuosity of the catheter was noted. Subsequent administration of intravenous contrast...http://content.nejm.org/cgi/content/short/358/22/2388?rss=1&ssource=collectionSearchRss&queryTerm=35Cesar A. Conde, M.D. and Roberto J. Cubeddu, M.D.Thu, 29  May  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/22/2388?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated...http://content.nejm.org/cgi/content/short/358/22/2355?rss=1&ssource=collectionSearchRss&queryTerm=35Unnur Styrkarsdottir, Ph.D., Bjarni V. Halldorsson, Ph.D., Solveig Gretarsdottir, Ph.D., Daniel F. Gudbjartsson, Ph.D., G. Bragi Walters, B.Sc., Thorvaldur Ingvarsson, M.D., Ph.D., Thorbjorg Jonsdottir, B.Sc., Jona Saemundsdottir, B.Sc., Jacqueline R. Center, M.B., B.S., Ph.D., Tuan V. Nguyen, Ph.D., Yu Bagger, M.D., Jeffrey R. Gulcher, M.D., Ph.D., John A. Eisman, M.B., B.S., Ph.D., Claus Christiansen, M.D., Gunnar Sigurdsson, M.D., Ph.D., Augustine Kong, Ph.D., Unnur Thorsteinsdottir, Ph.D., and Kari Stefansson, M.D., Ph.D.Thu, 29  May  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/22/2355?rss=1&ssource=collectionSearchRss&queryTerm=35A 46-year-old woman was seen in the orthopedic oncology clinic of this hospital because of pain in the right hip and leg. Several months earlier, pain had developed in her...http://content.nejm.org/cgi/content/short/358/21/2266?rss=1&ssource=collectionSearchRss&queryTerm=35Marie B. Demay, M.D., Daniel I. Rosenthal, M.D., and Vikram Deshpande, M.D.Thu, 22  May  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/21/2266?rss=1&ssource=collectionSearchRss&queryTerm=35A 65-year-old asymptomatic man is concerned about his risk of osteoporosis. His mother died after a hip fracture at 74 years of age. The patient has no history of fractures...http://content.nejm.org/cgi/content/short/358/14/1474?rss=1&ssource=collectionSearchRss&queryTerm=35Peter R. Ebeling, M.D.Thu, 03  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/14/1474?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. Steven E. Smullin (Oral and Maxillofacial Surgery): A 65-year-old woman was seen in the oral surgery clinic of this hospital because of a nonhealing ulcer of the mandible.<br/><br/>Three years...http://content.nejm.org/cgi/content/short/358/12/1283?rss=1&ssource=collectionSearchRss&queryTerm=35Thomas B. Dodson, D.M.D., M.P.H., Noopur S. Raje, M.D., Paul A. Caruso, M.D., and Andrew E. Rosenberg, M.D.Thu, 20  Mar  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/12/1283?rss=1&ssource=collectionSearchRss&queryTerm=35An 87-year-old woman was referred to the endocrinology clinic in 1979 for hypophosphatemia (serum phosphate level consistently <1.5 mg per deciliter [0.48 mmol per liter]) causing cramps and myalgia; tumor-induced...http://content.nejm.org/cgi/content/short/358/12/1282?rss=1&ssource=collectionSearchRss&queryTerm=35Jill E. Vollbrecht, M.D. and D. Sudhaker Rao, M.B., B.S.Thu, 20  Mar  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/12/1282?rss=1&ssource=collectionSearchRss&queryTerm=35A 43-year-old woman presented with pain, swelling, and stiffness in the hands and feet; she reported having had the symptoms for the previous 5 years. Possible rheumatoid arthritis had been...http://content.nejm.org/cgi/content/short/358/7/e7?rss=1&ssource=collectionSearchRss&queryTerm=35Avnit Ahuja, M.D. and Mythili Seetharaman, M.D.Thu, 14  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/7/e7?rss=1&ssource=collectionSearchRss&queryTerm=35A 55-year-old man presented with a 2-year history of painful jaw enlargement and progressively ill-fitting dentures. He had no headaches or visual-field defects and did not have hyperhidrosis, oily skin,...http://content.nejm.org/cgi/content/short/358/6/625?rss=1&ssource=collectionSearchRss&queryTerm=35Mayank B. Patel, M.B., M.R.C.P. and Ashok Bhalla, M.D., F.R.C.P.Thu, 07  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/6/625?rss=1&ssource=collectionSearchRss&queryTerm=35A 46-year-old man presented with a hard subcutaneous mass in the left side of the forehead (Panel A). He reported that the lesion had developed rapidly after a head trauma...http://content.nejm.org/cgi/content/short/358/5/e5?rss=1&ssource=collectionSearchRss&queryTerm=35Ali-Reza Fathi, M.D. and Dominique Erni, M.D.Thu, 31  Jan  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/5/e5?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. Gabriela Rolz-Cruz (Dermatology): An 80-year-old woman was seen in the outpatient clinic of this hospital for management of recurrent ulcerated skin lesions on the scalp.<br/><br/>When the patient was approximately...http://content.nejm.org/cgi/content/short/358/4/393?rss=1&ssource=collectionSearchRss&queryTerm=35Ervin H. Epstein, M.D., Jo-Anne O. Shepard, M.D., and Thomas J. Flotte, M.D.Thu, 24  Jan  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/4/393?rss=1&ssource=collectionSearchRss&queryTerm=35Glucocorticoids are widely used because of their important and efficacious immunosuppressive and antiinflammatory properties. However, glucocorticoid-induced osteoporosis, a major adverse event, is a common clinical problem. The risk of osteoporosis...http://content.nejm.org/cgi/content/short/357/20/2084?rss=1&ssource=collectionSearchRss&queryTerm=35Philip N. Sambrook, M.D.Thu, 15  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/20/2084?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Bisphosphonate therapy is the current standard of care for the prevention and treatment of glucocorticoid-induced osteoporosis. Studies of anabolic therapy in patients who are receiving long-term glucocorticoids and are...http://content.nejm.org/cgi/content/short/357/20/2028?rss=1&ssource=collectionSearchRss&queryTerm=35Kenneth G. Saag, M.D., Elizabeth Shane, M.D., Steven Boonen, M.D., Ph.D., Fernando Marín, M.D., David W. Donley, Ph.D., Kathleen A. Taylor, Ph.D., Gail P. Dalsky, Ph.D., and Robert Marcus, M.D.Thu, 15  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/20/2028?rss=1&ssource=collectionSearchRss&queryTerm=35More than 300,000 hip fractures occur annually in the United States,1 the majority related to osteoporosis and falls in older people. Not surprisingly, the public health implications and economic burden...http://content.nejm.org/cgi/content/short/357/18/1861?rss=1&ssource=collectionSearchRss&queryTerm=35Karim Anton Calis, Pharm.D., M.P.H., and Frank Pucino, Pharm.D.Thu, 01  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/18/1861?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Mortality is increased after a hip fracture, and strategies that improve outcomes are needed.<br/><br/><em>Methods:</em> In this randomized, double-blind, placebo-controlled trial, 1065 patients were assigned to receive yearly intravenous zoledronic...http://content.nejm.org/cgi/content/short/357/18/1799?rss=1&ssource=collectionSearchRss&queryTerm=35Kenneth W. Lyles, M.D., Cathleen S. Colón-Emeric, M.D., M.H.Sc., Jay S. Magaziner, Ph.D., Jonathan D. Adachi, M.D., Carl F. Pieper, D.P.H., Carlos Mautalen, M.D., Lars Hyldstrup, M.D., D.M.Sc., Chris Recknor, M.D., Lars Nordsletten, M.D., Ph.D., Kathy A. Moore, R.N., Catherine Lavecchia, M.S., Jie Zhang, Ph.D., Peter Mesenbrink, Ph.D., Patricia K. Hodgson, B.A., Ken Abrams, M.D., John J. Orloff, M.D., Zebulun Horowitz, M.D., Erik Fink Eriksen, M.D., D.M.Sc., and Steven Boonen, M.D., Ph.D., for the HORIZON Recurrent Fracture TrialThu, 01  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/18/1799?rss=1&ssource=collectionSearchRss&queryTerm=35A 70-year-old man reports a gradual onset of hip pain that has limited his activities for about a year. The pain initially occurred only with walking and was limited to...http://content.nejm.org/cgi/content/short/357/14/1413?rss=1&ssource=collectionSearchRss&queryTerm=35Nancy E. Lane, M.D.Thu, 04  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/14/1413?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoporosis, a major worldwide health problem, affects 4 million to 6 million women and 1 million to 2 million men in the United States. Even more people have decreased bone...http://content.nejm.org/cgi/content/short/357/9/905?rss=1&ssource=collectionSearchRss&queryTerm=35Ernesto Canalis, M.D., Andrea Giustina, M.D., and John P. Bilezikian, M.D.Thu, 30  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/9/905?rss=1&ssource=collectionSearchRss&queryTerm=35The ultrasound system used by bats, dolphins, and whales has developed into a technology that has found numerous applications in diverse fields, including the biomedical domain, where it has been...http://content.nejm.org/cgi/content/short/357/7/705?rss=1&ssource=collectionSearchRss&queryTerm=35Francis A. Waldvogel, M.D.Thu, 16  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/7/705?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Culturing of samples of periprosthetic tissue is the standard method used for the microbiologic diagnosis of prosthetic-joint infection, but this method is neither sensitive nor specific. In prosthetic-joint infection,...http://content.nejm.org/cgi/content/short/357/7/654?rss=1&ssource=collectionSearchRss&queryTerm=35Andrej Trampuz, M.D., Kerryl E. Piper, M.S., Melissa J. Jacobson, A.S., Arlen D. Hanssen, M.D., Krishnan K. Unni, M.D., Douglas R. Osmon, M.D., Jayawant N. Mandrekar, Ph.D., Franklin R. Cockerill, M.D., James M. Steckelberg, M.D., James F. Greenleaf, Ph.D., and Robin Patel, M.D.Thu, 16  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/7/654?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. Laura Chapman (Pediatrics): A 9-year-old boy with autism was admitted to this hospital because of pain in the hip, refusal to walk, and the recent onset of a rash...http://content.nejm.org/cgi/content/short/357/4/392?rss=1&ssource=collectionSearchRss&queryTerm=35Christopher P. Duggan, M.D., M.P.H., Sjirk J. Westra, M.D., and Andrew E. Rosenberg, M.D.Thu, 26  Jul  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/4/392?rss=1&ssource=collectionSearchRss&queryTerm=35Once foods were fortified with vitamin d and rickets appeared to have been conquered, many health care professionals thought the major health problems resulting from vitamin D deficiency had been...http://content.nejm.org/cgi/content/short/357/3/266?rss=1&ssource=collectionSearchRss&queryTerm=35Michael F. Holick, M.D., Ph.D.Thu, 19  Jul  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/3/266?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. Margo McKenna Benoit (Otolaryngology): An 11-year-old boy was referred to a pediatric otolaryngologist at the Massachusetts Eye and Ear Infirmary because of headaches and a right nasal mass. Bifrontal...http://content.nejm.org/cgi/content/short/356/26/2721?rss=1&ssource=collectionSearchRss&queryTerm=35Michael J. Cunningham, M.D., Derrick T. Lin, M.D., William T. Curry, Jr., M.D., David H. Ebb, M.D., Torunn I. Yock, M.D., M.C.H., Hugh D. Curtin, M.D., and William C. Faquin, M.D., Ph.D.Thu, 28  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/26/2721?rss=1&ssource=collectionSearchRss&queryTerm=35A 55-year-old asymptomatic woman, who is 5 years postmenopausal, is concerned about osteoporosis, since her mother had a hip fracture at the age of 70 years. The patient has no...http://content.nejm.org/cgi/content/short/356/22/2293?rss=1&ssource=collectionSearchRss&queryTerm=35Sundeep Khosla, M.D., and L. Joseph Melton III, M.D., M.P.H.Thu, 31  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/22/2293?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Management of degenerative spondylolisthesis with spinal stenosis is controversial. Surgery is widely used, but its effectiveness in comparison with that of nonsurgical treatment has not been demonstrated in controlled...http://content.nejm.org/cgi/content/short/356/22/2257?rss=1&ssource=collectionSearchRss&queryTerm=35James N. Weinstein, D.O., Jon D. Lurie, M.D., Tor D. Tosteson, Sc.D., Brett Hanscom, M.S., Anna N.A. Tosteson, Sc.D., Emily A. Blood, M.S., Nancy J.O. Birkmeyer, Ph.D., Alan S. Hilibrand, M.D., Harry Herkowitz, M.D., Frank P. Cammisa, M.D., Todd J. Albert, M.D., Sanford E. Emery, M.D., M.B.A., Lawrence G. Lenke, M.D., William A. Abdu, M.D., Michael Longley, M.D., Thomas J. Errico, M.D., and Serena S. Hu, M.D.Thu, 31  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/22/2257?rss=1&ssource=collectionSearchRss&queryTerm=35Bisphosphonates are an important option for the prevention of fractures in postmenopausal women. However, the complex instructions for the administration of oral bisphosphonates are inconvenient or unsuitable for many patients,...http://content.nejm.org/cgi/content/short/356/18/1878?rss=1&ssource=collectionSearchRss&queryTerm=35Juliet Compston, M.D., F.R.C.P., F.R.C.Path., F.Med.Sci.Thu, 03  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/18/1878?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> A single infusion of intravenous zoledronic acid decreases bone turnover and improves bone density at 12 months in postmenopausal women with osteoporosis. We assessed the effects of annual infusions...http://content.nejm.org/cgi/content/short/356/18/1809?rss=1&ssource=collectionSearchRss&queryTerm=35Dennis M. Black, Ph.D., Pierre D. Delmas, M.D., Ph.D., Richard Eastell, M.D., Ian R. Reid, M.D., Steven Boonen, M.D., Ph.D., Jane A. Cauley, Dr.P.H., Felicia Cosman, M.D., Péter Lakatos, M.D., Ph.D., Ping Chung Leung, M.D., Zulema Man, M.D., Carlos Mautalen, M.D., Peter Mesenbrink, Ph.D., Huilin Hu, Ph.D., John Caminis, M.D., Karen Tong, B.S., Theresa Rosario-Jansen, Ph.D., Joel Krasnow, M.D., Trisha F. Hue, M.P.H., Deborah Sellmeyer, M.D., Erik Fink Eriksen, M.D., D.M.Sc., and Steven R. Cummings, M.D., for the HORIZON Pivotal Fracture TrialThu, 03  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/18/1809?rss=1&ssource=collectionSearchRss&queryTerm=35A 50-year-old man presented for a routine physical examination for the first time in 10 years. He reported having had no recent health problems. He had a 60 pack-year smoking...http://content.nejm.org/cgi/content/short/356/17/1759?rss=1&ssource=collectionSearchRss&queryTerm=35Khiem T. Tran, M.D., M.H.A. and Marcia Shannon, F.N.P.Thu, 26  Apr  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/17/1759?rss=1&ssource=collectionSearchRss&queryTerm=35Dr. Maha R. Farhat (Medicine): A 59-year-old woman was admitted to the hospital because of a nonhealing ulcer on the right heel and painful ulcers on the right thigh and...http://content.nejm.org/cgi/content/short/356/10/1049?rss=1&ssource=collectionSearchRss&queryTerm=35Hasan Bazari, M.D., Michael R. Jaff, D.O., Michael Mannstadt, M.D., and Shaofeng Yan, M.D., Ph.D.Thu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/1049?rss=1&ssource=collectionSearchRss&queryTerm=35An afebrile 8-year-old Ethiopian girl presented with a limp. Two years earlier, she had had mild trauma followed by “bone infection” and had received short courses of oral antibiotics. Examination...http://content.nejm.org/cgi/content/short/356/8/e7?rss=1&ssource=collectionSearchRss&queryTerm=35Avigdor Hevroni, M.D. and Benjamin Z. Koplewitz, M.D.Thu, 22  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/8/e7?rss=1&ssource=collectionSearchRss&queryTerm=35Osteogenesis imperfecta is a heritable disorder caused by mutations in the gene for type I collagen. The Sillence classification of osteogenesis imperfecta (types I through IV) is based on clinical...http://content.nejm.org/cgi/content/short/355/26/e28?rss=1&ssource=collectionSearchRss&queryTerm=35Janet Reeder, M.S., P.A.-C. and Eric Orwoll, M.D.Thu, 28  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/26/e28?rss=1&ssource=collectionSearchRss&queryTerm=35Classic osteogenesis imperfecta, an autosomal dominant disorder associated with osteoporosis and bone fragility, is caused by mutations in the genes for type I collagen. A recessive form of the disorder...http://content.nejm.org/cgi/content/short/355/26/2757?rss=1&ssource=collectionSearchRss&queryTerm=35Aileen M. Barnes, M.S., Weizhong Chang, Ph.D., Roy Morello, Ph.D., Wayne A. Cabral, B.A., MaryAnn Weis, B.S., David R. Eyre, Ph.D., Sergey Leikin, Ph.D., Elena Makareeva, Ph.D., Natalia Kuznetsova, Ph.D., Thomas E. Uveges, Ph.D., Aarthi Ashok, Ph.D., Armando W. Flor, M.D., John J. Mulvihill, M.D., Patrick L. Wilson, M.S., Usha T. Sundaram, M.D., Brendan Lee, M.D., Ph.D., and Joan C. Marini, M.D., Ph.D.Thu, 28  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/26/2757?rss=1&ssource=collectionSearchRss&queryTerm=35A 32-year-old man infected with the human immunodeficiency virus (HIV) who had a CD4 count of 9 cells per cubic millimeter had a 9-month history of weight loss, with progressive...http://content.nejm.org/cgi/content/short/355/25/2677?rss=1&ssource=collectionSearchRss&queryTerm=35Gleusa Castro, M.D. and Roberto Martinez, M.D.Thu, 21  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/25/2677?rss=1&ssource=collectionSearchRss&queryTerm=35A 68-year-old woman with severe postmenopausal osteoporosis was referred because of a 6-month history of erosive mucositis of the hard palate, accompanied by intense pain and dysphagia. The patient had...http://content.nejm.org/cgi/content/short/355/22/e25?rss=1&ssource=collectionSearchRss&queryTerm=35Pietro Rubegni, M.D. and Michele Fimiani, M.D.Thu, 30  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/22/e25?rss=1&ssource=collectionSearchRss&queryTerm=35A 54-year-old man with a 3-year history of IgG myeloma, complicated by hypercalcemia, who was being treated with dexamethasone, lenalidomide, filgrastim, darbepoetin alfa, and pamidronate, presented with a 1-month history...http://content.nejm.org/cgi/content/short/355/22/2348?rss=1&ssource=collectionSearchRss&queryTerm=35Nathaniel Treister, D.M.D., D.M.Sc. and Sook-Bin Woo, D.M.D.Thu, 30  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/22/2348?rss=1&ssource=collectionSearchRss&queryTerm=35Nitrogen-containing bisphosphonates are used widely for the management of metastatic cancer in bone (intravenous zoledronic acid or pamidronate), for the prevention and treatment of osteoporosis (oral alendronate, risedronate, and ibandronate...http://content.nejm.org/cgi/content/short/355/22/2278?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 30  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/22/2278?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture.<br/><br/><em>Methods:</em> We performed a randomized, double-placebo, double-blind clinical trial of...http://content.nejm.org/cgi/content/short/355/7/675?rss=1&ssource=collectionSearchRss&queryTerm=35Ron N.J. de Nijs, M.D., Ph.D., Johannes W.G. Jacobs, M.D., Ph.D., Willem F. Lems, M.D., Ph.D., Roland F.J. Laan, M.D., Ph.D., Ale Algra, M.D., Ph.D., Anne-Margriet Huisman, M.D., Ph.D., Erik Buskens, M.D., Ph.D., Chris E.D. de Laet, M.D., Ph.D., Ans C.M. Oostveen, M.D., Ph.D., Piet P.M.M. Geusens, M.D., Ph.D., George A.W. Bruyn, M.D., Ph.D., Ben A.C. Dijkmans, M.D., Ph.D., and Johannes W.J. Bijlsma, M.D., Ph.D., for the STOP InvestigatorsThu, 17  Aug  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/7/675?rss=1&ssource=collectionSearchRss&queryTerm=35Progress in understanding the pathogenesis of bone fragility is hampered by the inaccessibility of bone for investigation. Bone densitometry is an effective, noninvasive, and quantitative method for the assessment of...http://content.nejm.org/cgi/content/short/354/21/2250?rss=1&ssource=collectionSearchRss&queryTerm=35Ego Seeman, M.D., M.B., B.S., and Pierre D. Delmas, M.D., Ph.D.Thu, 25  May  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/21/2250?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Imatinib mesylate inhibits several tyrosine kinases, including BCR-ABL, the C-KIT receptor, and the platelet-derived growth factor receptors α and β, all of which are associated with disease. We observed...http://content.nejm.org/cgi/content/short/354/19/2006?rss=1&ssource=collectionSearchRss&queryTerm=35Ellin Berman, M.D., Maria Nicolaides, M.D., Robert G. Maki, M.D., Ph.D., Martin Fleisher, Ph.D., Suzanne Chanel, R.N., Kelly Scheu, R.N., Bri-Anne Wilson, B.A., Glenn Heller, Ph.D., and Nicholas P. Sauter, M.D.Thu, 11  May  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/19/2006?rss=1&ssource=collectionSearchRss&queryTerm=35In 2004, the Surgeon General's report on bone health highlighted osteoporosis as an important and growing national medical problem.1 The authors of this report recognized that identification and treatment of...http://content.nejm.org/cgi/content/short/354/8/860?rss=1&ssource=collectionSearchRss&queryTerm=35Michael P. Whyte, M.D.Thu, 23  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/8/860?rss=1&ssource=collectionSearchRss&queryTerm=35An asymptomatic 19-year-old man underwent a routine outpatient evaluation. He was born after a normal pregnancy and delivery. Both parents and two siblings (27 and 25 years of age) were...http://content.nejm.org/cgi/content/short/354/8/849?rss=1&ssource=collectionSearchRss&queryTerm=35Fernando Ruiz-Palomo, M.D., Ph.D.Thu, 23  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/8/849?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast differentiation, activation, and survival. The fully human monoclonal antibody denosumab (formerly known as AMG 162) binds RANKL with...http://content.nejm.org/cgi/content/short/354/8/821?rss=1&ssource=collectionSearchRss&queryTerm=35Michael R. McClung, M.D., E. Michael Lewiecki, M.D., Stanley B. Cohen, M.D., Michael A. Bolognese, M.D., Grattan C. Woodson, M.D., Alfred H. Moffett, M.D., Munro Peacock, M.D., Paul D. Miller, M.D., Samuel N. Lederman, M.D., Charles H. Chesnut, M.D., Douglas Lain, M.D., Alan J. Kivitz, M.D., Donna L. Holloway, Ph.D., Charlie Zhang, Ph.D., Mark C. Peterson, Ph.D., and Pirow J. Bekker, M.D., Ph.D., for the AMG 162 Bone Loss Study GroupThu, 23  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/8/821?rss=1&ssource=collectionSearchRss&queryTerm=35There are many therapies that reduce the risk of fracture in people with osteoporosis. Calcium and vitamin D are the most widely used therapies for osteoporosis, even though their efficacy...http://content.nejm.org/cgi/content/short/354/7/750?rss=1&ssource=collectionSearchRss&queryTerm=35Joel S. Finkelstein, M.D.Thu, 16  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/7/750?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal.<br/><br/><em>Methods:</em> We recruited 36,282 postmenopausal women, 50 to 79 years...http://content.nejm.org/cgi/content/short/354/7/669?rss=1&ssource=collectionSearchRss&queryTerm=35Rebecca D. Jackson, M.D., Andrea Z. LaCroix, Ph.D., Margery Gass, M.D., Robert B. Wallace, M.D., John Robbins, M.D., Cora E. Lewis, M.D., Tamsen Bassford, M.D., Shirley A.A. Beresford, Ph.D., Henry R. Black, M.D., Patricia Blanchette, M.D., Denise E. Bonds, M.D., Robert L. Brunner, Ph.D., Robert G. Brzyski, M.D., Bette Caan, Dr.P.H., Jane A. Cauley, Dr.P.H., Rowan T. Chlebowski, M.D., Steven R. Cummings, M.D., Iris Granek, M.D., Jennifer Hays, Ph.D., Gerardo Heiss, M.D., Susan L. Hendrix, D.O., Barbara V. Howard, Ph.D., Judith Hsia, M.D., F. Allan Hubbell, M.D., Karen C. Johnson, M.D., Howard Judd, M.D., Jane Morley Kotchen, M.D., Lewis H. Kuller, M.D., Robert D. Langer, M.D., Norman L. Lasser, M.D., Marian C. Limacher, M.D., Shari Ludlam, M.P.H., JoAnn E. Manson, M.D., Karen L. Margolis, M.D., Joan McGowan, Ph.D., Judith K. Ockene, Ph.D., Mary Jo O'Sullivan, M.D., Lawrence Phillips, M.D., Ross L. Prentice, Ph.D., Gloria E. Sarto, M.D., Marcia L. Stefanick, Ph.D., Linda Van Horn, Ph.D., Jean Wactawski-Wende, Ph.D., Evelyn Whitlock, M.D., Garnet L. Anderson, Ph.D., Annlouise R. Assaf, Ph.D., and David Barad, M.D., for the Women's Health Initiative InvestigatorsThu, 16  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/7/669?rss=1&ssource=collectionSearchRss&queryTerm=35An 85-year-old woman presented with right shoulder pain and swelling and a large hematoma extending into the chest wall. Active range of motion was severely limited, and passive mobility was...http://content.nejm.org/cgi/content/short/354/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=35Marcia S. Genta, M.D. and Cem Gabay, M.D.Thu, 12  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=35A 38-year-old man with an incomplete spinal cord injury secondary to a diving accident some years before, which caused tetraplegia but preserved some sensation below the neck, reported new pain...http://content.nejm.org/cgi/content/short/354/1/e1?rss=1&ssource=collectionSearchRss&queryTerm=35Eric L. Altschuler, M.D., Ph.D. and Thomas N. Bryce, M.D.Thu, 05  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/1/e1?rss=1&ssource=collectionSearchRss&queryTerm=35A 21-year-old male college student presented to the student health center after two days of extreme fatigue. Over the course of the previous two months, frequent headaches, difficulty concentrating, and...http://content.nejm.org/cgi/content/short/353/18/1956?rss=1&ssource=collectionSearchRss&queryTerm=35William J. Janssen, M.D., Harold R. Collard, M.D., Sanjay Saint, M.D., M.P.H., and Steven E. Weinberger, M.D.Thu, 03  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/18/1956?rss=1&ssource=collectionSearchRss&queryTerm=35A 38-year-old woman with a five-year history of rheumatoid arthritis had complete remission after 17 months of weekly monotherapy with 4 mg of methotrexate. Radiographs of both hands and feet...http://content.nejm.org/cgi/content/short/353/15/e13?rss=1&ssource=collectionSearchRss&queryTerm=35Katsunori Ikari, M.D., Ph.D. and Shigeki Momohara, M.D., Ph.D.Thu, 13  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/15/e13?rss=1&ssource=collectionSearchRss&queryTerm=35Juvenile Paget's disease, a genetic bone disease characterized by accelerated bone turnover, results from inactivating mutations in the gene encoding osteoprotegerin — a key regulator of osteoclastogenesis. The effects of...http://content.nejm.org/cgi/content/short/353/9/918?rss=1&ssource=collectionSearchRss&queryTerm=35Tim Cundy, M.D., James Davidson, Ph.D., Michael D. Rutland, M.B., B.S., Carolyn Stewart, M.M.Sc., and Alex M. DePaoli, M.D.Thu, 01  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/9/918?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> The advent of bisphosphonates advanced therapy for Paget's disease, but more effective and convenient agents are needed to increase adherence. Zoledronic acid, a bisphosphonate administered as a single intravenous...http://content.nejm.org/cgi/content/short/353/9/898?rss=1&ssource=collectionSearchRss&queryTerm=35Ian R. Reid, M.D., Paul Miller, M.D., Kenneth Lyles, M.D., William Fraser, M.D., Jacques P. Brown, M.D., Youssef Saidi, Ph.D., Peter Mesenbrink, Ph.D., Guoqin Su, Ph.D., Judy Pak, Pharm.D., Ken Zelenakas, M.S., Monica Luchi, M.D., Peter Richardson, B.M., B.S., and David Hosking, M.D.Thu, 01  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/9/898?rss=1&ssource=collectionSearchRss&queryTerm=35Fifty years of steady clinical progress and five years of accelerated basic research in understanding the cellular and molecular biology of the osteoclast have led to the development of two...http://content.nejm.org/cgi/content/short/353/9/872?rss=1&ssource=collectionSearchRss&queryTerm=35L.J. Deftos, M.D., J.D.Thu, 01  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/9/872?rss=1&ssource=collectionSearchRss&queryTerm=35For an investment approaching $1 billion, a pharmaceutical manufacturer may obtain approval from regulatory agencies to market a specific dose of a given medication for the treatment or prevention of...http://content.nejm.org/cgi/content/short/353/6/624?rss=1&ssource=collectionSearchRss&queryTerm=35Robert P. Heaney, M.D., and Robert R. Recker, M.D.Thu, 11  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/6/624?rss=1&ssource=collectionSearchRss&queryTerm=35A 63-year-old woman presents with a history of acute low back pain. She had menopause at 44 years of age but never received postmenopausal hormone-replacement therapy. She reports a history...http://content.nejm.org/cgi/content/short/353/6/595?rss=1&ssource=collectionSearchRss&queryTerm=35Clifford J. Rosen, M.D.Thu, 11  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/6/595?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> We evaluated whether patients with osteoporosis treated with long-term alendronate have a response to parathyroid hormone treatment and whether short, three-month cycles of parathyroid hormone therapy could be as...http://content.nejm.org/cgi/content/short/353/6/566?rss=1&ssource=collectionSearchRss&queryTerm=35Felicia Cosman, M.D., Jeri Nieves, Ph.D., Marsha Zion, M.S., Lillian Woelfert, R.N., Marjorie Luckey, M.D., and Robert Lindsay, M.D.Thu, 11  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/6/566?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Since the use of parathyroid hormone as a treatment for osteoporosis is limited to two years or less, the question of whether antiresorptive therapy should follow parathyroid hormone therapy...http://content.nejm.org/cgi/content/short/353/6/555?rss=1&ssource=collectionSearchRss&queryTerm=35Dennis M. Black, Ph.D., John P. Bilezikian, M.D., Kristine E. Ensrud, M.D., M.P.H., Susan L. Greenspan, M.D., Lisa Palermo, M.A., Trisha Hue, M.A., Thomas F. Lang, Ph.D., Joan A. McGowan, Ph.D., and Clifford J. Rosen, M.D., for the PaTH Study InvestigatorsThu, 11  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/6/555?rss=1&ssource=collectionSearchRss&queryTerm=35A 44-year-old woman came to the emergency department because of pain in her right thigh shortly after she had a minor fall. A right femoral-neck fracture was diagnosed, and she...http://content.nejm.org/cgi/content/short/353/5/509?rss=1&ssource=collectionSearchRss&queryTerm=35Tali Cukierman, M.D., Moshe E. Gatt, M.D., Nurith Hiller, M.D., and Tova Chajek-Shaul, M.D.Thu, 04  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/5/509?rss=1&ssource=collectionSearchRss&queryTerm=35At her annual visit, a 60-year-old woman asks her physician whether she should have a bone-density test to screen for osteoporosis. The patient went through menopause at age 52 and...http://content.nejm.org/cgi/content/short/353/2/164?rss=1&ssource=collectionSearchRss&queryTerm=35Lawrence G. Raisz, M.D.Thu, 14  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/2/164?rss=1&ssource=collectionSearchRss&queryTerm=35A 22-year-old black woman was transferred to this hospital because of respiratory failure.<br/><br/>A diagnosis of sickle cell anemia had been made when the patient was a child, at six years...http://content.nejm.org/cgi/content/short/352/23/2425?rss=1&ssource=collectionSearchRss&queryTerm=35Benjamin D. Medoff, M.D., Jo-Anne O. Shepard, M.D., R. Neal Smith, M.D., and Alexander Kratz, M.D., Ph.D.Thu, 09  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/23/2425?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Avascular necrosis of the femoral head (ANFH) causes disability that often requires surgical intervention. Most cases of ANFH are sporadic, but we identified three families in which there was...http://content.nejm.org/cgi/content/short/352/22/2294?rss=1&ssource=collectionSearchRss&queryTerm=35Yu-Fen Liu, Ph.D., Wei-Ming Chen, M.D., Yung-Feng Lin, M.S., Ruei-Cheng Yang, M.D., Ming-Wei Lin, Ph.D., Ling-Hui Li, Ph.D., Ya-Hui Chang, M.S., Yuh-Shan Jou, Ph.D., Pei-Yu Lin, M.D., Jih-Shyun Su, M.S., Shiu-Feng Huang, M.D., Ph.D., Kwang-Jen Hsiao, Ph.D., Cathy S.J. Fann, Ph.D., Hun-Way Hwang, M.D., Yuan-Tsong Chen, M.D., Ph.D., and Shih-Feng Tsai, M.D., Ph.D.Thu, 02  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/22/2294?rss=1&ssource=collectionSearchRss&queryTerm=35All of us carry millions of variations in the sequences of our genomes and thousands of mutations in genes, some of which alter the amino acid sequences of proteins. The...http://content.nejm.org/cgi/content/short/352/22/2268?rss=1&ssource=collectionSearchRss&queryTerm=35Darwin J. Prockop, M.D., Ph.D.Thu, 02  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/22/2268?rss=1&ssource=collectionSearchRss&queryTerm=35A 10-year-old boy was seen in the clinic because of pain in the upper portion of his right thigh. The pain had begun six months earlier and was made worse...http://content.nejm.org/cgi/content/short/352/11/1122?rss=1&ssource=collectionSearchRss&queryTerm=35Mark C. Gebhardt, M.D., Daniel I. Rosenthal, M.D., and Paula M. Arnell, M.D.Thu, 17  Mar  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/11/1122?rss=1&ssource=collectionSearchRss&queryTerm=35A 47-year-old woman with a history of breast cancer presents with confusion and dehydration. The serum calcium level is 18.0 mg per deciliter (4.5 mmol per liter). She has postural...http://content.nejm.org/cgi/content/short/352/4/373?rss=1&ssource=collectionSearchRss&queryTerm=35Andrew F. Stewart, M.D.Thu, 27  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/4/373?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> The use of androgen-deprivation therapy for prostate cancer has increased substantially over the past 15 years. This treatment is associated with a loss of bone-mineral density, but the risk...http://content.nejm.org/cgi/content/short/352/2/154?rss=1&ssource=collectionSearchRss&queryTerm=35Vahakn B. Shahinian, M.D., Yong-Fang Kuo, Ph.D., Jean L. Freeman, Ph.D., and James S. Goodwin, M.D.Thu, 13  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/2/154?rss=1&ssource=collectionSearchRss&queryTerm=35A previously healthy 54-year-old woman presented with a two-week history of pelvic pain. On physical examination, she had limited movement, without tenderness in the bones. An initial radiographic survey of...http://content.nejm.org/cgi/content/short/351/27/2850?rss=1&ssource=collectionSearchRss&queryTerm=35Daniela Katz, M.D. and Dvora Aharoni, M.D.Thu, 30  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/27/2850?rss=1&ssource=collectionSearchRss&queryTerm=35Bone is a dynamic tissue in which osteoblasts synthesize bone matrix while osteoclasts resorb bone. Therefore, bone density is dependent on the relative function of these two types of cells....http://content.nejm.org/cgi/content/short/351/27/2839?rss=1&ssource=collectionSearchRss&queryTerm=35Jakub Tolar, M.D., Ph.D., Steven L. Teitelbaum, M.D., and Paul J. Orchard, M.D.Thu, 30  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/27/2839?rss=1&ssource=collectionSearchRss&queryTerm=35A 76-year-old woman was admitted with an exacerbation of chronic obstructive pulmonary disease. Her condition improved with bronchodilators, prednisolone, an antibiotic, oxygen, and supportive measures. Two years previously, she had...http://content.nejm.org/cgi/content/short/351/18/1874?rss=1&ssource=collectionSearchRss&queryTerm=35Suresh R. Nair, M.D. and Stanley B. Pearson, D.M.Thu, 28  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/18/1874?rss=1&ssource=collectionSearchRss&queryTerm=35Multiple myeloma is a plasma-cell neoplasm that is characterized by skeletal destruction, renal failure, anemia, and hypercalcemia.1 Although myeloma remains incurable, recent advances in its treatment, including the use of...http://content.nejm.org/cgi/content/short/351/18/1860?rss=1&ssource=collectionSearchRss&queryTerm=35Robert A. Kyle, M.D., and S. Vincent Rajkumar, M.D.Thu, 28  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/18/1860?rss=1&ssource=collectionSearchRss&queryTerm=35Diagnostic and therapeutic guidelines used for children are commonly extrapolated from studies conducted in adults. There are potential dangers in assuming that children will have the same response to disease...http://content.nejm.org/cgi/content/short/351/9/924?rss=1&ssource=collectionSearchRss&queryTerm=35Laura K. Bachrach, M.D.Thu, 26  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/9/924?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Glucocorticoids suppress bone formation, impair growth, and induce obesity. We determined the effects of long-term treatment with glucocorticoids on bone mineral content in children with glucocorticoid-sensitive nephrotic syndrome, a...http://content.nejm.org/cgi/content/short/351/9/868?rss=1&ssource=collectionSearchRss&queryTerm=35Mary B. Leonard, M.D., M.S.C.E., Harold I. Feldman, M.D., M.S.C.E., Justine Shults, Ph.D., Babette S. Zemel, Ph.D., Bethany J. Foster, M.D., M.S.C.E., and Virginia A. Stallings, M.D.Thu, 26  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/9/868?rss=1&ssource=collectionSearchRss&queryTerm=35Two shadows have recently been cast over the exciting field of gene therapy. One was cast by the unfortunate death of an 18-year-old man at the University of Pennsylvania in...http://content.nejm.org/cgi/content/short/350/22/2302?rss=1&ssource=collectionSearchRss&queryTerm=35Darwin J. Prockop, M.D., Ph.D.Thu, 27  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/22/2302?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoporotic fractures are a major health problem in the industrialized nations, a problem that is likely to become even greater throughout the world as the population ages. One way to...http://content.nejm.org/cgi/content/short/350/20/2089?rss=1&ssource=collectionSearchRss&queryTerm=35Lawrence G. Raisz, M.D.Thu, 13  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/20/2089?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> The increased prevalence of osteoporosis among people with homocystinuria suggests that a high serum homocysteine concentration may weaken bone by interfering with collagen cross-linking, thereby increasing the risk of...http://content.nejm.org/cgi/content/short/350/20/2042?rss=1&ssource=collectionSearchRss&queryTerm=35Robert R. McLean, M.P.H., Paul F. Jacques, D.Sc., Jacob Selhub, Ph.D., Katherine L. Tucker, Ph.D., Elizabeth J. Samelson, Ph.D., Kerry E. Broe, M.P.H., Marian T. Hannan, D.Sc., L. Adrienne Cupples, Ph.D., and Douglas P. Kiel, M.D.Thu, 13  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/20/2042?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Very high plasma homocysteine levels are characteristic of homocystinuria, a rare autosomal recessive disease accompanied by the early onset of generalized osteoporosis. We therefore hypothesized that mildly elevated homocysteine...http://content.nejm.org/cgi/content/short/350/20/2033?rss=1&ssource=collectionSearchRss&queryTerm=35Joyce B.J. van Meurs, Ph.D., Rosalie A.M. Dhonukshe-Rutten, M.Sc., Saskia M.F. Pluijm, Ph.D., Marjolein van der Klift, M.D., Ph.D., Robert de Jonge, Ph.D., Jan Lindemans, Ph.D., Lisette C.P.G.M. de Groot, Ph.D., Albert Hofman, M.D., Ph.D., Jacqueline C.M. Witteman, Ph.D., Johannes P.T.M. van Leeuwen, Ph.D., Monique M.B. Breteler, M.D., Ph.D., Paul Lips, M.D., Ph.D., Huibert A.P. Pols, M.D., Ph.D., and André G. Uitterlinden, Ph.D.Thu, 13  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/20/2033?rss=1&ssource=collectionSearchRss&queryTerm=35More than 25 million people, most of whom are menopausal or elderly women, have a progressive loss of bone mass, which increases their susceptibility to fracture. The increasing prevalence and...http://content.nejm.org/cgi/content/short/350/18/1902?rss=1&ssource=collectionSearchRss&queryTerm=35Charles N. Serhan, Ph.D.Thu, 29  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/18/1902?rss=1&ssource=collectionSearchRss&queryTerm=35A 60-year-old woman is noted incidentally to have a calcium level of 10.8 mg per deciliter (2.70 mmol per liter; normal range, 8.4 to 10.2 mg per deciliter [2.10 to...http://content.nejm.org/cgi/content/short/350/17/1746?rss=1&ssource=collectionSearchRss&queryTerm=35John P. Bilezikian, M.D., and Shonni J. Silverberg, M.D.Thu, 22  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/17/1746?rss=1&ssource=collectionSearchRss&queryTerm=35Bone metastases are a frequent complication of cancer, occurring in up to 70 percent of patients with advanced breast or prostate cancer1 and in approximately 15 to 30 percent of...http://content.nejm.org/cgi/content/short/350/16/1655?rss=1&ssource=collectionSearchRss&queryTerm=35G. David Roodman, M.D., Ph.D.Thu, 15  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/16/1655?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Antiresorptive agents are widely used to treat osteoporosis. We report the results of a multinational randomized, double-blind study, in which postmenopausal women with osteoporosis were treated with alendronate for...http://content.nejm.org/cgi/content/short/350/12/1189?rss=1&ssource=collectionSearchRss&queryTerm=35Henry G. Bone, M.D., David Hosking, M.D., Jean-Pierre Devogelaer, M.D., Joseph R. Tucci, M.D., Ronald D. Emkey, M.D., Richard P. Tonino, M.D., Jose Adolfo Rodriguez-Portales, M.D., Robert W. Downs, M.D., Jayanti Gupta, Ph.D., Arthur C. Santora, M.D., Ph.D., and Uri A. Liberman, M.D., Ph.D., for the Alendronate Phase III Osteoporosis Treatment Study GroupThu, 18  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/12/1189?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoporosis takes an enormous toll among postmenopausal women. A 50-year-old woman in the United States has a 40 percent lifetime risk of an osteoporotic fracture. One woman in three and...http://content.nejm.org/cgi/content/short/350/12/1172?rss=1&ssource=collectionSearchRss&queryTerm=35Gordon J. Strewler, M.D.Thu, 18  Mar  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/12/1172?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Osteoporosis is a well-known complication of cardiac transplantation. We conducted a randomized trial comparing alendronate with calcitriol for the prevention of bone loss during the first year after cardiac...http://content.nejm.org/cgi/content/short/350/8/767?rss=1&ssource=collectionSearchRss&queryTerm=35Elizabeth Shane, M.D., Vicki Addesso, B.S., Pearila B. Namerow, Ph.D., Donald J. McMahon, M.S., Shaw-Hwa Lo, Ph.D., Ronald B. Staron, M.D., Mark Zucker, M.D., Susan Pardi, N.P., Simon Maybaum, M.D., and Donna Mancini, M.D.Thu, 19  Feb  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/8/767?rss=1&ssource=collectionSearchRss&queryTerm=35Although clinicians generally consider osteoporosis to be a disease primarily affecting postmenopausal women, other populations are also at high risk. One such group is recipients of organ transplants, who, as...http://content.nejm.org/cgi/content/short/350/8/751?rss=1&ssource=collectionSearchRss&queryTerm=35Robert Lindsay, M.D.Thu, 19  Feb  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/8/751?rss=1&ssource=collectionSearchRss&queryTerm=35The use of spinal-fusion surgery in the United States is rapidly increasing. National survey data indicate that the annual number of spinal-fusion operations rose by 77 percent between 1996 and...http://content.nejm.org/cgi/content/short/350/7/722?rss=1&ssource=collectionSearchRss&queryTerm=35Richard A. Deyo, M.D., M.P.H., Alf Nachemson, M.D., Ph.D., and Sohail K. Mirza, M.D.Thu, 12  Feb  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/7/722?rss=1&ssource=collectionSearchRss&queryTerm=35Spinal arthrodesis (the creation of a fusion) was developed for the treatment of instability and deformity due to tuberculosis, scoliosis, and traumatic injury. Modern spinal surgery was helped by the...http://content.nejm.org/cgi/content/short/350/7/643?rss=1&ssource=collectionSearchRss&queryTerm=35Stephen J. Lipson, M.D.Thu, 12  Feb  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/7/643?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoporosis was originally described in literature and art hundreds of years ago. Our ability to treat this disease lay dormant for centuries, but in the past 10 years, clinical trials...http://content.nejm.org/cgi/content/short/350/5/504?rss=1&ssource=collectionSearchRss&queryTerm=35Ghada El-Hajj Fuleihan, M.D., M.P.H.Thu, 29  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/5/504?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Osteoporotic structural damage and bone fragility result from reduced bone formation and increased bone resorption. In a phase 2 clinical trial, strontium ranelate, an orally active drug that dissociates...http://content.nejm.org/cgi/content/short/350/5/459?rss=1&ssource=collectionSearchRss&queryTerm=35Pierre J. Meunier, M.D., Christian Roux, M.D., Ph.D., Ego Seeman, M.D., Sergio Ortolani, M.D., Janusz E. Badurski, M.D., Tim D. Spector, M.D., Jorge Cannata, M.D., Adam Balogh, M.D., Ernst-Martin Lemmel, M.D., Stig Pors-Nielsen, M.D., René Rizzoli, M.D., Harry K. Genant, M.D., and Jean-Yves Reginster, M.D.Thu, 29  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/5/459?rss=1&ssource=collectionSearchRss&queryTerm=35Contrary to a widely held belief, multiple myeloma is not a rare, rapidly fatal disorder that affects only elderly patients. Instead, it is the second most common hematologic cancer after...http://content.nejm.org/cgi/content/short/349/26/2551?rss=1&ssource=collectionSearchRss&queryTerm=35Edward A. Stadtmauer, M.D.Thu, 25  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/26/2551?rss=1&ssource=collectionSearchRss&queryTerm=35An 81-year-old man had had mild dysphagia for several years. During the six months before admission, the dysphagia worsened, and he had occasional hemoptysis. For several days before admission he...http://content.nejm.org/cgi/content/short/349/26/2540?rss=1&ssource=collectionSearchRss&queryTerm=35Paul Aronowitz, M.D. and Fabiola Cobarrubias, M.D.Thu, 25  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/26/2540?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> We conducted a randomized trial of the treatment of multiple myeloma with high-dose chemotherapy followed by either one or two successive autologous stem-cell transplantations.<br/><br/><em>Methods:</em> At the time of diagnosis,...http://content.nejm.org/cgi/content/short/349/26/2495?rss=1&ssource=collectionSearchRss&queryTerm=35Michel Attal, M.D., Jean-Luc Harousseau, M.D., Thierry Facon, M.D., François Guilhot, M.D., Chantal Doyen, M.D., Jean-Gabriel Fuzibet, M.D., Mathieu Monconduit, M.D., Cyrille Hulin, M.D., Denis Caillot, M.D., Reda Bouabdallah, M.D., Laurent Voillat, M.D., Jean-Jacques Sotto, M.D., Bernard Grosbois, M.D., and Regis Bataille, M.D., for the InterGroupe Francophone du MyélomeThu, 25  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/26/2495?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Myeloma cells may secrete factors that affect the function of osteoblasts, osteoclasts, or both.<br/><br/><em>Methods:</em> We subjected purified plasma cells from the bone marrow of patients with newly diagnosed multiple...http://content.nejm.org/cgi/content/short/349/26/2483?rss=1&ssource=collectionSearchRss&queryTerm=35Erming Tian, B.S., Fenghuang Zhan, Ph.D., Ronald Walker, M.D., Erik Rasmussen, M.S., Yupo Ma, M.D., Ph.D., Bart Barlogie, M.D., Ph.D., and John D. Shaughnessy, Jr., Ph.D.Thu, 25  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/26/2483?rss=1&ssource=collectionSearchRss&queryTerm=35Multiple myeloma is a cancer in which immunoglobulin-producing plasma cells undergo clonal expansion. Its characteristic feature is the monoclonal, or M, spike, usually detectable in serum or urine by protein...http://content.nejm.org/cgi/content/short/349/26/2479?rss=1&ssource=collectionSearchRss&queryTerm=35Donald A. Glass, II, B.A., Millan S. Patel, M.D., and Gerard Karsenty, M.D., Ph.D.Thu, 25  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/26/2479?rss=1&ssource=collectionSearchRss&queryTerm=35A 94-year-old woman had rheumatoid arthritis that was diagnosed when she was 8 years old. She had not sought treatment for arthritis until she was in her 60s, and by...http://content.nejm.org/cgi/content/short/349/20/1935?rss=1&ssource=collectionSearchRss&queryTerm=35Robert Monger, M.D. and Virginia Hrywnak, D.O.Thu, 13  Nov  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/20/1935?rss=1&ssource=collectionSearchRss&queryTerm=35A 16-year-old boy reported a two-to-three-month history of back pain during sports activities. The pain radiated to the buttocks, but without signs of sciatica. The patient had no history of...http://content.nejm.org/cgi/content/short/349/18/e17?rss=1&ssource=collectionSearchRss&queryTerm=35Jörg Pförtner, M.D. and Matthias Hövel, M.D.Thu, 30  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/18/e17?rss=1&ssource=collectionSearchRss&queryTerm=35The past 10 years have witnessed tremendous advances in our ability to treat osteoporosis. The old mainstays of therapy, estrogen and calcitonin, have fallen out of favor because of concern...http://content.nejm.org/cgi/content/short/349/13/1277?rss=1&ssource=collectionSearchRss&queryTerm=35Sundeep Khosla, M.D.Thu, 25  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/13/1277?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Because parathyroid hormone increases both bone formation and bone resorption, it is possible that combining parathyroid hormone with an antiresorptive agent will enhance its effect on bone mineral density.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/349/13/1216?rss=1&ssource=collectionSearchRss&queryTerm=35Joel S. Finkelstein, M.D., Annmarie Hayes, M.S.N., R.N.C., N.P., Joy L. Hunzelman, M.S.N., N.P., Jason J. Wyland, B.A., Hang Lee, Ph.D., and Robert M. Neer, M.D.Thu, 25  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/13/1216?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Parathyroid hormone increases bone strength primarily by stimulating bone formation, whereas antiresorptive drugs reduce bone resorption. We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to...http://content.nejm.org/cgi/content/short/349/13/1207?rss=1&ssource=collectionSearchRss&queryTerm=35Dennis M. Black, Ph.D., Susan L. Greenspan, M.D., Kristine E. Ensrud, M.D., M.P.H., Lisa Palermo, M.A., Joan A. McGowan, Ph.D.,Thomas F. Lang, Ph.D., Patrick Garnero, Ph.D., Mary L. Bouxsein, Ph.D., John P. Bilezikian, M.D., and Clifford J. Rosen, M.D., for the PaTH Study InvestigatorsThu, 25  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/13/1207?rss=1&ssource=collectionSearchRss&queryTerm=35A 52-year-old man who had been receiving hemodialysis for 11 years had severe secondary hyperparathyroidism. His serum level of intact parathyroid hormone was 1489 pg per milliliter. His bone mineral...http://content.nejm.org/cgi/content/short/349/12/e12?rss=1&ssource=collectionSearchRss&queryTerm=35Yoshiaki Nishioka, M.D. and Masanobu Miyazaki, M.D.Thu, 18  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/12/e12?rss=1&ssource=collectionSearchRss&queryTerm=35Bisphosphonates, synthetic analogues of inorganic pyrophosphate, potently inhibit skeletal resorption by suppressing the recruitment and activity of osteoclasts and shortening their life span.1 Consequently, several bisphosphonates were developed to treat...http://content.nejm.org/cgi/content/short/349/5/457?rss=1&ssource=collectionSearchRss&queryTerm=35Michael P. Whyte, M.D., Deborah Wenkert, M.D., Karen L. Clements, R.N., William H. McAlister, M.D., and Steven Mumm, Ph.D.Thu, 31  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/5/457?rss=1&ssource=collectionSearchRss&queryTerm=35Bisphosphonates such as alendronate (Fosamax, Merck) and pamidronate (Aredia, Ciba–Geigy) are synthetic analogues of inorganic pyrophosphate. The main effect of bisphosphonates, which are deposited on the surface of bone and...http://content.nejm.org/cgi/content/short/349/5/423?rss=1&ssource=collectionSearchRss&queryTerm=35Joan C. Marini, M.D., Ph.D.Thu, 31  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/5/423?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Bone loss increases after menopause. However, bone strength also depends on structural characteristics such as bone size. Whether bone size increases as a result of periosteal apposition and whether...http://content.nejm.org/cgi/content/short/349/4/327?rss=1&ssource=collectionSearchRss&queryTerm=35Henrik G. Ahlborg, M.D., Olof Johnell, M.D., Ph.D., Charles H. Turner, Ph.D., Gunnar Rannevik, M.D., Ph.D., and Magnus K. Karlsson, M.D., Ph.D.Thu, 24  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/4/327?rss=1&ssource=collectionSearchRss&queryTerm=35Life forms that have low body mass can hunt for food on the undersurface of branches or along shear cliff faces quite unperturbed by gravity. For larger animals, the hunt...http://content.nejm.org/cgi/content/short/349/4/320?rss=1&ssource=collectionSearchRss&queryTerm=35Ego Seeman, M.D.Thu, 24  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/4/320?rss=1&ssource=collectionSearchRss&queryTerm=35Radiographs of the right humerus obtained at 4 years of age (Panel A), 24 years of age (Panel B), and 30 years of age (Panel C) in a patient with...http://content.nejm.org/cgi/content/short/349/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=35Herberto De Jesus, M.D.Thu, 10  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/2/e2?rss=1&ssource=collectionSearchRss&queryTerm=35A nine-year-old girl was admitted to the hospital because of hepatosplenomegaly and pain in the thigh.<br/><br/>The patient had been well until three years earlier, when she began to have frequent...http://content.nejm.org/cgi/content/short/348/26/2669?rss=1&ssource=collectionSearchRss&queryTerm=35Eric C. Larsen, M.D., Susan A. Connolly, M.D., and Andrew E. Rosenberg, M.D.Thu, 26  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/26/2669?rss=1&ssource=collectionSearchRss&queryTerm=35A 77-year-old man with diabetes presented with a four-day history of fever and worsening left-sided neck and shoulder pain accompanied by numbness and paresthesias in the fingers of the hand...http://content.nejm.org/cgi/content/short/348/25/2525?rss=1&ssource=collectionSearchRss&queryTerm=35Michelle V. Lee, M.D. and Anthony Minotti, M.D.Thu, 19  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/25/2525?rss=1&ssource=collectionSearchRss&queryTerm=35An 81-year-old woman was admitted with increasing generalized weakness, anorexia, and a weight loss of 7 kg (15 lb) over the previous three months. The only finding on physical examination...http://content.nejm.org/cgi/content/short/348/24/2423?rss=1&ssource=collectionSearchRss&queryTerm=35Kenneth S. Stewart, D.O. and Donald L. Steinweg, M.D.Thu, 12  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/24/2423?rss=1&ssource=collectionSearchRss&queryTerm=35Oncogenic osteomalacia has fascinated physiology-minded physicians for decades. The traditional name for this peculiar disorder connotes its classification as a paraneoplastic phenomenon. Such a characterization is a bit off the...http://content.nejm.org/cgi/content/short/348/17/1705?rss=1&ssource=collectionSearchRss&queryTerm=35Thomas O. Carpenter, M.D.Thu, 24  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/17/1705?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Mutations in fibroblast growth factor 23 (FGF-23) cause autosomal dominant hypophosphatemic rickets. Clinical and laboratory findings in this disorder are similar to those in oncogenic osteomalacia, in which tumors...http://content.nejm.org/cgi/content/short/348/17/1656?rss=1&ssource=collectionSearchRss&queryTerm=35Kenneth B. Jonsson, M.D., Ph.D., Richard Zahradnik, B.S., Tobias Larsson, M.D., Kenneth E. White, Ph.D., Toshitsugu Sugimoto, M.D., Yasuo Imanishi, M.D., Takehisa Yamamoto, M.D., Geeta Hampson, M.D., Hiroyuki Koshiyama, M.D., Östen Ljunggren, M.D., Koichi Oba, M.D., In Myung Yang, M.D., Akimitsu Miyauchi, M.D., Michael J. Econs, M.D., Jeffrey Lavigne, B.A., and Harald Jüppner, M.D.Thu, 24  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/17/1656?rss=1&ssource=collectionSearchRss&queryTerm=35In a 1953 editorial entitled “The Need for an Inhibitor of Gonadotropin,” Lawson Wilkins noted that a “method of suppressing the secretion of pituitary gonadotropins . . . might lead...http://content.nejm.org/cgi/content/short/348/10/942?rss=1&ssource=collectionSearchRss&queryTerm=35Mary M. Lee, M.D.Thu, 06  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/10/942?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Treatment with a luteinizing hormone–releasing hormone (LHRH) agonist increases adult height in children with LHRH-dependent precocious puberty and is prescribed by some practitioners to augment height in short adolescents....http://content.nejm.org/cgi/content/short/348/10/908?rss=1&ssource=collectionSearchRss&queryTerm=35Jack A. Yanovski, M.D., Ph.D., Susan R. Rose, M.D., Giovanna Municchi, M.D., Ora H. Pescovitz, M.D., Suvimol C. Hill, M.D., Fernando G. Cassorla, M.D., and Gordon B. Cutler, Jr., M.D.Thu, 06  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/10/908?rss=1&ssource=collectionSearchRss&queryTerm=35The selective estrogen-receptor modulators (SERMs) represent a major therapeutic advance for clinical practice. Unlike estrogens, which are uniformly agonists, and antiestrogens, which are uniformly antagonists, the SERMs exert selective agonist...http://content.nejm.org/cgi/content/short/348/7/618?rss=1&ssource=collectionSearchRss&queryTerm=35B. Lawrence Riggs, M.D., and Lynn C. Hartmann, M.D.Thu, 13  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/7/618?rss=1&ssource=collectionSearchRss&queryTerm=35The toxicity of certain foods that contain high amounts of vitamin A has been recognized for centuries. The 1597 diary of Gerrit de Veer, which he wrote while taking refuge...http://content.nejm.org/cgi/content/short/348/4/347?rss=1&ssource=collectionSearchRss&queryTerm=35Paul Lips, M.D., Ph.D.Thu, 23  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/4/347?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Although studies in animals and epidemiologic studies have indicated that a high vitamin A intake is associated with increased bone fragility, no biologic marker of vitamin A status has...http://content.nejm.org/cgi/content/short/348/4/287?rss=1&ssource=collectionSearchRss&queryTerm=35Karl Michaëlsson, M.D., Hans Lithell, M.D., Bengt Vessby, M.D., and Håkan Melhus, M.D.Thu, 23  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/4/287?rss=1&ssource=collectionSearchRss&queryTerm=35A 46-year-old woman from the Philippines with no history of serious medical conditions was hospitalized with fatigue, body aches, and a weight loss of 4.5 kg (10 lb) over the...http://content.nejm.org/cgi/content/short/348/1/59?rss=1&ssource=collectionSearchRss&queryTerm=35Brendan M. Reilly, M.D., Peter Clarke, M.D., and Petros Nikolinakos, M.D.Thu, 02  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/1/59?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Alkaptonuria, caused by mutations in the HGO gene and a deficiency of homogentisate 1,2-dioxygenase, results in an accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue. There...http://content.nejm.org/cgi/content/short/347/26/2111?rss=1&ssource=collectionSearchRss&queryTerm=35Chanika Phornphutkul, M.D., Wendy J. Introne, M.D., Monique B. Perry, M.D., Isa Bernardini, M.Ed., Mark D. Murphey, M.D., Diana L. Fitzpatrick, B.A., Paul D. Anderson, B.A., Marjan Huizing, Ph.D., Yair Anikster, M.D., Lynn H. Gerber, M.D., and William A. Gahl, M.D., Ph.D.Thu, 26  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/26/2111?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Fibrous dysplasia of bone frequently involves the anterior base of the cranium and results in encasement of the optic-nerve canals. It has been assumed that such encasement leads to...http://content.nejm.org/cgi/content/short/347/21/1670?rss=1&ssource=collectionSearchRss&queryTerm=35Janice S. Lee, D.D.S., M.D., Edmond FitzGibbon, M.D., John A. Butman, M.D., Ph.D., Craig R. Dufresne, M.D., Harvey Kushner, Ph.D., Shlomo Wientroub, M.D., Pamela G. Robey, Ph.D., and Michael T. Collins, M.D.Thu, 21  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/21/1670?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Epidemiologic studies suggest that genetic factors confer a predisposition to the formation of renal calcium stones or bone demineralization. Low serum phosphate concentrations due to a decrease in renal...http://content.nejm.org/cgi/content/short/347/13/983?rss=1&ssource=collectionSearchRss&queryTerm=35Dominique Prié, M.D., Ph.D., Virginie Huart, M.S., Naziha Bakouh, M.S., Gabrielle Planelles, M.D., Ph.D., Olivier Dellis, Ph.D., Bénédicte Gérard, D.Pharm., Philippe Hulin, M.S., François Benqué-Blanchet, D.Pharm., Caroline Silve, M.D., Ph.D., Bernard Grandchamp, M.D., Ph.D., and Gérard Friedlander, M.D., Ph.D.Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/983?rss=1&ssource=collectionSearchRss&queryTerm=35Phosphate leads two lives — an ancient intracellular one and a more recent extracellular one. Inside cells, phosphate has a structural role in nucleic acids and phospholipids, forms high-energy ester...http://content.nejm.org/cgi/content/short/347/13/1022?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/1022?rss=1&ssource=collectionSearchRss&queryTerm=35Figure 1. An 87-year-old asymptomatic woman was incidentally found to have an elevated alkaline phosphatase level (216 IU per liter; upper limit of the normal range, 136). The remainder of...http://content.nejm.org/cgi/content/short/347/5/e2?rss=1&ssource=collectionSearchRss&queryTerm=35Kirsten M. Leu, M.D. and Gregory P. Kalemkerian, M.D.Thu, 01  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/5/e2?rss=1&ssource=collectionSearchRss&queryTerm=35Over the past decade, we have learned a great deal about how skeletal development and remodeling are controlled.1 Some of our knowledge has been derived from genetic analysis of diseases...http://content.nejm.org/cgi/content/short/347/3/210?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 18  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/3/210?rss=1&ssource=collectionSearchRss&queryTerm=35A 37-year-old man was admitted to the hospital because of three weeks of intermittent fever and abdominal and back pain.<br/><br/>The patient had been well until about seven months earlier, one...http://content.nejm.org/cgi/content/short/347/3/200?rss=1&ssource=collectionSearchRss&queryTerm=35James T. Noble and Eugene J. MarkThu, 18  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/3/200?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoporosis affects several million people and is associated with medical costs of up to $15 billion per year in the United States alone.12 Thus, identifying the molecular mechanisms that control...http://content.nejm.org/cgi/content/short/346/20/1572?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 16  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/20/1572?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Osteoporosis is a major public health problem of largely unknown cause. Loss-of-function mutations in the gene for low-density lipoprotein receptor–related protein 5 (LRP5), which acts in the Wnt signaling...http://content.nejm.org/cgi/content/short/346/20/1513?rss=1&ssource=collectionSearchRss&queryTerm=35Lynn M. Boyden, Ph.D., Junhao Mao, Ph.D., Joseph Belsky, M.D., Lyle Mitzner, M.D., Anita Farhi, R.N., Mary A. Mitnick, Ph.D., Dianqing Wu, Ph.D., Karl Insogna, M.D., and Richard P. Lifton, M.D., Ph.D.Thu, 16  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/20/1513?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Bisphosphonates are effective agents for the management of osteoporosis. 02022827.xml Their low bioavailability and low potency necessitate frequent administration on an empty stomach, which may reduce compliance. 02022827.xml Gastrointestinal...http://content.nejm.org/cgi/content/short/346/9/653?rss=1&ssource=collectionSearchRss&queryTerm=35Ian R. Reid, M.D., Jacques P. Brown, M.D., Peter Burckhardt, M.D., Zebulun Horowitz, M.D., Peter Richardson, M.R.C.P., Ulrich Trechsel, M.D., Albert Widmer, Dipl.Stat., Jean-Pierre Devogelaer, M.D., Jean-Marc Kaufman, M.D., Ph.D., Philippe Jaeger, M.D., Jean-Jacques Body, M.D., Ph.D., Maria Luisa Brandi, M.D., Johann Broell, M.D., Raffaele Di Micco, M.D., Andrea Riccardo Genazzani, M.D., Dieter Felsenberg, M.D., Joachim Happ, M.D., Michael J. Hooper, F.R.A.C.P., Jochen Ittner, M.D., Georg Leb, M.D., Hans Mallmin, M.D., Ph.D., Timothy Murray, M.D., Sergio Ortolani, M.D., Alessandro Rubinacci, M.D., Maria Sääf, M.D., Ph.D., Goran Samsioe, M.D., Ph.D., Leon Verbruggen, M.D., Ph.D., and Pierre J. Meunier, M.D.Thu, 28  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/9/653?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoporosis affects millions of postmenopausal women in the United States alone. For white women who reach 50 years of age, the lifetime risk of vertebral fracture is about one in...http://content.nejm.org/cgi/content/short/346/9/642?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 28  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/9/642?rss=1&ssource=collectionSearchRss&queryTerm=35In this issue of the Journal, two groups of investigators report that the treatment of a primary medical condition resulted in accelerated bone loss.12 In one study, by Smith et...http://content.nejm.org/cgi/content/short/345/13/989?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 27  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/13/989?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Treatment with a gonadotropin-releasing hormone agonist decreases bone mineral density and increases the risk of fracture in men with prostate cancer. We conducted a controlled study of the prevention...http://content.nejm.org/cgi/content/short/345/13/948?rss=1&ssource=collectionSearchRss&queryTerm=35Matthew R. Smith, M.D., Ph.D., Francis J. McGovern, M.D., Anthony L. Zietman, M.D., Mary Anne Fallon, L.P.N., Douglas L. Hayden, M.A., David A. Schoenfeld, Ph.D., Philip W. Kantoff, M.D., and Joel S. Finkelstein, M.D.Thu, 27  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/13/948?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Inhaled glucocorticoids are the most commonly used medications for the long-term treatment of patients with asthma. Whether long-term therapy with inhaled glucocorticoids reduces bone mass, as oral glucocorticoid therapy...http://content.nejm.org/cgi/content/short/345/13/941?rss=1&ssource=collectionSearchRss&queryTerm=35Elliot Israel, M.D., Taruna R. Banerjee, M.P.H., Garrett M. Fitzmaurice, Sc.D., Tania V. Kotlov, M.S., Karen LaHive, M.D., and Meryl S. LeBoff, M.D.Thu, 27  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/13/941?rss=1&ssource=collectionSearchRss&queryTerm=35A 14-year-old boy was admitted to the hospital because of bone pain and skeletal abnormalities.<br/><br/>The patient had been vigorously active until one year before admission, when he began to have...http://content.nejm.org/cgi/content/short/345/12/903?rss=1&ssource=collectionSearchRss&queryTerm=35Richard M. Terek, M.D., and G. Petur Nielsen, M.D.Thu, 20  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/12/903?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Once-daily injections of parathyroid hormone or its amino-terminal fragments increase bone formation and bone mass without causing hypercalcemia, but their effects on fractures are unknown.<br/><br/><em>Methods:</em> We randomly assigned 1637...http://content.nejm.org/cgi/content/short/344/19/1434?rss=1&ssource=collectionSearchRss&queryTerm=35Robert M. Neer, Claude D. Arnaud, Jose R. Zanchetta, Richard Prince, Gregory A. Gaich, Jean-Yves Reginster, Anthony B. Hodsman, Erik F. Eriksen, Sophia Ish-Shalom, Harry K. Genant, Ouhong Wang, Dan Mellström, Erik S. Oefjord, Ewa Marcinowska-Suchowierska, Jorma Salmi, Henk Mulder, Johan Halse, Andrzej Z. Sawicki, and Bruce H. MitlakThu, 10  May  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/19/1434?rss=1&ssource=collectionSearchRss&queryTerm=35The use of estrogen-replacement therapy has been associated with a lower risk of Alzheimer's disease1 and preserved or enhanced cognitive performance in postmenopausal women.2 Despite the consistency of these observations,...http://content.nejm.org/cgi/content/short/344/16/1242?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 19  Apr  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/16/1242?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> In postmenopausal women, estrogen may have a beneficial effect on cognition or reduce the risk of decline in cognitive function. Whether raloxifene, a selective estrogen-receptor modulator, might have similar...http://content.nejm.org/cgi/content/short/344/16/1207?rss=1&ssource=collectionSearchRss&queryTerm=35Kristine Yaffe, M.D., Kathyrn Krueger, M.D., Somnath Sarkar, Ph.D., Deborah Grady, M.D., M.P.H., Elizabeth Barrett-Connor, M.D., David A. Cox, Ph.D., and Thomas Nickelsen, M.D., for the Multiple Outcomes of Raloxifene Evaluation InvestigatorsThu, 19  Apr  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/16/1207?rss=1&ssource=collectionSearchRss&queryTerm=35A 61-year-old man was admitted to the hospital because of transient quadriplegia and apnea.<br/><br/>The patient had been well until the morning of admission, when stiffness and pain developed in his...http://content.nejm.org/cgi/content/short/344/11/832?rss=1&ssource=collectionSearchRss&queryTerm=35Eric T.Wong, David N. LouisThu, 15  Mar  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/11/832?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Risedronate increases bone mineral density in elderly women, but whether it prevents hip fracture is not known.<br/><br/><em>Methods:</em> We studied 5445 women 70 to 79 years old who had osteoporosis...http://content.nejm.org/cgi/content/short/344/5/333?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 01  Feb  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/5/333?rss=1&ssource=collectionSearchRss&queryTerm=35A 59-year-old man was admitted to the hospital because of right-sided visual loss and oculomotor-nerve palsy.<br/><br/>The patient had had type 2 diabetes mellitus for 25 years; during most of those...http://content.nejm.org/cgi/content/short/344/4/286?rss=1&ssource=collectionSearchRss&queryTerm=35Richard B. Brown, Stephen K. LauThu, 25  Jan  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/4/286?rss=1&ssource=collectionSearchRss&queryTerm=35A 26-year-old man was admitted to the hospital because of a mass in the knee.<br/><br/>The patient had been in good health except for a nine-year history of intermittent pain in...http://content.nejm.org/cgi/content/short/344/2/124?rss=1&ssource=collectionSearchRss&queryTerm=35Thomas A. Einhorn, G. Petur NielsenThu, 11  Jan  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/2/124?rss=1&ssource=collectionSearchRss&queryTerm=35Hip fractures are one of the most devastating and costly problems commonly faced by elderly people. Each year in the United States, more than 300,000 people 65 years old or...http://content.nejm.org/cgi/content/short/343/21/1562?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 23  Nov  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/21/1562?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Hip fractures are common in frail elderly adults worldwide. We investigated the effect of an anatomically designed external hip protector on the risk of these age-related fractures.<br/><br/><em>Methods:</em> We randomly...http://content.nejm.org/cgi/content/short/343/21/1506?rss=1&ssource=collectionSearchRss&queryTerm=35Pekka Kannus, M.D., Ph.D., Jari Parkkari, M.D., Ph.D., Seppo Niemi, Matti Pasanen, M.Sc., Mika Palvanen, M.D., Markku Järvinen, M.D., Ph.D., and Ilkka Vuori, M.D., Ph.D.Thu, 23  Nov  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/21/1506?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Despite its association with disability, death, and increased medical costs, osteoporosis in men has been relatively neglected as a subject of study. There have been no large, controlled trials...http://content.nejm.org/cgi/content/short/343/9/604?rss=1&ssource=collectionSearchRss&queryTerm=35Eric Orwoll, M.D., Mark Ettinger, M.D., Stuart Weiss, M.D., Paul Miller, M.D., David Kendler, M.D., John Graham, M.B., B.S., Silvano Adami, M.D., Kurt Weber, M.D., Roman Lorenc, M.D., Ph.D., Peter Pietschmann, M.D., Kristel Vandormael, M.S., and Antonio Lombardi, M.D.Thu, 31  Aug  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/9/604?rss=1&ssource=collectionSearchRss&queryTerm=35Osteogenesis imperfecta is an autosomal dominant disorder of the connective tissue, which is also known as “brittle-bone disease” because it renders those affected susceptible to fractures after minimal trauma. Clinically...http://content.nejm.org/cgi/content/short/339/14/986?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 01  Oct  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/14/986?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Severe osteogenesis imperfecta is a disorder characterized by osteopenia, frequent fractures, progressive deformity, loss of mobility, and chronic bone pain. There is no effective therapy for the disorder. We...http://content.nejm.org/cgi/content/short/339/14/947?rss=1&ssource=collectionSearchRss&queryTerm=35Francis H. Glorieux, M.D., Ph.D., Nicholas J. Bishop, M.D., Horacio Plotkin, M.D., Gilles Chabot, M.D., Ginette Lanoue, R.N., and Rose Travers, R.T.Thu, 01  Oct  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/14/947?rss=1&ssource=collectionSearchRss&queryTerm=35The central role of estrogen deficiency in postmenopausal bone loss was demonstrated many years ago.1 We know estrogen can inhibit bone resorption and decrease bone turnover, but the precise pathways...http://content.nejm.org/cgi/content/short/339/11/767?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 10  Sep  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/11/767?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> and <em>Methods:</em> In postmenopausal women, the serum concentrations of endogenous sex hormones and vitamin D might influence the risk of hip and vertebral fractures. In a study of a...http://content.nejm.org/cgi/content/short/339/11/733?rss=1&ssource=collectionSearchRss&queryTerm=35Steven R. Cummings, M.D., Warren S. Browner, M.D., M.P.H., Douglas Bauer, M.D., Katie Stone, Ph.D., Kristine Ensrud, M.D., M.P.H., Sophie Jamal, M.D., and Bruce Ettinger, M.D., for the Study of Osteoporotic Fractures Research GroupThu, 10  Sep  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/11/733?rss=1&ssource=collectionSearchRss&queryTerm=35During childhood and young adulthood, the skeleton accrues virtually all the bone mineral it will ever have.1 Since the aging process is associated with bone loss, the more bone mass...http://content.nejm.org/cgi/content/short/339/9/599?rss=1&ssource=collectionSearchRss&queryTerm=35John P. Bilezikian, M.D., Akira Morishima, M.D., Jennifer Bell, M.D., and Melvin M. Grumbach, M.D.Thu, 27  Aug  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/9/599?rss=1&ssource=collectionSearchRss&queryTerm=35The clinical use of bisphosphonates has increased dramatically during the past five years. The most common indication for these compounds is osteoporosis, but their use in osteolytic bone disease has...http://content.nejm.org/cgi/content/short/339/6/398?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 06  Aug  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/6/398?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Osteoporosis is a common complication of long-term glucocorticoid therapy for which there is no well-proved preventive or restorative treatment.<br/><br/><em>Methods:</em> We carried out two 48-week, randomized, placebo-controlled studies of two...http://content.nejm.org/cgi/content/short/339/5/292?rss=1&ssource=collectionSearchRss&queryTerm=35Kenneth G. Saag, M.D., Ronald Emkey, M.D., Thomas J. Schnitzer, M.D., Ph.D., Jacques P. Brown, M.D., Federico Hawkins, M.D., Stefan Goemaere, M.D., Gorm Thamsborg, M.D., Uri A. Liberman, M.D., Ph.D., Pierre D. Delmas, M.D., Ph.D., Marie-Pierre Malice, Ph.D., Michelle Czachur, M.P.H., and Anastasia G. Daifotis, M.D., Nancy Lane, M.D., Ricardo Correa-Rotter, M.D., Melissa Yanover, M.D., Rene Westhovens, M.D., Sol Epstein, M.D., Jonathan D. Adachi, M.D., Patrice Poubelle, M.D., D.Sc., Jose Melo-Gomes, M.D., Jose A. Rodriguez-Portales, M.D., for the Glucocorticoid-Induced Osteoporosis Intervention Study GroupThu, 30  Jul  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/5/292?rss=1&ssource=collectionSearchRss&queryTerm=35Over the past decade, we have applied the power of molecular biology to the study of human diseases, and we have identified genetic defects causing over 100 different diseases. Evidence...http://content.nejm.org/cgi/content/short/338/15/1061?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 09  Apr  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/15/1061?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Osteoporosis is a common disorder with a strong genetic component. One way in which the genetic component could be expressed is through polymorphism of COLIA1, the gene for collagen...http://content.nejm.org/cgi/content/short/338/15/1016?rss=1&ssource=collectionSearchRss&queryTerm=35André G. Uitterlinden, Ph.D., Huibert Burger, M.D., Ph.D., Qiuju Huang, M.D., Fang Yue, M.D., Fiona E.A. McGuigan, B.Sc., Struan F.A. Grant, Ph.D., Albert Hofman, M.D., Ph.D., Johannes P.T.M. van Leeuwen, Ph.D., Huibert A.P. Pols, M.D., Ph.D., and Stuart H. Ralston, M.D.Thu, 09  Apr  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/15/1016?rss=1&ssource=collectionSearchRss&queryTerm=35Vitamin D is an essential precursor of 1,25-dihydroxyvitamin D, the steroid hormone required not only for bone development and growth in children and maintenance of bone in adults, but also...http://content.nejm.org/cgi/content/short/338/12/828?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 19  Mar  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/12/828?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Vitamin D deficiency is a major risk factor for bone loss and fracture. Although hypovitaminosis D has been detected frequently in elderly and housebound people, the prevalence of vitamin...http://content.nejm.org/cgi/content/short/338/12/777?rss=1&ssource=collectionSearchRss&queryTerm=35Melissa K. Thomas, M.D., Ph.D., Donald M. Lloyd-Jones, M.D., Ravi I. Thadhani, M.D., M.P.H., Albert C. Shaw, M.D., Ph.D., Donald J. Deraska, M.D., Barrett T. Kitch, M.D., Eleftherios C. Vamvakas, M.D., Ph.D., Ian M. Dick, M.Sc., Richard L. Prince, M.D., and Joel S. Finkelstein, M.D.Thu, 19  Mar  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/12/777?rss=1&ssource=collectionSearchRss&queryTerm=35Osteoporosis affects an estimated 75 million people in Europe, the United States, and Japan.1 It is a preventable and treatable condition, yet many people with osteoporosis remain unrecognized and untreated....http://content.nejm.org/cgi/content/short/338/11/736?rss=1&ssource=collectionSearchRss&queryTerm=35Richard Eastell, M.D.Thu, 12  Mar  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/11/736?rss=1&ssource=collectionSearchRss&queryTerm=35The typical clinical picture of rickets, first clearly described in the 17th century, includes growth-plate abnormalities and delayed growth, weakening and bowing of weight-bearing bones, hypoplasia of tooth enamel, and...http://content.nejm.org/cgi/content/short/338/10/681?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 05  Mar  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/10/681?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Estrogen-replacement therapy prevents osteoporosis in postmenopausal women by inhibiting bone resorption, but the balance between its long-term risks and benefits remains unclear. Whether other antiresorptive therapies can prevent osteoporosis...http://content.nejm.org/cgi/content/short/338/8/485?rss=1&ssource=collectionSearchRss&queryTerm=35David Hosking, M.D., Clair E.D. Chilvers, D.Sc., Claus Christiansen, M.D., Pernille Ravn, M.D., Richard Wasnich, M.D., Philip Ross, Ph.D., Michael McClung, M.D., Ana Balske, M.D., Ph.D., Desmond Thompson, Ph.D., Marianne Daley, B.A., and A. John Yates, M.D., for the Early Postmenopausal Intervention Cohort Study GroupThu, 19  Feb  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/8/485?rss=1&ssource=collectionSearchRss&queryTerm=35As life expectancy continues to increase, women will soon be postmenopausal for one third of their lives. The human and economic costs of this increased longevity in an estrogen-deficient state...http://content.nejm.org/cgi/content/short/337/23/1686?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 04  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/23/1686?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Long-term estrogen therapy can reduce the risk of osteoporotic fracture and cardiovascular disease in postmenopausal women. At present, however, these beneficial effects are not separable from undesirable stimulation of...http://content.nejm.org/cgi/content/short/337/23/1641?rss=1&ssource=collectionSearchRss&queryTerm=35Pierre D. Delmas, M.D., Ph.D., Nina H. Bjarnason, M.D., Bruce H. Mitlak, M.D., Anne-Catherine Ravoux, M.D., Aarti S. Shah, Ph.D., William J. Huster, Ph.D., Michael Draper, M.D., Ph.D., and Claus Christiansen, M.D.Thu, 04  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/23/1641?rss=1&ssource=collectionSearchRss&queryTerm=35One of the striking demographic features of all countries in the late 20th century is the increasing longevity of both men and women. Unfortunately, this extension of life expectancy has...http://content.nejm.org/cgi/content/short/337/10/701?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 04  Sep  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/10/701?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons.<br/><br/><em>Methods:</em> We studied the effects of three years of dietary supplementation...http://content.nejm.org/cgi/content/short/337/10/670?rss=1&ssource=collectionSearchRss&queryTerm=35Bess Dawson-Hughes, M.D., Susan S. Harris, D.Sc., Elizabeth A. Krall, Ph.D., and Gerard E. Dallal, Ph.D.Thu, 04  Sep  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/10/670?rss=1&ssource=collectionSearchRss&queryTerm=35Nursing mothers provide an average of 200 to 250 mg of calcium per day to their infants, and as much as 400 mg per day.1 Given that women absorb only...http://content.nejm.org/cgi/content/short/337/8/558?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 21  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/8/558?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Women may lose bone during lactation because of calcium lost in breast milk. We studied whether calcium supplementation prevents bone loss during lactation or augments bone gain after weaning.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/337/8/523?rss=1&ssource=collectionSearchRss&queryTerm=35Heidi J. Kalkwarf, Ph.D., Bonny L. Specker, Ph.D., Donna C. Bianchi, M.Ed., Julie Ranz, R.N., and Mona Ho, M.S.Thu, 21  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/8/523?rss=1&ssource=collectionSearchRss&queryTerm=35Glucocorticoid hormones have revolutionized the management of many illnesses, reducing morbidity in conditions such as rheumatoid arthritis and mortality in other diseases such as asthma. However, they have many side...http://content.nejm.org/cgi/content/short/337/6/420?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 07  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/6/420?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> and <em>Methods:</em> Osteoporosis is a recognized complication of corticosteroid therapy. Whether it can be prevented is not known. We conducted a 12-month, randomized, placebo-controlled study of intermittent etidronate (400...http://content.nejm.org/cgi/content/short/337/6/382?rss=1&ssource=collectionSearchRss&queryTerm=35Jonathan D. Adachi, M.D., William G. Bensen, M.D., Jacques Brown, M.D., David Hanley, M.D., Anthony Hodsman, M.D., Robert Josse, M.D., David L. Kendler, M.D., Brian Lentle, M.D., Wojciech Olszynski, M.D., Louis-George Ste.-Marie, M.D., Alan Tenenhouse, M.D., and Arkadi A. Chines, M.D., Algis Jovaisas, M.D, William C. Sturtridge, M.D, Tassos P. Anastassiades, M.D., John G. Hanly, M.D. , Janet E. Pope, M.D. , Reginald Dias, B.Sc., Zebulun D. Horowitz, M.D., and Simon Pack, Ph.D.Thu, 07  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/6/382?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Bone mass is under strong genetic control, and recent studies in adults have suggested that allelic differences in the gene for the vitamin D receptor may account for inherited...http://content.nejm.org/cgi/content/short/337/2/77?rss=1&ssource=collectionSearchRss&queryTerm=35Jesus Sainz, Ph.D., Jan M. Van Tornout, M.D., M. Luiza Loro, M.D., James Sayre, Ph.D., Thomas F. Roe, M.D., and Vicente Gilsanz, M.D., Ph.D.Thu, 10  Jul  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/2/77?rss=1&ssource=collectionSearchRss&queryTerm=35Bone density is known to have strong genetic determinants. On the basis of studies of twins and mother–daughter pairs, it is estimated that heredity accounts for up to 70 percent...http://content.nejm.org/cgi/content/short/337/2/125?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 10  Jul  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/2/125?rss=1&ssource=collectionSearchRss&queryTerm=35In this issue of the Journal, Grodstein and colleagues1 present important data from a large study of the risks and benefits associated with postmenopausal hormone-replacement therapy. Like previous investigators, they...http://content.nejm.org/cgi/content/short/336/25/1821?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 19  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/25/1821?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Postmenopausal hormone therapy has both benefits and hazards, including decreased risks of osteoporosis and cardiovascular disease and an increased risk of breast cancer.<br/><br/><em>Methods:</em> We examined the relation between the...http://content.nejm.org/cgi/content/short/336/25/1769?rss=1&ssource=collectionSearchRss&queryTerm=35Francine Grodstein, Sc.D., Meir J. Stampfer, M.D., Graham A. Colditz, M.B., B.S., Walter C. Willett, M.D., JoAnn E. Manson, M.D., Marshall Joffe, M.D., Bernard Rosner, M.D., Charles Fuchs, M.D., Susan E. Hankinson, Sc.D., David J. Hunter, M.B., B.S., Charles H. Hennekens, M.D., and Frank E. Speizer, M.D.Thu, 19  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/25/1769?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Recent studies have shown a direct relation between serum estrogen levels assessed at a single point in time and the risk of breast cancer, but no evidence links estrogen...http://content.nejm.org/cgi/content/short/336/9/611?rss=1&ssource=collectionSearchRss&queryTerm=35Yuqing Zhang, D.Sc., M.B., Douglas P. Kiel, M.D., M.P.H., Bernard E. Kreger, M.D., M.P.H., L. Adrienne Cupples, Ph.D., R. Curtis Ellison, M.D., Joanne F. Dorgan, Ph.D., M.P.H., Arthur Schatzkin, M.D., Dr.Ph., Daniel Levy, M.D., and David T. Felson, M.D., M.P.H.Thu, 27  Feb  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/9/611?rss=1&ssource=collectionSearchRss&queryTerm=35Bisphosphonates are drugs that inhibit bone turnover by decreasing the resorption of bone. They do this both directly, by inhibiting the recruitment and function of osteoclasts (the bone-resorbing cells), and...http://content.nejm.org/cgi/content/short/335/24/1836?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 12  Dec  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/24/1836?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Depression is associated with alterations in behavior and neuroendocrine systems that are risk factors for decreased bone mineral density. This study was undertaken to determine whether women with past...http://content.nejm.org/cgi/content/short/335/16/1176?rss=1&ssource=collectionSearchRss&queryTerm=35David Michelson, M.D., Constantine Stratakis, M.D., Ph.D., Lauren Hill, B.S., James Reynolds, M.D., Elise Galliven, B.S., George Chrousos, M.D., and Philip Gold, M.D.Thu, 17  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/16/1176?rss=1&ssource=collectionSearchRss&queryTerm=35Esophageal mucosal injury from the noxious effect of gastric contents refluxing up the esophagus is a common condition. Much less common is esophagitis from injurious agents passing down the esophagus,...http://content.nejm.org/cgi/content/short/335/14/1058?rss=1&ssource=collectionSearchRss&queryTerm=35Thu, 03  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/14/1058?rss=1&ssource=collectionSearchRss&queryTerm=35<em>Background:</em> Alendronate, an aminobisphosphonate and a selective inhibitor of osteoclast-mediated bone resorption, is used to treat osteoporosis in postmenopausal women and Paget's disease of bone. Aminobisphosphonates can irritate the upper...http://content.nejm.org/cgi/content/short/335/14/1016?rss=1&ssource=collectionSearchRss&queryTerm=35Piet C. de Groen, M.D., Dieter F. Lubbe, M.B., Ch.B., Laurence J. Hirsch, M.D., Anastasia Daifotis, M.D., Wendy Stephenson, M.D., M.P.H., Debra Freedholm, B.S.N., Suzanne Pryor-Tillotson, M.S., Mitchel J. Seleznick, M.D., Haim Pinkas, M.D., and Kenneth K. Wang, M.D.Thu, 03  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/14/1016?rss=1&ssource=collectionSearchRss&queryTerm=35Hip fractures, particularly in older persons, result in problems that extend far beyond the orthopedic injury, with repercussions in the areas of medicine, rehabilitation, psychiatry, social work, and health care...http://content.nejm.org/cgi/content/short/334/23/1519?rss=1&ssource=collectionSearchRss&queryTerm=35Joseph D. Zuckerman, M.D.Thu, 06  Jun  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/23/1519?rss=1&ssource=collectionSearchRss&queryTerm=35