NEJM â Collection Updates for Obesity

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Î±-Adrenergic Receptors and Type 2 Diabetes

Fiona M. Gribble, D.Phil., B.M., B.Ch. — Thu, 28Â JanÂ 2010 00:00:00 -05:00

The global epidemic of type 2 diabetes mellitus is undoubtedly driven by soaring levels of obesity. Although increased body fat impairs the action of insulin, the risk of type 2...

OTHER POINTS OF VIEW: Taxing âSin Foodsâ â Obesity Prevention and Public Health Policy

Thu, 10Â DecÂ 2009 00:00:00 -05:00

As the United States struggles to combat obesity, some health policy experts have asserted that a tax on sugar-sweetened beverages such as soda would lead to reduced consumption of sodas...

SPECIAL ARTICLE: Forecasting the Effects of Obesity and Smoking on U.S. Life Expectancy

Thu, 03Â DecÂ 2009 00:00:00 -05:00

Background: Although increases in obesity over the past 30 years have adversely affected the health of the U.S. population, there have been concomitant improvements in health because of reductions in...

BOOK REVIEW:

Thu, 13Â AugÂ 2009 00:00:00 -05:00

In The Evolution of Obesity, Michael Power and Jay Schulkin present an excellent and comprehensive explanation for the increased incidence of obesity. The underlying theme of the book is an...

EDITORIAL: Surgical Treatment of Obesity â Weighing the Facts

Malcolm K. Robinson, M.D. — Thu, 30Â JulÂ 2009 00:00:00 -05:00

There has been an explosion in the number of bariatric surgical procedures performed worldwide. It is estimated that in 2005, the number of procedures performed in the United States was...

ORIGINAL ARTICLE: Perioperative Safety in the Longitudinal Assessment of Bariatric Surgery

The Longitudinal Assessment of Bariatric Surgery (LABS) Consortium — Thu, 30Â JulÂ 2009 00:00:00 -05:00

Background: To improve decision making in the treatment of extreme obesity, the risks of bariatric surgical procedures require further characterization.

Methods: We performed a prospective, multicenter, observational study of 30-day outcomes...

BOOK REVIEW:

Thu, 25Â JunÂ 2009 00:00:00 -05:00

This is the second edition of a book that was well received when it was first published. It has been updated substantially and now has a focus on problems of...

BOOK REVIEW:

Thu, 25Â JunÂ 2009 00:00:00 -05:00

The title and subtitle of this book promise a comprehensive examination of an important public health problem. However, the editors immediately disabuse readers of this notion by stating that the...

HEALTH LAW, ETHICS, AND HUMAN RIGHTS: New York City's War on Fat

Michelle M. Mello, J.D., Ph.D. — Thu, 07Â MayÂ 2009 00:00:00 -05:00

In February, a federal appeals court handed public health officials in New York City an important victory in their ongoing war on obesity and chronic disease.1 In the past 3...

EDITORIAL: Brown Adipose Tissue â When It Pays to Be Inefficient

Francesco S. Celi, M.D. — Thu, 09Â AprÂ 2009 00:00:00 -05:00

Obesity has reached epidemic proportions, and complications related to obesity contribute substantially to health care costs and mortality. Since the accumulation of fat is the net result of a prolonged...

ORIGINAL ARTICLE: Functional Brown Adipose Tissue in Healthy Adults

Thu, 09Â AprÂ 2009 00:00:00 -05:00

Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy...

ORIGINAL ARTICLE: Identification and Importance of Brown Adipose Tissue in Adult Humans

Thu, 09Â AprÂ 2009 00:00:00 -05:00

Background: Obesity results from an imbalance between energy intake and expenditure. In rodents and newborn humans, brown adipose tissue helps regulate energy expenditure by thermogenesis mediated by the expression of...

ORIGINAL ARTICLE: Cold-Activated Brown Adipose Tissue in Healthy Men

Thu, 09Â AprÂ 2009 00:00:00 -05:00

Background: Studies in animals indicate that brown adipose tissue is important in the regulation of body weight, and it is possible that individual variation in adaptive thermogenesis can be attributed...

EDITORIAL: Weight-Loss Diets for the Prevention and Treatment of Obesity

Martijn B. Katan, Ph.D. — Thu, 26Â FebÂ 2009 00:00:00 -05:00

No medical condition has generated as many dietary remedies as obesity. All diets have their followers, but hard data on the efficacy of the diets are scarce. In this issue...

ORIGINAL ARTICLE: Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates

Thu, 26Â FebÂ 2009 00:00:00 -05:00

Background: The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year.

Methods:...

ORIGINAL ARTICLE: Weight Loss to Treat Urinary Incontinence in Overweight and Obese Women

Thu, 29Â JanÂ 2009 00:00:00 -05:00

Background: Obesity is an established and modifiable risk factor for urinary incontinence, but conclusive evidence for a beneficial effect of weight loss on urinary incontinence is lacking.

Methods: We randomly assigned...

ORIGINAL ARTICLE: Modulation of Blood Pressure by Central Melanocortinergic Pathways

Thu, 01Â JanÂ 2009 00:00:00 -05:00

Background: Weight gain and weight loss are associated with changes in blood pressure through unknown mechanisms. Central melanocortinergic signaling is implicated in the control of energy balance and blood pressure...

EDITORIAL: Energy In, Energy Out, and the Effects of Obesity-Related Genes

Rudolph L. Leibel, M.D. — Thu, 11Â DecÂ 2008 00:00:00 -05:00

More than 100 genes have been implicated in the determination of body weight. These genes, acting primarily in or through the central nervous system (primarily the hypothalamus and brain stem),...

ORIGINAL ARTICLE: An Obesity-Associated Gene Variant and Increased Energy Intake in Children

Thu, 11Â DecÂ 2008 00:00:00 -05:00

Background: Variation in the fat mass and obesityâassociated (FTO) gene has provided the most robust associations with common obesity to date. However, the role of FTO variants in modulating specific...

ORIGINAL ARTICLE: General and Abdominal Adiposity and Risk of Death in Europe

Thu, 13Â NovÂ 2008 00:00:00 -05:00

Background: Previous studies have relied predominantly on the body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity...

CLINICAL IMPLICATIONS OF BASIC RESEARCH: The Exercise Pill â Too Good to Be True?

Laurie J. Goodyear, Ph.D. — Thu, 23Â OctÂ 2008 00:00:00 -05:00

Regular physical exercise has undisputed health benefits in the prevention â and in some cases, the treatment â of many diseases. The problem is that for the great majority of...

BOOK REVIEW:

Thu, 18Â SepÂ 2008 00:00:00 -05:00

Obesity is ultimately the result of an imbalance between energy intake and energy expenditure, but this simplistic equation belies the fact that obesity is also a multifactorial disease with complex...

ORIGINAL ARTICLE: Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome

Thu, 28Â AugÂ 2008 00:00:00 -05:00

Background: Brain-derived neurotrophic factor (BDNF) has been found to be important in energy homeostasis in animal models, but little is known about its role in energy balance in humans. Heterozygous,...

PERSPECTIVE: The Power of the Extreme in Elucidating Obesity

Thu, 28Â AugÂ 2008 00:00:00 -05:00

Despite the worrisome statistics that 16% of children in the United States are obese and that the number of adults with a body-mass index (the weight in kilograms divided by...

ORIGINAL ARTICLE: Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet

Thu, 17Â JulÂ 2008 00:00:00 -05:00

Background: Trials comparing the effectiveness and safety of weight-loss diets are frequently limited by short follow-up times and high dropout rates.

Methods: In this 2-year trial, we randomly assigned 322 moderately...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 20-2008 â A 57-Year-Old Woman with Abdominal Pain and Weakness after Gastric Bypass Surgery

Thu, 26Â JunÂ 2008 00:00:00 -05:00

Dr. Allyson K. Bloom (Medicine): A 57-year-old woman was admitted to this hospital because of abdominal pain and weakness. One month earlier, a laparoscopic Roux-en-Y gastric bypass and cholecystectomy were...

CLINICAL PRACTICE: Nonsurgical Management of Obesity in Adults

Robert H. Eckel, M.D. — Thu, 01Â MayÂ 2008 00:00:00 -05:00

A 44-year-old woman desires weight reduction. Her history is notable for hypertension, snoring, daytime somnolence, and osteoarthritis. Her father was obese and had type 2 diabetes. On physical examination, her...

ORIGINAL ARTICLE: Association between Obesity during Pregnancy and Increased Use of Health Care

Thu, 03Â AprÂ 2008 00:00:00 -05:00

Background: In the United States, obesity during pregnancy is common and increases obstetrical risks. An estimate of the increase in use of health care services associated with obesity during pregnancy...

CLINICAL DECISIONS: Management of Type 2 Diabetes

Thu, 17Â JanÂ 2008 00:00:00 -05:00

A 55-year-old woman with type 2 diabetes, obesity, and hypertension has been under your care for the past 2 years. She has no history of microalbuminuria, retinopathy, or neuropathy. She...

SPECIAL ARTICLE: Adolescent Overweight and Future Adult Coronary Heart Disease

Thu, 06Â DecÂ 2007 00:00:00 -05:00

Background: The effect of adolescent overweight on future adult coronary heart disease (CHD) is not known.

Methods: We estimated the prevalence of obese 35-year-olds in 2020 on the basis of adolescent...

ORIGINAL ARTICLE: Childhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood

Thu, 06Â DecÂ 2007 00:00:00 -05:00

Background: The worldwide epidemic of childhood obesity is progressing at an alarming rate. Risk factors for coronary heart disease (CHD) are already identifiable in overweight children. The severity of the...

PERSPECTIVE: Childhood Obesity â The Shape of Things to Come

Thu, 06Â DecÂ 2007 00:00:00 -05:00

Last week, I met with the G. family in the Optimal Weight for Life (OWL) clinic at my hospital. One of the parents was overweight, and the other was obese....

CLINICAL PRACTICE: Hypertriglyceridemia

John D. Brunzell, M.D. — Thu, 06Â SepÂ 2007 00:00:00 -05:00

Hypertriglyceridemia is a common form of dyslipidemia1 that is frequently associated with premature coronary artery disease,2345 which is generally defined by the occurrence of a myocardial infarction or the need...

EDITORIAL: The Missing Link â Lose Weight, Live Longer

George A. Bray, M.D. — Thu, 23Â AugÂ 2007 00:00:00 -05:00

In this issue of the Journal, two articles â by SjÃ¶strÃ¶m et al.1 and Adams et al.2 â may provide the missing link between intentional weight loss and lives saved...

ORIGINAL ARTICLE: Long-Term Mortality after Gastric Bypass Surgery

Thu, 23Â AugÂ 2007 00:00:00 -05:00

Background: Although gastric bypass surgery accounts for 80% of bariatric surgery in the United States, only limited long-term data are available on mortality among patients who have undergone this procedure...

ORIGINAL ARTICLE: Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects

Thu, 23Â AugÂ 2007 00:00:00 -05:00

Background: Obesity is associated with increased mortality. Weight loss improves cardiovascular risk factors, but no prospective interventional studies have reported whether weight loss decreases overall mortality. In fact, many observational...

EDITORIAL: Network Medicine â From Obesity to the âDiseasomeâ

Albert-LÃ¡szlÃ³ BarabÃ¡si, Ph.D. — Thu, 26Â JulÂ 2007 00:00:00 -05:00

A recent study reported that among people who carried a single copy of the high-risk allele for the FTO gene, which is associated with fat mass and obesity, the risk...

SPECIAL ARTICLE: The Spread of Obesity in a Large Social Network over 32 Years

Nicholas A. Christakis, M.D., Ph.D., M.P.H., and James H. Fowler, Ph.D. — Thu, 26Â JulÂ 2007 00:00:00 -05:00

Background: The prevalence of obesity has increased substantially over the past 30 years. We performed a quantitative analysis of the nature and extent of the person-to-person spread of obesity as...

CLINICAL THERAPEUTICS: Bariatric Surgery for Morbid Obesity

Eric J. DeMaria, M.D. — Thu, 24Â MayÂ 2007 00:00:00 -05:00

A 44-year-old obese woman (height, 1.7 m [65 in.]) has seen her primary care physician for the past 10 years for management of conditions related to her obesity, including diabetes,...

ORIGINAL ARTICLE: Clinical and Molecular Genetic Spectrum of Congenital Deficiency of the Leptin Receptor

Thu, 18Â JanÂ 2007 00:00:00 -05:00

Background: A single family has been described in which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset obesity has...

PERSPECTIVE: Obesity and Diabetes in the Developing World â A Growing Challenge

Thu, 18Â JanÂ 2007 00:00:00 -05:00

Globally, the prevalence of chronic, noncommunicable diseases is increasing at an alarming rate. About 18 million people die every year from cardiovascular disease, for which diabetes and hypertension are major...

EDITORIAL: Angiotensin-ConvertingâEnzyme Inhibitors for Impaired Glucose Tolerance â Is There Still Hope?

Julie R. Ingelfinger, M.D., and Caren G. Solomon, M.D., M.P.H. — Thu, 12Â OctÂ 2006 00:00:00 -05:00

In our increasingly sedentary society, the rates of overnutrition, the metabolic syndrome, and frank diabetes mellitus are rising at an alarming rate.1 Once diabetes has developed, the risks of cardiovascular...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 31-2006 â A 15-Year-Old Girl with Severe Obesity

Thu, 12Â OctÂ 2006 00:00:00 -05:00

A 15 1/2-year-old girl was seen in the outpatient Weight Center of this hospital for the evaluation of severe obesity. She had had a normal gestation without complications and had...

IMAGES IN CLINICAL MEDICINE: Skin Redundancy after Massive Weight Loss

Arin K. Greene, M.D. and Jonathan M. Winograd, M.D. — Thu, 24Â AugÂ 2006 00:00:00 -05:00

A 30-year-old man presented at our plastic-surgery clinic to request body contouring after massive weight loss (Panels A and B; inset shows patient before weight loss). Two years earlier, the...

ORIGINAL ARTICLE: Body-Mass Index and Mortality in Korean Men and Women

Thu, 24Â AugÂ 2006 00:00:00 -05:00

Background: Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial.

Methods: We examined the association between body weight and...

ORIGINAL ARTICLE: Overweight, Obesity, and Mortality in a Large Prospective Cohort of Persons 50 to 71 Years Old

Thu, 24Â AugÂ 2006 00:00:00 -05:00

Background: Obesity, defined by a body-mass index (BMI) (the weight in kilograms divided by the square of the height in meters) of 30.0 or more, is associated with an increased...

PERSPECTIVE: Overweight and Mortality among Baby Boomers â Now We're Getting Personal

Thu, 24Â AugÂ 2006 00:00:00 -05:00

I am a baby boomer, and my body-mass index (BMI) is 27.3. I am also an epidemiologist, so for both personal and professional reasons, I have closely followed the sometimes...

HEALTH POLICY REPORT: Obesity â The New Frontier of Public Health Law

Thu, 15Â JunÂ 2006 00:00:00 -05:00

The law is now firmly established as a powerful instrument of public health.1 Some of the most important public health victories in the United States in the past century â...

EDITORIAL: Retinol-Binding Protein 4, Insulin Resistance, and Type 2 Diabetes

Kenneth S. Polonsky, M.D. — Thu, 15Â JunÂ 2006 00:00:00 -05:00

The current pandemic of type 2 diabetes is closely associated with obesity and insulin resistance. It is therefore essential that we gain a greater understanding of the pathogenesis of these...

ORIGINAL ARTICLE: Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

Thu, 15Â JunÂ 2006 00:00:00 -05:00

Background: Insulin resistance has a causal role in type 2 diabetes. Serum levels of retinol-binding protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant states. Experiments in...

PERSPECTIVE: Food Marketing and Childhood Obesity â A Matter of Policy

Thu, 15Â JunÂ 2006 00:00:00 -05:00

Everyone knows that American children are becoming fatter, but not everyone agrees on the cause. Many of today's children routinely consume more calories than they expend in physical activity, but...

ORIGINAL ARTICLE: Body-Mass Index and Symptoms of Gastroesophageal Reflux in Women

Thu, 01Â JunÂ 2006 00:00:00 -05:00

Background: Overweight and obese persons are at increased risk for gastroesophageal reflux disease. An association between body-mass index (BMI) â the weight in kilograms divided by the square of the...

IMAGES IN CLINICAL MEDICINE: Pellagra-like Dermatitis

Neda Ashourian, M.D. and Nico Mousdicas, M.D. — Thu, 13Â AprÂ 2006 00:00:00 -05:00

Three months after undergoing Roux-en-Y bariatric surgery, a 32-year-old woman presented with glossitis, angular cheilitis, and an erythematous, desquamative dermatitis with a distribution indicative of photosensitivity causing a burning sensation...

EDITORIAL:

Susan Z. Yanovski, M.D. — Thu, 17Â NovÂ 2005 00:00:00 -05:00

In 2005, a majority of adult Americans are overweight or obese,1 putting millions of them at increased risk for serious medical conditions, including cardiovascular disease, type 2 diabetes mellitus, and...

ORIGINAL ARTICLE: Effects of Rimonabant on Metabolic Risk Factors in Overweight Patients with Dyslipidemia

Thu, 17Â NovÂ 2005 00:00:00 -05:00

Background: Rimonabant, a selective cannabinoid-1 receptor (CB1) blocker, has been shown to reduce body weight and improve cardiovascular risk factors in obese patients. The Rimonabant in ObesityâLipids (RIO-Lipids) study examined...

ORIGINAL ARTICLE: Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity

Thu, 17Â NovÂ 2005 00:00:00 -05:00

Background: Weight-loss medications are recommended as an adjunct to a comprehensive program of diet, exercise, and behavior therapy but are typically prescribed with minimal or no lifestyle modification. This practice...

EDITORIAL: Developmental Origins of Health and Disease

Matthew W. Gillman, M.D. — Thu, 27Â OctÂ 2005 00:00:00 -05:00

At first glance, it may seem implausible that your mother's exposure to stress or toxins while she was pregnant with you, how she fed you when you were an infant,...

REVIEW ARTICLE: Retinoid X Receptor Heterodimers in the Metabolic Syndrome

Andrew I. Shulman, Ph.D., and David J. Mangelsdorf, Ph.D. — Thu, 11Â AugÂ 2005 00:00:00 -05:00

The metabolic syndrome, also known as syndrome X, is characterized by abdominal obesity, atherogenic dyslipidemia, hypertension, insulin resistance, inflammation, and prothrombotic states.1 05081128.xml 05081128.xml 05081128.xml 05081128.xml Diagnostic of the metabolic...

EDITORIAL: Gastric Bypass and Nesidioblastosis â Too Much of a Good Thing for Islets?

David E. Cummings, M.D. — Thu, 21Â JulÂ 2005 00:00:00 -05:00

As the obesity pandemic continues to worsen and medical interventions remain only moderately effective, bariatric surgery is at present the only method that reliably results in major, long-term weight loss.12...

ORIGINAL ARTICLE: Hyperinsulinemic Hypoglycemia with Nesidioblastosis after Gastric-Bypass Surgery

Thu, 21Â JulÂ 2005 00:00:00 -05:00

We describe six patients (five women and one man; median age, 47 years; range, 39 to 54) with postprandial symptoms of neuroglycopenia owing to endogenous hyperinsulinemic hypoglycemia after Roux-en-Y gastric...

CLINICAL PRACTICE: Overweight Children and Adolescents

William H. Dietz, M.D., Ph.D., and Thomas N. Robinson, M.D., M.P.H. — Thu, 19Â MayÂ 2005 00:00:00 -05:00

A seven-year-old girl is 130 cm tall (51 in., the 90th percentile for girls of the same age) and weighs 34.6 kg (76 lb, above the 95th percentile), with a...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 12-2005 â A 30-Year-Old Woman with a Mediastinal Mass

Margaret A. Shipp, M.D., Suzanne L. Aquino, M.D., and Nancy Lee Harris, M.D. — Thu, 21Â AprÂ 2005 00:00:00 -05:00

Dr. Rameen Beroukhim (Medical Oncology): A 30-year-old woman was admitted to the hospital because of a fever and a mediastinal mass.

The patient had been in her usual state of health...

PERSPECTIVE: A Nutrition Paradox â Underweight and Obesity in Developing Countries

Benjamin Caballero, M.D., Ph.D. — Thu, 14Â AprÂ 2005 00:00:00 -05:00

A few years ago, I was visiting a primary care clinic in the slums of SÃ£o Paulo. The waiting room was full of mothers with thin, stunted young children, exhibiting...

SPECIAL REPORT: A Potential Decline in Life Expectancy in the United States in the 21st Century

Thu, 17Â MarÂ 2005 00:00:00 -05:00

Forecasts of life expectancy are an important component of public policy that influence age-based entitlement programs such as Social Security and Medicare. Although the Social Security Administration recently raised its...

EDITORIAL: Deadweight? â The Influence of Obesity on Longevity

Samuel H. Preston, Ph.D. — Thu, 17Â MarÂ 2005 00:00:00 -05:00

Obesity has clearly become a major personal and public health problem for Americans; it affects many aspects of our society. In this issue of the Journal, Olshansky et al.1 make...

EDITORIAL: Physical Activity, Relative Body Weight, and Risk of Death among Women

David R. Jacobs, Jr., Ph.D., and Mark A. Pereira, Ph.D. — Thu, 23Â DecÂ 2004 00:00:00 -05:00

In 1949, the late Ancel Keys warned of a possible epidemic of obesity.1 Keys wrote that under the right economic and social circumstances, obesity from overeating would be a dominant...

EDITORIAL: Bariatric Surgery â Quick Fix or Long-Term Solution?

Caren G. Solomon, M.D., M.P.H., and Robert G. Dluhy, M.D. — Thu, 23Â DecÂ 2004 00:00:00 -05:00

More than 30 percent of the U.S. population is obese (body-mass index [the weight in kilograms divided by the square of the height in meters], 30 or greater), and 4.9...

ORIGINAL ARTICLE: Adiposity as Compared with Physical Activity in Predicting Mortality among Women

Thu, 23Â DecÂ 2004 00:00:00 -05:00

Background: Whether higher levels of physical activity can counteract the elevated risk of death associated with adiposity is controversial.

Methods: We examined the associations of the body-mass index and physical activity...

ORIGINAL ARTICLE: Lifestyle, Diabetes, and Cardiovascular Risk Factors 10 Years after Bariatric Surgery

Thu, 23Â DecÂ 2004 00:00:00 -05:00

Background: Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown.

Methods: The prospective, controlled Swedish Obese Subjects...

REVIEW ARTICLE: Thiazolidinediones

Hannele Yki-JÃ¤rvinen, M.D., F.R.C.P. — Thu, 09Â SepÂ 2004 00:00:00 -05:00

Insulin resistance both precedes and predicts type 2 diabetes mellitus.1 Although exercise and weight loss ameliorate insulin resistance and may in some cases prevent or delay onset of the disease,2...

CLINICAL PROBLEM-SOLVING: Undercover and Overlooked

Andrew Wang, M.D., and Thomas M. Bashore, M.D. — Thu, 02Â SepÂ 2004 00:00:00 -05:00

A 67-year-old overweight man was seen by his physician because of a two-month history of shortness of breath, a nonproductive cough, and bilateral swelling of the lower extremities. He also...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 25-2004 â A 49-Year-Old Woman with Severe Obesity, Diabetes, and Hypertension

Thu, 12Â AugÂ 2004 00:00:00 -05:00

A 49-year-old woman was evaluated at this hospital for the management of obesity. She had been overweight since childhood; at the age of 10 years she weighed 45.4 kg, at...

ORIGINAL ARTICLE: Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease

Thu, 17Â JunÂ 2004 00:00:00 -05:00

Background: Liposuction has been proposed as a potential treatment for the metabolic complications of obesity. We evaluated the effect of large-volume abdominal liposuction on metabolic risk factors for coronary heart...

PERSPECTIVE: Thermodynamics, Liposuction, and Metabolism

David E. Kelley, M.D. — Thu, 17Â JunÂ 2004 00:00:00 -05:00

The regulation of body weight adheres to the principles of thermodynamics: a positive energy balance causes weight gain, and weight loss occurs when the energy expenditure exceeds intake. More than...

ORIGINAL ARTICLE: Obesity and the Metabolic Syndrome in Children and Adolescents

Thu, 03Â JunÂ 2004 00:00:00 -05:00

Background: The prevalence and magnitude of childhood obesity are increasing dramatically. We examined the effect of varying degrees of obesity on the prevalence of the metabolic syndrome and its relation...

PERSPECTIVE: Surgery for Severe Obesity

Robert Steinbrook, M.D. — Thu, 11Â MarÂ 2004 00:00:00 -05:00

The epidemic of obesity in the United States has spawned a second epidemic â of bariatric surgery. The number of gastrointestinal surgeries performed annually for severe obesity increased from about...

ORIGINAL ARTICLE: Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood

Thu, 26Â FebÂ 2004 00:00:00 -05:00

Background: The risk of type 2 diabetes mellitus is increased in people who have low birth weights and who subsequently become obese as adults. Whether their obesity originates in childhood...

PERSPECTIVE: Overweight in Childhood and Adolescence

William H. Dietz, M.D., Ph.D. — Thu, 26Â FebÂ 2004 00:00:00 -05:00

The prevalence of overweight doubled among children 6 to 11 years of age and tripled among those 12 to 17 years of age between the second National Health and Nutrition...

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Nerves, Fat, and Insulin Resistance

Guenther Boden, M.D., and Robert D. Hoeldtke, Ph.D., M.D. — Thu, 13Â NovÂ 2003 00:00:00 -05:00

Free fatty acids, the chief constituents of fat, are the main fuel for the heart and skeletal muscle under normal circumstances. Under special circumstances â such as exercise or exposure...

ORIGINAL ARTICLE: Inhibition of Food Intake in Obese Subjects by Peptide YY

Thu, 04Â SepÂ 2003 00:00:00 -05:00

Background: The gut hormone fragment peptide YY3â36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces food...

PERSPECTIVE: Prescription-Drug Coverage for Medicare Beneficiaries

John K. Iglehart — Thu, 04Â SepÂ 2003 00:00:00 -05:00

The Congressional Budget Office has estimated that all spending for prescription drugs by and on behalf of Medicare's eligible population will total $1.8 trillion during the period from 2004 through...

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Genetic Medicine and Obesity

Timothy John Aitman, M.D., Ph.D. — Thu, 22Â MayÂ 2003 00:00:00 -05:00

Almost all common diseases, such as coronary heart disease, diabetes, and obesity, are genetically complex traits. Although they appear to run in families, they have no clear pattern of inheritance...

EDITORIAL: Interpreting Incomplete Data in Studies of Diet and Weight Loss

James H. Ware, Ph.D. — Thu, 22Â MayÂ 2003 00:00:00 -05:00

The prevalence of obesity among Americans 20 to 74 years of age increased from 15 percent during the period between 1976 and 1980 to 27 percent in 19991 and continues...

ORIGINAL ARTICLE: A Randomized Trial of a Low-Carbohydrate Diet for Obesity

Thu, 22Â MayÂ 2003 00:00:00 -05:00

Background: Despite the popularity of the low-carbohydrate, high-protein, high-fat (Atkins) diet, no randomized, controlled trials have evaluated its efficacy.

Methods: We conducted a one-year, multicenter, controlled trial involving 63 obese men...

ORIGINAL ARTICLE: A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity

Thu, 22Â MayÂ 2003 00:00:00 -05:00

Background: The effects of a carbohydrate-restricted diet on weight loss and risk factors for atherosclerosis have been incompletely assessed.

Methods: We randomly assigned 132 severely obese subjects (including 77 blacks and...

PERSPECTIVE: Diet, Obesity, and Cardiovascular Risk

Robert O. Bonow, M.D., and Robert H. Eckel, M.D. — Thu, 22Â MayÂ 2003 00:00:00 -05:00

The growing prevalence of obesity and type 2 diabetes in the United States has attracted the attention and concern of the medical profession, the media, policymakers, and the American public....

ORIGINAL ARTICLE: Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

Thu, 24Â AprÂ 2003 00:00:00 -05:00

Background: The influence of excess body weight on the risk of death from cancer has not been fully characterized.

Methods: In a prospectively studied population of more than 900,000 U.S. adults...

PERSPECTIVE: Obesity and Mortality from Cancer

Hans-Olov Adami, M.D., and Dimitrios Trichopoulos, M.D. — Thu, 24Â AprÂ 2003 00:00:00 -05:00

Laboratory investigators have long known that animals in which energy intake is reduced to about 60 percent of the intake of animals that are fed as much as they want...

EDITORIAL: Exercise to Reduce Cardiovascular Risk â How Much Is Enough?

Thu, 07Â NovÂ 2002 00:00:00 -05:00

Increasing levels of physical activity are associated with a decrease in cardiovascular events. Controlled clinical trials suggest that exercise has benefits in persons with coronary artery disease and in those...

ORIGINAL ARTICLE: Effects of the Amount and Intensity of Exercise on Plasma Lipoproteins

Thu, 07Â NovÂ 2002 00:00:00 -05:00

Background: Increased physical activity is related to reduced risk of cardiovascular disease, possibly because it leads to improvement in the lipoprotein profile. However, the amount of exercise training required for...

CLINICAL PRACTICE: Initial Management of Glycemia in Type 2 Diabetes Mellitus

David M. Nathan, M.D. — Thu, 24Â OctÂ 2002 00:00:00 -05:00

After an overnight fast, an asymptomatic 45-year-old Hispanic man has a plasma glucose level of 142 mg per deciliter (7.9 mmol per liter) on initial evaluation and 139 mg per...

ORIGINAL ARTICLE: Decline in Physical Activity in Black Girls and White Girls during Adolescence

Thu, 05Â SepÂ 2002 00:00:00 -05:00

Background: Physical activity declines during adolescence, but the underlying reasons remain unknown.

Methods: We prospectively followed 1213 black girls and 1166 white girls enrolled in the National Heart, Lung, and Blood...

PERSPECTIVE: Physical Inactivity among Young People

Thu, 05Â SepÂ 2002 00:00:00 -05:00

It is widely recognized that the increasing proportion of overweight children and adolescents in the United States is a serious public health issue. Fifteen percent of young Americans are overweight...

CLINICAL PRACTICE: Obstructive Sleep Apnea

W. Ward Flemons, M.D. — Thu, 15Â AugÂ 2002 00:00:00 -05:00

A 43-year-old man presents with heavy snoring; his bed partner reports that he sometimes stops breathing while he sleeps. He admits to feeling sleepy at times when he drives, although...

EDITORIAL: Obesity and Heart Failure â Risk Factor or Mechanism?

Thu, 01Â AugÂ 2002 00:00:00 -05:00

As has been noted repeatedly by expert panels and the lay press, nearly 60 percent of the adult population of the United States is overweight or obese, with substantial resulting...

ORIGINAL ARTICLE: Obesity and the Risk of Heart Failure

Thu, 01Â AugÂ 2002 00:00:00 -05:00

Background: Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk.

Methods: We investigated the...

EDITORIAL: The Stomach Speaks â Ghrelin and Weight Regulation

Thu, 23Â MayÂ 2002 00:00:00 -05:00

Recent years have witnessed explosive growth in knowledge of the physiologic factors regulating appetite and body weight.1 Among these are neural, metabolic, and endocrine signals from the periphery that reflect...

ORIGINAL ARTICLE: Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery

Thu, 23Â MayÂ 2002 00:00:00 -05:00

Background: Weight loss causes changes in appetite and energy expenditure that promote weight regain. Ghrelin is a hormone that increases food intake in rodents and humans. If circulating ghrelin participates...

EDITORIAL: Childhood Obesity and a Diabetes Epidemic

Thu, 14Â MarÂ 2002 00:00:00 -05:00

Childhood obesity has reached epidemic proportions; worldwide, approximately 22 million children under five years of age are overweight.1 During the past three decades, the number of overweight children in the...

ORIGINAL ARTICLE: Prevalence of Impaired Glucose Tolerance among Children and Adolescents with Marked Obesity

Thu, 14Â MarÂ 2002 00:00:00 -05:00

Background: Childhood obesity, epidemic in the United States, has been accompanied by an increase in the prevalence of type 2 diabetes among children and adolescents. We determined the prevalence of...

REVIEW ARTICLE: Obesity

Susan Z. Yanovski, M.D., and Jack A. Yanovski, M.D., Ph.D. — Thu, 21Â FebÂ 2002 00:00:00 -05:00

Overweight and obesity are the most common nutritional disorders in the United States, affecting the majority of adults in the country. Given a normal body-mass index (defined as the weight...

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Resistin, Obesity, and Insulin Resistance â The Emerging Role of the Adipocyte as an Endocrine Organ

Thu, 01Â NovÂ 2001 00:00:00 -05:00

One hundred years ago, type 2 diabetes mellitus was considered a rare disease, but recently there has been an explosive increase in its incidence. About 16 million Americans have type...

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Inhibition of Food Intake by Inhibitors of Fatty Acid Synthase

Thu, 21Â DecÂ 2000 00:00:00 -05:00

According to a recent report from the World Health Organization, it can be estimated that worldwide about 250 million adults â 7 percent of the population â are obese, defined...

SPECIAL ARTICLE: A Prospective Study of Holiday Weight Gain

Thu, 23Â MarÂ 2000 00:00:00 -05:00

Background: It is commonly asserted that the average American gains 5 lb (2.3 kg) or more over the holiday period between Thanksgiving and New Year's Day, yet few data support...

EDITORIAL: Dieting and Exercise in Overweight, Lactating Women

Thu, 17Â FebÂ 2000 00:00:00 -05:00

In this issue of the Journal, Lovelady et al.1 report the results of a 10-week intervention trial in which 40 overweight, lactating women were randomly assigned either to a diet-and-exercise...

ORIGINAL ARTICLE: The Effect of Weight Loss in Overweight, Lactating Women on the Growth of Their Infants

Thu, 17Â FebÂ 2000 00:00:00 -05:00

Background: The retention of weight gained during pregnancy may contribute to obesity. Lactation should promote weight loss, but weight loss is highly variable among lactating women. The risks associated with...

EDITORIAL: The Prevention of Obesity

Thu, 07Â OctÂ 1999 00:00:00 -05:00

Until we have better data about the risks of being overweight and the benefits and risks of trying to lose weight, we should remember that the cure for obesity may...

ORIGINAL ARTICLE: Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults

Thu, 07Â OctÂ 1999 00:00:00 -05:00

Background: Body-mass index (the weight in kilograms divided by the square of the height in meters) is known to be associated with overall mortality. We investigated the effects of age,...

EDITORIAL: The Role of Leptin in Human Physiology

Thu, 16Â SepÂ 1999 00:00:00 -05:00

In humans, the relative long-term constancy of body weight, the difficulty of successfully sustaining intentional weight loss, and the metabolic and behavioral alterations that accompany weight change provide strong evidence...

ORIGINAL ARTICLE: Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

Thu, 16Â SepÂ 1999 00:00:00 -05:00

Severely obese (ob/ob) mice are deficient in the adipocyte-derived hormone leptin, which acts on the hypothalamus to control appetite and energy expenditure.1 The administration of leptin to these mice corrects...

REVIEW ARTICLE: Guidelines for Healthy Weight

Thu, 05Â AugÂ 1999 00:00:00 -05:00

Excess body fat is a cause of cardiovascular diseases, several important cancers, and numerous other medical conditions1 and is a growing problem in many countries. In the United States, for...

SOUNDING BOARD: Making Medicines Safer â The Need for an Independent Drug Safety Board

Thu, 17Â DecÂ 1998 00:00:00 -05:00

Dexfenfluramine (Redux) was withdrawn from the market in the United States in 1997 amid speculation that millions who used it could have been harmed.123 More recently, mibefradil (Posicor) was withdrawn...

ORIGINAL ARTICLE: Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

Thu, 01Â OctÂ 1998 00:00:00 -05:00

Background: There is increasing evidence of genetic factors leading to obesity, but the exact genes involved have not been defined. Peroxisome-proliferatorâactivated receptor Î³2 (PPARÎ³2) is a transcription factor that has...

EDITORIAL: Appetite Suppressants and Valvular Heart Disease

Thu, 10Â SepÂ 1998 00:00:00 -05:00

The populations of industrialized nations are becoming steadily more overweight as a result of changes in physical activity and diet. In recent years, concern about health and appearance has led...

ORIGINAL ARTICLE: An Assessment of Heart-Valve Abnormalities in Obese Patients Taking Dexfenfluramine, Sustained-Release Dexfenfluramine, or Placebo

Thu, 10Â SepÂ 1998 00:00:00 -05:00

Background: The appetite-suppressant drug fenfluramine, usually given in combination with phentermine, has been reported to be associated with cardiac valvular regurgitation. Concern has been raised that the d-enantiomer of fenfluramine,...

ORIGINAL ARTICLE: A Population-Based Study of Appetite-Suppressant Drugs and the Risk of Cardiac-Valve Regurgitation

Thu, 10Â SepÂ 1998 00:00:00 -05:00

Background: Recent case reports suggest that a combination of the appetite suppressants fenfluramine and phentermine is associated with an increased risk of cardiac-valve regurgitation. There are also reports of valvular...

ORIGINAL ARTICLE: The Prevalence of Cardiac Valvular Insufficiency Assessed by Transthoracic Echocardiography in Obese Patients Treated with Appetite-Suppressant Drugs

Thu, 10Â SepÂ 1998 00:00:00 -05:00

Background: After case reports of cardiac-valve abnormalities related to the use of appetite suppressants were published, we undertook a study to determine the prevalence of the problem using transthoracic echocardiography.

Methods:...

ORIGINAL ARTICLE: Effects of Metformin on Spontaneous and Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome

Thu, 25Â JunÂ 1998 00:00:00 -05:00

Background: Obese women with the polycystic ovary syndrome are relatively unresponsive to the induction of ovulation by clomiphene. We hypothesized that reducing insulin secretion by administering metformin would increase the...

EDITORIAL: High Prepregnancy Body-Mass Index â A MaternalâFetal Risk Factor

Thu, 15Â JanÂ 1998 00:00:00 -05:00

Obesity is one of the most common nutritional problems complicating pregnancy in developed countries. Maternal obesity has been defined in various ways, including a body weight above 80 to 114...

ORIGINAL ARTICLE: Prepregnancy Weight and the Risk of Adverse Pregnancy Outcomes

Thu, 15Â JanÂ 1998 00:00:00 -05:00

Background: Obesity before pregnancy is associated with an increased risk of several adverse outcomes of pregnancy. The risk profiles among lean, normal, or mildly overweight women are not, however, well...

EDITORIAL: Losing Weight â An Ill-Fated New Year's Resolution

Thu, 01Â JanÂ 1998 00:00:00 -05:00

Today, at the start of the new year, millions of Americans will resolve to lose weight, but by tomorrow, or next week, or maybe next month, most of them will...

ORIGINAL ARTICLE: The Effect of Age on the Association between Body-Mass Index and Mortality

Thu, 01Â JanÂ 1998 00:00:00 -05:00

Background: The effect of age on optimal body weight is controversial, and few studies have had adequate numbers of subjects to analyze mortality as a function of body-mass index across...

EDITORIAL: Obesity in Adulthood â The Importance of Childhood and Parental Obesity

Thu, 25Â SepÂ 1997 00:00:00 -05:00

Obesity is a common condition with delayed and usually late-onset consequences. Since the prevalence of obesity is high and still growing, it is important to understand who is at risk...

ORIGINAL ARTICLE: Predicting Obesity in Young Adulthood from Childhood and Parental Obesity

Thu, 25Â SepÂ 1997 00:00:00 -05:00

Background: Childhood obesity increases the risk of obesity in adulthood, but how parental obesity affects the chances of a child's becoming an obese adult is unknown. We investigated the risk...

EDITORIAL: Diet Pills Redux

Thu, 28Â AugÂ 1997 00:00:00 -05:00

Between 1967 and 1972, there was a serious outbreak of primary pulmonary hypertension in Western Europe.1 The incidence of the disorder among patients seen at major cardiac catheterization centers in...

EDITORIAL: Diet Pills Redux

Thu, 28Â AugÂ 1997 00:00:00 -05:00

ORIGINAL ARTICLE: Fatal Pulmonary Hypertension Associated with Short-Term Use of Fenfluramine and Phentermine

Thu, 28Â AugÂ 1997 00:00:00 -05:00

The dangers inherent in marked obesity have prompted physicians to advocate more aggressive strategies for weight reduction. One current strategy is the prescription of fenfluramine,12 either alone or in combination...

ORIGINAL ARTICLE: Fatal Pulmonary Hypertension Associated with Short-Term Use of Fenfluramine and Phentermine

Thu, 28Â AugÂ 1997 00:00:00 -05:00

REVIEW ARTICLE: Obesity

Michael Rosenbaum, M.D., Rudolph L. Leibel, M.D., and Jules Hirsch, M.D. — Thu, 07Â AugÂ 1997 00:00:00 -05:00

Obesity is the most common and costly nutritional problem in the United States, affecting approximately 33 percent of adults.1 Health care costs directly attributable to obesity amount to approximately $68...

EDITORIAL: Pharmacotherapy for Obesity â Do the Benefits Outweigh the Risks?

Thu, 29Â AugÂ 1996 00:00:00 -05:00

An association between appetite-suppressant drugs and primary pulmonary hypertension is reported by Abenhaim et al. in this issue of the Journal.1 This important finding requires careful assessment, because the prevalence...

EDITORIAL: Insulin and the Polycystic Ovary Syndrome

Thu, 29Â AugÂ 1996 00:00:00 -05:00

The cardinal clinical manifestations of the polycystic ovary syndrome are hirsutism and anovulation, oligomenorrhea, or amenorrhea. About half the women with this syndrome are obese, and some have diabetes mellitus....

ORIGINAL ARTICLE: Decreases in Ovarian Cytochrome P450c17Î± Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome

John E. Nestler, M.D., and Daniela J. Jakubowicz, M.D. — Thu, 29Â AugÂ 1996 00:00:00 -05:00

Background: Insulin resistance and increased ovarian cytochrome P450c17Î± activity are both features of the polycystic ovary syndrome. P450c17Î±, which is involved in androgen biosynthesis, has both 17Î±-hydroxylase and 17,20-lyase activities....

REVIEW ARTICLE: Non-Insulin-Dependent Diabetes Mellitus â A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance

Kenneth S. Polonsky, M.D., Jeppe Sturis, Ph.D., and Graeme I. Bell, Ph.D. — Thu, 21Â MarÂ 1996 00:00:00 -05:00

Non-insulin-dependent diabetes mellitus (NIDDM), the commonest form of diabetes, affects approximately 5 percent of the population of the United States. Although the pathophysiology of this condition has not been fully...

EDITORIAL: Obesity, Leptin, and the Brain

Thu, 01Â FebÂ 1996 00:00:00 -05:00

The notion that genetic abnormalities contribute to obesity gained important support with the identification of the ob gene and its protein product in 1994.1 The ob protein, termed âleptinâ from...

ORIGINAL ARTICLE: Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Thu, 01Â FebÂ 1996 00:00:00 -05:00

Background: Leptin, the product of the ob gene, is a hormone secreted by adipocytes. Animals with mutations in the ob gene are obese and lose weight when given leptin, but...

REVIEW ARTICLE: Obstructive Sleep Apnea

Patrick J. Strollo, Jr., M.D., and Robert M. Rogers, M.D. — Thu, 11Â JanÂ 1996 00:00:00 -05:00

Our understanding of the nature and consequences of upper-airway obstruction in adults during sleep has evolved considerably over the past two decades. Sleep apnea â defined as repeated episodes of...

NEJM â Collection Updates for Obesity

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Î±-Adrenergic Receptors and Type 2 Diabetes

OTHER POINTS OF VIEW: Taxing âSin Foodsâ â Obesity Prevention and Public Health Policy

SPECIAL ARTICLE: Forecasting the Effects of Obesity and Smoking on U.S. Life Expectancy

BOOK REVIEW:

EDITORIAL: Surgical Treatment of Obesity â Weighing the Facts

ORIGINAL ARTICLE: Perioperative Safety in the Longitudinal Assessment of Bariatric Surgery

BOOK REVIEW:

BOOK REVIEW:

HEALTH LAW, ETHICS, AND HUMAN RIGHTS: New York City's War on Fat

EDITORIAL: Brown Adipose Tissue â When It Pays to Be Inefficient

ORIGINAL ARTICLE: Functional Brown Adipose Tissue in Healthy Adults

ORIGINAL ARTICLE: Identification and Importance of Brown Adipose Tissue in Adult Humans

ORIGINAL ARTICLE: Cold-Activated Brown Adipose Tissue in Healthy Men

EDITORIAL: Weight-Loss Diets for the Prevention and Treatment of Obesity

ORIGINAL ARTICLE: Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates

ORIGINAL ARTICLE: Weight Loss to Treat Urinary Incontinence in Overweight and Obese Women

ORIGINAL ARTICLE: Modulation of Blood Pressure by Central Melanocortinergic Pathways

EDITORIAL: Energy In, Energy Out, and the Effects of Obesity-Related Genes

ORIGINAL ARTICLE: An Obesity-Associated Gene Variant and Increased Energy Intake in Children

ORIGINAL ARTICLE: General and Abdominal Adiposity and Risk of Death in Europe

CLINICAL IMPLICATIONS OF BASIC RESEARCH: The Exercise Pill â Too Good to Be True?

BOOK REVIEW:

ORIGINAL ARTICLE: Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome

PERSPECTIVE: The Power of the Extreme in Elucidating Obesity

ORIGINAL ARTICLE: Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 20-2008 â A 57-Year-Old Woman with Abdominal Pain and Weakness after Gastric Bypass Surgery

CLINICAL PRACTICE: Nonsurgical Management of Obesity in Adults

ORIGINAL ARTICLE: Association between Obesity during Pregnancy and Increased Use of Health Care

CLINICAL DECISIONS: Management of Type 2 Diabetes

SPECIAL ARTICLE: Adolescent Overweight and Future Adult Coronary Heart Disease

ORIGINAL ARTICLE: Childhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood

PERSPECTIVE: Childhood Obesity â The Shape of Things to Come

CLINICAL PRACTICE: Hypertriglyceridemia

EDITORIAL: The Missing Link â Lose Weight, Live Longer

ORIGINAL ARTICLE: Long-Term Mortality after Gastric Bypass Surgery

ORIGINAL ARTICLE: Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects

EDITORIAL: Network Medicine â From Obesity to the âDiseasomeâ

SPECIAL ARTICLE: The Spread of Obesity in a Large Social Network over 32 Years

CLINICAL THERAPEUTICS: Bariatric Surgery for Morbid Obesity

ORIGINAL ARTICLE: Clinical and Molecular Genetic Spectrum of Congenital Deficiency of the Leptin Receptor

PERSPECTIVE: Obesity and Diabetes in the Developing World â A Growing Challenge

EDITORIAL: Angiotensin-ConvertingâEnzyme Inhibitors for Impaired Glucose Tolerance â Is There Still Hope?

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 31-2006 â A 15-Year-Old Girl with Severe Obesity

IMAGES IN CLINICAL MEDICINE: Skin Redundancy after Massive Weight Loss

ORIGINAL ARTICLE: Body-Mass Index and Mortality in Korean Men and Women

ORIGINAL ARTICLE: Overweight, Obesity, and Mortality in a Large Prospective Cohort of Persons 50 to 71 Years Old

PERSPECTIVE: Overweight and Mortality among Baby Boomers â Now We're Getting Personal

HEALTH POLICY REPORT: Obesity â The New Frontier of Public Health Law

EDITORIAL: Retinol-Binding Protein 4, Insulin Resistance, and Type 2 Diabetes

ORIGINAL ARTICLE: Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

PERSPECTIVE: Food Marketing and Childhood Obesity â A Matter of Policy

ORIGINAL ARTICLE: Body-Mass Index and Symptoms of Gastroesophageal Reflux in Women

IMAGES IN CLINICAL MEDICINE: Pellagra-like Dermatitis

EDITORIAL:

ORIGINAL ARTICLE: Effects of Rimonabant on Metabolic Risk Factors in Overweight Patients with Dyslipidemia

ORIGINAL ARTICLE: Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity

EDITORIAL: Developmental Origins of Health and Disease

REVIEW ARTICLE: Retinoid X Receptor Heterodimers in the Metabolic Syndrome

EDITORIAL: Gastric Bypass and Nesidioblastosis â Too Much of a Good Thing for Islets?

ORIGINAL ARTICLE: Hyperinsulinemic Hypoglycemia with Nesidioblastosis after Gastric-Bypass Surgery

CLINICAL PRACTICE: Overweight Children and Adolescents

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 12-2005 â A 30-Year-Old Woman with a Mediastinal Mass

PERSPECTIVE: A Nutrition Paradox â Underweight and Obesity in Developing Countries

SPECIAL REPORT: A Potential Decline in Life Expectancy in the United States in the 21st Century

EDITORIAL: Deadweight? â The Influence of Obesity on Longevity

EDITORIAL: Physical Activity, Relative Body Weight, and Risk of Death among Women

EDITORIAL: Bariatric Surgery â Quick Fix or Long-Term Solution?

ORIGINAL ARTICLE: Adiposity as Compared with Physical Activity in Predicting Mortality among Women

ORIGINAL ARTICLE: Lifestyle, Diabetes, and Cardiovascular Risk Factors 10 Years after Bariatric Surgery

REVIEW ARTICLE: Thiazolidinediones

CLINICAL PROBLEM-SOLVING: Undercover and Overlooked

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 25-2004 â A 49-Year-Old Woman with Severe Obesity, Diabetes, and Hypertension

ORIGINAL ARTICLE: Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease

PERSPECTIVE: Thermodynamics, Liposuction, and Metabolism

ORIGINAL ARTICLE: Obesity and the Metabolic Syndrome in Children and Adolescents

PERSPECTIVE: Surgery for Severe Obesity

ORIGINAL ARTICLE: Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood

PERSPECTIVE: Overweight in Childhood and Adolescence

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Nerves, Fat, and Insulin Resistance

NEJM â Collection Updates for Obesity

OTHER POINTS OF VIEW: Taxing âSin Foodsâ â Obesity Prevention and Public Health Policy

EDITORIAL: Surgical Treatment of Obesity â Weighing the Facts

EDITORIAL: Brown Adipose Tissue â When It Pays to Be Inefficient

CLINICAL IMPLICATIONS OF BASIC RESEARCH: The Exercise Pill â Too Good to Be True?

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 20-2008 â A 57-Year-Old Woman with Abdominal Pain and Weakness after Gastric Bypass Surgery

PERSPECTIVE: Childhood Obesity â The Shape of Things to Come

EDITORIAL: The Missing Link â Lose Weight, Live Longer

EDITORIAL: Network Medicine â From Obesity to the âDiseasomeâ

PERSPECTIVE: Obesity and Diabetes in the Developing World â A Growing Challenge

EDITORIAL: Angiotensin-ConvertingâEnzyme Inhibitors for Impaired Glucose Tolerance â Is There Still Hope?

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 31-2006 â A 15-Year-Old Girl with Severe Obesity

PERSPECTIVE: Overweight and Mortality among Baby Boomers â Now We're Getting Personal

HEALTH POLICY REPORT: Obesity â The New Frontier of Public Health Law

PERSPECTIVE: Food Marketing and Childhood Obesity â A Matter of Policy

EDITORIAL: Gastric Bypass and Nesidioblastosis â Too Much of a Good Thing for Islets?

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 12-2005 â A 30-Year-Old Woman with a Mediastinal Mass

PERSPECTIVE: A Nutrition Paradox â Underweight and Obesity in Developing Countries

EDITORIAL: Deadweight? â The Influence of Obesity on Longevity

EDITORIAL: Bariatric Surgery â Quick Fix or Long-Term Solution?

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 25-2004 â A 49-Year-Old Woman with Severe Obesity, Diabetes, and Hypertension

EDITORIAL: Exercise to Reduce Cardiovascular Risk â How Much Is Enough?

EDITORIAL: Obesity and Heart Failure â Risk Factor or Mechanism?

EDITORIAL: The Stomach Speaks â Ghrelin and Weight Regulation

CLINICAL IMPLICATIONS OF BASIC RESEARCH: Resistin, Obesity, and Insulin Resistance â The Emerging Role of the Adipocyte as an Endocrine Organ

SOUNDING BOARD: Making Medicines Safer â The Need for an Independent Drug Safety Board

EDITORIAL: High Prepregnancy Body-Mass Index â A MaternalâFetal Risk Factor

EDITORIAL: Losing Weight â An Ill-Fated New Year's Resolution

EDITORIAL: Obesity in Adulthood â The Importance of Childhood and Parental Obesity

EDITORIAL: Pharmacotherapy for Obesity â Do the Benefits Outweigh the Risks?

REVIEW ARTICLE: Non-Insulin-Dependent Diabetes Mellitus â A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance