http://content.nejm.org/ The New England Journal of Medicine (NEJM) RSS feed — collection updates for Coronary Disease. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. http://content.nejm.org/icons/nejm_name_220.gifhttp://content.nejm.org/The New England Journal of Medicine is owned, published, and copyrighted © 2010 Massachusetts Medical Society. All rights reserved.en-usLp(a) lipoprotein, which was initially described in 1963,1 is a circulating macromolecule consisting of a low-density lipoprotein (LDL) particle that is covalently linked to a protein called apolipoprotein(a). Plasma Lp(a)...http://content.nejm.org/cgi/content/short/361/26/2573?rss=1&ssource=collectionSearchRss&queryTerm=10Sekar Kathiresan, M.D.Thu, 24  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/26/2573?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In most patients with stable coronary artery disease, plasma cardiac troponin T levels are below the limit of detection for the conventional assay. The distribution and determinants of very...http://content.nejm.org/cgi/content/short/361/26/2538?rss=1&ssource=collectionSearchRss&queryTerm=10Torbjørn Omland, M.D., Ph.D., M.P.H., James A. de Lemos, M.D., Marc S. Sabatine, M.D., M.P.H., Costas A. Christophi, Ph.D., Madeline Murguia Rice, Ph.D., Kathleen A. Jablonski, Ph.D., Solve Tjora, M.D., Michael J. Domanski, M.D., Bernard J. Gersh, M.B., Ch.B., D.Phil., Jean L. Rouleau, M.D., Marc A. Pfeffer, M.D., Ph.D., and Eugene Braunwald, M.D., for the Prevention of Events with Angiotensin Converting Enzyme Inhibition (PEACE) Trial InvestigatorsThu, 24  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/26/2538?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> An increased level of Lp(a) lipoprotein has been identified as a risk factor for coronary artery disease that is highly heritable. The genetic determinants of the Lp(a) lipoprotein level...http://content.nejm.org/cgi/content/short/361/26/2518?rss=1&ssource=collectionSearchRss&queryTerm=10Robert Clarke, F.R.C.P., John F. Peden, Ph.D., Jemma C. Hopewell, Ph.D., Theodosios Kyriakou, Ph.D., Anuj Goel, M.Sc., Simon C. Heath, Ph.D., Sarah Parish, D.Phil., Simona Barlera, M.S., Maria Grazia Franzosi, Ph.D., Stephan Rust, Ph.D., Derrick Bennett, Ph.D., Angela Silveira, Ph.D., Anders Malarstig, Ph.D., Fiona R. Green, Ph.D., Mark Lathrop, Ph.D., Bruna Gigante, M.D., Karin Leander, Ph.D., Ulf de Faire, M.D., Udo Seedorf, Ph.D., Anders Hamsten, F.R.C.P., Rory Collins, F.R.C.P., Hugh Watkins, F.R.C.P., and Martin Farrall, F.R.C.Path., for the PROCARDIS ConsortiumThu, 24  Dec  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/26/2518?rss=1&ssource=collectionSearchRss&queryTerm=10The thienopyridine clopidogrel, which irreversibly blocks the adenosine diphosphate (ADP) receptor P2Y12 on platelets, has become an essential component of therapy in patients with acute coronary syndromes, because it significantly...http://content.nejm.org/cgi/content/short/361/11/1108?rss=1&ssource=collectionSearchRss&queryTerm=10Albert Schömig, M.D.Thu, 10  Sep  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/11/1108?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel.<br/><br/><em>Methods:</em> In this multicenter,...http://content.nejm.org/cgi/content/short/361/11/1045?rss=1&ssource=collectionSearchRss&queryTerm=10Lars Wallentin, M.D., Ph.D., Richard C. Becker, M.D., Andrzej Budaj, M.D., Ph.D., Christopher P. Cannon, M.D., Håkan Emanuelsson, M.D., Ph.D., Claes Held, M.D., Ph.D., Jay Horrow, M.D., Steen Husted, M.D., D.Sc., Stefan James, M.D., Ph.D., Hugo Katus, M.D., Kenneth W. Mahaffey, M.D., Benjamin M. Scirica, M.D., M.P.H.,Allan Skene, Ph.D., Philippe Gabriel Steg, M.D., Robert F. Storey, M.D., D.M., and Robert A. Harrington, M.D., for the PLATO InvestigatorsThu, 10  Sep  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/11/1045?rss=1&ssource=collectionSearchRss&queryTerm=10The Food and Drug Administration (FDA) approved prasugrel on July 10, 2009. Developed by Eli Lilly and Daiichi Sankyo, prasugrel is a thienopyridine that inhibits platelet aggregation. It was approved...http://content.nejm.org/cgi/content/short/361/10/942?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 03  Sep  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/10/942?rss=1&ssource=collectionSearchRss&queryTerm=10On July 10, 2009, after an 18-month review, the Food and Drug Administration (FDA) approved the thienopyridine prasugrel for use in patients with unstable angina or myocardial infarction who undergo...http://content.nejm.org/cgi/content/short/361/10/940?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 03  Sep  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/10/940?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Vein-graft harvesting with the use of endoscopy (endoscopic harvesting) is a technique that is widely used to reduce postoperative wound complications after coronary-artery bypass grafting (CABG), but the long-term...http://content.nejm.org/cgi/content/short/361/3/235?rss=1&ssource=collectionSearchRss&queryTerm=10Renato D. Lopes, M.D., Ph.D., Gail E. Hafley, M.S., Keith B. Allen, M.D., T. Bruce Ferguson, M.D., Eric D. Peterson, M.D., M.P.H., Robert A. Harrington, M.D., Rajendra H. Mehta, M.D., C. Michael Gibson, M.D., Michael J. Mack, M.D., Nicholas T. Kouchoukos, M.D., Robert M. Califf, M.D., and John H. Alexander, M.D., M.H.S.Thu, 16  Jul  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/361/3/235?rss=1&ssource=collectionSearchRss&queryTerm=10The prevalence of diabetes mellitus is rising at an alarming rate and is projected to more than double by 2030.1 The disease currently afflicts 171 million people worldwide, with 23.6...http://content.nejm.org/cgi/content/short/360/24/2570?rss=1&ssource=collectionSearchRss&queryTerm=10William E. Boden, M.D., and David P. Taggart, M.D., Ph.D.Thu, 11  Jun  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/24/2570?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Optimal treatment for patients with both type 2 diabetes mellitus and stable ischemic heart disease has not been established.<br/><br/><em>Methods:</em> We randomly assigned 2368 patients with both type 2 diabetes...http://content.nejm.org/cgi/content/short/360/24/2503?rss=1&ssource=collectionSearchRss&queryTerm=10The BARI 2D Study GroupThu, 11  Jun  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/24/2503?rss=1&ssource=collectionSearchRss&queryTerm=10In the United States, more than a million people are hospitalized annually with unstable angina or myocardial infarction without ST-segment elevation, so-called acute coronary syndromes. For these patients, several treatments...http://content.nejm.org/cgi/content/short/360/21/2237?rss=1&ssource=collectionSearchRss&queryTerm=10L. David Hillis, M.D., and Richard A. Lange, M.D.Thu, 21  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/21/2237?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Glycoprotein IIb/IIIa inhibitors are indicated in patients with acute coronary syndromes who are undergoing an invasive procedure. The optimal timing of the initiation of such therapy is unknown.<br/><br/><em>Methods:</em> We...http://content.nejm.org/cgi/content/short/360/21/2176?rss=1&ssource=collectionSearchRss&queryTerm=10Robert P. Giugliano, M.D., S.M., Jennifer A. White, M.S., Christoph Bode, M.D., Paul W. Armstrong, M.D., Gilles Montalescot, M.D., Basil S. Lewis, M.D., Arnoud van `t Hof, M.D., Lisa G. Berdan, P.A., M.H.S., Kerry L. Lee, Ph.D., John T. Strony, M.D., Steven Hildemann, M.D., Enrico Veltri, M.D., Frans Van de Werf, M.D., Ph.D., Eugene Braunwald, M.D., Robert A. Harrington, M.D., Robert M. Califf, M.D., and L. Kristin Newby, M.D., M.H.S., for the EARLY ACS InvestigatorsThu, 21  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/21/2176?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Earlier trials have shown that a routine invasive strategy improves outcomes in patients with acute coronary syndromes without ST-segment elevation. However, the optimal timing of such intervention remains uncertain.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/360/21/2165?rss=1&ssource=collectionSearchRss&queryTerm=10Shamir R. Mehta, M.D., M.Sc., Christopher B. Granger, M.D., William E. Boden, M.D., Philippe Gabriel Steg, M.D., Jean-Pierre Bassand, M.D., David P. Faxon, M.D., Rizwan Afzal, M.Sc., Susan Chrolavicius, R.N., Sanjit S. Jolly, M.D., M.Sc., Petr Widimsky, M.D., Alvaro Avezum, M.D., Hans-Jurgen Rupprecht, M.D., Jun Zhu, M.D., Jacques Col, M.D., Madhu K. Natarajan, M.D., M.Sc., Craig Horsman, B.Sc., Keith A.A. Fox, M.B., Ch.B., and Salim Yusuf, M.B., B.S., D.Phil., for the TIMACS InvestigatorsThu, 21  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/21/2165?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> There is no consensus regarding the safety and efficacy of drug-eluting stents, as compared with bare-metal stents, in patients with ST-segment elevation myocardial infarction who are undergoing primary percutaneous...http://content.nejm.org/cgi/content/short/360/19/1946?rss=1&ssource=collectionSearchRss&queryTerm=10Gregg W. Stone, M.D., Alexandra J. Lansky, M.D., Stuart J. Pocock, Ph.D.,Bernard J. Gersh, M.B., Ch.B., D.Phil., George Dangas, M.D., Ph.D., S. Chiu Wong, M.D., Bernhard Witzenbichler, M.D., Giulio Guagliumi, M.D., Jan Z. Peruga, M.D., Bruce R. Brodie, M.D., Dariusz Dudek, M.D., Martin Möckel, M.D., Andrzej Ochala, M.D., Alison Kellock, B.S., Helen Parise, Sc.D., and Roxana Mehran, M.D., for the HORIZONS-AMI Trial InvestigatorsThu, 07  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/19/1946?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The long-term safety and efficacy of drug-eluting coronary stents have been questioned.<br/><br/><em>Methods:</em> We evaluated 47,967 patients in Sweden who received a coronary stent and were entered into the Swedish...http://content.nejm.org/cgi/content/short/360/19/1933?rss=1&ssource=collectionSearchRss&queryTerm=10Stefan K. James, M.D., Ph.D., Ulf Stenestrand, M.D., Ph.D., Johan Lindbäck, M.Sc., Jörg Carlsson, M.D., Ph.D., Fredrik Scherstén, M.D., Ph.D., Tage Nilsson, M.D., Ph.D., Lars Wallentin, M.D., Ph.D., and Bo Lagerqvist, M.D., Ph.D., for the SCAAR Study GroupThu, 07  May  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/19/1933?rss=1&ssource=collectionSearchRss&queryTerm=10Congestive heart failure is one of the leading causes of death and complications in the developed world, and coronary artery disease is the major cause of heart failure. Efforts to...http://content.nejm.org/cgi/content/short/360/17/1781?rss=1&ssource=collectionSearchRss&queryTerm=10Howard J. Eisen, M.D.Thu, 23  Apr  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/17/1781?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Surgical ventricular reconstruction is a specific procedure designed to reduce left ventricular volume in patients with heart failure caused by coronary artery disease. We conducted a trial to address...http://content.nejm.org/cgi/content/short/360/17/1705?rss=1&ssource=collectionSearchRss&queryTerm=10Robert H. Jones, M.D., Eric J. Velazquez, M.D., Robert E. Michler, M.D., George Sopko, M.D., Jae K. Oh, M.D., Christopher M. O'Connor, M.D., James A. Hill, M.D., Lorenzo Menicanti, M.D., Zygmunt Sadowski, M.D., Patrice Desvigne-Nickens, M.D., Jean-Lucien Rouleau, M.D., and Kerry L. Lee, Ph.D., for the STICH Hypothesis 2 InvestigatorsThu, 23  Apr  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/17/1705?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Percutaneous coronary intervention (PCI) involving drug-eluting stents is increasingly used to treat complex coronary artery disease, although coronary-artery bypass grafting (CABG) has been the treatment of choice historically. Our...http://content.nejm.org/cgi/content/short/360/10/961?rss=1&ssource=collectionSearchRss&queryTerm=10Patrick W. Serruys, M.D., Ph.D., Marie-Claude Morice, M.D., A. Pieter Kappetein, M.D., Ph.D., Antonio Colombo, M.D., David R. Holmes, M.D., Michael J. Mack, M.D., Elisabeth Ståhle, M.D., Ted E. Feldman, M.D., Marcel van den Brand, M.D., Eric J. Bass, B.A., Nic Van Dyck, R.N., Katrin Leadley, M.D., Keith D. Dawkins, M.D., and Friedrich W. Mohr, M.D., Ph.D., for the SYNTAX InvestigatorsThu, 05  Mar  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/10/961?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary-artery bypass grafting (CABG), introduced in 1968, was the only method of coronary revascularization until 1977, when percutaneous balloon angioplasty was first performed. The complications of balloon angioplasty (acute vessel...http://content.nejm.org/cgi/content/short/360/10/1024?rss=1&ssource=collectionSearchRss&queryTerm=10Richard A. Lange, M.D., and L. David Hillis, M.D.Thu, 05  Mar  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/10/1024?rss=1&ssource=collectionSearchRss&queryTerm=10In the international SYNTAX trial, 1800 patients with three-vessel or left main coronary artery disease were randomly assigned to either revascularization with coronary-artery bypass grafting (CABG) or percutaneous coronary intervention...http://content.nejm.org/cgi/content/short/360/8/e10?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 19  Feb  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/8/e10?rss=1&ssource=collectionSearchRss&queryTerm=10The broad goals of treatment for patients with coronary artery disease are improvement in survival and a reduction in the risk of myocardial infarction and symptoms of coronary disease. The...http://content.nejm.org/cgi/content/short/360/3/292?rss=1&ssource=collectionSearchRss&queryTerm=10Stephen G. Ellis, M.D.Thu, 15  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/3/292?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients with multivessel coronary artery disease who are undergoing percutaneous coronary intervention (PCI), coronary angiography is the standard method for guiding the placement of the stent. It is...http://content.nejm.org/cgi/content/short/360/3/213?rss=1&ssource=collectionSearchRss&queryTerm=10Pim A.L. Tonino, M.D., Bernard De Bruyne, M.D., Ph.D., Nico H.J. Pijls, M.D., Ph.D., Uwe Siebert, M.D., M.P.H., Sc.D., Fumiaki Ikeno, M.D., Marcel van `t Veer, M.Sc., Volker Klauss, M.D., Ph.D., Ganesh Manoharan, M.D., Thomas Engstrøm, M.D., Ph.D., Keith G. Oldroyd, M.D., Peter N. Ver Lee, M.D., Philip A. MacCarthy, M.D., Ph.D., and William F. Fearon, M.D., for the FAME Study InvestigatorsThu, 15  Jan  2009 00:00:00 -05:00http://content.nejm.org/cgi/content/short/360/3/213?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The accuracy of multidetector computed tomographic (CT) angiography involving 64 detectors has not been well established.<br/><br/><em>Methods:</em> We conducted a multicenter study to examine the accuracy of 64-row, 0.5-mm multidetector...http://content.nejm.org/cgi/content/short/359/22/2324?rss=1&ssource=collectionSearchRss&queryTerm=10Julie M. Miller, M.D., Carlos E. Rochitte, M.D., Marc Dewey, M.D., Armin Arbab-Zadeh, M.D., Hiroyuki Niinuma, M.D., Ph.D., Ilan Gottlieb, M.D., Narinder Paul, M.D., Melvin E. Clouse, M.D., Edward P. Shapiro, M.D., John Hoe, M.D., Albert C. Lardo, Ph.D., David E. Bush, M.D., Albert de Roos, M.D., Christopher Cox, Ph.D., Jeffery Brinker, M.D., and João A.C. Lima, M.D.Thu, 27  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/22/2324?rss=1&ssource=collectionSearchRss&queryTerm=10Persons who survive a myocardial infarction are at increased risk for sudden death from cardiac causes, owing largely to ventricular tachyarrhythmias.12 The risk of sudden death after a myocardial infarction...http://content.nejm.org/cgi/content/short/359/21/2245?rss=1&ssource=collectionSearchRss&queryTerm=10Robert J. Myerburg, M.D.Thu, 20  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/21/2245?rss=1&ssource=collectionSearchRss&queryTerm=10To the Editor: Recognition of characteristic changes in an electrocardiogram (ECG) that are associated with acute occlusion of a coronary artery guides decisions regarding immediate reperfusion therapy.123 Working from our...http://content.nejm.org/cgi/content/short/359/19/2071?rss=1&ssource=collectionSearchRss&queryTerm=10Robbert J. de Winter, M.D., Ph.D., Niels J.W. Verouden, M.D., Hein J.J. Wellens, M.D., Ph.D., Arthur A.M. Wilde, M.D., Ph.D., and of the Academic Medical CenterThu, 06  Nov  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/19/2071?rss=1&ssource=collectionSearchRss&queryTerm=10Twenty-five years ago, care for patients with symptomatic coronary artery disease centered on the selection and titration of antianginal medications. Percutaneous coronary intervention (PCI), which was limited at that time...http://content.nejm.org/cgi/content/short/359/7/751?rss=1&ssource=collectionSearchRss&queryTerm=10Eric D. Peterson, M.D., M.P.H., and John S. Rumsfeld, M.D., Ph.D.Thu, 14  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/7/751?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Whether bivalirudin is superior to unfractionated heparin in patients with stable or unstable angina who undergo percutaneous coronary intervention (PCI) after pretreatment with clopidogrel is unknown.<br/><br/><em>Methods:</em> We enrolled 4570...http://content.nejm.org/cgi/content/short/359/7/688?rss=1&ssource=collectionSearchRss&queryTerm=10Adnan Kastrati, M.D., Franz-Josef Neumann, M.D., Julinda Mehilli, M.D., Robert A. Byrne, M.B., M.R.C.P.I., Raisuke Iijima, M.D., Heinz Joachim Büttner, M.D., Ahmed A. Khattab, M.D., Stefanie Schulz, M.D., James C. Blankenship, M.D., Jürgen Pache, M.D., Jan Minners, M.D., Melchior Seyfarth, M.D., Isolde Graf, Pharm.D., Kimberly A. Skelding, M.D., Josef Dirschinger, M.D., Gert Richardt, M.D., Peter B. Berger, M.D., and Albert Schömig, M.D., for the ISAR-REACT 3 Trial InvestigatorsThu, 14  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/7/688?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> It has not been clearly established whether percutaneous coronary intervention (PCI) can provide an incremental benefit in quality of life over that provided by optimal medical therapy among patients...http://content.nejm.org/cgi/content/short/359/7/677?rss=1&ssource=collectionSearchRss&queryTerm=10William S. Weintraub, M.D., John A. Spertus, M.D., M.P.H., Paul Kolm, Ph.D., David J. Maron, M.D., Zefeng Zhang, M.D., Ph.D., Claudine Jurkovitz, M.D., M.P.H., Wei Zhang, M.S., Pamela M. Hartigan, Ph.D., Cheryl Lewis, R.N., Emir Veledar, Ph.D., Jim Bowen, B.S., Sandra B. Dunbar, D.S.N., Christi Deaton, Ph.D., Stanley Kaufman, M.D., Robert A. O'Rourke, M.D., Ron Goeree, M.S., Paul G. Barnett, Ph.D., Koon K. Teo, M.D., and William E. Boden, M.D., for the COURAGE Trial Research GroupThu, 14  Aug  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/7/677?rss=1&ssource=collectionSearchRss&queryTerm=10Every year, 500,000 people in the United States have an ST-elevation myocardial infarction.1 Timely and effective reperfusion with the use of either primary percutaneous coronary intervention (PCI) or thrombolytic therapy...http://content.nejm.org/cgi/content/short/359/5/518?rss=1&ssource=collectionSearchRss&queryTerm=10Derek J. Hausenloy, M.D., Ph.D., and Derek M. Yellon, Ph.D., D.Sc.Thu, 31  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/5/518?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Previous studies have suggested a reduction in the total number of hospital admissions for acute coronary syndrome after the enactment of legislation banning smoking in public places. However, it...http://content.nejm.org/cgi/content/short/359/5/482?rss=1&ssource=collectionSearchRss&queryTerm=10Jill P. Pell, M.D., Sally Haw, B.Sc., Stuart Cobbe, M.D., David E. Newby, Ph.D., Alastair C.H. Pell, M.D., Colin Fischbacher, M.B., Ch.B., Alex McConnachie, Ph.D., Stuart Pringle, M.D., David Murdoch, M.B., Ch.B., Frank Dunn, M.D., Keith Oldroyd, M.D., Paul MacIntyre, M.D., Brian O'Rourke, M.D., and William Borland, B.Sc.Thu, 31  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/5/482?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Experimental evidence suggests that cyclosporine, which inhibits the opening of mitochondrial permeability-transition pores, attenuates lethal myocardial injury that occurs at the time of reperfusion. In this pilot trial, we...http://content.nejm.org/cgi/content/short/359/5/473?rss=1&ssource=collectionSearchRss&queryTerm=10Christophe Piot, M.D., Ph.D., Pierre Croisille, M.D., Patrick Staat, M.D., Hélène Thibault, M.D., Gilles Rioufol, M.D., Ph.D., Nathan Mewton, M.D., Rachid Elbelghiti, M.D., Thien Tri Cung, M.D., Eric Bonnefoy, M.D., Ph.D., Denis Angoulvant, M.D., Christophe Macia, M.D., Franck Raczka, M.D., Catherine Sportouch, M.D., Gerald Gahide, M.D., Gérard Finet, M.D., Ph.D., Xavier André-Fouët, M.D., Didier Revel, M.D., Ph.D., Gilbert Kirkorian, M.D., Ph.D., Jean-Pierre Monassier, M.D., Geneviève Derumeaux, M.D., Ph.D., and Michel Ovize, M.D., Ph.D.Thu, 31  Jul  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/359/5/473?rss=1&ssource=collectionSearchRss&queryTerm=10A recent meta-analysis, report, and editorial all agreed with the need for a randomized trial of percutaneous coronary intervention (PCI) as compared with coronary-artery bypass grafting (CABG) in patients with...http://content.nejm.org/cgi/content/short/358/17/1851?rss=1&ssource=collectionSearchRss&queryTerm=10Robert H. Jones, M.D.Thu, 24  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/17/1851?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Several studies have compared the treatment effects of coronary stenting and coronary-artery bypass grafting (CABG). However, there are limited data regarding the long-term outcomes of these two interventions for...http://content.nejm.org/cgi/content/short/358/17/1781?rss=1&ssource=collectionSearchRss&queryTerm=10Ki Bae Seung, M.D., Duk-Woo Park, M.D., Young-Hak Kim, M.D., Seung-Whan Lee, M.D., Cheol Whan Lee, M.D., Myeong-Ki Hong, M.D., Seong-Wook Park, M.D., Sung-Cheol Yun, Ph.D., Hyeon-Cheol Gwon, M.D., Myung-Ho Jeong, M.D., Yangsoo Jang, M.D., Hyo-Soo Kim, M.D., Pum Joon Kim, M.D., In-Whan Seong, M.D., Hun Sik Park, M.D., Taehoon Ahn, M.D., In-Ho Chae, M.D., Seung-Jea Tahk, M.D., Wook-Sung Chung, M.D., and Seung-Jung Park, M.D.Thu, 24  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/17/1781?rss=1&ssource=collectionSearchRss&queryTerm=10A 71-year-old woman underwent successful elective mitral annuloplasty and coronary-artery bypass grafting, with a left internal thoracic artery graft to her left anterior descending coronary artery and saphenous-vein grafts to...http://content.nejm.org/cgi/content/short/358/15/1603?rss=1&ssource=collectionSearchRss&queryTerm=10Nick P. Jenkins, M.B., B.S. and Huon Gray, M.D.Thu, 10  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/15/1603?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> We previously reported that, in a randomized trial, carotid stenting with the use of an emboli-protection device is not inferior to carotid endarterectomy for the treatment of carotid artery...http://content.nejm.org/cgi/content/short/358/15/1572?rss=1&ssource=collectionSearchRss&queryTerm=10Hitinder S. Gurm, M.D., Jay S. Yadav, M.D., Pierre Fayad, M.D., Barry T. Katzen, M.D., Gregory J. Mishkel, M.D., Tanvir K. Bajwa, M.D., Gary Ansel, M.D., Neil E. Strickman, M.D., Hong Wang, M.D., M.P.H., Sidney A. Cohen, M.D., Ph.D., Joseph M. Massaro, Ph.D., and Donald E. Cutlip, M.D., for the SAPPHIRE InvestigatorsThu, 10  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/15/1572?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on the progression of atherosclerosis remains unknown.<br/><br/><em>Methods:</em> We...http://content.nejm.org/cgi/content/short/358/14/1431?rss=1&ssource=collectionSearchRss&queryTerm=10John J.P. Kastelein, M.D., Ph.D., Fatima Akdim, M.D., Erik S.G. Stroes, M.D., Ph.D., Aeilko H. Zwinderman, Ph.D., Michiel L. Bots, M.D., Ph.D., Anton F.H. Stalenhoef, M.D., Ph.D., F.R.C.P., Frank L.J. Visseren, M.D., Ph.D., Eric J.G. Sijbrands, M.D., Ph.D., Mieke D. Trip, M.D., Ph.D., Evan A. Stein, M.D., Ph.D., Daniel Gaudet, M.D., Ph.D., Raphael Duivenvoorden, M.D., Enrico P. Veltri, M.D., A. David Marais, M.D., Ph.D., and Eric de Groot, M.D., Ph.D., for the ENHANCE InvestigatorsThu, 03  Apr  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/14/1431?rss=1&ssource=collectionSearchRss&queryTerm=10The thoughtful clinician takes it to be self-evident that intensity of therapy should be proportional to risk of disease.12 Ever since Bigger coined the term “risk stratification” to characterize this...http://content.nejm.org/cgi/content/short/358/13/1394?rss=1&ssource=collectionSearchRss&queryTerm=10William S. Weintraub, M.D., and George A. Diamond, M.D.Thu, 27  Mar  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/13/1394?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors. However, it is not known whether coronary-artery calcium predicts coronary...http://content.nejm.org/cgi/content/short/358/13/1336?rss=1&ssource=collectionSearchRss&queryTerm=10Robert Detrano, M.D., Ph.D., Alan D. Guerci, M.D., J. Jeffrey Carr, M.D., M.S.C.E., Diane E. Bild, M.D., M.P.H., Gregory Burke, M.D., Ph.D., Aaron R. Folsom, M.D., Kiang Liu, Ph.D., Steven Shea, M.D., Moyses Szklo, M.D., Dr.P.H., David A. Bluemke, M.D., Ph.D., Daniel H. O'Leary, M.D., Russell Tracy, Ph.D., Karol Watson, M.D., Ph.D., Nathan D. Wong, Ph.D., and Richard A. Kronmal, Ph.D.Thu, 27  Mar  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/13/1336?rss=1&ssource=collectionSearchRss&queryTerm=10Aprotinin, a hemostatic agent that inhibits the fibrinolytic enzyme plasmin,1 was approved by the Food and Drug Administration (FDA) in 1993 for reducing blood loss during coronary-artery bypass grafting (CABG)....http://content.nejm.org/cgi/content/short/358/8/840?rss=1&ssource=collectionSearchRss&queryTerm=10Wayne A. Ray, Ph.D.Thu, 21  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/8/840?rss=1&ssource=collectionSearchRss&queryTerm=10A 59-year-old man with a medical history of hypertension, hyperlipidemia, and coronary artery disease presented with transient, painless visual obscuration in the left eye, and he was referred for retinal...http://content.nejm.org/cgi/content/short/358/8/826?rss=1&ssource=collectionSearchRss&queryTerm=10Michael Colucciello, M.D.Thu, 21  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/8/826?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Aprotinin has recently been associated with adverse outcomes in patients undergoing cardiac surgery. We reviewed our experience with this agent in patients undergoing cardiac surgery at Duke University Medical...http://content.nejm.org/cgi/content/short/358/8/784?rss=1&ssource=collectionSearchRss&queryTerm=10Andrew D. Shaw, M.B., Mark Stafford-Smith, M.D., William D. White, M.P.H., Barbara Phillips-Bute, Ph.D., Madhav Swaminathan, M.D., Carmelo Milano, M.D., Ian J. Welsby, M.B., Solomon Aronson, M.D., Joseph P. Mathew, M.D., Eric D. Peterson, M.D., M.P.H., and Mark F. Newman, M.D.Thu, 21  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/8/784?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Aprotinin (Trasylol) is used to mitigate bleeding during coronary-artery bypass grafting (CABG). Accumulating evidence suggests that this practice increases mortality.<br/><br/><em>Methods:</em> Using electronic administrative records of the Premier Perspective Comparative...http://content.nejm.org/cgi/content/short/358/8/771?rss=1&ssource=collectionSearchRss&queryTerm=10Sebastian Schneeweiss, M.D., Sc.D., John D. Seeger, Pharm.D., Dr.P.H., Joan Landon, M.P.H., and Alexander M. Walker, M.D., Dr.P.H.Thu, 21  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/8/771?rss=1&ssource=collectionSearchRss&queryTerm=10A little over 50 years ago, my father had a heart attack. He was driven to the hospital by friends after having “indigestion” for 2 days. He spent 2 weeks...http://content.nejm.org/cgi/content/short/358/6/634?rss=1&ssource=collectionSearchRss&queryTerm=10George W. Vetrovec, M.D.Thu, 07  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/6/634?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Primary percutaneous coronary intervention (PCI) is effective in opening the infarct-related artery in patients with myocardial infarction with ST-segment elevation. However, the embolization of atherothrombotic debris induces microvascular obstruction...http://content.nejm.org/cgi/content/short/358/6/557?rss=1&ssource=collectionSearchRss&queryTerm=10Tone Svilaas, M.D., Pieter J. Vlaar, M.Sc., Iwan C. van der Horst, M.D., Ph.D., Gilles F.H. Diercks, M.D., Ph.D., Bart J.G.L. de Smet, M.D., Ph.D., Ad F.M. van den Heuvel, M.D., Ph.D., Rutger L. Anthonio, M.D., Ph.D., Gillian A. Jessurun, M.D., Ph.D., Eng-Shiong Tan, M.D., Albert J.H. Suurmeijer, M.D., Ph.D., and Felix Zijlstra, M.D., Ph.D.Thu, 07  Feb  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/6/557?rss=1&ssource=collectionSearchRss&queryTerm=10Unlike jurors, clinicians frequently must make decisions without the luxury of the totality of evidence. When we speak of evidence-based medicine, it is important to remember that available data may...http://content.nejm.org/cgi/content/short/358/4/405?rss=1&ssource=collectionSearchRss&queryTerm=10Joseph P. Carrozza, Jr., M.D.Thu, 24  Jan  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/4/405?rss=1&ssource=collectionSearchRss&queryTerm=10A 57-year-old man presented with a sudden onset of chest pain, which suggested the possibility of myocardial infarction. Coronary angiography revealed a myocardial bridge in the left anterior descending coronary...http://content.nejm.org/cgi/content/short/358/4/392?rss=1&ssource=collectionSearchRss&queryTerm=10Dirk Bose, M.D. and Sebastian Philipp, M.D.Thu, 24  Jan  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/4/392?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Recent reports suggest that off-label use of drug-eluting stents is associated with an increased incidence of adverse events. Whether the use of bare-metal stents would yield different results is...http://content.nejm.org/cgi/content/short/358/4/342?rss=1&ssource=collectionSearchRss&queryTerm=10Oscar C. Marroquin, M.D., Faith Selzer, Ph.D., Suresh R. Mulukutla, M.D., David O. Williams, M.D., Helen A. Vlachos, M.Sc., Robert L. Wilensky, M.D., Jean-François Tanguay, M.D., Elizabeth M. Holper, M.D., J. Dawn Abbott, M.D., Joon S. Lee, M.D., Conrad Smith, M.D., William D. Anderson, M.D., Sheryl F. Kelsey, Ph.D., and Kevin E. Kip, Ph.D.Thu, 24  Jan  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/4/342?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Numerous studies have compared the outcomes of two competing interventions for multivessel coronary artery disease: coronary-artery bypass grafting (CABG) and coronary stenting. However, little information has become available since...http://content.nejm.org/cgi/content/short/358/4/331?rss=1&ssource=collectionSearchRss&queryTerm=10Edward L. Hannan, Ph.D., Chuntao Wu, M.D., Ph.D., Gary Walford, M.D., Alfred T. Culliford, M.D., Jeffrey P. Gold, M.D., Craig R. Smith, M.D., Robert S.D. Higgins, M.D., Russell E. Carlson, M.D., and Robert H. Jones, M.D.Thu, 24  Jan  2008 00:00:00 -05:00http://content.nejm.org/cgi/content/short/358/4/331?rss=1&ssource=collectionSearchRss&queryTerm=10In late October, we presented the case of a patient with stable coronary artery disease in Clinical Decisions,1 an interactive feature designed to assess how readers would manage a clinical...http://content.nejm.org/cgi/content/short/357/24/e28?rss=1&ssource=collectionSearchRss&queryTerm=10Susan Cheng, M.D., and John Jarcho, M.D.Thu, 13  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/24/e28?rss=1&ssource=collectionSearchRss&queryTerm=10Platelets are essential for primary hemostasis and repair of the endothelium, but they also play a key role in the development of acute coronary syndromes and contribute to cerebrovascular events....http://content.nejm.org/cgi/content/short/357/24/2482?rss=1&ssource=collectionSearchRss&queryTerm=10Giovanni Davì, M.D., and Carlo Patrono, M.D.Thu, 13  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/24/2482?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The effect of adolescent overweight on future adult coronary heart disease (CHD) is not known.<br/><br/><em>Methods:</em> We estimated the prevalence of obese 35-year-olds in 2020 on the basis of adolescent...http://content.nejm.org/cgi/content/short/357/23/2371?rss=1&ssource=collectionSearchRss&queryTerm=10Kirsten Bibbins-Domingo, Ph.D., M.D., Pamela Coxson, Ph.D., Mark J. Pletcher, M.D., M.P.H., James Lightwood, Ph.D., and Lee Goldman, M.D., M.P.H.Thu, 06  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/23/2371?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The worldwide epidemic of childhood obesity is progressing at an alarming rate. Risk factors for coronary heart disease (CHD) are already identifiable in overweight children. The severity of the...http://content.nejm.org/cgi/content/short/357/23/2329?rss=1&ssource=collectionSearchRss&queryTerm=10Jennifer L. Baker, Ph.D., Lina W. Olsen, Ph.D., and Thorkild I.A. Sørensen, M.D., Dr.Med.Sci.Thu, 06  Dec  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/23/2329?rss=1&ssource=collectionSearchRss&queryTerm=10Raising plasma levels of high-density lipoprotein (HDL) cholesterol has been a therapeutic goal ever since the strong inverse association between HDL levels and the risk of coronary heart disease was...http://content.nejm.org/cgi/content/short/357/21/2180?rss=1&ssource=collectionSearchRss&queryTerm=10Daniel J. Rader, M.D.Thu, 22  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/21/2180?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Inhibition of cholesteryl ester transfer protein (CETP) has been shown to have a substantial effect on plasma lipoprotein levels. We investigated whether torcetrapib, a potent CETP inhibitor, might reduce...http://content.nejm.org/cgi/content/short/357/21/2109?rss=1&ssource=collectionSearchRss&queryTerm=10Philip J. Barter, M.D., Ph.D., Mark Caulfield, M.D., M.B., B.S., Mats Eriksson, M.D., Ph.D., Scott M. Grundy, M.D., Ph.D., John J.P. Kastelein, M.D., Ph.D., Michel Komajda, M.D., Jose Lopez-Sendon, M.D., Ph.D., Lori Mosca, M.D., M.P.H., Ph.D., Jean-Claude Tardif, M.D., David D. Waters, M.D., Charles L. Shear, Dr.P.H., James H. Revkin, M.D., Kevin A. Buhr, Ph.D., Marian R. Fisher, Ph.D., Alan R. Tall, M.B., B.S., and Bryan Brewer, M.D., Ph.D., for the ILLUMINATE InvestigatorsThu, 22  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/21/2109?rss=1&ssource=collectionSearchRss&queryTerm=10In Greek mythology, Scylla was a ferocious beast and Charybdis was a monstrous whirlpool. The wily Odysseus successfully navigated between these two dangers by steering closer to Scylla, though he...http://content.nejm.org/cgi/content/short/357/20/2078?rss=1&ssource=collectionSearchRss&queryTerm=10Deepak L. Bhatt, M.D.Thu, 15  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/20/2078?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention.<br/><br/><em>Methods:</em> To compare prasugrel, a new...http://content.nejm.org/cgi/content/short/357/20/2001?rss=1&ssource=collectionSearchRss&queryTerm=10Stephen D. Wiviott, M.D., Eugene Braunwald, M.D., Carolyn H. McCabe, B.S., Gilles Montalescot, M.D., Ph.D., Witold Ruzyllo, M.D., Shmuel Gottlieb, M.D., Franz-Joseph Neumann, M.D., Diego Ardissino, M.D., Stefano De Servi, M.D., Sabina A. Murphy, M.P.H., Jeffrey Riesmeyer, M.D., Govinda Weerakkody, Ph.D., C. Michael Gibson, M.D., and Elliott M. Antman, M.D., for the TRITON–TIMI 38 InvestigatorsThu, 15  Nov  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/20/2001?rss=1&ssource=collectionSearchRss&queryTerm=10This interactive feature allows readers to decide on the diagnosis or management of a clinical case. A case vignette is followed by specific clinical options, none of which can be...http://content.nejm.org/cgi/content/short/357/17/1762?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 25  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/17/1762?rss=1&ssource=collectionSearchRss&queryTerm=10Early administration of reperfusion therapy improves survival in patients with ST-elevation myocardial infarction by reestablishing coronary blood flow within the occluded infarct-related artery.1 Primary percutaneous coronary intervention (PCI) is superior...http://content.nejm.org/cgi/content/short/357/16/1631?rss=1&ssource=collectionSearchRss&queryTerm=10Brahmajee K. Nallamothu, M.D., M.P.H., Elizabeth H. Bradley, Ph.D., and Harlan M. Krumholz, M.D., S.M.Thu, 18  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/16/1631?rss=1&ssource=collectionSearchRss&queryTerm=10The development and progression of atherosclerosis is an intricate inflammatory process dependent on intimal entry of low-density lipoprotein (LDL) cholesterol. Although myriad genetic and environmental factors modulate this process, the...http://content.nejm.org/cgi/content/short/357/15/1543?rss=1&ssource=collectionSearchRss&queryTerm=10Michael J. Domanski, M.D.Thu, 11  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/15/1543?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The West of Scotland Coronary Prevention Study was a randomized clinical trial comparing pravastatin with placebo in men with hypercholesterolemia who did not have a history of myocardial infarction,...http://content.nejm.org/cgi/content/short/357/15/1477?rss=1&ssource=collectionSearchRss&queryTerm=10Ian Ford, Ph.D., Heather Murray, M.Sc., Chris J. Packard, D.Sc., James Shepherd, M.D., Peter W. Macfarlane, D.Sc., and Stuart M. Cobbe, M.D., for the West of Scotland Coronary Prevention Study GroupThu, 11  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/15/1477?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The placement of drug-eluting stents decreases the frequency of repeat revascularization procedures in patients undergoing percutaneous coronary intervention (PCI) in randomized clinical trials. However, there is uncertainty about the...http://content.nejm.org/cgi/content/short/357/14/1393?rss=1&ssource=collectionSearchRss&queryTerm=10Jack V. Tu, M.D., Ph.D., James Bowen, B.Sc.Phm., M.Sc., Maria Chiu, M.Sc., Dennis T. Ko, M.D., M.Sc., Peter C. Austin, Ph.D., Yaohua He, M.D., Ph.D., Robert Hopkins, M.A., Jean-Eric Tarride, Ph.D., Gord Blackhouse, M.B.A., M.Sc., Charles Lazzam, M.D., Eric A. Cohen, M.D., and Ron Goeree, M.A.Thu, 04  Oct  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/14/1393?rss=1&ssource=collectionSearchRss&queryTerm=10There is mounting evidence that exposure to higher levels of air pollution is associated with adverse cardiovascular consequences. A recent scientific statement from the American Heart Association concluded that transient...http://content.nejm.org/cgi/content/short/357/11/1147?rss=1&ssource=collectionSearchRss&queryTerm=10Murray A. Mittleman, M.D., Dr.P.H.Thu, 13  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/11/1147?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary heart disease is the leading cause of death worldwide, and 3.8 million men and 3.4 million women die of the disease each year. After an acute myocardial infarction, early...http://content.nejm.org/cgi/content/short/357/11/1121?rss=1&ssource=collectionSearchRss&queryTerm=10Derek M. Yellon, D.Sc., and Derek J. Hausenloy, Ph.D.Thu, 13  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/11/1121?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Exposure to air pollution from traffic is associated with adverse cardiovascular events. The mechanisms for this association are unknown. We conducted a controlled exposure to dilute diesel exhaust in...http://content.nejm.org/cgi/content/short/357/11/1075?rss=1&ssource=collectionSearchRss&queryTerm=10Nicholas L. Mills, M.D., Håkan Törnqvist, M.D., Manuel C. Gonzalez, M.D., Elen Vink, B.Sc., Simon D. Robinson, M.D., Stefan Söderberg, M.D., Ph.D., Nicholas A. Boon, M.D., Ken Donaldson, Ph.D., Thomas Sandström, M.D., Ph.D., Anders Blomberg, M.D., Ph.D., and David E. Newby, M.D., Ph.D.Thu, 13  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/11/1075?rss=1&ssource=collectionSearchRss&queryTerm=10A 64-year-old man with a history of coronary artery disease and peripheral vascular disease was admitted to the hospital with a several-month history of fevers, chills, and fatigue. These symptoms...http://content.nejm.org/cgi/content/short/357/10/1029?rss=1&ssource=collectionSearchRss&queryTerm=10Christopher J. Graber, M.D., M.P.H., Adam S. Lauring, M.D., Ph.D., and Peter V. Chin-Hong, M.D.Thu, 06  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/10/1029?rss=1&ssource=collectionSearchRss&queryTerm=10Hypertriglyceridemia is a common form of dyslipidemia1 that is frequently associated with premature coronary artery disease,2345 which is generally defined by the occurrence of a myocardial infarction or the need...http://content.nejm.org/cgi/content/short/357/10/1009?rss=1&ssource=collectionSearchRss&queryTerm=10John D. Brunzell, M.D.Thu, 06  Sep  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/10/1009?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary artery disease remains an enormous clinical problem, affecting more than 15 million people in the United States alone, where it is the most common cause of death (accounting for...http://content.nejm.org/cgi/content/short/357/5/497?rss=1&ssource=collectionSearchRss&queryTerm=10Anthony Rosenzweig, M.D.Thu, 02  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/5/497?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease.<br/><br/><em>Methods:</em> We first...http://content.nejm.org/cgi/content/short/357/5/443?rss=1&ssource=collectionSearchRss&queryTerm=10Nilesh J. Samani, F.Med.Sci., Jeanette Erdmann, Ph.D., Alistair S. Hall, F.R.C.P., Christian Hengstenberg, M.D., Massimo Mangino, Ph.D., Bjoern Mayer, M.D., Richard J. Dixon, Ph.D., Thomas Meitinger, M.D., Peter Braund, M.Sc., H.-Erich Wichmann, M.D., Jennifer H. Barrett, Ph.D., Inke R. König, Ph.D., Suzanne E. Stevens, M.Sc., Silke Szymczak, M.Sc., David-Alexandre Tregouet, Ph.D., Mark M. Iles, Ph.D., Friedrich Pahlke, M.Sc., Helen Pollard, M.Sc., Wolfgang Lieb, M.D., Francois Cambien, M.D., Marcus Fischer, M.D., Willem Ouwehand, F.R.C.Path., Stefan Blankenberg, M.D., Anthony J. Balmforth, Ph.D., Andrea Baessler, M.D., Stephen G. Ball, F.R.C.P., Tim M. Strom, M.D., Ingrid Brænne, M.Sc., Christian Gieger, Ph.D., Panos Deloukas, Ph.D., Martin D. Tobin, M.F.P.H.M., Andreas Ziegler, Ph.D., John R. Thompson, Ph.D., and Heribert Schunkert, M.D., for the WTCCC and the Cardiogenics ConsortiumThu, 02  Aug  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/357/5/443?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Calcified plaque in the coronary arteries is a marker for atheromatous-plaque burden and is predictive of future risk of cardiovascular events. We examined the relationship between estrogen therapy and...http://content.nejm.org/cgi/content/short/356/25/2591?rss=1&ssource=collectionSearchRss&queryTerm=10JoAnn E. Manson, M.D., Dr.P.H., Matthew A. Allison, M.D., M.P.H., Jacques E. Rossouw, M.D., J. Jeffrey Carr, M.D., Robert D. Langer, M.D., M.P.H., Judith Hsia, M.D., Lewis H. Kuller, M.D., Dr.P.H., Barbara B. Cochrane, Ph.D., Julie R. Hunt, Ph.D., Shari E. Ludlam, M.P.H., Mary B. Pettinger, M.S., Margery Gass, M.D., Karen L. Margolis, M.D., M.P.H., Lauren Nathan, M.D., Judith K. Ockene, Ph.D., Ross L. Prentice, Ph.D., John Robbins, M.D., and Marcia L. Stefanick, Ph.D., for the WHI and WHI-CACS InvestigatorsThu, 21  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/25/2591?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Mortality from coronary heart disease in the United States has decreased substantially in recent decades. We conducted a study to determine how much of this decrease could be explained...http://content.nejm.org/cgi/content/short/356/23/2388?rss=1&ssource=collectionSearchRss&queryTerm=10Earl S. Ford, M.D., M.P.H., Umed A. Ajani, M.B., B.S., M.P.H., Janet B. Croft, Ph.D., Julia A. Critchley, D.Phil., M.Sc., Darwin R. Labarthe, M.D., M.P.H., Ph.D., Thomas E. Kottke, M.D., Wayne H. Giles, M.D., M.S., and Simon Capewell, M.D.Thu, 07  Jun  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/23/2388?rss=1&ssource=collectionSearchRss&queryTerm=10The pathogenesis of an acute myocardial infarction consists of the rupture of atherosclerotic plaque, followed by a sudden thrombotic coronary occlusion. Pioneering studies performed more than 40 years ago, even...http://content.nejm.org/cgi/content/short/356/18/1880?rss=1&ssource=collectionSearchRss&queryTerm=10Jan J. Piek, M.D., Ph.D.Thu, 03  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/18/1880?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Microvascular perfusion is often impaired after primary percutaneous coronary intervention (PCI). We proposed that in situ thrombosis might contribute to poor myocardial perfusion in this setting. To test this...http://content.nejm.org/cgi/content/short/356/18/1823?rss=1&ssource=collectionSearchRss&queryTerm=10Murat Sezer, M.D., Hüseyin Oflaz, M.D., Taner Gören, M.D., İrem Okçular, M.D., Berrin Umman, M.D., Yilmaz Nişanci, M.D., Ahmet Kaya Bilge, M.D., Yasemin Şanli, M.D., Mehmet Meriç, M.D., and Sabahattin Umman, M.D.Thu, 03  May  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/18/1823?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Torcetrapib, an inhibitor of cholesteryl ester transfer protein, may reduce atherosclerotic vascular disease by increasing levels of high-density lipoprotein (HDL) cholesterol.<br/><br/><em>Methods:</em> A total of 850 patients with heterozygous familial...http://content.nejm.org/cgi/content/short/356/16/1620?rss=1&ssource=collectionSearchRss&queryTerm=10John J.P. Kastelein, M.D., Ph.D., Sander I. van Leuven, M.D., Leslie Burgess, M.D., Greg W. Evans, M.A., Jan A. Kuivenhoven, Ph.D., Philip J. Barter, M.D., Ph.D., James H. Revkin, M.D., Diederick E. Grobbee, M.D., Ph.D., Ward A. Riley, Ph.D., Charles L. Shear, Dr.P.H., William T. Duggan, Ph.D., and Michiel L. Bots, M.D., Ph.D., for the RADIANCE 1 InvestigatorsThu, 19  Apr  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/16/1620?rss=1&ssource=collectionSearchRss&queryTerm=10Treatments are designed to make people feel better or live longer. Percutaneous coronary intervention (PCI) is effective at reducing angina in patients with symptomatic coronary artery disease and at reducing...http://content.nejm.org/cgi/content/short/356/15/1572?rss=1&ssource=collectionSearchRss&queryTerm=10Judith S. Hochman, M.D., and P. Gabriel Steg, M.D.Thu, 12  Apr  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/15/1572?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients with stable coronary artery disease, it remains unclear whether an initial management strategy of percutaneous coronary intervention (PCI) with intensive pharmacologic therapy and lifestyle intervention (optimal medical...http://content.nejm.org/cgi/content/short/356/15/1503?rss=1&ssource=collectionSearchRss&queryTerm=10William E. Boden, M.D., Robert A. O'Rourke, M.D., Koon K. Teo, M.B., B.Ch., Ph.D., Pamela M. Hartigan, Ph.D., David J. Maron, M.D., William J. Kostuk, M.D., Merril Knudtson, M.D., Marcin Dada, M.D., Paul Casperson, Ph.D., Crystal L. Harris, Pharm.D., Bernard R. Chaitman, M.D., Leslee Shaw, Ph.D., Gilbert Gosselin, M.D., Shah Nawaz, M.D., Lawrence M. Title, M.D., Gerald Gau, M.D., Alvin S. Blaustein, M.D., David C. Booth, M.D., Eric R. Bates, M.D., John A. Spertus, M.D., M.P.H., Daniel S. Berman, M.D., G.B. John Mancini, M.D., and William S. Weintraub, M.D., for the COURAGE Trial Research GroupThu, 12  Apr  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/15/1503?rss=1&ssource=collectionSearchRss&queryTerm=10Plasma levels of high-density lipoprotein (HDL) cholesterol are inversely related to the incidence of coronary heart disease and stroke. The lowering of low-density lipoprotein (LDL) cholesterol with statin therapy reduces...http://content.nejm.org/cgi/content/short/356/13/1364?rss=1&ssource=collectionSearchRss&queryTerm=10Alan R. Tall, M.B., B.S.Thu, 29  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/13/1364?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, increases HDL cholesterol levels, but the functional effects associated...http://content.nejm.org/cgi/content/short/356/13/1304?rss=1&ssource=collectionSearchRss&queryTerm=10Steven E. Nissen, M.D., Jean-Claude Tardif, M.D., Stephen J. Nicholls, M.B., B.S., Ph.D., James H. Revkin, M.D., Charles L. Shear, Dr.P.H., William T. Duggan, Ph.D., Witold Ruzyllo, M.D., William B. Bachinsky, M.D., Gregory P. Lasala, M.D., and E. Murat Tuzcu, M.D., for the ILLUSTRATE InvestigatorsThu, 29  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/13/1304?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The safety of drug-eluting stents has been called into question by recent reports of increased stent thrombosis, myocardial infarction, and death. Such studies have been inconclusive because of their...http://content.nejm.org/cgi/content/short/356/10/998?rss=1&ssource=collectionSearchRss&queryTerm=10Gregg W. Stone, M.D., Jeffrey W. Moses, M.D., Stephen G. Ellis, M.D., Joachim Schofer, M.D., Keith D. Dawkins, M.D., Marie-Claude Morice, M.D., Antonio Colombo, M.D., Erick Schampaert, M.D., Eberhard Grube, M.D., Ajay J. Kirtane, M.D., Donald E. Cutlip, M.D., Martin Fahy, M.Sc., Stuart J. Pocock, Ph.D., Roxana Mehran, M.D., and Martin B. Leon, M.D.Thu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/998?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Although randomized studies have shown a beneficial effect of drug-eluting stents in reducing the risk of repeated revascularization, these trials were underpowered to compare rates of death and myocardial...http://content.nejm.org/cgi/content/short/356/10/989?rss=1&ssource=collectionSearchRss&queryTerm=10Christian Spaulding, M.D., Joost Daemen, M.D., Eric Boersma, Ph.D., Donald E. Cutlip, M.D., and Patrick W. Serruys, M.D., Ph.D.Thu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/989?rss=1&ssource=collectionSearchRss&queryTerm=10In the light of recent studies suggesting that drug-eluting stents may pose a risk of thrombosis that was not observed during pre-market testing, the Food and Drug Administration (FDA) convened...http://content.nejm.org/cgi/content/short/356/10/984?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/984?rss=1&ssource=collectionSearchRss&queryTerm=10After recognizing coronary drug-eluting stents as a “breakthrough technology” and granting them expedited review status, the Food and Drug Administration (FDA) approved two such devices for use in 2003 (Cordis's...http://content.nejm.org/cgi/content/short/356/10/981?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/981?rss=1&ssource=collectionSearchRss&queryTerm=10In this issue of the Journal, we publish five Original Articles and two Perspective articles on the subject of drug-eluting coronary stents.1234567 Our motivation is the recent concern that the...http://content.nejm.org/cgi/content/short/356/10/1059?rss=1&ssource=collectionSearchRss&queryTerm=10Gregory D. Curfman, M.D., Stephen Morrissey, Ph.D., John A. Jarcho, M.D., and Jeffrey M. Drazen, M.D.Thu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/1059?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The long-term effects of treatment with sirolimus-eluting stents, as compared with bare-metal stents, have not been established.<br/><br/><em>Methods:</em> We performed an analysis of individual data on 4958 patients enrolled in...http://content.nejm.org/cgi/content/short/356/10/1030?rss=1&ssource=collectionSearchRss&queryTerm=10Adnan Kastrati, M.D., Julinda Mehilli, M.D., Jürgen Pache, M.D., Christoph Kaiser, M.D., Marco Valgimigli, M.D., Ph.D., Henning Kelbæk, M.D., Maurizio Menichelli, M.D., Manel Sabaté, M.D., Maarten J. Suttorp, M.D., Ph.D., Dietrich Baumgart, M.D., Melchior Seyfarth, M.D., Matthias E. Pfisterer, M.D., and Albert Schömig, M.D.Thu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/1030?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Definitions of stent thrombosis that have been used in clinical trials of drug-eluting stents have been restrictive and have not been used in a uniform manner.<br/><br/><em>Methods:</em> We applied a...http://content.nejm.org/cgi/content/short/356/10/1020?rss=1&ssource=collectionSearchRss&queryTerm=10Laura Mauri, M.D., Wen-hua Hsieh, Ph.D., Joseph M. Massaro, Ph.D., Kalon K.L. Ho, M.D., Ralph D'Agostino, Ph.D., and Donald E. Cutlip, M.D.Thu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/1020?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Recent reports have indicated that there may be an increased risk of late stent thrombosis with the use of drug-eluting stents, as compared with bare-metal stents.<br/><br/><em>Methods:</em> We evaluated 6033...http://content.nejm.org/cgi/content/short/356/10/1009?rss=1&ssource=collectionSearchRss&queryTerm=10Bo Lagerqvist, M.D., Ph.D., Stefan K. James, M.D., Ph.D., Ulf Stenestrand, M.D., Ph.D., Johan Lindbäck, M.Sc., Tage Nilsson, M.D., Ph.D., and Lars Wallentin, M.D., Ph.D., for the SCAAR Study GroupThu, 08  Mar  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/10/1009?rss=1&ssource=collectionSearchRss&queryTerm=10The link between myocardial ischemia and obstructive atherosclerosis of the epicardial coronary arteries is well established, and coronary angiography has demonstrated a relationship between the severity and extent of coronary...http://content.nejm.org/cgi/content/short/356/8/830?rss=1&ssource=collectionSearchRss&queryTerm=10Paolo G. Camici, M.D., and Filippo Crea, M.D.Thu, 22  Feb  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/8/830?rss=1&ssource=collectionSearchRss&queryTerm=10A 58-year-old man has chest pain at 9:30 a.m.; 3 hours later, he calls for an ambulance. Paramedics arrive, provide standard treatment, and transport him to the nearest emergency department....http://content.nejm.org/cgi/content/short/356/1/47?rss=1&ssource=collectionSearchRss&queryTerm=10Ellen C. Keeley, M.D., and L. David Hillis, M.D.Thu, 04  Jan  2007 00:00:00 -05:00http://content.nejm.org/cgi/content/short/356/1/47?rss=1&ssource=collectionSearchRss&queryTerm=10In patients with acute myocardial infarction, the prompt restoration of antegrade flow in the infarct-related coronary artery, whether accomplished pharmacologically1 or mechanically,2 improves left ventricular systolic function and reduces mortality....http://content.nejm.org/cgi/content/short/355/23/2475?rss=1&ssource=collectionSearchRss&queryTerm=10L. David Hillis, M.D., and Richard A. Lange, M.D.Thu, 07  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/23/2475?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> It is unclear whether stable, high-risk patients with persistent total occlusion of the infarct-related coronary artery identified after the currently accepted period for myocardial salvage has passed should undergo...http://content.nejm.org/cgi/content/short/355/23/2395?rss=1&ssource=collectionSearchRss&queryTerm=10Judith S. Hochman, M.D., Gervasio A. Lamas, M.D., Christopher E. Buller, M.D., Vladimir Dzavik, M.D., Harmony R. Reynolds, M.D., Staci J. Abramsky, M.P.H., Sandra Forman, M.A., Witold Ruzyllo, M.D., Aldo P. Maggioni, M.D., Harvey White, M.D., Zygmunt Sadowski, M.D., Antonio C. Carvalho, M.D., Jamie M. Rankin, M.D., Jean P. Renkin, M.D., P. Gabriel Steg, M.D., Alice M. Mascette, M.D., George Sopko, M.D., Matthias E. Pfisterer, M.D., Jonathan Leor, M.D., Viliam Fridrich, M.D., Daniel B. Mark, M.D., M.P.H., and Genell L. Knatterud, Ph.D., for the Occluded Artery Trial InvestigatorsThu, 07  Dec  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/23/2395?rss=1&ssource=collectionSearchRss&queryTerm=10The treatment of patients with acute coronary syndromes is straightforward in principle but complex in practice. With the increase in referrals of moderate- or high-risk patients for invasive cardiac procedures...http://content.nejm.org/cgi/content/short/355/21/2249?rss=1&ssource=collectionSearchRss&queryTerm=10John A. Bittl, M.D.Thu, 23  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/21/2249?rss=1&ssource=collectionSearchRss&queryTerm=10A 38-year-old man was scheduled to undergo invasive coronary angiography after cardiac scintigraphy revealed silent ischemia of the anterior myocardial wall. He was a smoker and had no other medical...http://content.nejm.org/cgi/content/short/355/21/2236?rss=1&ssource=collectionSearchRss&queryTerm=10Michele Hamon, M.D. and Martial Hamon, M.D.Thu, 23  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/21/2236?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Current guidelines for patients with moderate- or high-risk acute coronary syndromes recommend an early invasive approach with concomitant antithrombotic therapy, including aspirin, clopidogrel, unfractionated or low-molecular-weight heparin, and glycoprotein...http://content.nejm.org/cgi/content/short/355/21/2203?rss=1&ssource=collectionSearchRss&queryTerm=10Gregg W. Stone, M.D., Brent T. McLaurin, M.D., David A. Cox, M.D., Michel E. Bertrand, M.D., A. Michael Lincoff, M.D., Jeffrey W. Moses, M.D., Harvey D. White, M.D., Stuart J. Pocock, Ph.D., James H. Ware, Ph.D., Frederick Feit, M.D., Antonio Colombo, M.D., Philip E. Aylward, M.D., Angel R. Cequier, M.D., Harald Darius, M.D., Walter Desmet, M.D., Ramin Ebrahimi, M.D., Martial Hamon, M.D., Lars H. Rasmussen, M.D., Hans-Jürgen Rupprecht, M.D., James Hoekstra, M.D., Roxana Mehran, M.D., and E. Magnus Ohman, M.D., for the ACUITY InvestigatorsThu, 23  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/21/2203?rss=1&ssource=collectionSearchRss&queryTerm=10The full safety profile of a new drug is rarely known at the time of approval by the Food and Drug Administration (FDA). Most drug-development programs designed for treatments of...http://content.nejm.org/cgi/content/short/355/21/2171?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 23  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/21/2171?rss=1&ssource=collectionSearchRss&queryTerm=10A 2-day-old boy was admitted to the special care nursery of this hospital because of hypotonia.<br/><br/>He was delivered at another hospital to a 40-year-old mother (gravida 2, para 2) at...http://content.nejm.org/cgi/content/short/355/20/2132?rss=1&ssource=collectionSearchRss&queryTerm=10Robert H. Brown, Jr., M.D., D.Phil., P. Ellen Grant, M.D., and Christopher R. Pierson, M.D., Ph.D.Thu, 16  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/20/2132?rss=1&ssource=collectionSearchRss&queryTerm=10Dr. David S. Frankel (Medicine): A 72-year-old woman was admitted to this hospital because of respiratory failure and hypotension.<br/><br/>During the week before admission, the patient and other members of her...http://content.nejm.org/cgi/content/short/355/19/2022?rss=1&ssource=collectionSearchRss&queryTerm=10Paula A. Johnson, M.D., M.P.H., Farouc A. Jaffer, M.D., Ph.D., Tomas G. Neilan, M.D., Jo-Anne O. Shepard, M.D., and James R. Stone, M.D., Ph.D.Thu, 09  Nov  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/19/2022?rss=1&ssource=collectionSearchRss&queryTerm=10Primary percutaneous coronary intervention (PCI), when performed by an experienced team in a timely fashion, is a better reperfusion therapy than in-hospital thrombolysis in patients who have acute myocardial infarction...http://content.nejm.org/cgi/content/short/355/11/1169?rss=1&ssource=collectionSearchRss&queryTerm=10Frans Van de Werf, M.D., Ph.D.Thu, 14  Sep  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/11/1169?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Drug-eluting coronary-artery stents have been shown to decrease restenosis and therefore the likelihood that additional procedures will be required after percutaneous coronary intervention (PCI). We evaluated the use of...http://content.nejm.org/cgi/content/short/355/11/1105?rss=1&ssource=collectionSearchRss&queryTerm=10Gerrit J. Laarman, M.D., Ph.D., Maarten J. Suttorp, M.D., Ph.D., Maurits T. Dirksen, M.D., Loek van Heerebeek, M.D., Ferdinand Kiemeneij, M.D., Ph.D., Ton Slagboom, M.D., L. Ron van der Wieken, M.D., Jan G.P. Tijssen, Ph.D., Benno J. Rensing, M.D., Ph.D., and Mark Patterson, M.R.C.P.Thu, 14  Sep  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/11/1105?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Sirolimus-eluting stents reduce rates of restenosis and reintervention, as compared with uncoated stents. Data are limited regarding the safety and efficacy of such stents in primary percutaneous coronary intervention...http://content.nejm.org/cgi/content/short/355/11/1093?rss=1&ssource=collectionSearchRss&queryTerm=10Christian Spaulding, M.D., Patrick Henry, M.D., Ph.D., Emmanuel Teiger, M.D., Ph.D., Kevin Beatt, M.B., B.S., Ph.D., Ezio Bramucci, M.D., Didier Carrié, M.D., Michel S. Slama, M.D., Bela Merkely, M.D., Ph.D., Andrejs Erglis, M.D., Ph.D., Massimo Margheri, M.D., Olivier Varenne, M.D., Ph.D., Ana Cebrian, Ph.D., Hans-Peter Stoll, M.D., David B. Snead, Ph.D., and Christoph Bode, M.D., for the TYPHOON InvestigatorsThu, 14  Sep  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/355/11/1093?rss=1&ssource=collectionSearchRss&queryTerm=10Just when we thought we understood everything about low-density lipoprotein (LDL) cholesterol and its relationship to cardiovascular risk, along comes a discovery that reveals a new control mechanism and suggests...http://content.nejm.org/cgi/content/short/354/12/1310?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 23  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/12/1310?rss=1&ssource=collectionSearchRss&queryTerm=10A 72-year-old man presented with unstable angina. An urgent cardiac catheterization showed clinically significant disease in the right coronary artery, which was stented. Twelve hours after the procedure, livedo reticularis...http://content.nejm.org/cgi/content/short/354/12/1294?rss=1&ssource=collectionSearchRss&queryTerm=10Omar Rana, M.B., B.S. and William McCrea, F.R.C.P.Thu, 23  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/12/1294?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in plasma LDL cholesterol...http://content.nejm.org/cgi/content/short/354/12/1264?rss=1&ssource=collectionSearchRss&queryTerm=10Jonathan C. Cohen, Ph.D., Eric Boerwinkle, Ph.D., Thomas H. Mosley, Jr., Ph.D., and Helen H. Hobbs, M.D.Thu, 23  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/12/1264?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The enzyme acyl–coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some animal models, ACAT inhibitors have antiatherosclerotic effects.<br/><br/><em>Methods:</em> We performed intravascular ultrasonography in 408 patients...http://content.nejm.org/cgi/content/short/354/12/1253?rss=1&ssource=collectionSearchRss&queryTerm=10Steven E. Nissen, M.D., E. Murat Tuzcu, M.D., H. Bryan Brewer, M.D., Ilke Sipahi, M.D., Stephen J. Nicholls, M.B., B.S., Ph.D., Peter Ganz, M.D., Paul Schoenhagen, M.D., David D. Waters, M.D., Carl J. Pepine, M.D., Tim D. Crowe, B.S., Michael H. Davidson, M.D., John E. Deanfield, M.D., Lisa M. Wisniewski, R.N., James J. Hanyok, Pharm.D., and Laurent M. Kassalow, M.S., for the ACAT Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) InvestigatorsThu, 23  Mar  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/12/1253?rss=1&ssource=collectionSearchRss&queryTerm=10Translation, translation, translation. Around the halls of academic medicine, translation is the mantra of the moment. In the literary world, translation is the process of interpreting an extant body of...http://content.nejm.org/cgi/content/short/354/8/789?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 23  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/8/789?rss=1&ssource=collectionSearchRss&queryTerm=10The use of percutaneously introduced prosthetic devices to maintain the luminal integrity of diseased blood vessels was proposed by Dotter and Judkins in 1964,1 well before the introduction of coronary...http://content.nejm.org/cgi/content/short/354/5/483?rss=1&ssource=collectionSearchRss&queryTerm=10Patrick W. Serruys, M.D., Ph.D., Michael J.B. Kutryk, M.D., Ph.D., and Andrew T.L. Ong, M.B., B.S.Thu, 02  Feb  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/5/483?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The majority of patients undergoing surgical treatment for ST-elevation myocardial infarction receive antifibrinolytic therapy to limit blood loss. This approach appears counterintuitive to the accepted medical treatment of the...http://content.nejm.org/cgi/content/short/354/4/353?rss=1&ssource=collectionSearchRss&queryTerm=10Dennis T. Mangano, Ph.D., M.D., Iulia C. Tudor, Ph.D., and Cynthia Dietzel, M.D., for the Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education FoundationThu, 26  Jan  2006 00:00:00 -05:00http://content.nejm.org/cgi/content/short/354/4/353?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The appropriate treatment for patients in whom reperfusion fails to occur after thrombolytic therapy for acute myocardial infarction remains unclear. There are few data comparing emergency percutaneous coronary intervention...http://content.nejm.org/cgi/content/short/353/26/2758?rss=1&ssource=collectionSearchRss&queryTerm=10Anthony H. Gershlick, M.B., B.S., Amanda Stephens-Lloyd, R.N., M.Sc., Sarah Hughes, R.N., B.A., Keith R. Abrams, Ph.D., Suzanne E. Stevens, M.Sc., Neal G. Uren, M.D., Adam de Belder, M.D., John Davis, M.B., B.S., Michael Pitt, M.B., B.S., Adrian Banning, M.D., Andreas Baumbach, M.D., Man Fai Shiu, M.D., Peter Schofield, M.D., Keith D. Dawkins, M.D., Robert A. Henderson, M.D., Keith G. Oldroyd, M.D., and Robert Wilcox, M.D., for the REACT Trial InvestigatorsThu, 29  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/26/2758?rss=1&ssource=collectionSearchRss&queryTerm=10The obstructive sleep apnea syndrome is a common chronic disease of adults. It is estimated to afflict 2 percent of middle-aged women and 4 percent of middle-aged men, based on...http://content.nejm.org/cgi/content/short/353/24/2604?rss=1&ssource=collectionSearchRss&queryTerm=10Daniel J. Gottlieb, M.D., M.P.H.Thu, 15  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/24/2604?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The role of atrial overdrive pacing (AOP) in sleep apnea remains uncertain. We prospectively evaluated the effect of AOP after 24 hours and after one month in patients with...http://content.nejm.org/cgi/content/short/353/24/2568?rss=1&ssource=collectionSearchRss&queryTerm=10Emmanuel N. Simantirakis, M.D., Sophia E. Schiza, M.D., Stavros I. Chrysostomakis, M.D., Gregory I. Chlouverakis, Ph.D., Nikolaos C. Klapsinos, M.D., Nikolaos M. Siafakas, M.D., Ph.D., and Panos E. Vardas, M.D., Ph.D.Thu, 15  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/24/2568?rss=1&ssource=collectionSearchRss&queryTerm=10Dr. Alex Manini (Emergency Medicine): A 35-year-old man was brought to the emergency department of this hospital by ambulance after a cardiac arrest while sleeping.<br/><br/>According to his partner and his...http://content.nejm.org/cgi/content/short/353/23/2492?rss=1&ssource=collectionSearchRss&queryTerm=10Keith A. Marill, M.D., and Patrick T. Ellinor, M.D., Ph.D.Thu, 08  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/23/2492?rss=1&ssource=collectionSearchRss&queryTerm=10An 80-year-old man presented to his physician's office for evaluation of shortness of breath and fatigue four weeks after repair of a hiatal hernia. He reported a mild, nonproductive cough...http://content.nejm.org/cgi/content/short/353/22/2385?rss=1&ssource=collectionSearchRss&queryTerm=10Donald D. Hegland, M.D., Geoffrey A. Kunz, M.D., J. Kevin Harrison, M.D., and Andrew Wang, M.D.Thu, 01  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/22/2385?rss=1&ssource=collectionSearchRss&queryTerm=10A 38-year-old man notes abrupt loss of vision in his right visual field while reading. He has no significant medical history and reports that he neither smokes nor uses alcohol...http://content.nejm.org/cgi/content/short/353/22/2361?rss=1&ssource=collectionSearchRss&queryTerm=10Jorge R. Kizer, M.D., and Richard B. Devereux, M.D.Thu, 01  Dec  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/22/2361?rss=1&ssource=collectionSearchRss&queryTerm=10Stress testing for the detection of coronary artery disease is most useful in patients considered on clinical grounds to be at intermediate risk.1 The patient's age and sex and the...http://content.nejm.org/cgi/content/short/353/18/1963?rss=1&ssource=collectionSearchRss&queryTerm=10Thomas H. Marwick, M.B., B.S., Ph.D.Thu, 03  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/18/1963?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Although dyspnea is a common symptom, there has been only limited investigation of its prognostic significance among patients referred for cardiac evaluation.<br/><br/><em>Methods:</em> We studied 17,991 patients undergoing myocardial-perfusion single-photon-emission...http://content.nejm.org/cgi/content/short/353/18/1889?rss=1&ssource=collectionSearchRss&queryTerm=10Aiden Abidov, M.D., Ph.D., Alan Rozanski, M.D., Rory Hachamovitch, M.D., Sean W. Hayes, M.D., Fatma Aboul-Enein, M.D., Ishac Cohen, Ph.D., John D. Friedman, M.D., Guido Germano, Ph.D., and Daniel S. Berman, M.D.Thu, 03  Nov  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/18/1889?rss=1&ssource=collectionSearchRss&queryTerm=10At first glance, it may seem implausible that your mother's exposure to stress or toxins while she was pregnant with you, how she fed you when you were an infant,...http://content.nejm.org/cgi/content/short/353/17/1848?rss=1&ssource=collectionSearchRss&queryTerm=10Matthew W. Gillman, M.D.Thu, 27  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/17/1848?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Low birth weight is a risk factor for coronary heart disease. It is uncertain how postnatal growth affects disease risk.<br/><br/><em>Methods:</em> We studied 8760 people born in Helsinki from 1934...http://content.nejm.org/cgi/content/short/353/17/1802?rss=1&ssource=collectionSearchRss&queryTerm=10David J.P. Barker, F.R.S., Clive Osmond, Ph.D., Tom J. Forsén, M.D., Eero Kajantie, M.D., and Johan G. Eriksson, M.D.Thu, 27  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/17/1802?rss=1&ssource=collectionSearchRss&queryTerm=10The remarkable reduction of 50 percent or more in the age-adjusted mortality rate from coronary heart disease over the past four decades in the United States1 has been driven by...http://content.nejm.org/cgi/content/short/353/14/1513?rss=1&ssource=collectionSearchRss&queryTerm=10Lee Goldman, M.D.Thu, 06  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/14/1513?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Eight randomized trials have evaluated whether the prophylactic use of an implantable cardioverter–defibrillator (ICD) improves survival among patients who are at risk for sudden death due to left ventricular...http://content.nejm.org/cgi/content/short/353/14/1471?rss=1&ssource=collectionSearchRss&queryTerm=10Gillian D. Sanders, Ph.D., Mark A. Hlatky, M.D., and Douglas K. Owens, M.D.Thu, 06  Oct  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/14/1471?rss=1&ssource=collectionSearchRss&queryTerm=10During the past 15 years, there have been important advances in both percutaneous coronary intervention (PCI) and the pharmacotherapy of acute coronary syndromes without ST-segment elevation. Several carefully designed, randomized...http://content.nejm.org/cgi/content/short/353/11/1159?rss=1&ssource=collectionSearchRss&queryTerm=10William E. Boden, M.D.Thu, 15  Sep  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/11/1159?rss=1&ssource=collectionSearchRss&queryTerm=10A 67-year-old woman reported having progressive shortness of breath over several months, three years after undergoing aortic-valve replacement for aortic insufficiency. The patient had migraine headaches for which she had...http://content.nejm.org/cgi/content/short/353/7/712?rss=1&ssource=collectionSearchRss&queryTerm=10Micon Bijl, M.D. and R.B.A. van den Brink, M.D., Ph.D.Thu, 18  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/7/712?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Although increased attention has been paid to sex and racial differences in the management of myocardial infarction, it is unknown whether these differences have narrowed over time.<br/><br/><em>Methods:</em> With the...http://content.nejm.org/cgi/content/short/353/7/671?rss=1&ssource=collectionSearchRss&queryTerm=10Viola Vaccarino, M.D., Ph.D., Saif S. Rathore, M.P.H., Nanette K. Wenger, M.D., Paul D. Frederick, M.P.H., M.B.A., Jerome L. Abramson, Ph.D., Hal V. Barron, M.D., Ajay Manhapra, M.D., Susmita Mallik, M.D., and Harlan M. Krumholz, M.D., for the National Registry of Myocardial Infarction InvestigatorsThu, 18  Aug  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/7/671?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The Hospital Quality Alliance (HQA) is the first initiative that routinely reports data on hospitals' performance nationally. Heretofore, such data have been unavailable.<br/><br/><em>Methods:</em> We used data collected by the...http://content.nejm.org/cgi/content/short/353/3/265?rss=1&ssource=collectionSearchRss&queryTerm=10Ashish K. Jha, M.D., M.P.H., Zhonghe Li, M.A., E. John Orav, Ph.D., and Arnold M. Epstein, M.D.Thu, 21  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/3/265?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In July 2002, the Joint Commission on Accreditation of Healthcare Organizations implemented standardized performance measures that were designed to track the performance of accredited hospitals and encourage improvement in...http://content.nejm.org/cgi/content/short/353/3/255?rss=1&ssource=collectionSearchRss&queryTerm=10Scott C. Williams, Psy.D., Stephen P. Schmaltz, Ph.D., David J. Morton, M.S., Richard G. Koss, M.A., and Jerod M. Loeb, Ph.D.Thu, 21  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/3/255?rss=1&ssource=collectionSearchRss&queryTerm=10Almost 50 years after the first report of the use of cardiac pacing, in the Journal,1 pacing is playing an increasingly important role in the management of cardiac disease. Cardiologists...http://content.nejm.org/cgi/content/short/353/2/202?rss=1&ssource=collectionSearchRss&queryTerm=10Kenneth A. Ellenbogen, M.D., and Mark A. Wood, M.D.Thu, 14  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/2/202?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In the treatment of atrioventricular block, dual-chamber cardiac pacing is thought to confer a clinical benefit as compared with single-chamber ventricular pacing, but the supporting evidence is mainly from...http://content.nejm.org/cgi/content/short/353/2/145?rss=1&ssource=collectionSearchRss&queryTerm=10William D. Toff, M.D., A. John Camm, M.D., and J. Douglas Skehan, M.B., B.S., for the United Kingdom Pacing and Cardiovascular Events (UKPACE) Trial InvestigatorsThu, 14  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/2/145?rss=1&ssource=collectionSearchRss&queryTerm=10A 36-year-old woman in her 34th week of pregnancy presented to the emergency department after the onset of severe substernal chest pain. The chest pain was sudden in onset and...http://content.nejm.org/cgi/content/short/353/1/75?rss=1&ssource=collectionSearchRss&queryTerm=10Brahmajee K. Nallamothu, M.D., M.P.H., Mona Saint, M.D., M.P.H., Sanjay Saint, M.D., M.P.H., and Debabrata Mukherjee, M.D.Thu, 07  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/1/75?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Lp(a) lipoprotein binds proinflammatory oxidized phospholipids. We investigated whether levels of oxidized low-density lipoprotein (LDL) measured with use of monoclonal antibody E06 reflect the presence and extent of obstructive...http://content.nejm.org/cgi/content/short/353/1/46?rss=1&ssource=collectionSearchRss&queryTerm=10Sotirios Tsimikas, M.D., Emmanouil S. Brilakis, M.D., Elizabeth R. Miller, B.S., Joseph P. McConnell, Ph.D., Ryan J. Lennon, M.S., Kenneth S. Kornman, Ph.D., Joseph L. Witztum, M.D., and Peter B. Berger, M.D.Thu, 07  Jul  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/353/1/46?rss=1&ssource=collectionSearchRss&queryTerm=10Although the age-adjusted mortality from cardiovascular disease has declined in recent years, the number of sudden deaths has risen.1 According to data from the Centers for Disease Control and Prevention,...http://content.nejm.org/cgi/content/short/352/25/2638?rss=1&ssource=collectionSearchRss&queryTerm=10Alfred E. Buxton, M.D.Thu, 23  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/25/2638?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The risk of sudden death from cardiac causes is increased among survivors of acute myocardial infarction with reduced left ventricular systolic function. We assessed the risk and time course...http://content.nejm.org/cgi/content/short/352/25/2581?rss=1&ssource=collectionSearchRss&queryTerm=10Scott D. Solomon, M.D., Steve Zelenkofske, D.O., John J.V. McMurray, M.D., Peter V. Finn, M.D., Eric Velazquez, M.D., George Ertl, M.D., Adam Harsanyi, M.D., Jean L. Rouleau, M.D., Aldo Maggioni, M.D., Lars Kober, M.D., Harvey White, D.Sc., Frans Van de Werf, M.D., Ph.D., Karen Pieper, M.S., Robert M. Califf, M.D., and Marc A. Pfeffer, M.D., Ph.D., for the Valsartan in Acute Myocardial Infarction Trial (VALIANT) InvestigatorsThu, 23  Jun  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/25/2581?rss=1&ssource=collectionSearchRss&queryTerm=10During the past three decades, randomized trials and registries have provided extensive evidence regarding the indications for and preferred method of coronary revascularization.1 The initial trials focused on indications for...http://content.nejm.org/cgi/content/short/352/21/2235?rss=1&ssource=collectionSearchRss&queryTerm=10Bernard J. Gersh, M.B., Ch.B., D.Phil., and Robert L. Frye, M.D.Thu, 26  May  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/21/2235?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Several studies have compared outcomes for coronary-artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), but most were done before the availability of stenting, which has revolutionized the latter...http://content.nejm.org/cgi/content/short/352/21/2174?rss=1&ssource=collectionSearchRss&queryTerm=10Edward L. Hannan, Ph.D., Michael J. Racz, Ph.D., Gary Walford, M.D., Robert H. Jones, M.D., Thomas J. Ryan, M.D., Edward Bennett, M.D., Alfred T. Culliford, M.D., O. Wayne Isom, M.D., Jeffrey P. Gold, M.D., and Eric A. Rose, M.D.Thu, 26  May  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/21/2174?rss=1&ssource=collectionSearchRss&queryTerm=10Two large, high-quality, and convincingly negative clinical trials for the secondary prevention of coronary heart disease,12 published in this issue of the Journal, raise questions as to whether we are...http://content.nejm.org/cgi/content/short/352/16/1706?rss=1&ssource=collectionSearchRss&queryTerm=10Jeffrey L. Anderson, M.D.Thu, 21  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/16/1706?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Chlamydia pneumoniae has been found within atherosclerotic plaques, and elevated titers of antibody to this organism have been linked to a higher risk of coronary events. Pilot studies have...http://content.nejm.org/cgi/content/short/352/16/1646?rss=1&ssource=collectionSearchRss&queryTerm=10Christopher P. Cannon, M.D., Eugene Braunwald, M.D., Carolyn H. McCabe, B.S., J. Thomas Grayston, M.D., Brent Muhlestein, M.D., Robert P. Giugliano, M.D., Richard Cairns, M.Sc., and Allan M. Skene, Ph.D., for the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 InvestigatorsThu, 21  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/16/1646?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Epidemiologic, laboratory, animal, and clinical studies suggest that there is an association between Chlamydia pneumoniae infection and atherogenesis. We evaluated the efficacy of one year of azithromycin treatment for...http://content.nejm.org/cgi/content/short/352/16/1637?rss=1&ssource=collectionSearchRss&queryTerm=10J. Thomas Grayston, M.D., Richard A. Kronmal, Ph.D., Lisa A. Jackson, M.D., Alfred F. Parisi, M.D., Joseph B. Muhlestein, M.D., Jerome D. Cohen, M.D., William J. Rogers, M.D., John R. Crouse, M.D., Sandra L. Borrowdale, M.S., Eleanor Schron, M.S., and Charles Knirsch, M.D., for the ACES InvestigatorsThu, 21  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/16/1637?rss=1&ssource=collectionSearchRss&queryTerm=10The evidence of the effectiveness of statins in the treatment of stable coronary heart disease (CHD) continues to grow. Large-scale, randomized, secondary-prevention trials involving patients with CHD have shown that...http://content.nejm.org/cgi/content/short/352/14/1483?rss=1&ssource=collectionSearchRss&queryTerm=10Bertram Pitt, M.D.Thu, 07  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/14/1483?rss=1&ssource=collectionSearchRss&queryTerm=10Between 1949 and 2002, a patient underwent four lifesaving procedures that documented medical progress throughout the past 50 years. This plain chest radiograph, which was performed when the patient was...http://content.nejm.org/cgi/content/short/352/14/1473?rss=1&ssource=collectionSearchRss&queryTerm=10Ralf Ostermaier, M.D. and Marianne Taut, M.D.Thu, 07  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/14/1473?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The emergence of specialty hospitals focusing on narrow procedural areas has generated controversy, although little is known about their quality.<br/><br/><em>Methods:</em> We conducted a retrospective cohort study of 42,737 Medicare...http://content.nejm.org/cgi/content/short/352/14/1454?rss=1&ssource=collectionSearchRss&queryTerm=10Peter Cram, M.D., M.B.A., Gary E. Rosenthal, M.D., and Mary S. Vaughan-Sarrazin, Ph.D.Thu, 07  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/14/1454?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Previous trials have demonstrated that lowering low-density lipoprotein (LDL) cholesterol levels below currently recommended levels is beneficial in patients with acute coronary syndromes. We prospectively assessed the efficacy and...http://content.nejm.org/cgi/content/short/352/14/1425?rss=1&ssource=collectionSearchRss&queryTerm=10John C. LaRosa, M.D., Scott M. Grundy, M.D., Ph.D., David D. Waters, M.D., Charles Shear, Ph.D., Philip Barter, M.D., Ph.D., Jean-Charles Fruchart, Pharm.D., Ph.D., Antonio M. Gotto, M.D., D.Phil., Heiner Greten, M.D., John J.P. Kastelein, M.D., James Shepherd, M.D., and Nanette K. Wenger, M.D., for the Treating to New Targets (TNT) InvestigatorsThu, 07  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/14/1425?rss=1&ssource=collectionSearchRss&queryTerm=10Approximately 1000 active ingredients are currently in use in more than 100,000 over-the-counter medications in the United States, with combined annual sales exceeding $17 billion. Many drugs have recently been...http://content.nejm.org/cgi/content/short/352/14/1403?rss=1&ssource=collectionSearchRss&queryTerm=10Brian L. Strom, M.D., M.P.H.Thu, 07  Apr  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/14/1403?rss=1&ssource=collectionSearchRss&queryTerm=10In patients who have myocardial infarction with ST-segment elevation, rupture of an atherosclerotic plaque leads to platelet adhesion, activation, and aggregation, with subsequent vessel occlusion due to thrombus formation. In...http://content.nejm.org/cgi/content/short/352/12/1248?rss=1&ssource=collectionSearchRss&queryTerm=10Richard A. Lange, M.D., and L. David Hillis, M.D.Thu, 24  Mar  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/12/1248?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The level of the inactive N-terminal fragment of pro–brain (B-type) natriuretic peptide (BNP) is a strong predictor of mortality among patients with acute coronary syndromes and may be a...http://content.nejm.org/cgi/content/short/352/7/666?rss=1&ssource=collectionSearchRss&queryTerm=10Charlotte Kragelund, M.D., Bjørn Grønning, M.D., Lars Køber, D.M.Sc., Per Hildebrandt, D.M.Sc., and Rolf Steffensen, M.D.Thu, 17  Feb  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/7/666?rss=1&ssource=collectionSearchRss&queryTerm=10A 56-year-old man who had recently undergone coronary-artery bypass grafting and replacement of the mitral and aortic valves underwent aortobifemoral bypass surgery for Fontaine stage IIb arterial occlusive disease. The...http://content.nejm.org/cgi/content/short/352/4/e3?rss=1&ssource=collectionSearchRss&queryTerm=10Andreas J. Morguet, M.D. and Heinz-Peter Schultheiss, M.D.Thu, 27  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/4/e3?rss=1&ssource=collectionSearchRss&queryTerm=10If ever there were a perfect marriage of drug with disease it might be between statins and atherosclerosis. At first the relationship was simple: statins inhibited synthesis of the cholesterol...http://content.nejm.org/cgi/content/short/352/1/73?rss=1&ssource=collectionSearchRss&queryTerm=10Michael R. Ehrenstein, Ph.D., F.R.C.P., Elizabeth C. Jury, Ph.D., and Claudia Mauri, Ph.D.Thu, 06  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/1/73?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Recent trials have demonstrated better outcomes with intensive than with moderate statin treatment. Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting...http://content.nejm.org/cgi/content/short/352/1/29?rss=1&ssource=collectionSearchRss&queryTerm=10Steven E. Nissen, M.D., E. Murat Tuzcu, M.D., Paul Schoenhagen, M.D., Tim Crowe, B.S., William J. Sasiela, Ph.D., John Tsai, M.D., John Orazem, Ph.D., Raymond D. Magorien, M.D., Charles O'Shaughnessy, M.D., and Peter Ganz, M.D., for the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) InvestigatorsThu, 06  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/1/29?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Statins lower the levels of low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP). Whether this latter property affects clinical outcomes is unknown.<br/><br/><em>Methods:</em> We evaluated relationships between the LDL cholesterol...http://content.nejm.org/cgi/content/short/352/1/20?rss=1&ssource=collectionSearchRss&queryTerm=10Paul M Ridker, M.D., Christopher P. Cannon, M.D., David Morrow, M.D., Nader Rifai, Ph.D., Lynda M. Rose, M.S., Carolyn H. McCabe, B.S., Marc A. Pfeffer, M.D., Ph.D., and Eugene Braunwald, M.D., for the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 (PROVE IT–TIMI 22) InvestigatorsThu, 06  Jan  2005 00:00:00 -05:00http://content.nejm.org/cgi/content/short/352/1/20?rss=1&ssource=collectionSearchRss&queryTerm=10A 68-year-old woman who had been resuscitated after cardiac arrest was admitted because of chest pain. The electrocardiogram showed atrial fibrillation and ST-segment elevation in leads II, III, and aVF,...http://content.nejm.org/cgi/content/short/351/27/e25?rss=1&ssource=collectionSearchRss&queryTerm=10Tamás Tornóczky, M.D., Ph.D. and Zeno Ajtay, M.D.Thu, 30  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/27/e25?rss=1&ssource=collectionSearchRss&queryTerm=10The evaluation of cardiac risk before noncardiac surgical procedures and interventions aimed toward reducing that risk have become an integral part of the contemporary practice of medicine. In the nonoperative...http://content.nejm.org/cgi/content/short/351/27/2861?rss=1&ssource=collectionSearchRss&queryTerm=10Mauro Moscucci, M.D., and Kim A. Eagle, M.D.Thu, 30  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/27/2861?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The benefit of coronary-artery revascularization before elective major vascular surgery is unclear.<br/><br/><em>Methods:</em> We randomly assigned patients at increased risk for perioperative cardiac complications and clinically significant coronary artery disease...http://content.nejm.org/cgi/content/short/351/27/2795?rss=1&ssource=collectionSearchRss&queryTerm=10Edward O. McFalls, M.D., Ph.D., Herbert B. Ward, M.D., Ph.D., Thomas E. Moritz, M.S., Steven Goldman, M.D., William C. Krupski, M.D., Fred Littooy, M.D., Gordon Pierpont, M.D., Steve Santilli, M.D., Joseph Rapp, M.D., Brack Hattler, M.D., Kendrick Shunk, M.D., Ph.D., Connie Jaenicke, R.N., B.S.N., Lizy Thottapurathu, M.S., Nancy Ellis, M.S., Domenic J. Reda, Ph.D., and William G. Henderson, Ph.D.Thu, 30  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/27/2795?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> There is evidence that chronic inflammation may promote atherosclerotic disease. We tested the hypothesis that acute infection and vaccination increase the short-term risk of vascular events.<br/><br/><em>Methods:</em> We undertook within-person...http://content.nejm.org/cgi/content/short/351/25/2611?rss=1&ssource=collectionSearchRss&queryTerm=10Liam Smeeth, Ph.D., Sara L. Thomas, Ph.D., Andrew J. Hall, Ph.D., Richard Hubbard, D.M., Paddy Farrington, Ph.D., and Patrick Vallance, M.D.Thu, 16  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/25/2611?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Few studies have simultaneously investigated the role of soluble tumor necrosis factor α (TNF-α) receptors types 1 and 2 (sTNF-R1 and sTNF-R2), C-reactive protein, and interleukin-6 as predictors of...http://content.nejm.org/cgi/content/short/351/25/2599?rss=1&ssource=collectionSearchRss&queryTerm=10Jennifer K. Pai, M.H.S., Tobias Pischon, M.D., M.P.H., Jing Ma, M.D., Ph.D., JoAnn E. Manson, M.D., Dr.P.H., Susan E. Hankinson, Sc.D., Kaumudi Joshipura, B.D.S., Sc.D., Gary C. Curhan, M.D., Sc.D., Nader Rifai, Ph.D., Carolyn C. Cannuscio, Sc.D., Meir J. Stampfer, M.D., Dr.P.H., and Eric B. Rimm, Sc.D.Thu, 16  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/25/2599?rss=1&ssource=collectionSearchRss&queryTerm=10A number of clinical trials have been reported to show that the implantable cardioverter–defibrillator (ICD) prevents sudden death from cardiac causes and significantly reduces overall mortality among patients with left...http://content.nejm.org/cgi/content/short/351/24/2540?rss=1&ssource=collectionSearchRss&queryTerm=10Anne M. Gillis, M.D.Thu, 09  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/24/2540?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Implantable cardioverter–defibrillator (ICD) therapy has been shown to improve survival in patients with various heart conditions who are at high risk for ventricular arrhythmias. Whether benefit occurs in patients...http://content.nejm.org/cgi/content/short/351/24/2481?rss=1&ssource=collectionSearchRss&queryTerm=10Stefan H. Hohnloser, M.D., Karl Heinz Kuck, M.D., Paul Dorian, M.D., Robin S. Roberts, M.Tech., John R. Hampton, M.D., Robert Hatala, M.D., Eric Fain, M.D., Michael Gent, D.Sc., and Stuart J. Connolly, M.D., on behalf of the DINAMIT InvestigatorsThu, 09  Dec  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/24/2481?rss=1&ssource=collectionSearchRss&queryTerm=10Hypertensive retinopathy is a condition characterized by a spectrum of retinal vascular signs in people with elevated blood pressure.1 The detection of hypertensive retinopathy with the use of an ophthalmoscope...http://content.nejm.org/cgi/content/short/351/22/2310?rss=1&ssource=collectionSearchRss&queryTerm=10Tien Y. Wong, M.D., Ph.D., and Paul Mitchell, M.D., Ph.D.Thu, 25  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/22/2310?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In the past decade, the radial artery has frequently been used for coronary bypass surgery despite concern regarding the possibility of graft spasm. Graft patency is a key predictor...http://content.nejm.org/cgi/content/short/351/22/2302?rss=1&ssource=collectionSearchRss&queryTerm=10Nimesh D. Desai, M.D., Eric A. Cohen, M.D., C. David Naylor, M.D., D.Phil., and Stephen E. Fremes, M.D., for the Radial Artery Patency Study InvestigatorsThu, 25  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/22/2302?rss=1&ssource=collectionSearchRss&queryTerm=10The benefits of coronary bypass surgery last only as long as the grafts continue to function. Aorta-to-coronary saphenous-vein grafts (see diagram), the most widely used type of bypass graft, have...http://content.nejm.org/cgi/content/short/351/22/2262?rss=1&ssource=collectionSearchRss&queryTerm=10Bruce W. Lytle, M.D.Thu, 25  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/22/2262?rss=1&ssource=collectionSearchRss&queryTerm=10A 35-year-old woman was evaluated for presyncope several days after giving birth. The results of physical examination were unremarkable, but her electrocardiogram showed transient ST depressions in leads II, III,...http://content.nejm.org/cgi/content/short/351/20/e18?rss=1&ssource=collectionSearchRss&queryTerm=10Aaron Frimerman, M.D. and Simcha R. Meisel, M.D.Thu, 11  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/20/e18?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> 04111130.xml 04111130.xml 04111130.xml 04111130.xml Angiotensin-converting–enzyme (ACE) inhibitors are effective in reducing the risk of heart failure, myocardial infarction, and death from cardiovascular causes in patients with left ventricular systolic...http://content.nejm.org/cgi/content/short/351/20/2058?rss=1&ssource=collectionSearchRss&queryTerm=10The PEACE Trial InvestigatorsThu, 11  Nov  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/20/2058?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> An association between exposure to vehicular traffic in urban areas and the exacerbation of cardiovascular disease has been suggested in previous studies. This study was designed to assess whether...http://content.nejm.org/cgi/content/short/351/17/1721?rss=1&ssource=collectionSearchRss&queryTerm=10Annette Peters, Ph.D., Stephanie von Klot, M.P.H., Margit Heier, M.D., Ines Trentinaglia, B.S., Allmut Hörmann, M.S., H. Erich Wichmann, M.D., Ph.D., and Hannelore Löwel, M.D., for the Cooperative Health Research in the Region of Augsburg Study GroupThu, 21  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/17/1721?rss=1&ssource=collectionSearchRss&queryTerm=10Enormous progress made during the past few decades has dramatically enhanced our understanding of the pathobiology and pathophysiology responsible for acute myocardial infarction. Investigations in vascular biology have elucidated the...http://content.nejm.org/cgi/content/short/351/17/1716?rss=1&ssource=collectionSearchRss&queryTerm=10Peter H. Stone, M.D.Thu, 21  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/17/1716?rss=1&ssource=collectionSearchRss&queryTerm=10The introduction of drug-eluting coronary stents in the United States has rapidly and profoundly affected the field of interventional cardiology. Met with widespread anticipation by the clinical community, drug-eluting stents...http://content.nejm.org/cgi/content/short/351/16/1593?rss=1&ssource=collectionSearchRss&queryTerm=10Neal I. Muni, M.D., M.S.P.H., and Thomas P. Gross, M.D., M.P.H.Thu, 14  Oct  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/16/1593?rss=1&ssource=collectionSearchRss&queryTerm=10In April 1978, Dr. Andreas Grüntzig, of University Hospital, Zurich, told a patient who had a tightly narrowed left anterior descending coronary artery that he did not have enough experience...http://content.nejm.org/cgi/content/short/351/13/1332?rss=1&ssource=collectionSearchRss&queryTerm=10Samir R. Kapadia, M.D. and Maria Schlumpf, B.S.Thu, 23  Sep  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/13/1332?rss=1&ssource=collectionSearchRss&queryTerm=10A 38-year-old man presented to the emergency department with nausea, vomiting, and epigastric pain. The patient had type 1 diabetes mellitus and was being treated with insulin. He was also...http://content.nejm.org/cgi/content/short/351/6/593?rss=1&ssource=collectionSearchRss&queryTerm=10Kyuhyun Wang, M.D.Thu, 05  Aug  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/351/6/593?rss=1&ssource=collectionSearchRss&queryTerm=10Cardiologists agree that the best and safest percutaneous coronary intervention is the one that never becomes necessary. In this regard, new therapies that prevent restenosis and retard or reverse atherosclerosis...http://content.nejm.org/cgi/content/short/350/26/2708?rss=1&ssource=collectionSearchRss&queryTerm=10Howard C. Herrmann, M.D.Thu, 24  Jun  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/26/2708?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Vitamin therapy to lower homocysteine levels has recently been recommended for the prevention of restenosis after coronary angioplasty. We tested the effect of a combination of folic acid, vitamin...http://content.nejm.org/cgi/content/short/350/26/2673?rss=1&ssource=collectionSearchRss&queryTerm=10Helmut Lange, M.D., Harry Suryapranata, M.D., Giuseppe De Luca, M.D., Caspar Börner, M.D., Joep Dille, B.Sc., Klaus Kallmayer, M.D., M. Noor Pasalary, M.D., Eberhard Scherer, M.D., and Jan-Henk E. Dambrink, M.D.Thu, 24  Jun  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/26/2673?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Liposuction has been proposed as a potential treatment for the metabolic complications of obesity. We evaluated the effect of large-volume abdominal liposuction on metabolic risk factors for coronary heart...http://content.nejm.org/cgi/content/short/350/25/2549?rss=1&ssource=collectionSearchRss&queryTerm=10Samuel Klein, M.D., Luigi Fontana, M.D., Ph.D., V. Leroy Young, M.D., Andrew R. Coggan, Ph.D., Charles Kilo, M.D., Bruce W. Patterson, Ph.D., and B. Selma Mohammed, M.D., Ph.D.Thu, 17  Jun  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/25/2549?rss=1&ssource=collectionSearchRss&queryTerm=10The fundamental principle of evidence-based medicine is that clinical practice should rest on a sound scientific foundation established by clinical studies involving human subjects. The level of evidence needed for...http://content.nejm.org/cgi/content/short/350/21/2126?rss=1&ssource=collectionSearchRss&queryTerm=10Mark A. Hlatky, M.D.Thu, 20  May  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/21/2126?rss=1&ssource=collectionSearchRss&queryTerm=10In the management of atherosclerotic vascular disease, statin drugs have already surpassed all other classes of medicines in reducing the incidence of the major adverse outcomes of death, heart attack,...http://content.nejm.org/cgi/content/short/350/15/1562?rss=1&ssource=collectionSearchRss&queryTerm=10Eric J. Topol, M.D.Thu, 08  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/15/1562?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Decreased high-density lipoprotein (HDL) cholesterol levels constitute a major risk factor for coronary heart disease; however, there are no therapies that substantially raise HDL cholesterol levels. Inhibition of cholesteryl...http://content.nejm.org/cgi/content/short/350/15/1505?rss=1&ssource=collectionSearchRss&queryTerm=10Margaret E. Brousseau, Ph.D., Ernst J. Schaefer, M.D., Megan L. Wolfe, B.S., LeAnne T. Bloedon, M.S., R.D., Andres G. Digenio, M.D., Ph.D., Ronald W. Clark, M.S., James P. Mancuso, Ph.D., and Daniel J. Rader, M.D.Thu, 08  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/15/1505?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Lipid-lowering therapy with statins reduces the risk of cardiovascular events, but the optimal level of low-density lipoprotein (LDL) cholesterol is unclear.<br/><br/><em>Methods:</em> We enrolled 4162 patients who had been hospitalized...http://content.nejm.org/cgi/content/short/350/15/1495?rss=1&ssource=collectionSearchRss&queryTerm=10Christopher P. Cannon, M.D., Eugene Braunwald, M.D., Carolyn H. McCabe, B.S., Daniel J. Rader, M.D., Jean L. Rouleau, M.D., Rene Belder, M.D., Steven V. Joyal, M.D., Karen A. Hill, B.A., Marc A. Pfeffer, M.D., Ph.D., and Allan M. Skene, Ph.D., for the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 InvestigatorsThu, 08  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/15/1495?rss=1&ssource=collectionSearchRss&queryTerm=10In this issue of the Journal, Danesh and colleagues report that elevated levels of C-reactive protein (CRP) are associated with only a moderate increase in the risk of coronary heart...http://content.nejm.org/cgi/content/short/350/14/1450?rss=1&ssource=collectionSearchRss&queryTerm=10Alan R. Tall, M.B., B.S.Thu, 01  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/14/1450?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> C-reactive protein is an inflammatory marker believed to be of value in the prediction of coronary events. We report data from a large study of C-reactive protein and other...http://content.nejm.org/cgi/content/short/350/14/1387?rss=1&ssource=collectionSearchRss&queryTerm=10John Danesh, M.B., Ch.B., D.Phil., Jeremy G. Wheeler, M.Sc., Gideon M. Hirschfield, M.R.C.P., Shinichi Eda, Ph.D., Gudny Eiriksdottir, M.Sc., Ann Rumley, Ph.D., Gordon D.O. Lowe, M.D., F.R.C.P., Mark B. Pepys, M.D., Ph.D., and Vilmundur Gudnason, M.D., Ph.D.Thu, 01  Apr  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/14/1387?rss=1&ssource=collectionSearchRss&queryTerm=10Rupture or injury of an atherosclerotic coronary arterial plaque — as occurs spontaneously in patients with an acute coronary syndrome or as the result of a percutaneous coronary intervention —...http://content.nejm.org/cgi/content/short/350/3/277?rss=1&ssource=collectionSearchRss&queryTerm=10Richard A. Lange, M.D., and L. David Hillis, M.D.Thu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/277?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Whether the glycoprotein IIb/IIIa inhibitor abciximab is beneficial in patients undergoing elective percutaneous coronary intervention after pretreatment with clopidogrel is unknown.<br/><br/><em>Methods:</em> We enrolled 2159 patients with coronary artery disease...http://content.nejm.org/cgi/content/short/350/3/232?rss=1&ssource=collectionSearchRss&queryTerm=10Adnan Kastrati, M.D., Julinda Mehilli, M.D., Helmut Schühlen, M.D., Josef Dirschinger, M.D., Franz Dotzer, M.D., Jurriën M. ten Berg, M.D., Franz-Josef Neumann, M.D., Hildegard Bollwein, M.D., Christian Volmer, Meinrad Gawaz, M.D., Peter B. Berger, M.D., and Albert Schömig, M.D., for the Intracoronary Stenting and Antithrombotic Regimen–Rapid Early Action for Coronary Treatment (ISAR-REACT) Study InvestigatorsThu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/232?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Restenosis after coronary stenting necessitates repeated percutaneous or surgical revascularization procedures. The delivery of paclitaxel to the site of vascular injury may reduce the incidence of neointimal hyperplasia and...http://content.nejm.org/cgi/content/short/350/3/221?rss=1&ssource=collectionSearchRss&queryTerm=10Gregg W. Stone, M.D., Stephen G. Ellis, M.D., David A. Cox, M.D., James Hermiller, M.D., Charles O'Shaughnessy, M.D., James Tift Mann, M.D., Mark Turco, M.D., Ronald Caputo, M.D., Patrick Bergin, M.D., Joel Greenberg, M.D., Jeffrey J. Popma, M.D., and Mary E. Russell, M.D., for the TAXUS-IV InvestigatorsThu, 15  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/3/221?rss=1&ssource=collectionSearchRss&queryTerm=10In 1883, the eminent Viennese surgeon Theodor Billroth declared, “Let no man who hopes to retain the respect of his medical brethren dare to operate on the human heart.” Billroth...http://content.nejm.org/cgi/content/short/350/1/3?rss=1&ssource=collectionSearchRss&queryTerm=10Thomas E. MacGillivray, M.D., and Gus J. Vlahakes, M.D.Thu, 01  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/1/3?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The effect of the use of coronary-artery bypass surgery without cardiopulmonary bypass and cardiac arrest (“off pump”) on graft patency remains uncertain. We undertook a prospective, randomized, controlled study...http://content.nejm.org/cgi/content/short/350/1/21?rss=1&ssource=collectionSearchRss&queryTerm=10Natasha E. Khan, M.R.C.S., Anthony De Souza, F.R.C.S., Rebecca Mister, M.Sc., Marcus Flather, F.R.C.P., Jonathan Clague, M.D., Simon Davies, F.R.C.P., Peter Collins, M.D., Duolao Wang, Ph.D., Ulrich Sigwart, M.D., and John Pepper, M.Chir.Thu, 01  Jan  2004 00:00:00 -05:00http://content.nejm.org/cgi/content/short/350/1/21?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Premature coronary artery disease is a major cause of illness and death in patients with systemic lupus erythematosus, but little is known about the prevalence, extent, and causes of...http://content.nejm.org/cgi/content/short/349/25/2407?rss=1&ssource=collectionSearchRss&queryTerm=10Yu Asanuma, M.D., Ph.D., Annette Oeser, B.S., Ayumi K. Shintani, Ph.D., M.P.H., Elizabeth Turner, M.D., Nancy Olsen, M.D., Sergio Fazio, M.D., Ph.D., MacRae F. Linton, M.D., Paolo Raggi, M.D., and C. Michael Stein, M.D.Thu, 18  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/25/2407?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Intraplaque hemorrhage is common in advanced coronary atherosclerotic lesions. The relation between hemorrhage and the vulnerability of plaque to disruption may involve the accumulation of free cholesterol from erythrocyte...http://content.nejm.org/cgi/content/short/349/24/2316?rss=1&ssource=collectionSearchRss&queryTerm=10Frank D. Kolodgie, Ph.D., Herman K. Gold, M.D., Allen P. Burke, M.D., David R. Fowler, M.D., Howard S. Kruth, M.D., Deena K. Weber, M.S., Andrew Farb, M.D., L.J. Guerrero, B.S., Motoya Hayase, M.D., Robert Kutys, M.S., Jagat Narula, M.D., Ph.D., Aloke V. Finn, M.D., and Renu Virmani, M.D.Thu, 11  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/24/2316?rss=1&ssource=collectionSearchRss&queryTerm=10It is ironic and instructive that in the age of cellular and molecular biology, great advances in our understanding of the pathophysiology of cardiovascular disease continue to be made by...http://content.nejm.org/cgi/content/short/349/24/2285?rss=1&ssource=collectionSearchRss&queryTerm=10Donald D. Heistad, M.D.Thu, 11  Dec  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/24/2285?rss=1&ssource=collectionSearchRss&queryTerm=10Beta-blockers, angiotensin-converting–enzyme (ACE) inhibitors, and aldosterone antagonists have been shown to reduce the overall risk of death as well as the risk of major nonfatal cardiovascular events when they are...http://content.nejm.org/cgi/content/short/349/20/1963?rss=1&ssource=collectionSearchRss&queryTerm=10Douglas L. Mann, M.D., and Anita Deswal, M.D., M.P.H.Thu, 13  Nov  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/20/1963?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Angiotensin-converting–enzyme (ACE) inhibitors such as captopril reduce mortality and cardiovascular morbidity among patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both. In a double-blind...http://content.nejm.org/cgi/content/short/349/20/1893?rss=1&ssource=collectionSearchRss&queryTerm=10Marc A. Pfeffer, M.D., Ph.D., John J.V. McMurray, M.D., Eric J. Velazquez, M.D., Jean-Lucien Rouleau, M.D., Lars Køber, M.D., Aldo P. Maggioni, M.D., Scott D. Solomon, M.D., Karl Swedberg, M.D., Ph.D., Frans Van de Werf, M.D., Ph.D., Harvey White, D.Sc., Jeffrey D. Leimberger, Ph.D., Marc Henis, M.D., Susan Edwards, M.S., Steven Zelenkofske, D.O., Mary Ann Sellers, M.S.N., and Robert M. Califf, M.D., for the Valsartan in Acute Myocardial Infarction Trial InvestigatorsThu, 13  Nov  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/20/1893?rss=1&ssource=collectionSearchRss&queryTerm=10Despite advances in emergency medical systems and in techniques of resuscitation, sudden death from cardiac arrest remains a major public health problem. Most persons who have an out-of-hospital cardiac arrest...http://content.nejm.org/cgi/content/short/349/19/1836?rss=1&ssource=collectionSearchRss&queryTerm=10John P. DiMarco, M.D., Ph.D.Thu, 06  Nov  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/19/1836?rss=1&ssource=collectionSearchRss&queryTerm=10A 47-year-old man with no history of cardiac disease presented to a hospital, reporting severe substernal chest pressure associated with bilateral arm weakness. A standard 12-lead electrocardiogram (Panel A) showed...http://content.nejm.org/cgi/content/short/349/17/1636?rss=1&ssource=collectionSearchRss&queryTerm=10Aloke V. Finn, M.D. and Elliott M. Antman, M.D.Thu, 23  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/17/1636?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Cellular antioxidant enzymes such as glutathione peroxidase 1 and superoxide dismutase have a central role in the control of reactive oxygen species. In vitro data and studies in animal...http://content.nejm.org/cgi/content/short/349/17/1605?rss=1&ssource=collectionSearchRss&queryTerm=10Stefan Blankenberg, M.D., Hans J. Rupprecht, M.D., Christoph Bickel, M.D., Michael Torzewski, M.D., Gerd Hafner, M.D., Laurence Tiret, Ph.D., Marek Smieja, M.D., Ph.D., François Cambien, M.D., Jürgen Meyer, M.D., and Karl J. Lackner, M.D., for the AtheroGene InvestigatorsThu, 23  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/17/1605?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Inflammation is linked to adverse outcomes in acute coronary syndromes. Myeloperoxidase, an abundant leukocyte enzyme, is elevated in culprit lesions that have fissured or ruptured in patients with sudden...http://content.nejm.org/cgi/content/short/349/17/1595?rss=1&ssource=collectionSearchRss&queryTerm=10Marie-Luise Brennan, Ph.D., Marc S. Penn, M.D., Ph.D., Frederick Van Lente, Ph.D., Vijay Nambi, M.D., Mehdi H. Shishehbor, D.O., Ronnier J. Aviles, M.D., Marlene Goormastic, M.P.H., Michael L. Pepoy, B.S., Ellen S. McErlean, M.S.N., Eric J. Topol, M.D., Steven E. Nissen, M.D., and Stanley L. Hazen, M.D., Ph.D.Thu, 23  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/17/1595?rss=1&ssource=collectionSearchRss&queryTerm=10A growing understanding of the importance of the rupture of atherosclerotic plaque in the pathogenesis of coronary events has led to the identification of an expanding array of markers of...http://content.nejm.org/cgi/content/short/349/17/1587?rss=1&ssource=collectionSearchRss&queryTerm=10Teri Manolio, M.D., Ph.D.Thu, 23  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/17/1587?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Nephropathy induced by exposure to radiocontrast agents, a possible complication of percutaneous coronary interventions, is associated with significant in-hospital and long-term morbidity and mortality. Patients with preexisting renal failure...http://content.nejm.org/cgi/content/short/349/14/1333?rss=1&ssource=collectionSearchRss&queryTerm=10Giancarlo Marenzi, M.D., Ivana Marana, M.D., Gianfranco Lauri, M.D., Emilio Assanelli, M.D., Marco Grazi, M.D., Jeness Campodonico, M.D., Daniela Trabattoni, M.D., Franco Fabbiocchi, M.D., Piero Montorsi, M.D., and Antonio L. Bartorelli, M.D.Thu, 02  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/14/1333?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Preliminary reports of studies involving simple coronary lesions indicate that a sirolimus-eluting stent significantly reduces the risk of restenosis after percutaneous coronary revascularization.<br/><br/><em>Methods:</em> We conducted a randomized, double-blind trial...http://content.nejm.org/cgi/content/short/349/14/1315?rss=1&ssource=collectionSearchRss&queryTerm=10Jeffrey W. Moses, M.D., Martin B. Leon, M.D., Jeffrey J. Popma, M.D., Peter J. Fitzgerald, M.D., Ph.D., David R. Holmes, M.D., Charles O'Shaughnessy, M.D., Ronald P. Caputo, M.D., Dean J. Kereiakes, M.D., David O. Williams, M.D., Paul S. Teirstein, M.D., Judith L. Jaeger, B.A., and Richard E. Kuntz, M.D., for the SIRIUS InvestigatorsThu, 02  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/14/1315?rss=1&ssource=collectionSearchRss&queryTerm=10Invasive cardiovascular procedures offer many patients substantial diagnostic and therapeutic benefits. Vascular angioplasty, electrophysiological ablation procedures, and transjugular intrahepatic portosystemic shunt procedures are among the important therapeutic procedures that provide...http://content.nejm.org/cgi/content/short/349/14/1311?rss=1&ssource=collectionSearchRss&queryTerm=10John W. Hirshfeld, Jr., M.D.Thu, 02  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/14/1311?rss=1&ssource=collectionSearchRss&queryTerm=10Sirolimus (rapamycin), an inhibitor of in-stent restenosis in the coronary arteries, is having a substantial effect on the care of patients with coronary artery disease, was discovered in a soil...http://content.nejm.org/cgi/content/short/349/14/1307?rss=1&ssource=collectionSearchRss&queryTerm=10Andrew R. Marks, M.D.Thu, 02  Oct  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/14/1307?rss=1&ssource=collectionSearchRss&queryTerm=10A 39-year-old man without a history of cardiac disease presented with left-sided chest pain. Myocardial infarction was ruled out. A subsequent stress test revealed no signs of myocardial ischemia. A...http://content.nejm.org/cgi/content/short/349/11/1047?rss=1&ssource=collectionSearchRss&queryTerm=10Holger Eggebrecht, M.D. and Stefan Möhlenkamp, M.D.Thu, 11  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/11/1047?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Microvascular dysfunction, reflected by an inadequate increase in myocardial blood flow in response to dipyridamole infusion, is a recognized feature of hypertrophic cardiomyopathy. Its long-term effect on the prognosis...http://content.nejm.org/cgi/content/short/349/11/1027?rss=1&ssource=collectionSearchRss&queryTerm=10Franco Cecchi, M.D., Iacopo Olivotto, M.D., Roberto Gistri, M.D., Roberto Lorenzoni, M.D., Giampaolo Chiriatti, M.D., and Paolo G. Camici, M.D.Thu, 11  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/11/1027?rss=1&ssource=collectionSearchRss&queryTerm=10Hypertrophic cardiomyopathy has fascinated clinicians and clinical investigators since its initial description almost 50 years ago because of the unique physical findings, often bizarre electrocardiographic aspects, unusual shape of the...http://content.nejm.org/cgi/content/short/349/11/1016?rss=1&ssource=collectionSearchRss&queryTerm=10Richard O. Cannon III, M.D.Thu, 11  Sep  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/11/1016?rss=1&ssource=collectionSearchRss&queryTerm=10Nearly two decades after clinical trials established that fibrinolytic therapy for acute myocardial infarction preserves left ventricular function and reduces mortality, there is evidence that mechanical reperfusion therapy is superior...http://content.nejm.org/cgi/content/short/349/8/798?rss=1&ssource=collectionSearchRss&queryTerm=10Alice K. Jacobs, M.D.Thu, 21  Aug  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/8/798?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> For the treatment of myocardial infarction with ST-segment elevation, primary angioplasty is considered superior to fibrinolysis for patients who are admitted to hospitals with angioplasty facilities. Whether this benefit...http://content.nejm.org/cgi/content/short/349/8/733?rss=1&ssource=collectionSearchRss&queryTerm=10Henning R. Andersen, M.D., Torsten T. Nielsen, M.D., Klaus Rasmussen, M.D., Leif Thuesen, M.D., Henning Kelbaek, M.D., Per Thayssen, M.D., Ulrik Abildgaard, M.D., Flemming Pedersen, M.D., Jan K. Madsen, M.D., Peer Grande, M.D., Anton B. Villadsen, M.D., Lars R. Krusell, M.D., Torben Haghfelt, M.D., Preben Lomholt, M.D., Steen E. Husted, M.D., Else Vigholt, M.D., Henrik K. Kjaergard, M.D., and Leif Spange Mortensen, M.Sc., for the DANAMI-2 InvestigatorsThu, 21  Aug  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/8/733?rss=1&ssource=collectionSearchRss&queryTerm=10A 19-year-old man was admitted to the trauma unit after being struck in the left temple by a brick. Surgery to evacuate an intracranial hemorrhage was performed, and an electrocardiogram...http://content.nejm.org/cgi/content/short/349/6/561?rss=1&ssource=collectionSearchRss&queryTerm=10W. Brian Bailey, M.D. and Bernard R. Chaitman, M.D.Thu, 07  Aug  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/6/561?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In postmenopausal women with coronary artery disease, conjugated equine estrogen with or without continuous administration of medroxyprogesterone acetate has failed to slow the progression of atherosclerosis. Whether 17β-estradiol (the...http://content.nejm.org/cgi/content/short/349/6/535?rss=1&ssource=collectionSearchRss&queryTerm=10Howard N. Hodis, M.D., Wendy J. Mack, Ph.D., Stanley P. Azen, Ph.D., Roger A. Lobo, M.D., Donna Shoupe, M.D., Peter R. Mahrer, M.D., David P. Faxon, M.D., Linda Cashin-Hemphill, M.D., Miguel E. Sanmarco, M.D., William J. French, M.D., Thomas L. Shook, M.D., Thomas D. Gaarder, M.D., Anilkumar O. Mehra, M.D., Ramin Rabbani, M.D., Alex Sevanian, Ph.D., Asit B. Shil, M.D., Mina Torres, M.S., K. Heiner Vogelbach, M.D., and Robert H. Selzer, M.S., for the Women's Estrogen–Progestin Lipid-Lowering Hormone Atherosclerosis Regression Trial Research GroupThu, 07  Aug  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/6/535?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Recent randomized clinical trials have suggested that estrogen plus progestin does not confer cardiac protection and may increase the risk of coronary heart disease (CHD). In this report, we...http://content.nejm.org/cgi/content/short/349/6/523?rss=1&ssource=collectionSearchRss&queryTerm=10JoAnn E. Manson, M.D., Dr.P.H., Judith Hsia, M.D., Karen C. Johnson, M.D., M.P.H., Jacques E. Rossouw, M.D., Annlouise R. Assaf, Ph.D., Norman L. Lasser, M.D., Ph.D., Maurizio Trevisan, M.D., Henry R. Black, M.D., Susan R. Heckbert, M.D., Ph.D., Robert Detrano, M.D., Ph.D., Ora L. Strickland, Ph.D., Nathan D. Wong, Ph.D., John R. Crouse, M.D., Evan Stein, M.D., and Mary Cushman, M.D., for the Women's Health Initiative InvestigatorsThu, 07  Aug  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/6/523?rss=1&ssource=collectionSearchRss&queryTerm=10A healthy 40-year-old man exercises regularly, uses no tobacco, and has no cardiac symptoms. His blood pressure is 120/80 mm Hg, his total cholesterol concentration is 180 mg per deciliter...http://content.nejm.org/cgi/content/short/349/5/465?rss=1&ssource=collectionSearchRss&queryTerm=10Philip Greenland, M.D., and J. Michael Gaziano, M.D., M.P.H.Thu, 31  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/5/465?rss=1&ssource=collectionSearchRss&queryTerm=10A 55-year-old man with a 24-year history of pseudohypoparathyroidism type 2 presented with a mass in the right buttock and reported difficulty walking. At the time of diagnosis, he had...http://content.nejm.org/cgi/content/short/349/5/464?rss=1&ssource=collectionSearchRss&queryTerm=10Tominaga Shimizu, M.D. and Teiji Takeda, M.D.Thu, 31  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/5/464?rss=1&ssource=collectionSearchRss&queryTerm=10A 39-year-old man with a history of smoking, alcohol abuse, and cocaine use but no other medical problems presented to the emergency department with frequent episodes of chest pain, shortness...http://content.nejm.org/cgi/content/short/349/1/e1?rss=1&ssource=collectionSearchRss&queryTerm=10H.S. Vincent Chen, M.D. and Duane S. Pinto, M.D.Thu, 03  Jul  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/349/1/e1?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Adherence to a Mediterranean diet may improve longevity, but relevant data are limited.<br/><br/><em>Methods:</em> We conducted a population-based, prospective investigation involving 22,043 adults in Greece who completed an extensive, validated,...http://content.nejm.org/cgi/content/short/348/26/2599?rss=1&ssource=collectionSearchRss&queryTerm=10Antonia Trichopoulou, M.D., Tina Costacou, Ph.D., Christina Bamia, Ph.D., and Dimitrios Trichopoulos, M.D.Thu, 26  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/26/2599?rss=1&ssource=collectionSearchRss&queryTerm=10The concept of the Mediterranean diet originated from the Seven Countries Study initiated by Ancel Keys in the 1950s. The study showed that, despite a high fat intake, the population...http://content.nejm.org/cgi/content/short/348/26/2595?rss=1&ssource=collectionSearchRss&queryTerm=10Frank B. Hu, M.D., Ph.D.Thu, 26  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/26/2595?rss=1&ssource=collectionSearchRss&queryTerm=10A 57-year-old woman was referred to our clinic because of malaise, dyspnea, and pedal edema four weeks after an extensive myocardial infarction. Physical examination revealed jugular venous distention and pulsus...http://content.nejm.org/cgi/content/short/348/23/e8?rss=1&ssource=collectionSearchRss&queryTerm=10Bernard Paelinck, M.D. and Paul A. Dendale, M.D., Ph.D.Thu, 05  Jun  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/23/e8?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Policies to concentrate or regionalize invasive procedures at high-volume medical centers are under active consideration. Such policies could improve outcomes among those who undergo procedures while increasing their underuse...http://content.nejm.org/cgi/content/short/348/22/2209?rss=1&ssource=collectionSearchRss&queryTerm=10Laura A. Petersen, M.D., M.P.H., Sharon-Lise T. Normand, Ph.D., Lucian L. Leape, M.D., and Barbara J. McNeil, M.D., Ph.D.Thu, 29  May  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/22/2209?rss=1&ssource=collectionSearchRss&queryTerm=10A 54-year-old man with a three-week history of exertional angina and abnormal results on an exercise test underwent selective coronary angiography, which showed a severe concentric stenosis of the distal...http://content.nejm.org/cgi/content/short/348/18/e5?rss=1&ssource=collectionSearchRss&queryTerm=10Egidio Traversi, M.D. and Roberto Tramarin, M.D.Thu, 01  May  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/18/e5?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Intimal hyperplasia and resulting restenosis limit the efficacy of coronary stenting. We studied a coronary stent coated with the antiproliferative agent paclitaxel as a means of preventing restenosis.<br/><br/><em>Methods:</em> We...http://content.nejm.org/cgi/content/short/348/16/1537?rss=1&ssource=collectionSearchRss&queryTerm=10Seung-Jung Park, M.D., Ph.D., Won Heum Shim, M.D., Ph.D., David S. Ho, M.B., B.S., Ph.D., Albert E. Raizner, M.D., Seong-Wook Park, M.D., Ph.D., Myeong-Ki Hong, M.D., Ph.D., Cheol Whan Lee, M.D., Ph.D., Donghoon Choi, M.D., Yangsoo Jang, M.D., Ph.D., Ricky Lam, M.D., Neil J. Weissman, M.D., and Gary S. Mintz, M.D.Thu, 17  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/16/1537?rss=1&ssource=collectionSearchRss&queryTerm=10A 71-year-old woman who had a myocardial infarction five years previously and underwent coronary-artery bypass surgery six months ago visits a primary care physician. She had no complications after surgery,...http://content.nejm.org/cgi/content/short/348/15/1456?rss=1&ssource=collectionSearchRss&queryTerm=10Mary E. Charlson, M.D., and O. Wayne Isom, M.D.Thu, 10  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/15/1456?rss=1&ssource=collectionSearchRss&queryTerm=10In the fall of 1999, a multicenter, randomized trial examining the effect of spironolactone on morbidity and mortality among patients with severe heart failure was published in the Journal.1 The...http://content.nejm.org/cgi/content/short/348/14/1380?rss=1&ssource=collectionSearchRss&queryTerm=10Mariell Jessup, M.D.Thu, 03  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/14/1380?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Aldosterone blockade reduces mortality and morbidity among patients with severe heart failure. 03040329.xml We conducted a double-blind, placebo-controlled study evaluating the effect of eplerenone, a selective aldosterone blocker, on...http://content.nejm.org/cgi/content/short/348/14/1309?rss=1&ssource=collectionSearchRss&queryTerm=10Bertram Pitt, M.D., Willem Remme, M.D., Faiez Zannad, M.D., James Neaton, Ph.D., Felipe Martinez, M.D., Barbara Roniker, M.D., Richard Bittman, Ph.D., Steve Hurley, B.S., Jay Kleiman, M.D., and Marjorie Gatlin, M.D., for the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study InvestigatorsThu, 03  Apr  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/14/1309?rss=1&ssource=collectionSearchRss&queryTerm=10Platelet activation is central to the formation of thrombus, which precipitates most unstable coronary syndromes. The angiographic severity of coronary stenoses may not predict the occurrence of acute cardiac events,...http://content.nejm.org/cgi/content/short/348/12/1163?rss=1&ssource=collectionSearchRss&queryTerm=10Jane E. Freedman, M.D.Thu, 20  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/12/1163?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> CD40 ligand is expressed on platelets and released from them on activation. We investigated the predictive value of soluble CD40 ligand as a marker for clinical outcome and the...http://content.nejm.org/cgi/content/short/348/12/1104?rss=1&ssource=collectionSearchRss&queryTerm=10Christopher Heeschen, M.D., Stefanie Dimmeler, Ph.D., Christian W. Hamm, M.D., Marcel J. van den Brand, M.D., Eric Boersma, Ph.D., Andreas M. Zeiher, M.D., and Maarten L. Simoons, M.D., for the CAPTURE Study InvestigatorsThu, 20  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/12/1104?rss=1&ssource=collectionSearchRss&queryTerm=10A 45-year-old man with a history of hypertension was admitted to the hospital because of nausea, dizziness, and chest pain. Three weeks previously, the patient had had angina pectoris for...http://content.nejm.org/cgi/content/short/348/10/e3?rss=1&ssource=collectionSearchRss&queryTerm=10Klaus Reynen, M.D. and Ruth H. Strasser, M.D.Thu, 06  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/10/e3?rss=1&ssource=collectionSearchRss&queryTerm=10The electrocardiogram remains a crucial tool in the identification and management of acute myocardial infarction. A detailed analysis of patterns of ST-segment elevation may influence decisions regarding the use of...http://content.nejm.org/cgi/content/short/348/10/933?rss=1&ssource=collectionSearchRss&queryTerm=10Peter J. Zimetbaum, M.D., and Mark E. Josephson, M.D.Thu, 06  Mar  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/10/933?rss=1&ssource=collectionSearchRss&queryTerm=10A 50-year-old woman suddenly became unconscious during her birthday celebration; there was no measurable pulse or blood pressure. Breathing and circulation returned spontaneously within a few minutes, but the exact...http://content.nejm.org/cgi/content/short/348/9/817?rss=1&ssource=collectionSearchRss&queryTerm=10Jesper Kelsen, M.D. and Annette Obel, M.D.Thu, 27  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/9/817?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Exercise-induced ventricular ectopy predicts an increased risk of death in population-based cohorts. We sought to examine in a clinical cohort the prognostic importance of ventricular ectopy immediately after exercise,...http://content.nejm.org/cgi/content/short/348/9/781?rss=1&ssource=collectionSearchRss&queryTerm=10Joseph P. Frolkis, M.D., Ph.D., Claire E. Pothier, M.S., Eugene H. Blackstone, M.D., and Michael S. Lauer, M.D.Thu, 27  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/9/781?rss=1&ssource=collectionSearchRss&queryTerm=10Since the introduction of treadmill exercise testing by Robert Bruce five decades ago, graded exercise testing has been a cornerstone of diagnostic procedures for coronary artery disease. An article in...http://content.nejm.org/cgi/content/short/348/9/775?rss=1&ssource=collectionSearchRss&queryTerm=10Gregory D. Curfman, M.D., and L. David Hillis, M.D.Thu, 27  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/9/775?rss=1&ssource=collectionSearchRss&queryTerm=10A 79-year-old man was admitted with atypical chest pain and electrocardiographic changes characteristic of an anterior myocardial infarction. The chest radiograph showed a widened mediastinum, raising the possibility of a...http://content.nejm.org/cgi/content/short/348/7/609?rss=1&ssource=collectionSearchRss&queryTerm=10Andrew Redfern, F.R.C.S., F.R.C.R. and James Smart, F.R.C.R.Thu, 13  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/7/609?rss=1&ssource=collectionSearchRss&queryTerm=10A 74-year-old woman with a history of hypertension, hypercholesterolemia, and non–Q-wave myocardial infarction presented with exertional angina that had worsened over the course of the preceding month. Coronary angiography revealed...http://content.nejm.org/cgi/content/short/348/6/e2?rss=1&ssource=collectionSearchRss&queryTerm=10Dale T. Ashby, M.B., B.S., Ph.D. and Michael B. Collins, M.D.Thu, 06  Feb  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/6/e2?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The performance of coronary bypass surgery without cardiopulmonary bypass (“off pump”) may reduce perioperative morbidity and costs, but it is uncertain whether the outcome is similar to that involving...http://content.nejm.org/cgi/content/short/348/5/394?rss=1&ssource=collectionSearchRss&queryTerm=10Hendrik M. Nathoe, M.D., Diederik van Dijk, M.D., Ph.D., Erik W.L. Jansen, M.D., Ph.D., Willem J.L. Suyker, M.D., Jan C. Diephuis, M.D., Wim-Jan van Boven, M.D., Aart Brutel de la Rivière, M.D., Ph.D., Cornelius Borst, M.D., Ph.D., Cor J. Kalkman, M.D., Ph.D., Diederick E. Grobbee, M.D., Ph.D., Erik Buskens, M.D., Ph.D., and Peter P.T. de Jaegere, M.D., Ph.D., for the Study GroupThu, 30  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/5/394?rss=1&ssource=collectionSearchRss&queryTerm=10Inspired in 1931 by a bedside vigil for a dying patient with massive pulmonary embolism, John Gibbon had by the early 1950s developed the heart–lung machine, or pump oxygenator. Although...http://content.nejm.org/cgi/content/short/348/5/379?rss=1&ssource=collectionSearchRss&queryTerm=10Eric A. Rose, M.D.Thu, 30  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/5/379?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear.<br/><br/><em>Methods:</em> We studied the association of alcohol consumption...http://content.nejm.org/cgi/content/short/348/2/109?rss=1&ssource=collectionSearchRss&queryTerm=10Kenneth J. Mukamal, M.D., M.P.H., Katherine M. Conigrave, M.B., B.S., Ph.D., Murray A. Mittleman, M.D., Dr.P.H., Carlos A. Camargo, Jr., M.D., Dr.P.H., Meir J. Stampfer, M.D., Dr.P.H., Walter C. Willett, M.D., Dr.P.H., and Eric B. Rimm, Sc.D.Thu, 09  Jan  2003 00:00:00 -05:00http://content.nejm.org/cgi/content/short/348/2/109?rss=1&ssource=collectionSearchRss&queryTerm=10Today, a person's genetic background is considered in every aspect of clinical medicine, ranging from susceptibility to diseases, pathogenesis, and clinical outcome to diversity in responses to drug treatment (pharmacogenomics)....http://content.nejm.org/cgi/content/short/347/24/1963?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 12  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/24/1963?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Although epidemiologic studies have suggested that several genetic variants increase the risk of myocardial infarction, large-scale association studies that examine many polymorphisms simultaneously are required to allow reliable prediction...http://content.nejm.org/cgi/content/short/347/24/1916?rss=1&ssource=collectionSearchRss&queryTerm=10Yoshiji Yamada, M.D., Ph.D., Hideo Izawa, M.D., Ph.D., Sahoko Ichihara, M.D., Ph.D., Fumimaro Takatsu, M.D., Ph.D., Hitoshi Ishihara, M.D., Ph.D., Haruo Hirayama, M.D., Ph.D., Takahito Sone, M.D., Ph.D., Masashi Tanaka, M.D., Ph.D., and Mitsuhiro Yokota, M.D., Ph.D.Thu, 12  Dec  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/24/1916?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. An important component of the second-year pathology course at medical school is becoming familiar with the microscopical manifestations of pathologic processes. While examining tissue from a patient with...http://content.nejm.org/cgi/content/short/347/22/1769?rss=1&ssource=collectionSearchRss&queryTerm=10James de la Torre and Julius BishopThu, 28  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/22/1769?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> A high dietary intake of mercury from consumption of fish has been hypothesized to increase the risk of coronary heart disease.<br/><br/><em>Methods:</em> Using a nested case–control design, we investigated the...http://content.nejm.org/cgi/content/short/347/22/1755?rss=1&ssource=collectionSearchRss&queryTerm=10Kazuko Yoshizawa, Sc.D., Eric B. Rimm, Sc.D., J. Steven Morris, Ph.D., Vickie L. Spate, Chung-cheng Hsieh, Sc.D., Donna Spiegelman, Sc.D., Meir J. Stampfer, M.D., and Walter C. Willett, M.D.Thu, 28  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/22/1755?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> It has been suggested that mercury, a highly reactive heavy metal with no known physiologic activity, increases the risk of cardiovascular disease. Because fish intake is a major source...http://content.nejm.org/cgi/content/short/347/22/1747?rss=1&ssource=collectionSearchRss&queryTerm=10Eliseo Guallar, M.D., Dr.P.H., M. Inmaculada Sanz-Gallardo, M.D., M.P.H., Pieter van't Veer, Ph.D., Peter Bode, Ph.D., Antti Aro, M.D., Ph.D., Jorge Gómez-Aracena, M.D., Ph.D., Jeremy D. Kark, M.D., Ph.D., Rudolph A. Riemersma, Ph.D., José M. Martín-Moreno, M.D., Dr.P.H., and Frans J. Kok, Ph.D., for the Heavy Metals and Myocardial Infarction Study GroupThu, 28  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/22/1747?rss=1&ssource=collectionSearchRss&queryTerm=10The seminal Institute of Medicine report, “Crossing the Quality Chasm,”1 identified several attributes of the health care system needed for the 21st century. These include equity; “providing care that does...http://content.nejm.org/cgi/content/short/347/21/1709?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 21  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/21/1709?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The outcome after myocardial infarction may be influenced by the type of physician providing ambulatory care.<br/><br/><em>Methods:</em> We studied 35,520 patients 65 years of age or older who were hospitalized...http://content.nejm.org/cgi/content/short/347/21/1678?rss=1&ssource=collectionSearchRss&queryTerm=10John Z. Ayanian, M.D., M.P.P., Mary Beth Landrum, Ph.D., Edward Guadagnoli, Ph.D., and Peter Gaccione, M.A.Thu, 21  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/21/1678?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. A 78-year-old man with long-standing end-stage renal failure and a previous mitral-valve replacement presented with a one-month history of episodes of effort-related syncope. Results of physical examination and...http://content.nejm.org/cgi/content/short/347/20/1584?rss=1&ssource=collectionSearchRss&queryTerm=10Saib S. Khogali, M.B., Ch.B. and Jonathan N. Townend, M.D.Thu, 14  Nov  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/20/1584?rss=1&ssource=collectionSearchRss&queryTerm=10When ventricular septal rupture complicates acute myocardial infarction, the mortality is high. Reperfusion therapy has reduced the incidence of septal rupture. However, rapid diagnosis, aggressive medical management, and surgical intervention...http://content.nejm.org/cgi/content/short/347/18/1426?rss=1&ssource=collectionSearchRss&queryTerm=10Yochai Birnbaum, M.D., Michael C. Fishbein, M.D., Carlos Blanche, M.D., and Robert J. Siegel, M.D.Thu, 31  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/18/1426?rss=1&ssource=collectionSearchRss&queryTerm=10Until a few years ago, we did not understand the pivotal role of platelets in orchestrating the process of inflammation. The discovery in 1998 that CD40 ligand is shed from...http://content.nejm.org/cgi/content/short/347/17/1359?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 24  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/17/1359?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. Chest pain and diaphoresis developed in an 81-year-old woman with chronic renal insufficiency and hypertension. Although the chest pain resolved, she saw her primary care physician three days...http://content.nejm.org/cgi/content/short/347/17/1334?rss=1&ssource=collectionSearchRss&queryTerm=10Duane S. Pinto, M.D. and Thomas M. Tu, M.D.Thu, 24  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/17/1334?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> There is no therapy known to reduce the risk of complications or death after coronary bypass surgery. Because platelet activation constitutes a pivotal mechanism for injury in patients with...http://content.nejm.org/cgi/content/short/347/17/1309?rss=1&ssource=collectionSearchRss&queryTerm=10Dennis T. Mangano, Ph.D., M.D., for the Multicenter Study of Perioperative Ischemia Research GroupThu, 24  Oct  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/17/1309?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The role of antithrombotic therapy in secondary prevention after myocardial infarction is well established. Although the available literature suggests that warfarin is superior to aspirin, aspirin is currently the...http://content.nejm.org/cgi/content/short/347/13/969?rss=1&ssource=collectionSearchRss&queryTerm=10Mette Hurlen, M.D., Michael Abdelnoor, M.P.H., Ph.D., Pål Smith, M.D., Ph.D., Jan Erikssen, M.D., Ph.D., and Harald Arnesen, M.D., Ph.D.Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/969?rss=1&ssource=collectionSearchRss&queryTerm=10From a historical perspective, there is perhaps no more interesting therapeutic saga than that of aspirin, which began as a folk remedy, distilled from willow bark, and became a lifesaving...http://content.nejm.org/cgi/content/short/347/13/1025?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/1025?rss=1&ssource=collectionSearchRss&queryTerm=10Despite encouraging trends over the past three decades, coronary heart disease remains the leading cause of death in the United States and other industrialized countries. Recent data from the National...http://content.nejm.org/cgi/content/short/347/13/1019?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 26  Sep  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/13/1019?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. A 57-year-old man presented with several hours of chest discomfort accompanied by ischemic changes on his electrocardiogram. He had undergone coronary-artery bypass grafting and subsequent percutaneous coronary intervention...http://content.nejm.org/cgi/content/short/347/8/581?rss=1&ssource=collectionSearchRss&queryTerm=10Pertha S. Chowdhury, M.D. and Renato G. Ramos, M.D.Thu, 22  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/8/581?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Minimally invasive bypass surgery and coronary-artery stenting are both accepted treatments for isolated stenosis of the proximal left anterior descending coronary artery. We compared the clinical outcomes after these...http://content.nejm.org/cgi/content/short/347/8/561?rss=1&ssource=collectionSearchRss&queryTerm=10Anno Diegeler, M.D., Holger Thiele, M.D., Volkmar Falk, M.D., Rainer Hambrecht, M.D., Niki Spyrantis, M.D., Peter Sick, M.D., Klaus W. Diederich, M.D., Friedrich W. Mohr, M.D., and Gerhard Schuler, M.D.Thu, 22  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/8/561?rss=1&ssource=collectionSearchRss&queryTerm=10The modern treatment of coronary artery disease began with the development of coronary bypass surgery more than three decades ago, which was followed by the development of coronary angioplasty more...http://content.nejm.org/cgi/content/short/347/8/551?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 22  Aug  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/8/551?rss=1&ssource=collectionSearchRss&queryTerm=10The realization that atherosclerosis is, morphologically, an inflammatory disease was originally derived from studies of animal models. Early after the initiation of an atherogenic diet in animals, monocytes adhere to...http://content.nejm.org/cgi/content/short/347/1/55?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 04  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/1/55?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Inflammation within vulnerable coronary plaques may cause unstable angina by promoting rupture and erosion. In unstable angina, activated leukocytes may be found in peripheral and coronary-sinus blood, but it...http://content.nejm.org/cgi/content/short/347/1/5?rss=1&ssource=collectionSearchRss&queryTerm=10Antonino Buffon, M.D., Luigi M. Biasucci, M.D., Giovanna Liuzzo, M.D., Giuseppe D'Onofrio, M.D., Filippo Crea, M.D., and Attilio Maseri, M.D.Thu, 04  Jul  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/347/1/5?rss=1&ssource=collectionSearchRss&queryTerm=10After the loss of integrity of cardiac myocyte membranes, intracellular macromolecules (cardiac biologic markers) diffuse into the cardiac interstitium, lymphatics, and microvasculature; eventually, they are detected in the peripheral circulation....http://content.nejm.org/cgi/content/short/346/26/2079?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 27  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/26/2079?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Among patients with suspected acute coronary syndromes, cardiac troponin T levels have prognostic value. However, there is concern that renal dysfunction may impair the prognostic value, because cardiac troponin...http://content.nejm.org/cgi/content/short/346/26/2047?rss=1&ssource=collectionSearchRss&queryTerm=10Ronnier J. Aviles, M.D., Arman T. Askari, M.D., Bertil Lindahl, M.D., Ph.D., Lars Wallentin, M.D., Ph.D., Gang Jia, M.S., E. Magnus Ohman, M.D., Kenneth W. Mahaffey, M.D., L. Kristin Newby, M.D., Robert M. Califf, M.D., Maarten L. Simoons, M.D., Eric J. Topol, M.D., Peter Berger, M.D., and Michael S. Lauer, M.D.Thu, 27  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/26/2047?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> 02062025.xml In cardiac syndrome X (a syndrome characterized by typical angina, abnormal exercise-test results, and normal coronary arteries), conventional investigations have not found that chest pain is due to...http://content.nejm.org/cgi/content/short/346/25/1948?rss=1&ssource=collectionSearchRss&queryTerm=10Jonathan R. Panting, M.B., M.R.C.P., Peter D. Gatehouse, Ph.D., Guang-Zhong Yang, Ph.D., Frank Grothues, M.D., David N. Firmin, Ph.D., Peter Collins, M.D., and Dudley J. Pennell, M.D.Thu, 20  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/25/1948?rss=1&ssource=collectionSearchRss&queryTerm=10Angina pectoris is usually caused by myocardial ischemia due to atherosclerotic narrowing of the epicardial coronary arteries, with or without local vasoconstriction or a superimposed thrombus, that limits the supply...http://content.nejm.org/cgi/content/short/346/25/1934?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 20  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/25/1934?rss=1&ssource=collectionSearchRss&queryTerm=10In this issue of the Journal, Gaspoz et al.1 examine the relative benefits of various therapeutic strategies for the secondary prevention of coronary heart disease. This is a critical area...http://content.nejm.org/cgi/content/short/346/23/1819?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 06  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/23/1819?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Both aspirin and clopidogrel reduce the rate of cardiovascular events in patients with coronary heart disease. We estimated the cost effectiveness of the increased use of aspirin, clopidogrel, or...http://content.nejm.org/cgi/content/short/346/23/1800?rss=1&ssource=collectionSearchRss&queryTerm=10Jean-Michel Gaspoz, M.D., Pamela G. Coxson, Ph.D., Paula A. Goldman, M.P.H., Lawrence W. Williams, M.Sc., Karen M. Kuntz, Sc.D., M.G. Myriam Hunink, M.D., Ph.D., and Lee Goldman, M.D., M.P.H.Thu, 06  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/23/1800?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle...http://content.nejm.org/cgi/content/short/346/23/1773?rss=1&ssource=collectionSearchRss&queryTerm=10Marie-Claude Morice, M.D., Patrick W. Serruys, M.D., Ph.D., J. Eduardo Sousa, M.D., Jean Fajadet, M.D., Ernesto Ban Hayashi, M.D., Marco Perin, M.D., Antonio Colombo, M.D., G. Schuler, M.D., Paul Barragan, M.D., Giulio Guagliumi, M.D., Ferenc Molnàr, M.D., and Robert Falotico, Ph.D., for the RAVEL Study GroupThu, 06  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/23/1773?rss=1&ssource=collectionSearchRss&queryTerm=10The story of sirolimus began in 1975 on Easter Island, in the South Pacific, a remote, enigmatic place known for the prominent stone statues that punctuate its landscape. An actinomycete,...http://content.nejm.org/cgi/content/short/346/23/1770?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 06  Jun  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/23/1770?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Coronary thrombosis and pulmonary thromboembolism are common causes of cardiac arrest. We assessed whether the administration of tissue plasminogen activator (t-PA) during cardiopulmonary resuscitation would benefit patients with cardiac...http://content.nejm.org/cgi/content/short/346/20/1522?rss=1&ssource=collectionSearchRss&queryTerm=10Riyad B. Abu-Laban, M.D., M.H.Sc., James M. Christenson, M.D., Grant D. Innes, M.D., Catherina A. van Beek, R.N., B.S.N., Karen P. Wanger, M.D., R. Douglas McKnight, M.D., Iain A. MacPhail, M.D., M.H.Sc., Joe Puskaric, E.M.A.-3, Richard P. Sadowski, E.M.A.-3, Joel Singer, Ph.D., Martin T. Schechter, M.D., Ph.D., and Victor M. Wood, M.D.Thu, 16  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/20/1522?rss=1&ssource=collectionSearchRss&queryTerm=10A 45-year-old man with a strong family history of premature heart disease has no symptoms of coronary disease and has a normal electrocardiogram. A fasting lipid analysis reveals a total...http://content.nejm.org/cgi/content/short/346/19/1468?rss=1&ssource=collectionSearchRss&queryTerm=10Michael S. Lauer, M.D.Thu, 09  May  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/19/1468?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Intracoronary radiation therapy is effective in reducing the recurrence of in-stent stenosis in native coronary arteries. We examined the effects of intravascular gamma radiation in patients with in-stent restenosis...http://content.nejm.org/cgi/content/short/346/16/1194?rss=1&ssource=collectionSearchRss&queryTerm=10Ron Waksman, M.D., Andrew E. Ajani, M.D., R. Larry White, M.D., Rosanna C. Chan, M.D., Lowell F. Satler, M.D., Kenneth M. Kent, M.D., Augusto D. Pichard, M.D., Ellen E. Pinnow, M.S., Anh B. Bui, M.D., Steven Ramee, M.D., Paul Teirstein, M.D., and Joseph Lindsay, M.D.Thu, 18  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/16/1194?rss=1&ssource=collectionSearchRss&queryTerm=10Over the past two decades, percutaneous coronary intervention has revolutionized the treatment of symptomatic coronary artery disease, sparing countless patients the need for surgical revascularization. This year, up to a...http://content.nejm.org/cgi/content/short/346/16/1182?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 18  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/16/1182?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Experimental data suggest that long-chain n–3 polyunsaturated fatty acids found in fish have antiarrhythmic properties, and a randomized trial suggested that dietary supplements of n–3 fatty acids may reduce...http://content.nejm.org/cgi/content/short/346/15/1113?rss=1&ssource=collectionSearchRss&queryTerm=10Christine M. Albert, M.D., M.P.H., Hannia Campos, Ph.D., Meir J. Stampfer, M.D., Dr.P.H., Paul M. Ridker, M.D., M.P.H., JoAnn E. Manson, M.D., Dr.P.H., Walter C. Willett, M.D., Dr.P.H., and Jing Ma, M.D., Ph.D.Thu, 11  Apr  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/15/1113?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Sequence variants in the gene encoding estrogen receptor α (ER-α) may modify the effects of hormone-replacement therapy on levels of high-density lipoprotein (HDL) cholesterol and other outcomes related to...http://content.nejm.org/cgi/content/short/346/13/967?rss=1&ssource=collectionSearchRss&queryTerm=10David M. Herrington, M.D., Timothy D. Howard, Ph.D., Gregory A. Hawkins, Ph.D., David M. Reboussin, Ph.D., Jianfeng Xu, M.D., Dr.P.H., Siqun L. Zheng, M.D., K. Bridget Brosnihan, Ph.D., Deborah A. Meyers, Ph.D., and Eugene R. Bleecker, M.D.Thu, 28  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/13/967?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> 02032824.xml As compared with thrombolytic therapy, primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction reduces the rates of death, reinfarction, and stroke, but recurrent ischemia, restenosis, and...http://content.nejm.org/cgi/content/short/346/13/957?rss=1&ssource=collectionSearchRss&queryTerm=10Gregg W. Stone, M.D., Cindy L. Grines, M.D., David A. Cox, M.D., Eulogio Garcia, M.D., James E. Tcheng, M.D., John J. Griffin, M.D., Giulio Guagliumi, M.D., Thomas Stuckey, M.D., Mark Turco, M.D., John D. Carroll, M.D., Barry D. Rutherford, M.D., and Alexandra J. Lansky, M.D., for the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) InvestigatorsThu, 28  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/13/957?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary arterial occlusion due to thrombosis is the cause of most cases of myocardial infarction accompanied by ST-segment elevation. Rapid restoration of blood flow to jeopardized myocardium limits necrosis and...http://content.nejm.org/cgi/content/short/346/13/954?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 28  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/13/954?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> 02032124.xml Patients with reduced left ventricular function after myocardial infarction are at risk for life-threatening ventricular arrhythmias. This randomized trial was designed to evaluate the effect of an implantable...http://content.nejm.org/cgi/content/short/346/12/877?rss=1&ssource=collectionSearchRss&queryTerm=10Arthur J. Moss, M.D., Wojciech Zareba, M.D., Ph.D., W. Jackson Hall, Ph.D., Helmut Klein, M.D., David J. Wilber, M.D., David S. Cannom, M.D., James P. Daubert, M.D., Steven L. Higgins, M.D., Mary W. Brown, M.S., and Mark L. Andrews, B.B.S., for the Multicenter Automatic Defibrillator Implantation Trial II InvestigatorsThu, 21  Mar  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/12/877?rss=1&ssource=collectionSearchRss&queryTerm=10In this issue of the Journal, the reported results of two randomized clinical trials, one in Australia1 and the other in Europe,2 showed a neurologic benefit of mild therapeutic hypothermia...http://content.nejm.org/cgi/content/short/346/8/612?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 21  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/8/612?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. A 60-year-old man who was taking no medications was resuscitated after out-of-hospital cardiac arrest. He was found in ventricular fibrillation and underwent successful DC cardioversion. Electrocardiography documented short...http://content.nejm.org/cgi/content/short/346/8/579?rss=1&ssource=collectionSearchRss&queryTerm=10Michael Geist, M.D. and Daniel Tarchitzky, M.D.Thu, 21  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/8/579?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Cardiac arrest outside the hospital is common and has a poor outcome. Studies in laboratory animals suggest that hypothermia induced shortly after the restoration of spontaneous circulation may improve...http://content.nejm.org/cgi/content/short/346/8/557?rss=1&ssource=collectionSearchRss&queryTerm=10Stephen A. Bernard, M.B., B.S., Timothy W. Gray, M.B., B.S., Michael D. Buist, M.B., B.S., Bruce M. Jones, M.B., B.S., William Silvester, M.B., B.S., Geoff Gutteridge, M.B., B.S., and Karen Smith, B.Sc.Thu, 21  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/8/557?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Cardiac arrest with widespread cerebral ischemia frequently leads to severe neurologic impairment. We studied whether mild systemic hypothermia increases the rate of neurologic recovery after resuscitation from cardiac arrest...http://content.nejm.org/cgi/content/short/346/8/549?rss=1&ssource=collectionSearchRss&queryTerm=10The Hypothermia after Cardiac Arrest Study GroupThu, 21  Feb  2002 00:00:00 -05:00http://content.nejm.org/cgi/content/short/346/8/549?rss=1&ssource=collectionSearchRss&queryTerm=10More than 1 million invasive diagnostic coronary angiography procedures are performed annually in the United States, and at present, x-ray coronary angiography is the only accepted method for the clinical...http://content.nejm.org/cgi/content/short/345/26/1909?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 27  Dec  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/26/1909?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> An accurate, noninvasive technique for the diagnosis of coronary disease would be an important advance. We investigated the accuracy of coronary magnetic resonance angiography among patients with suspected coronary...http://content.nejm.org/cgi/content/short/345/26/1863?rss=1&ssource=collectionSearchRss&queryTerm=10W. Yong Kim, M.D., Ph.D., Peter G. Danias, M.D., Ph.D., Matthias Stuber, Ph.D., Scott D. Flamm, M.D., Sven Plein, M.D., Eike Nagel, M.D., Susan E. Langerak, M.Sc., Oliver M. Weber, Ph.D., Erik M. Pedersen, M.D., Ph.D., Matthias Schmidt, M.D., René M. Botnar, Ph.D., and Warren J. Manning, M.D.Thu, 27  Dec  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/26/1863?rss=1&ssource=collectionSearchRss&queryTerm=10The use of oral contraceptives first became widespread some 40 years ago, and reports of an excess risk of cardiovascular disease among women who used these agents soon followed. Because...http://content.nejm.org/cgi/content/short/345/25/1841?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 20  Dec  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/25/1841?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> An association between the use of oral contraceptives and the risk of myocardial infarction has been found in some, but not all, studies. We investigated this association, according to...http://content.nejm.org/cgi/content/short/345/25/1787?rss=1&ssource=collectionSearchRss&queryTerm=10Bea C. Tanis, M.D., Maurice A.A.J. van den Bosch, M.D., Jeanet M. Kemmeren, Ph.D., Volkert Manger Cats, M.D., Frans M. Helmerhorst, M.D., Ale Algra, M.D., Yolanda van der Graaf, M.D., and Frits R. Rosendaal, M.D.Thu, 20  Dec  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/25/1787?rss=1&ssource=collectionSearchRss&queryTerm=10Recently, great strides have been made in the use of various pharmacologic interventions for the treatment of patients with cardiovascular disease. One strategy, the use of lipid-altering therapy for both...http://content.nejm.org/cgi/content/short/345/22/1636?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1636?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> We have previously demonstrated an association between elevated total plasma homocysteine levels and restenosis after percutaneous coronary angioplasty. We designed this study to evaluate the effect of lowering plasma...http://content.nejm.org/cgi/content/short/345/22/1593?rss=1&ssource=collectionSearchRss&queryTerm=10Guido Schnyder, M.D., Marco Roffi, M.D., Riccardo Pin, M.D., Yvonne Flammer, M.D., Helmut Lange, M.D., Franz R. Eberli, M.D., Bernhard Meier, M.D., Zoltan G. Turi, M.D., and Otto M. Hess, M.D.Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1593?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Both lipid-modifying therapy and antioxidant vitamins are thought to have benefit in patients with coronary disease. We studied simvastatin–niacin and antioxidant-vitamin therapy, alone and together, for cardiovascular protection in...http://content.nejm.org/cgi/content/short/345/22/1583?rss=1&ssource=collectionSearchRss&queryTerm=10B. Greg Brown, M.D., Ph.D., Xue-Qiao Zhao, M.D., Alan Chait, M.D., Lloyd D. Fisher, Ph.D., Marian C. Cheung, Ph.D., Josh S. Morse, B.S., Alice A. Dowdy, R.D., Emily K. Marino, M.S., Edward L. Bolson, M.S., Petar Alaupovic, Ph.D., Jiri Frohlich, M.D., Leny Serafini, B.S., Ellen Huss-Frechette, B.S., Shari Wang, B.S., Debbie DeAngelis, R.T., Arthur Dodek, M.D., and John J. Albers, Ph.D.Thu, 29  Nov  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/22/1583?rss=1&ssource=collectionSearchRss&queryTerm=10Questions surrounding the risks and costs associated with blood transfusion have led to a reevaluation of clinical transfusion practices during the past 15 years.1 Guidelines for blood transfusion have been...http://content.nejm.org/cgi/content/short/345/17/1272?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 25  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/17/1272?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Anemia may have adverse effects in patients with coronary artery disease. However, the benefit of blood transfusion in elderly patients with acute myocardial infarction and various degrees of anemia...http://content.nejm.org/cgi/content/short/345/17/1230?rss=1&ssource=collectionSearchRss&queryTerm=10Wen-Chih Wu, M.D., Saif S. Rathore, M.P.H., Yongfei Wang, M.S., Martha J. Radford, M.D., and Harlan M. Krumholz, M.D.Thu, 25  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/17/1230?rss=1&ssource=collectionSearchRss&queryTerm=10The acute coronary syndromes, which comprise unstable angina, myocardial infarction without ST-segment elevation, and myocardial infarction with ST-segment elevation, continue to be a major health problem. Recent important advances in...http://content.nejm.org/cgi/content/short/345/14/1057?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 04  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/14/1057?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Circulating markers indicating the instability of atherosclerotic plaques could have diagnostic value in unstable angina or acute myocardial infarction. We evaluated pregnancy-associated plasma protein A (PAPP-A), a potentially proatherosclerotic...http://content.nejm.org/cgi/content/short/345/14/1022?rss=1&ssource=collectionSearchRss&queryTerm=10Antoni Bayes-Genis, M.D., Cheryl A. Conover, Ph.D., Michael T. Overgaard, Ph.D., Kent R. Bailey, Ph.D., Michael Christiansen, M.D., David R. Holmes, Jr., M.D., Renu Virmani, M.D., Claus Oxvig, Ph.D., and Robert S. Schwartz, M.D.Thu, 04  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/14/1022?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Brain (B-type) natriuretic peptide is a neurohormone synthesized predominantly in ventricular myocardium. Although the circulating level of this neurohormone has been shown to provide independent prognostic information in patients...http://content.nejm.org/cgi/content/short/345/14/1014?rss=1&ssource=collectionSearchRss&queryTerm=10James A. de Lemos, M.D., David A. Morrow, M.D., M.P.H., Jane H. Bentley, B.Sc., Torbjørn Omland, M.D., Ph.D., M.P.H., Marc S. Sabatine, M.D., Carolyn H. McCabe, B.S., Christian Hall, M.D., Ph.D., Christopher P. Cannon, M.D., and Eugene Braunwald, M.D.Thu, 04  Oct  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/14/1014?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary heart disease is the leading cause of death in the United States among men and women.1 It is also a major cause of physical disability, particularly in the rapidly...http://content.nejm.org/cgi/content/short/345/12/892?rss=1&ssource=collectionSearchRss&queryTerm=10Philip A. Ades, M.D.Thu, 20  Sep  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/12/892?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Despite current treatments, patients who have acute coronary syndromes without ST-segment elevation have high rates of major vascular events. We evaluated the efficacy and safety of the antiplatelet agent...http://content.nejm.org/cgi/content/short/345/7/494?rss=1&ssource=collectionSearchRss&queryTerm=10The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial InvestigatorsThu, 16  Aug  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/7/494?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Where a person lives is not usually thought of as an independent predictor of his or her health, although physical and social features of places of residence may affect...http://content.nejm.org/cgi/content/short/345/2/99?rss=1&ssource=collectionSearchRss&queryTerm=10Ana V. Diez Roux, M.D., Ph.D., Sharon Stein Merkin, M.H.S., Donna Arnett, Ph.D., Lloyd Chambless, Ph.D., Mark Massing, M.D., Ph.D., F. Javier Nieto, M.D., Ph.D., Paul Sorlie, Ph.D., Moyses Szklo, M.D., Dr.P.H., Herman A. Tyroler, M.D., and Robert L. Watson, Ph.D.Thu, 12  Jul  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/2/99?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. A 14-year-old girl in whom Kawasaki's disease was diagnosed at the age of 2 years had a posterior myocardial infarction at the age of 3 years. When we...http://content.nejm.org/cgi/content/short/345/2/98?rss=1&ssource=collectionSearchRss&queryTerm=10Graeme F. Porter, M.B., Ch.B. and Thomas L. Gentles, F.R.A.C.P.Thu, 12  Jul  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/2/98?rss=1&ssource=collectionSearchRss&queryTerm=10Walk the slums of Dhaka, in Bangladesh, or Accra, in Ghana, and it is not difficult to see how the urban environment of poor countries could be responsible for bad...http://content.nejm.org/cgi/content/short/345/2/134?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 12  Jul  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/345/2/134?rss=1&ssource=collectionSearchRss&queryTerm=10C-reactive protein is the classic acute-phase reactant. During severe infection or inflammation, blood concentrations of C-reactive protein may increase by a factor of 500 or more. Although most other acute-phase...http://content.nejm.org/cgi/content/short/344/26/2016?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 28  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/26/2016?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Elevated levels of C-reactive protein, even in the absence of hyperlipidemia, are associated with an increased risk of coronary events. Statin therapy reduces the level of C-reactive protein independently...http://content.nejm.org/cgi/content/short/344/26/1959?rss=1&ssource=collectionSearchRss&queryTerm=10Paul M. Ridker, M.D., M.P.H., Nader Rifai, Ph.D., Michael Clearfield, D.O., John R. Downs, M.D., Stephen E. Weis, D.O., J. Shawn Miles, M.D., and Antonio M. Gotto, Jr., M.D., D.Phil., for the Air Force/Texas Coronary Atherosclerosis Prevention Study InvestigatorsThu, 28  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/26/1959?rss=1&ssource=collectionSearchRss&queryTerm=10The management of acute coronary syndromes has evolved rapidly over the past decade and continues to do so. Three studies on this topic appear in this issue of the Journal....http://content.nejm.org/cgi/content/short/344/25/1939?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 21  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/25/1939?rss=1&ssource=collectionSearchRss&queryTerm=10During the past 10 years there has been a revolution in the management of acute coronary syndromes, which include unstable angina and non–Q-wave myocardial infarction, and reductions in the rate...http://content.nejm.org/cgi/content/short/344/25/1937?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 21  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/25/1937?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. Two months after an inferoposterior myocardial infarction, a 71-year-old woman presented to her physician with a one-week history of acutely worsening shortness of breath and exertional dyspnea. At...http://content.nejm.org/cgi/content/short/344/25/1910?rss=1&ssource=collectionSearchRss&queryTerm=10Andrew Burger, M.D. and Howard B. Sherman, M.D.Thu, 21  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/25/1910?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> When administered in conjunction with primary coronary stenting for the treatment of acute myocardial infarction, a platelet glycoprotein IIb/IIIa inhibitor may provide additional clinical benefit, but data on this...http://content.nejm.org/cgi/content/short/344/25/1895?rss=1&ssource=collectionSearchRss&queryTerm=10Gilles Montalescot, M.D., Ph.D., Paul Barragan, M.D., Olivier Wittenberg, M.D., Patrick Ecollan, M.D., Simon Elhadad, M.D., Philippe Villain, M.D., Jean-Marc Boulenc, M.D., Marie-Claude Morice, M.D., Luc Maillard, M.D., Michel Pansiéri, M.D., Rémi Choussat, M.D., and Philippe Pinton, M.D., for the ADMIRAL InvestigatorsThu, 21  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/25/1895?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In the setting of percutaneous coronary revascularization, agents in the class known as platelet glycoprotein IIb/IIIa inhibitors have significantly reduced the incidence of death or nonfatal myocardial infarction at...http://content.nejm.org/cgi/content/short/344/25/1888?rss=1&ssource=collectionSearchRss&queryTerm=10Eric J. Topol, M.D., David J. Moliterno, M.D., Howard C. Herrmann, M.D., Eric R. Powers, M.D., Cindy L. Grines, M.D., David J. Cohen, M.D., Eric A. Cohen, M.D., Michel Bertrand, M.D., Franz-Josef Neumann, M.D., Gregg W. Stone, M.D., Peter M. DiBattiste, M.D., Steven J. Yakubov, M.D., Paul T. DeLucca, Ph.D., and Laura Demopoulos, M.D., for the TARGET InvestigatorsThu, 21  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/25/1888?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> There is continued debate as to whether a routine, early invasive strategy is superior to a conservative strategy for the management of unstable angina and myocardial infarction without ST-segment...http://content.nejm.org/cgi/content/short/344/25/1879?rss=1&ssource=collectionSearchRss&queryTerm=10Christopher P. Cannon, M.D., William S. Weintraub, M.D., Laura A. Demopoulos, M.D., Ralph Vicari, M.D., Martin J. Frey, M.D., Nasser Lakkis, M.D., Franz-Josef Neumann, M.D., Debbie H. Robertson, R.D., M.S., Paul T. DeLucca, Ph.D., Peter M. DiBattiste, M.D., C. Michael Gibson, M.D., and Eugene Braunwald, M.D., for the TACTICS–Thrombolysis in Myocardial Infarction 18 InvestigatorsThu, 21  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/25/1879?rss=1&ssource=collectionSearchRss&queryTerm=10A 58-year-old woman presents with chest discomfort while walking that is suggestive of coronary disease. She first noted the discomfort after beginning an exercise program three weeks earlier. The pain...http://content.nejm.org/cgi/content/short/344/24/1840?rss=1&ssource=collectionSearchRss&queryTerm=10Thomas H. Lee, M.D., and Charles A. Boucher, M.D.Thu, 14  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/24/1840?rss=1&ssource=collectionSearchRss&queryTerm=10Regeneration is an essential function of the human body. Our relatively long life span is predicated on processes that mend damaged muscles, repair broken bones, renew injured skin, replenish blood,...http://content.nejm.org/cgi/content/short/344/23/1785?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 07  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/23/1785?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The scarring of the heart that results from myocardial infarction has been interpreted as evidence that the heart is composed of myocytes that are unable to divide. However, recent...http://content.nejm.org/cgi/content/short/344/23/1750?rss=1&ssource=collectionSearchRss&queryTerm=10Antonio P. Beltrami, M.D., Konrad Urbanek, M.D., Jan Kajstura, Ph.D., Shao-Min Yan, M.D., Nicoletta Finato, M.D., Rossana Bussani, M.D., Bernardo Nadal-Ginard, M.D., Ph.D., Furio Silvestri, M.D., Annarosa Leri, M.D., C. Alberto Beltrami, M.D., and Piero Anversa, M.D.Thu, 07  Jun  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/23/1750?rss=1&ssource=collectionSearchRss&queryTerm=10The question of a viral contribution to allograft dysfunction after solid-organ transplantation has long been debated. This debate has focused primarily on cytomegalovirus, which has been identified as a risk...http://content.nejm.org/cgi/content/short/344/20/1545?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 17  May  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/20/1545?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The survival of recipients of cardiac allografts is limited by rejection and coronary vasculopathy. The purpose of this study in children who had received heart transplants was to evaluate...http://content.nejm.org/cgi/content/short/344/20/1498?rss=1&ssource=collectionSearchRss&queryTerm=10Girish S. Shirali, M.D., Jiyuan Ni, M.D., Richard E. Chinnock, M.D., Joyce K. Johnston, R.N., B.S., Geoffrey L. Rosenthal, M.D., Ph.D., Neil E. Bowles, Ph.D., and Jeffrey A. Towbin, M.D.Thu, 17  May  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/20/1498?rss=1&ssource=collectionSearchRss&queryTerm=10Many studies have shown that black Americans are less likely than whites to receive a wide range of medical services, including potentially lifesaving surgical procedures.12 Despite these data, which span...http://content.nejm.org/cgi/content/short/344/19/1471?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 10  May  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/19/1471?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Several studies have reported that black patients are less likely than white patients to undergo cardiac catheterization after acute myocardial infarction. The role of the race of the physician...http://content.nejm.org/cgi/content/short/344/19/1443?rss=1&ssource=collectionSearchRss&queryTerm=10Jersey Chen, M.D., M.P.H., Saif S. Rathore, M.P.H., Martha J. Radford, M.D., Yun Wang, M.S., and Harlan M. Krumholz, M.D.Thu, 10  May  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/19/1443?rss=1&ssource=collectionSearchRss&queryTerm=10At least 225,000 people in the United States will die suddenly this year from coronary heart disease before they reach a hospital.12 In addition, an estimated 370,000 to 750,000 patients...http://content.nejm.org/cgi/content/short/344/17/1304?rss=1&ssource=collectionSearchRss&queryTerm=10Mickey S. Eisenberg, M.D., Ph.D., and Terry J. Mengert, M.D.Thu, 26  Apr  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/17/1304?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. A 75-year-old man who was taking 8 mg of prednisone per day for systemic lupus erythematosus was admitted for the evaluation of an enlarging chest mass. Seventeen years...http://content.nejm.org/cgi/content/short/344/15/1139?rss=1&ssource=collectionSearchRss&queryTerm=10Donald Sutherland, M.D. and Peter C. Block, M.D.Thu, 12  Apr  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/15/1139?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The recent recognition that coronary-artery stenting has improved the short- and long-term outcomes of patients treated with angioplasty has made it necessary to reevaluate the relative benefits of bypass...http://content.nejm.org/cgi/content/short/344/15/1117?rss=1&ssource=collectionSearchRss&queryTerm=10Patrick W. Serruys, M.D., Felix Unger, M.D., J. Eduardo Sousa, M.D., Adib Jatene, M.D., Hans J.R.M. Bonnier, M.D., Jacques P.A.M. Schönberger, M.D., Nigel Buller, M.D., Robert Bonser, M.D., Marcel J.B. van den Brand, M.D., Lex A. van Herwerden, M.D., Marie-Angèle M. Morel, B.Sc., and Ben A. van Hout, Ph.D., for the Arterial Revascularization Therapies Study GroupThu, 12  Apr  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/15/1117?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> A polymorphism in the gene for alcohol dehydrogenase type 3 (ADH3 ) alters the rate of alcohol metabolism. We investigated the relation among the ADH3 polymorphism, the level of...http://content.nejm.org/cgi/content/short/344/8/549?rss=1&ssource=collectionSearchRss&queryTerm=10Lisa M. Hines, S.M., Meir J. Stampfer, M.D., Dr.P.H., Jing Ma, M.D., Ph.D., J. Michael Gaziano, M.D., Paul M. Ridker, M.D., Susan E. Hankinson, Sc.D., Frank Sacks, M.D., Eric B. Rimm, Sc.D., and David J. Hunter, M.B., B.S., Sc.D.Thu, 22  Feb  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/8/549?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary-artery bypass grafting (CABG) is a very effective procedure for reducing angina and stabilizing ventricular function. It is not surprising, therefore, that more than 500,000 bypass procedures are performed in...http://content.nejm.org/cgi/content/short/344/6/451?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 08  Feb  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/6/451?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Cognitive decline complicates early recovery after coronary-artery bypass grafting (CABG) and may be evident in as many as three quarters of patients at the time of discharge from the...http://content.nejm.org/cgi/content/short/344/6/395?rss=1&ssource=collectionSearchRss&queryTerm=10Mark F. Newman, M.D., Jerry L. Kirchner, B.S., Barbara Phillips-Bute, Ph.D., Vincent Gaver, B.S., Hilary Grocott, M.D., Robert H. Jones, M.D., Daniel B. Mark, M.D., Joseph G. Reves, M.D., and James A. Blumenthal, Ph.D., for the Neurological Outcome Research Group and the Cardiothoracic Anesthesiology Research Endeavors InvestigatorsThu, 08  Feb  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/6/395?rss=1&ssource=collectionSearchRss&queryTerm=10Recurrent coronary stenosis occurs in 20 to 30 percent of patients in whom stents have been implanted for the treatment of obstructive lesions; when it occurs within the stent, it...http://content.nejm.org/cgi/content/short/344/4/297?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 25  Jan  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/4/297?rss=1&ssource=collectionSearchRss&queryTerm=10On November 3, 2000, the Food and Drug Administration (FDA) granted approval for two devices that deliver intracoronary radiotherapy for in-stent restenosis. Given this approval, it is possible that there...http://content.nejm.org/cgi/content/short/344/4/295?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 25  Jan  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/4/295?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. A 77-year-old man presented with a two-month history of fever, chills, and malaise. Three months earlier, he had undergone valve replacement for calcific aortic stenosis at another institution....http://content.nejm.org/cgi/content/short/344/4/275?rss=1&ssource=collectionSearchRss&queryTerm=10Ishik C. Tuna, M.D. and Michael R. Harrison, M.D.Thu, 25  Jan  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/4/275?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Although the frequency of restenosis after coronary angioplasty is reduced by stenting, when restenosis develops within a stent, the risk of subsequent restenosis is greater than 50 percent. We...http://content.nejm.org/cgi/content/short/344/4/250?rss=1&ssource=collectionSearchRss&queryTerm=10Martin B. Leon, M.D., Paul S. Teirstein, M.D., Jeffrey W. Moses, M.D., Prabhakar Tripuraneni, M.D., Alexandra J. Lansky, M.D., Shirish Jani, M.D., S. Chiu Wong, M.D., David Fish, M.D., Stephen Ellis, M.D., David R. Holmes, M.D., Dean Kerieakes, M.D., and Richard E. Kuntz, M.D.Thu, 25  Jan  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/4/250?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Beta radiation is effective in reducing vascular neointimal proliferation in animals after injury caused by balloon angioplasty. However, the lowest dose that can prevent restenosis after coronary angioplasty has...http://content.nejm.org/cgi/content/short/344/4/243?rss=1&ssource=collectionSearchRss&queryTerm=10Vitali Verin, M.D., Youri Popowski, M.D., Bernard de Bruyne, M.D., Dietrich Baumgart, M.D., Wolfgang Sauerwein, M.D., Markus Lins, M.D., György Kovacs, M.D., Martyn Thomas, M.D., Francis Calman, M.D., Clemens Disco, M.Sc., Patrick W. Serruys, M.D., William Wijns, M.D., Marleen Piessens, Ph.D., John Kurtz, M.D., Ruediger Simon, M.D., Patrice Delafontaine, M.D., and Raimund Erbel, M.D., for the Dose-Finding Study GroupThu, 25  Jan  2001 00:00:00 -05:00http://content.nejm.org/cgi/content/short/344/4/243?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Some have the opinion that patients cared for in Veterans Health Administration (VHA) hospitals receive care of poorer quality than those cared for in non-VHA institutions. To assess the...http://content.nejm.org/cgi/content/short/343/26/1934?rss=1&ssource=collectionSearchRss&queryTerm=10Laura A. Petersen, M.D., M.P.H., Sharon-Lise T. Normand, Ph.D., Jennifer Daley, M.D., and Barbara J. McNeil, M.D., Ph.D.Thu, 28  Dec  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/26/1934?rss=1&ssource=collectionSearchRss&queryTerm=10Despite advances in medical therapy and improvements in techniques for myocardial revascularization, the prognosis remains poor for patients with ischemic cardiomyopathy, which is characterized by extensive coronary artery disease and...http://content.nejm.org/cgi/content/short/343/20/1488?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 16  Nov  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/20/1488?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Previous studies have documented that cardiac procedures are performed less frequently in patients enrolled in managed-care plans than in those with fee-for-service coverage. However, it is not known whether...http://content.nejm.org/cgi/content/short/343/20/1460?rss=1&ssource=collectionSearchRss&queryTerm=10Edward Guadagnoli, Ph.D., Mary Beth Landrum, Ph.D., Eric A. Peterson, M.Phil., Martin T. Gahart, Ph.D., Thomas J. Ryan, M.D., and Barbara J. McNeil, M.D., Ph.D.Thu, 16  Nov  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/20/1460?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Recent studies indicate that magnetic resonance imaging (MRI) after the administration of contrast material can be used to distinguish between reversible and irreversible myocardial ischemic injury regardless of the...http://content.nejm.org/cgi/content/short/343/20/1445?rss=1&ssource=collectionSearchRss&queryTerm=10Raymond J. Kim, M.D., Edwin Wu, M.D., Allen Rafael, M.D., Enn-Ling Chen, Ph.D., Michele A. Parker, M.S., Orlando Simonetti, Ph.D., Francis J. Klocke, M.D., Robert O. Bonow, M.D., and Robert M. Judd, Ph.D.Thu, 16  Nov  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/20/1445?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The relation between psychological variables and clinically evident coronary artery disease has been studied extensively, although the potential mechanisms of such a relation remain speculative. We studied the relation...http://content.nejm.org/cgi/content/short/343/18/1298?rss=1&ssource=collectionSearchRss&queryTerm=10Patrick G. O'Malley, M.D., M.P.H., David L. Jones, M.D., M.P.H., Irwin M. Feuerstein, M.D., and Allen J. Taylor, M.D.Thu, 02  Nov  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/18/1298?rss=1&ssource=collectionSearchRss&queryTerm=10The past decade has been characterized by growing interest in the idea that atherosclerosis is an inflammatory disease1 and by the finding that serum levels of markers of inflammation can...http://content.nejm.org/cgi/content/short/343/16/1179?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 19  Oct  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/16/1179?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Chronic inflammation is believed to increase the risk of coronary events by making atherosclerotic plaques in coronary vessels prone to rupture. We examined blood constituents potentially affected by inflammation...http://content.nejm.org/cgi/content/short/343/16/1148?rss=1&ssource=collectionSearchRss&queryTerm=10Chris J. Packard, D.Sc., Denis S.J. O'Reilly, M.D., Muriel J. Caslake, Ph.D., Alex D. McMahon, Ph.D., Ian Ford, Ph.D., Josephine Cooney, Colin H. Macphee, Ph.D., Keith E. Suckling, D.Sc., Mala Krishna, Ph.D., Francis E. Wilkinson, Ph.D., Ann Rumley, Ph.D., Gillian Docherty, B.Sc., John D. Burczak, Ph.D., and Gordon D.O. Lowe, M.D., for the West of Scotland Coronary Prevention Study GroupThu, 19  Oct  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/16/1148?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients with unstable coronary artery disease, there is a relation between the short-term risk of death and blood levels of troponin T (a marker of myocardial damage) and...http://content.nejm.org/cgi/content/short/343/16/1139?rss=1&ssource=collectionSearchRss&queryTerm=10Bertil Lindahl, M.D., Ph.D., Henrik Toss, M.D., Agneta Siegbahn, M.D., Ph.D., Per Venge, M.D., Ph.D., and Lars Wallentin, M.D., Ph.D., for the FRISC Study GroupThu, 19  Oct  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/16/1139?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Acute myocardial infarction is believed to be caused by rupture of an unstable coronary-artery plaque that appears as a single lesion on angiography. However, plaque instability might be caused...http://content.nejm.org/cgi/content/short/343/13/915?rss=1&ssource=collectionSearchRss&queryTerm=10James A. Goldstein, M.D., Demetris Demetriou, M.D., Cindy L. Grines, M.D., Mark Pica, B.S., Mazen Shoukfeh, M.D., and William W. O'Neill, M.D.Thu, 28  Sep  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/13/915?rss=1&ssource=collectionSearchRss&queryTerm=10Exercise stress testing is a well-established procedure that has been in widespread clinical use for more than 30 years.1 The great majority of exercise stress tests are performed in patients...http://content.nejm.org/cgi/content/short/343/12/879?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 21  Sep  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/12/879?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The offspring of patients with premature coronary disease may be at increased risk for atherosclerosis. We undertook a study to determine whether changes in brachial-artery reactivity and the thickness...http://content.nejm.org/cgi/content/short/343/12/840?rss=1&ssource=collectionSearchRss&queryTerm=10Giovanni Gaeta, M.D., Mario De Michele, M.D., Sergio Cuomo, M.D., Pasquale Guarini, M.D., Maria C. Foglia, M.D., M. Gene Bond, Ph.D., and Maurizio Trevisan, M.D.Thu, 21  Sep  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/12/840?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Exercise testing is widely used in the diagnosis of coronary artery disease, but the long-term outcome for asymptomatic persons with exercise-induced premature ventricular depolarizations remains unclear. We used data...http://content.nejm.org/cgi/content/short/343/12/826?rss=1&ssource=collectionSearchRss&queryTerm=10Xavier Jouven, M.D., Mahmoud Zureik, M.D., Ph.D., Michel Desnos, M.D., Dominique Courbon, M.Sc., and Pierre Ducimetière, Ph.D.Thu, 21  Sep  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/12/826?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> High plasma levels of coagulation factor VII have been suggested to be predictors of death due to coronary artery disease. Since polymorphisms in the factor VII gene contribute to...http://content.nejm.org/cgi/content/short/343/11/774?rss=1&ssource=collectionSearchRss&queryTerm=10Domenico Girelli, M.D., Ph.D., Carla Russo, M.D., Paolo Ferraresi, B.S., Oliviero Olivieri, M.D., Mirko Pinotti, Ph.D., Simonetta Friso, M.D., Franco Manzato, M.D., Alessandro Mazzucco, M.D., Francesco Bernardi, M.S., and Roberto Corrocher, M.D.Thu, 14  Sep  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/11/774?rss=1&ssource=collectionSearchRss&queryTerm=10Cardiovascular disease, including stroke, is the leading killer of women in the United States and in most developed countries. In 1997, cardiovascular disease accounted for 43 percent of all deaths...http://content.nejm.org/cgi/content/short/343/8/572?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 24  Aug  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/8/572?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Previous studies have found concurrent declines in blood pressure, serum cholesterol levels, and the incidence of and mortality from coronary disease. However, the effects of changes in diet and...http://content.nejm.org/cgi/content/short/343/8/530?rss=1&ssource=collectionSearchRss&queryTerm=10Frank B. Hu, M.D., Ph.D., Meir J. Stampfer, M.D., Dr.P.H., JoAnn E. Manson, M.D., Dr.P.H., Francine Grodstein, D.Sc., Graham A. Colditz, M.D., Dr.P.H., Frank E. Speizer, M.D., and Walter C. Willett, M.D., Dr.P.H.Thu, 24  Aug  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/8/530?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Heart disease is a major cause of illness and death in women. To understand better the role of estrogen in the treatment and prevention of heart disease, more information...http://content.nejm.org/cgi/content/short/343/8/522?rss=1&ssource=collectionSearchRss&queryTerm=10David M. Herrington, M.D., M.H.S., David M. Reboussin, Ph.D., K. Bridget Brosnihan, Ph.D., Penny C. Sharp, Ed.D., Sally A. Shumaker, Ph.D., Thomas E. Snyder, M.D., Curt D. Furberg, M.D., Ph.D., Glen J. Kowalchuk, M.D., Thomas D. Stuckey, M.D., William J. Rogers, M.D., David H. Givens, M.D., and David Waters, M.D.Thu, 24  Aug  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/8/522?rss=1&ssource=collectionSearchRss&queryTerm=10Figure 1. A 74-year-old man presented with a one-week history of exertional angina and dizziness. Treadmill testing showed deep, prolonged depression of the ST segment and hypotension at a low...http://content.nejm.org/cgi/content/short/343/6/403?rss=1&ssource=collectionSearchRss&queryTerm=10Chester M. Boltwood, Jr., M.D. and Terril Spitze, M.D.Thu, 10  Aug  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/6/403?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Prevention of myocardial damage is the main goal of all reperfusion therapies in patients with acute myocardial infarction. The relative efficacy of various reperfusion strategies is under intensive investigation....http://content.nejm.org/cgi/content/short/343/6/385?rss=1&ssource=collectionSearchRss&queryTerm=10Albert Schömig, M.D., Adnan Kastrati, M.D., Josef Dirschinger, M.D., Julinda Mehilli, M.D., Ullrich Schricke, M.D., Jürgen Pache, M.D., Stefan Martinoff, M.D., Franz-Josef Neumann, M.D., and Markus Schwaiger, M.D., for the Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study InvestigatorsThu, 10  Aug  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/6/385?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Previous studies have suggested that women with acute myocardial infarction receive less aggressive therapy than men. We used data from the Cooperative Cardiovascular Project to determine whether women and...http://content.nejm.org/cgi/content/short/343/1/8?rss=1&ssource=collectionSearchRss&queryTerm=10Sandra C. Gan, M.D., Shelli K. Beaver, M.S., Peter M. Houck, M.D., Richard F. MacLehose, M.S., Herschel W. Lawson, M.D., and Leighton Chan, M.D., M.P.H.Thu, 06  Jul  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/1/8?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Many lifestyle-related risk factors for coronary heart disease have been identified, but little is known about their effect on the risk of disease when they are considered together.<br/><br/><em>Methods:</em> We...http://content.nejm.org/cgi/content/short/343/1/16?rss=1&ssource=collectionSearchRss&queryTerm=10Meir J. Stampfer, M.D., Frank B. Hu, M.D., JoAnn E. Manson, M.D., Eric B. Rimm, Sc.D., and Walter C. Willett, M.D.Thu, 06  Jul  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/343/1/16?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The mortality rate among patients with coronary artery disease, abnormal ventricular function, and unsustained ventricular tachycardia is high. The usefulness of electrophysiologic testing for risk stratification in these patients...http://content.nejm.org/cgi/content/short/342/26/1937?rss=1&ssource=collectionSearchRss&queryTerm=10Alfred E. Buxton, M.D., Kerry L. Lee, Ph.D., Lorenzo DiCarlo, M.D., Michael R. Gold, M.D., G. Stephen Greer, M.D., Eric N. Prystowsky, M.D., Michael F. O'Toole, M.D., Anthony Tang, M.D., John D. Fisher, M.D., James Coromilas, M.D., Mario Talajic, M.D., and Gail Hafley, M.S., for the Multicenter Unsustained Tachycardia Trial InvestigatorsThu, 29  Jun  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/26/1937?rss=1&ssource=collectionSearchRss&queryTerm=10The development of coronary artery disease, and specifically myocardial infarction, involves hyperplasia of arterial smooth muscle, the development of fatty streaks, atheroma formation, plaque rupture, and ultimately thrombus formation and...http://content.nejm.org/cgi/content/short/342/24/1792?rss=1&ssource=collectionSearchRss&queryTerm=10Hans P. Kohler, M.D., and Peter J. Grant, M.D.Thu, 15  Jun  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/24/1792?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The cardiovascular effects of sildenafil are important because of the frequent presence of underlying cardiac disease in men with erectile dysfunction and reports indicating serious cardiac events temporally associated...http://content.nejm.org/cgi/content/short/342/22/1622?rss=1&ssource=collectionSearchRss&queryTerm=10Howard C. Herrmann, M.D., Gene Chang, M.D., Bruce D. Klugherz, M.D., and Paul D. Mahoney, M.D.Thu, 01  Jun  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/22/1622?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> There is an inverse relation between mortality from cardiovascular causes and the number of elective cardiac procedures (coronary angioplasty, stenting, or coronary bypass surgery) performed by individual practitioners or...http://content.nejm.org/cgi/content/short/342/21/1573?rss=1&ssource=collectionSearchRss&queryTerm=10John G. Canto, M.D., M.S.P.H., Nathan R. Every, M.D., M.P.H., David J. Magid, M.D., M.P.H., William J. Rogers, M.D., Judith A. Malmgren, Ph.D., Paul D. Frederick, M.P.H., M.B.A., William J. French, M.D., Alan J. Tiefenbrunn, M.D., Vijay K. Misra, M.D., Catarina I. Kiefe, Ph.D., M.D., and Hal V. Barron, M.D., for the National Registry of Myocardial Infarction 2 InvestigatorsThu, 25  May  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/21/1573?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Cardiovascular disease is common in older adults with end-stage renal disease who are undergoing regular dialysis, but little is known about the prevalence and extent of cardiovascular disease in...http://content.nejm.org/cgi/content/short/342/20/1478?rss=1&ssource=collectionSearchRss&queryTerm=10William G. Goodman, M.D., Jonathan Goldin, M.D., Ph.D., Beatriz D. Kuizon, M.D., Chun Yoon, M.D., Ph.D., Barbara Gales, R.N., Donna Sider, R.N., Yan Wang, Ph.D., Joanie Chung, M.S., Aletha Emerick, Lloyd Greaser, M.P.H., Robert M. Elashoff, Ph.D., and Isidro B. Salusky, M.D.Thu, 18  May  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/20/1478?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> When administered intravenously at the time of percutaneous coronary revascularization, glycoprotein IIb/IIIa receptor antagonists decrease the incidence of death and nonfatal myocardial infarction and the need for urgent revascularization....http://content.nejm.org/cgi/content/short/342/18/1316?rss=1&ssource=collectionSearchRss&queryTerm=10William W. O'Neill, M.D., Patrick Serruys, M.D., Ph.D., Merrill Knudtson, M.D., Gerrit-Anne van Es, Ph.D., Gerald C. Timmis, M.D., Coen van der Zwaan, M.D., Jay Kleiman, M.D., Jianjian Gong, Ph.D., Ellen B. Roecker, Ph.D., Roger Dreiling, M.D., John Alexander, M.D., M.P.H., and Robert Anders, Pharm.D., for the EXCITE Trial InvestigatorsThu, 04  May  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/18/1316?rss=1&ssource=collectionSearchRss&queryTerm=10Patients with suspected acute coronary syndromes, or acute cardiac ischemia, account for nearly 1.7 million hospital admissions per year in the United States. Between 2 and 8 percent of patients...http://content.nejm.org/cgi/content/short/342/16/1207?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 20  Apr  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/16/1207?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Discharging patients with acute myocardial infarction or unstable angina from the emergency department because of missed diagnoses can have dire consequences. We studied the incidence of, factors related to,...http://content.nejm.org/cgi/content/short/342/16/1163?rss=1&ssource=collectionSearchRss&queryTerm=10J. Hector Pope, M.D., Tom P. Aufderheide, M.D., Robin Ruthazer, M.P.H., Robert H. Woolard, M.D., James A. Feldman, M.D., Joni R. Beshansky, R.N., M.P.H., John L. Griffith, Ph.D., and Harry P. Selker, M.D., M.S.P.H.Thu, 20  Apr  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/16/1163?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> There are few reports describing the combined influence of the race and sex of a patient on the use of reperfusion therapy for acute myocardial infarction.<br/><br/><em>Methods:</em> To determine the...http://content.nejm.org/cgi/content/short/342/15/1094?rss=1&ssource=collectionSearchRss&queryTerm=10John G. Canto, M.D., M.S.P.H., Jeroan J. Allison, M.D., Catarina I. Kiefe, Ph.D., M.D., Contessa Fincher, M.P.H., Robert Farmer, B.Sc., Padmini Sekar, M.S., Sharina Person, Ph.D., and Norman W. Weissman, Ph.D.Thu, 13  Apr  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/15/1094?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Acute myocardial infarction in patients with diabetes is associated with high mortality. We studied whether previous revascularization by coronary-artery bypass grafting (CABG), as compared with percutaneous transluminal coronary angioplasty...http://content.nejm.org/cgi/content/short/342/14/989?rss=1&ssource=collectionSearchRss&queryTerm=10Katherine M. Detre, M.D., Dr.P.H., Manuel S. Lombardero, M.S., Maria Mori Brooks, Ph.D., Regina M. Hardison, M.S., Richard Holubkov, Ph.D., George Sopko, M.D., M.P.H., Robert L. Frye, M.D., and Bernard R. Chaitman, M.D., for the Bypass Angioplasty Revascularization Investigation InvestigatorsThu, 06  Apr  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/14/989?rss=1&ssource=collectionSearchRss&queryTerm=10Type 2 diabetes increases the risk of coronary heart disease by a factor of two to four.1 The relative increase in the rate of coronary heart disease among patients with...http://content.nejm.org/cgi/content/short/342/14/1040?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 06  Apr  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/14/1040?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction...http://content.nejm.org/cgi/content/short/342/12/836?rss=1&ssource=collectionSearchRss&queryTerm=10Paul M. Ridker, M.D., Charles H. Hennekens, M.D., Julie E. Buring, Sc.D., and Nader Rifai, Ph.D.Thu, 23  Mar  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/12/836?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> After hospitalization for chest pain, women are more likely than men to have normal coronary angiograms. In such women, myocardial ischemia in the absence of clinically significant coronary-artery obstruction...http://content.nejm.org/cgi/content/short/342/12/829?rss=1&ssource=collectionSearchRss&queryTerm=10Steven D. Buchthal, Ph.D., Jan A. den Hollander, Ph.D., C. Noel Bairey Merz, M.D., William J. Rogers, M.D., Carl J. Pepine, M.D., Nathaniel Reichek, M.D., Barry L. Sharaf, M.D., Steven Reis, M.D., Sheryl F. Kelsey, Ph.D., and Gerald M. Pohost, M.D.Thu, 23  Mar  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/12/829?rss=1&ssource=collectionSearchRss&queryTerm=10“Doctor, how much damage was there to my heart?” “When can I go home?” Any physician who has worked in a coronary care unit will recognize these two questions as...http://content.nejm.org/cgi/content/short/342/11/808?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 16  Mar  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/11/808?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Reducing the length of hospitalizations can reduce short-term costs, but there are few data on the long-term clinical and economic consequences of early discharge after uncomplicated myocardial infarction.<br/><br/><em>Methods:</em> Using...http://content.nejm.org/cgi/content/short/342/11/749?rss=1&ssource=collectionSearchRss&queryTerm=10L. Kristin Newby, M.D., Eric L. Eisenstein, D.B.A., Robert M. Califf, M.D., Trevor D. Thompson, B.S., Charlotte L. Nelson, M.S., Eric D. Peterson, M.D., M.P.H., Paul W. Armstrong, M.D., Frans Van de Werf, M.D., Harvey D. White, D.Sc., Eric J. Topol, M.D., and Daniel B. Mark, M.D., M.P.H.Thu, 16  Mar  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/11/749?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> When the myocardium is deprived of blood, a process of ischemia, infarction, and myocardial remodeling is initiated. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of vascular endothelial growth...http://content.nejm.org/cgi/content/short/342/9/626?rss=1&ssource=collectionSearchRss&queryTerm=10Sang H. Lee, M.D., Paul L. Wolf, M.D., Ryan Escudero, B.S., Reena Deutsch, Ph.D., Stuart W. Jamieson, M.B., F.R.C.S., and Patricia A. Thistlethwaite, M.D., Ph.D.Thu, 02  Mar  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/9/626?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Studies of the cardioprotective effects of exercise training in patients with coronary artery disease have yielded contradictory results. Exercise training has been associated with improvement in myocardial perfusion even...http://content.nejm.org/cgi/content/short/342/7/454?rss=1&ssource=collectionSearchRss&queryTerm=10Rainer Hambrecht, M.D., Anamaria Wolf, M.D., Stephan Gielen, M.D., Axel Linke, M.D., Jürgen Hofer, B.S., Sandra Erbs, M.D., Nina Schoene, M.D., and Gerhard Schuler, M.D.Thu, 17  Feb  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/7/454?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Observational and experimental studies suggest that the amount of vitamin E ingested in food and in supplements is associated with a lower risk of coronary heart disease and atherosclerosis.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/342/3/154?rss=1&ssource=collectionSearchRss&queryTerm=10The Heart Outcomes Prevention Evaluation Study InvestigatorsThu, 20  Jan  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/3/154?rss=1&ssource=collectionSearchRss&queryTerm=10Unstable angina accounts for more than 1 million hospital admissions annually1; 6 to 8 percent of patients with this condition have nonfatal myocardial infarction or die within the first year...http://content.nejm.org/cgi/content/short/342/2/101?rss=1&ssource=collectionSearchRss&queryTerm=10Yerem Yeghiazarians, M.D., Joel B. Braunstein, M.D., Arman Askari, M.D., and Peter H. Stone, M.D.Thu, 13  Jan  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/2/101?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Elevated blood pressure is known to be a risk factor for death from coronary heart disease (CHD). However, it is unclear whether the risk of death from CHD in...http://content.nejm.org/cgi/content/short/342/1/1?rss=1&ssource=collectionSearchRss&queryTerm=10Peggy C.W. van den Hoogen, M.Sc., Edith J.M. Feskens, Ph.D., Nico J.D. Nagelkerke, Ph.D., Alessandro Menotti, Ph.D., M.D., Aulikki Nissinen, Ph.D., M.D., and Daan Kromhout, Ph.D., M.P.H., for the Seven Countries Study Research GroupThu, 06  Jan  2000 00:00:00 -05:00http://content.nejm.org/cgi/content/short/342/1/1?rss=1&ssource=collectionSearchRss&queryTerm=10Plasma lipoproteins transport fats (cholesterol and triglyceride) and hence have a key role in atherosclerotic cardiovascular disease. Low-density lipoprotein (LDL) cholesterol promotes atherogenesis, and high-density lipoprotein (HDL) cholesterol inhibits it....http://content.nejm.org/cgi/content/short/341/26/2011?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 23  Dec  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/26/2011?rss=1&ssource=collectionSearchRss&queryTerm=10Since the introduction of coronary stents into clinical practice in the early 1990s, the number of stent implantations has increased so rapidly that stents are currently used in 60 to...http://content.nejm.org/cgi/content/short/341/26/2005?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 23  Dec  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/26/2005?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The introduction and refinement of coronary-artery stenting dramatically changed the practice of percutaneous coronary revascularization in the mid-1990s. We analyzed one-year follow-up data for all percutaneous coronary interventions performed...http://content.nejm.org/cgi/content/short/341/26/1957?rss=1&ssource=collectionSearchRss&queryTerm=10James M. Rankin, M.B., B.S., John J. Spinelli, Ph.D., Ronald G. Carere, M.D., Donald R. Ricci, M.D., Ian M. Penn, M.B., B.S., J. David Hilton, M.D., Mark A. Henderson, M.D., Robert I. Hayden, M.D., and Christopher E. Buller, M.D.Thu, 23  Dec  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/26/1957?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Coronary-stent implantation is frequently performed for treatment of acute myocardial infarction. However, few studies have compared stent implantation with primary angioplasty alone.<br/><br/><em>Methods:</em> We designed a multicenter study to compare...http://content.nejm.org/cgi/content/short/341/26/1949?rss=1&ssource=collectionSearchRss&queryTerm=10Cindy L. Grines, M.D., David A. Cox, M.D., Gregg W. Stone, M.D., Eulogio Garcia, M.D., Luiz A. Mattos, M.D., Alessandro Giambartolomei, M.D., Bruce R. Brodie, M.D., Olivier Madonna, M.D., Marcel Eijgelshoven, Ph.D., Alexandra J. Lansky, M.D., William W. O'Neill, M.D., and Marie-Claude Morice, M.D., for the Stent Primary Angioplasty in Myocardial Infarction Study GroupThu, 23  Dec  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/26/1949?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Empirical antiarrhythmic therapy has not reduced mortality among patients with coronary artery disease and asymptomatic ventricular arrhythmias. Previous studies have suggested that antiarrhythmic therapy guided by electrophysiologic testing might...http://content.nejm.org/cgi/content/short/341/25/1882?rss=1&ssource=collectionSearchRss&queryTerm=10Alfred E. Buxton, M.D., Kerry L. Lee, Ph.D., John D. Fisher, M.D., Mark E. Josephson, M.D., Eric N. Prystowsky, M.D., and Gail Hafley, M.S., for the Multicenter Unsustained Tachycardia Trial InvestigatorsThu, 16  Dec  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/25/1882?rss=1&ssource=collectionSearchRss&queryTerm=10The role of mechanical reperfusion as compared with thrombolytic therapy for the treatment of acute myocardial infarction has remained controversial since Rentrop et al.1 first reestablished perfusion in patients with...http://content.nejm.org/cgi/content/short/341/19/1464?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 04  Nov  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/19/1464?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> As compared with thrombolytic therapy, primary coronary angioplasty results in a higher rate of patency of the infarct-related coronary artery, lower rates of stroke and reinfarction, and higher in-hospital...http://content.nejm.org/cgi/content/short/341/19/1413?rss=1&ssource=collectionSearchRss&queryTerm=10Felix Zijlstra, Ph.D., Jan C.A. Hoorntje, Ph.D., Menko-Jan de Boer, Ph.D., Stoffer Reiffers, Ph.D., Kor Miedema, Ph.D., Jan Paul Ottervanger, Ph.D., Arnoud W.J. van 't Hof, Ph.D., and Harry Suryapranata, Ph.D.Thu, 04  Nov  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/19/1413?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Universal health care systems seek to ensure access to care on the basis of need rather than income and to improve the health status of all citizens. We examined...http://content.nejm.org/cgi/content/short/341/18/1359?rss=1&ssource=collectionSearchRss&queryTerm=10David A. Alter, M.D., C. David Naylor, M.D., D.Phil., Peter Austin, Ph.D., and Jack V. Tu, M.D., Ph.D.Thu, 28  Oct  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/18/1359?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The increase in heart rate that accompanies exercise is due in part to a reduction in vagal tone. Recovery of the heart rate immediately after exercise is a function...http://content.nejm.org/cgi/content/short/341/18/1351?rss=1&ssource=collectionSearchRss&queryTerm=10Christopher R. Cole, M.D., Eugene H. Blackstone, M.D., Fredric J. Pashkow, M.D., Claire E. Snader, M.A., and Michael S. Lauer, M.D.Thu, 28  Oct  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/18/1351?rss=1&ssource=collectionSearchRss&queryTerm=10To perform transmyocardial laser revascularization, the surgeon exposes the beating heart through a lateral thoracotomy, places a laser (carbon dioxide or holmium) on the epicardial surface of the left ventricle,...http://content.nejm.org/cgi/content/short/341/14/1075?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 30  Sep  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/14/1075?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Transmyocardial revascularization involves the creation of channels in the myocardium with a laser to relieve angina. We compared the safety and efficacy of transmyocardial revascularization performed with a holmium...http://content.nejm.org/cgi/content/short/341/14/1029?rss=1&ssource=collectionSearchRss&queryTerm=10Keith B. Allen, M.D., Robert D. Dowling, M.D., Tommy L. Fudge, M.D., G. Phillip Schoettle, M.D., Samuel L. Selinger, M.D., Deepak M. Gangahar, M.D., William W. Angell, M.D., Michael R. Petracek, M.D., Carl J. Shaar, Ph.D., and William W. O'Neill, M.D.Thu, 30  Sep  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/14/1029?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The construction of subendocardial channels to perfuse ischemic areas of the myocardium has been investigated since the 1950s. We assessed the safety and efficacy of transmyocardial revascularization with a...http://content.nejm.org/cgi/content/short/341/14/1021?rss=1&ssource=collectionSearchRss&queryTerm=10O.H. Frazier, M.D., Robert J. March, M.D., and Keith A. Horvath, M.D., for the Transmyocardial Carbon Dioxide Laser Revascularization Study GroupThu, 30  Sep  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/14/1021?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The role of walking, as compared with vigorous exercise, in the prevention of coronary heart disease remains controversial, and data for women on this topic are sparse.<br/><br/><em>Methods:</em> We prospectively...http://content.nejm.org/cgi/content/short/341/9/650?rss=1&ssource=collectionSearchRss&queryTerm=10JoAnn E. Manson, M.D., Dr.P.H., Frank B. Hu, M.D., Ph.D., Janet W. Rich-Edwards, Sc.D., Graham A. Colditz, M.D., Dr.P.H., Meir J. Stampfer, M.D., Dr.P.H., Walter C. Willett, M.D., Dr.P.H., Frank E. Speizer, M.D., and Charles H. Hennekens, M.D., Dr.P.H.Thu, 26  Aug  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/9/650?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Although it is generally accepted that lowering elevated serum levels of low-density lipoprotein (LDL) cholesterol in patients with coronary heart disease is beneficial, there are few data to guide...http://content.nejm.org/cgi/content/short/341/6/410?rss=1&ssource=collectionSearchRss&queryTerm=10Hanna Bloomfield Rubins, M.D., M.P.H., Sander J. Robins, M.D., Dorothea Collins, Sc.D., Carol L. Fye, R.Ph., M.S., James W. Anderson, M.D., Marshall B. Elam, M.D., Ph.D., Fred H. Faas, M.D., Esteban Linares, M.D., Ernst J. Schaefer, M.D., Gordon Schectman, M.D., Timothy J. Wilt, M.D., M.P.H., and Janet Wittes, Ph.D., for the Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study GroupThu, 05  Aug  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/6/410?rss=1&ssource=collectionSearchRss&queryTerm=10The news that cardiovascular disease is the leading cause of death among women has been so prominently publicized recently that researchers are occasionally asked to explain this apparent epidemic. In...http://content.nejm.org/cgi/content/short/341/4/275?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 22  Jul  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/4/275?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Studies have reported that women with acute myocardial infarction have in-hospital and long-term outcomes that are worse than those of men.<br/><br/><em>Methods:</em> To assess sex-based differences in presentation and outcome,...http://content.nejm.org/cgi/content/short/341/4/226?rss=1&ssource=collectionSearchRss&queryTerm=10Judith S. Hochman, M.D., Jacqueline E. Tamis, M.D., Trevor D. Thompson, B.S., W. Douglas Weaver, M.D., Harvey D. White, M.B., D.Sc., Frans Van de Werf, M.D., Phil Aylward, B.M., B.Ch., Eric J. Topol, M.D., and Robert M. Califf, M.D., for the Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes IIb InvestigatorsThu, 22  Jul  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/4/226?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> There is conflicting information about whether short-term mortality after myocardial infarction is higher among women than among men after adjustment for age and other prognostic factors. We hypothesized that...http://content.nejm.org/cgi/content/short/341/4/217?rss=1&ssource=collectionSearchRss&queryTerm=10Viola Vaccarino, M.D., Ph.D., Lori Parsons, B.S., Nathan R. Every, M.D., M.P.H., Hal V. Barron, M.D., and Harlan M. Krumholz, M.D., for the National Registry of Myocardial Infarction 2 ParticipantsThu, 22  Jul  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/4/217?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Percutaneous coronary revascularization is widely used in improving symptoms and exercise performance in patients with ischemic heart disease and stable angina pectoris. In this study, we compared percutaneous coronary...http://content.nejm.org/cgi/content/short/341/2/70?rss=1&ssource=collectionSearchRss&queryTerm=10Bertram Pitt, M.D., David Waters, M.D., William Virgil Brown, M.D., Ad J. van Boven, M.D., Ph.D., Leonard Schwartz, M.D., Lawrence M. Title, M.D., Daniel Eisenberg, M.D., Linda Shurzinske, M.S., and Lisa S. McCormick, Pharm.D., for the Atorvastatin versus Revascularization Treatment InvestigatorsThu, 08  Jul  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/341/2/70?rss=1&ssource=collectionSearchRss&queryTerm=10Trans unsaturated fatty acids are produced commercially in large quantities by heating vegetable oils in the presence of metal catalysts and hydrogen to form shortening and margarine.1 They are so...http://content.nejm.org/cgi/content/short/340/25/1994?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 24  Jun  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/25/1994?rss=1&ssource=collectionSearchRss&queryTerm=10The incidence of cardiovascular disease differs significantly between men and women, in part because of differences in risk factors and hormones.1 The incidence of atherosclerotic diseases is low in premenopausal...http://content.nejm.org/cgi/content/short/340/23/1801?rss=1&ssource=collectionSearchRss&queryTerm=10Michael E. Mendelsohn, M.D., and Richard H. Karas, M.D., Ph.D.Thu, 10  Jun  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/23/1801?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The sale of cigars in the United States has been increasing since 1993. Cigar smoking is a known risk factor for certain cancers and for chronic obstructive pulmonary disease...http://content.nejm.org/cgi/content/short/340/23/1773?rss=1&ssource=collectionSearchRss&queryTerm=10Carlos Iribarren, M.D., M.P.H., Ph.D., Irene S. Tekawa, M.A., Stephen Sidney, M.D., M.P.H., and Gary D. Friedman, M.D.Thu, 10  Jun  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/23/1773?rss=1&ssource=collectionSearchRss&queryTerm=10Twenty years ago, Luft and colleagues1 showed that hospitals that had higher volumes of specific surgical procedures had significantly lower inpatient mortality rates than did their lower-volume counterparts. Since that...http://content.nejm.org/cgi/content/short/340/21/1677?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 27  May  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/21/1677?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Patients with chest pain thought to be due to acute coronary ischemia are typically taken by ambulance to the nearest hospital. The potential benefit of field triage directly to...http://content.nejm.org/cgi/content/short/340/21/1640?rss=1&ssource=collectionSearchRss&queryTerm=10David R. Thiemann, M.D., Josef Coresh, M.D., Ph.D., William J. Oetgen, M.D., M.B.A., and Neil R. Powe, M.D., M.P.H., M.B.A.Thu, 27  May  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/21/1640?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients with refractory unstable angina, the platelet glycoprotein IIb/IIIa–receptor antibody abciximab reduces the incidence of cardiac events before and during coronary angioplasty. We investigated whether serum troponin T...http://content.nejm.org/cgi/content/short/340/21/1623?rss=1&ssource=collectionSearchRss&queryTerm=10Christian W. Hamm, M.D., Christopher Heeschen, M.D., Britta Goldmann, M.D., Alec Vahanian, M.D., Jennifer Adgey, M.D., Carlos Macaya Miguel, M.D., Wolfgang Rutsch, M.D., Juergen Berger, Ph.D., Jille Kootstra, and Maarten L. Simoons, M.D., for the c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study InvestigatorsThu, 27  May  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/21/1623?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of neural-tube defects in...http://content.nejm.org/cgi/content/short/340/19/1449?rss=1&ssource=collectionSearchRss&queryTerm=10Paul F. Jacques, Sc.D., Jacob Selhub, Ph.D., Andrew G. Bostom, M.D., Peter W.F. Wilson, M.D., and Irwin H. Rosenberg, M.D.Thu, 13  May  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/19/1449?rss=1&ssource=collectionSearchRss&queryTerm=10Meta-analysis — the formal combination of the research results from multiple studies — is widely used, but with little general understanding of its limitations and uncertainties. There is something quite...http://content.nejm.org/cgi/content/short/340/12/958?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 25  Mar  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/12/958?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The effect of passive smoking on the risk of coronary heart disease is controversial. We conducted a meta-analysis of the risk of coronary heart disease associated with passive smoking...http://content.nejm.org/cgi/content/short/340/12/920?rss=1&ssource=collectionSearchRss&queryTerm=10Jiang He, M.D., Ph.D., Suma Vupputuri, M.P.H., Krista Allen, M.P.H., Monica R. Prerost, M.S., Janet Hughes, Ph.D., and Paul K. Whelton, M.D.Thu, 25  Mar  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/12/920?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Epidemiologic studies have reported differences in the use of cardiovascular procedures according to the race and sex of the patient. Whether the differences stem from differences in the recommendations...http://content.nejm.org/cgi/content/short/340/8/618?rss=1&ssource=collectionSearchRss&queryTerm=10Kevin A. Schulman, M.D., Jesse A. Berlin, Sc.D., William Harless, Ph.D., Jon F. Kerner, Ph.D., Shyrl Sistrunk, M.D., Bernard J. Gersh, M.B., Ch.B., D.Phil., Ross Dubé, Christopher K. Taleghani, M.D., Jennifer E. Burke, M.A., M.S., Sankey Williams, M.D., John M. Eisenberg, M.D., William Ayers, M.D., and José J. Escarce, M.D., Ph.D.Thu, 25  Feb  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/8/618?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Exercise electrocardiography is an imperfect test for the detection of coronary artery disease. We attempted to improve the diagnostic accuracy of exercise testing as a noninvasive method for the...http://content.nejm.org/cgi/content/short/340/5/340?rss=1&ssource=collectionSearchRss&queryTerm=10Andreas P. Michaelides, M.D., Zoi D. Psomadaki, M.D., Polychronis E. Dilaveris, M.D., Dimitris J. Richter, M.D., George K. Andrikopoulos, M.D., Konstantina D. Aggeli, M.D., Christodoulos I. Stefanadis, M.D., and Pavlos K. Toutouzas, M.D.Thu, 04  Feb  1999 00:00:00 -05:00http://content.nejm.org/cgi/content/short/340/5/340?rss=1&ssource=collectionSearchRss&queryTerm=10Electron-beam computed tomography (CT) is a new, increasingly widely promoted technique for the detection of calcification within coronary atherosclerotic lesions. Evidence supporting the use of this test in screening for...http://content.nejm.org/cgi/content/short/339/27/2018?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 31  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/27/2018?rss=1&ssource=collectionSearchRss&queryTerm=10Atherosclerosis has been a serious health epidemic in developed countries in the late 20th century, and its rising prevalence in developing nations suggests that it will become the chief cause...http://content.nejm.org/cgi/content/short/339/27/2014?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 31  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/27/2014?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Angiographic studies of the regression of coronary artery disease are invasive and costly, and they permit only limited assessment of changes in the extent of atherosclerotic disease. Electron-beam computed...http://content.nejm.org/cgi/content/short/339/27/1972?rss=1&ssource=collectionSearchRss&queryTerm=10Tracy Q. Callister, M.D., Paolo Raggi, M.D., Bruce Cooil, Ph.D., Nicholas J. Lippolis, M.D., and Donald J. Russo, M.D.Thu, 31  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/27/1972?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Reliable noninvasive assessment of coronary-artery stenoses and occlusions would constitute an advantage in the care of patients with known or suspected coronary artery disease. We investigated the accuracy of...http://content.nejm.org/cgi/content/short/339/27/1964?rss=1&ssource=collectionSearchRss&queryTerm=10Stephan Achenbach, M.D., Werner Moshage, M.D., Dieter Ropers, M.D., Jörg Nossen, M.D., and Werner G. Daniel, M.D.Thu, 31  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/27/1964?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Nearly half of patients hospitalized with unstable angina eventually receive a non–cardiac-related diagnosis, yet 5 percent of patients with myocardial infarction are inappropriately discharged from the emergency department. We...http://content.nejm.org/cgi/content/short/339/26/1882?rss=1&ssource=collectionSearchRss&queryTerm=10Michael E. Farkouh, M.D., Peter A. Smars, M.D., Guy S. Reeder, M.D., Alan R. Zinsmeister, Ph.D., Roger W. Evans, Ph.D., Thomas D. Meloy, M.D., Stephen L. Kopecky, M.D., Marvin Allen, M.D., Thomas G. Allison, Ph.D., Raymond J. Gibbons, M.D., and Sherine E. Gabriel, M.D., for the Chest Pain Evaluation in the Emergency Room (CHEER) InvestigatorsThu, 24  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/26/1882?rss=1&ssource=collectionSearchRss&queryTerm=10Carvedilol is a β-adrenoreceptor–antagonist drug with α1-adrenoreceptor–antagonist activity. It was approved in the United States in September 1995 for the treatment of patients with essential hypertension and in May 1997,...http://content.nejm.org/cgi/content/short/339/24/1759?rss=1&ssource=collectionSearchRss&queryTerm=10William H. Frishman, M.D.Thu, 10  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/24/1759?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary stenting is now the predominant form of nonsurgical myocardial revascularization and accounts for well over 60 percent of the percutaneous coronary-revascularization procedures performed in the United States. The number...http://content.nejm.org/cgi/content/short/339/23/1702?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 03  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/23/1702?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Intracoronary stenting reduces the rate of restenosis after angioplasty in patients with new coronary lesions. We conducted a prospective, randomized, multicenter study to determine whether intracoronary stenting, as compared...http://content.nejm.org/cgi/content/short/339/23/1672?rss=1&ssource=collectionSearchRss&queryTerm=10Raimund Erbel, M.D., Michael Haude, M.D., Hans W. Höpp, M.D., Damian Franzen, M.D., Hans Jürgen Rupprecht, M.D., Bernd Heublein, M.D., Klaus Fischer, M.D., Peter de Jaegere, M.D., Patrick Serruys, M.D., Wolfgang Rutsch, M.D., and Peter Probst, M.D., for the Restenosis Stent Study GroupThu, 03  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/23/1672?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Antithrombotic drugs are used after coronary-artery stenting to prevent stent thrombosis. We compared the efficacy and safety of three antithrombotic-drug regimens — aspirin alone, aspirin and warfarin, and aspirin...http://content.nejm.org/cgi/content/short/339/23/1665?rss=1&ssource=collectionSearchRss&queryTerm=10Martin B. Leon, M.D., Donald S. Baim, M.D., Jeffrey J. Popma, M.D., Paul C. Gordon, M.D., Donald E. Cutlip, M.D., Kalon K.L. Ho, M.D., Alex Giambartolomei, M.D., Daniel J. Diver, M.D., David M. Lasorda, D.O., David O. Williams, M.D., Stuart J. Pocock, Ph.D., and Richard E. Kuntz, M.D., for the Stent Anticoagulation Restenosis Study InvestigatorsThu, 03  Dec  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/23/1665?rss=1&ssource=collectionSearchRss&queryTerm=10Congestive heart failure affects about 1 percent of adults in the United States1 and is a contributing factor in over 250,000 deaths annually.2 It is diagnosed in 400,000 Americans each...http://content.nejm.org/cgi/content/short/339/21/1522?rss=1&ssource=collectionSearchRss&queryTerm=10Daniel J. Goldstein, M.D., Mehmet C. Oz, M.D., and Eric A. Rose, M.D.Thu, 19  Nov  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/21/1522?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients with coronary heart disease and a broad range of cholesterol levels, cholesterol-lowering therapy reduces the risk of coronary events, but the effects on mortality from coronary heart...http://content.nejm.org/cgi/content/short/339/19/1349?rss=1&ssource=collectionSearchRss&queryTerm=10The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study GroupThu, 05  Nov  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/19/1349?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Myocardial bridging may cause compression of a coronary artery, and it has been suggested that myocardial ischemia may result. The clinical significance and prognostic value of myocardial bridging of...http://content.nejm.org/cgi/content/short/339/17/1201?rss=1&ssource=collectionSearchRss&queryTerm=10Anji T. Yetman, M.D., Brian W. McCrindle, M.D., Cathy MacDonald, M.D., Robert M. Freedom, M.D., and Robert Gow, M.B., B.S.Thu, 22  Oct  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/17/1201?rss=1&ssource=collectionSearchRss&queryTerm=10In the late 1940s, recognition of coronary heart disease (CHD) as the leading cause of death in the United States prompted efforts to identify factors promoting its occurrence, in the...http://content.nejm.org/cgi/content/short/339/13/915?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 24  Sep  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/13/915?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> and <em>Methods:</em> To clarify the determinants of contemporary trends in mortality from coronary heart disease (CHD), we conducted surveillance of hospital admissions for myocardial infarction and of in-hospital and...http://content.nejm.org/cgi/content/short/339/13/861?rss=1&ssource=collectionSearchRss&queryTerm=10Wayne D. Rosamond, Ph.D., Lloyd E. Chambless, Ph.D., Aaron R. Folsom, M.D., Lawton S. Cooper, M.D., David E. Conwill, M.D., Limin Clegg, Ph.D., Chin-Hua Wang, Ph.D., and Gerardo Heiss, M.D., Ph.D.Thu, 24  Sep  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/13/861?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Cardiovascular disease is common in patients on long-term dialysis, and it accounts for 44 percent of overall mortality in this group. We undertook a study to assess long-term survival...http://content.nejm.org/cgi/content/short/339/12/799?rss=1&ssource=collectionSearchRss&queryTerm=10Charles A. Herzog, M.D., Jennie Z. Ma, Ph.D., and Allan J. Collins, M.D.Thu, 17  Sep  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/12/799?rss=1&ssource=collectionSearchRss&queryTerm=10During the 1960s, Sir James W. Black developed propranolol, which the Nobel Committee in 1988 called “the greatest breakthrough when it comes to pharmaceuticals against heart illness since the discovery...http://content.nejm.org/cgi/content/short/339/8/551?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 20  Aug  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/8/551?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Long-term administration of beta-adrenergic blockers to patients after myocardial infarction improves survival. However, physicians are reluctant to administer beta-blockers to many patients, such as older patients and those with...http://content.nejm.org/cgi/content/short/339/8/489?rss=1&ssource=collectionSearchRss&queryTerm=10Stephen S. Gottlieb, M.D., Robert J. McCarter, Sc.D., and Robert A. Vogel, M.D.Thu, 20  Aug  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/8/489?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Aggregation of platelets is the pathophysiologic basis of the acute coronary syndromes. Eptifibatide, a synthetic cyclic heptapeptide, is a selective high-affinity inhibitor of the platelet glycoprotein IIb/IIIa receptor, which...http://content.nejm.org/cgi/content/short/339/7/436?rss=1&ssource=collectionSearchRss&queryTerm=10The PURSUIT Trial InvestigatorsThu, 13  Aug  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/7/436?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Type 2 (non-insulin-dependent) diabetes is associated with a marked increase in the risk of coronary heart disease. It has been debated whether patients with diabetes who have not had...http://content.nejm.org/cgi/content/short/339/4/229?rss=1&ssource=collectionSearchRss&queryTerm=10Steven M. Haffner, M.D., Seppo Lehto, M.D., Tapani Rönnemaa, M.D., Kalevi Pyörälä, M.D., and Markku Laakso, M.D.Thu, 23  Jul  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/339/4/229?rss=1&ssource=collectionSearchRss&queryTerm=10Over the past two decades, clinical and pathological studies have examined the pathophysiology of the acute coronary syndromes, unstable angina, and non–Q-wave and Q-wave myocardial infarction. In these conditions, rupture...http://content.nejm.org/cgi/content/short/338/25/1838?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 18  Jun  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/25/1838?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Non–Q-wave myocardial infarction is usually managed according to an “invasive” strategy (i.e., one of routine coronary angiography followed by myocardial revascularization).<br/><br/><em>Methods:</em> We randomly assigned 920 patients to either “invasive”...http://content.nejm.org/cgi/content/short/338/25/1785?rss=1&ssource=collectionSearchRss&queryTerm=10William E. Boden, M.D., Robert A. O'Rourke, M.D., Michael H. Crawford, M.D., Alvin S. Blaustein, M.D., Prakash C. Deedwania, M.D., Robert G. Zoble, M.D., Ph.D., Laura F. Wexler, M.D., Robert E. Kleiger, M.D., Carl J. Pepine, M.D., David R. Ferry, M.D., Bruce K. Chow, M.S., and Philip W. Lavori, Ph.D., for the Veterans Affairs Non–Q-Wave Infarction Strategies in Hospital (VANQWISH) Trial InvestigatorsThu, 18  Jun  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/25/1785?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Familial hypercholesterolemia leads to premature ischemic heart disease and is often caused by mutations in the gene for the low-density lipoprotein receptor. Mutations in the apolipoprotein B gene, which...http://content.nejm.org/cgi/content/short/338/22/1577?rss=1&ssource=collectionSearchRss&queryTerm=10Anne Tybjærg-Hansen, M.D., D.M.Sc., Rolf Steffensen, M.D., Hans Meinertz, M.D., Peter Schnohr, M.D., and Børge G. Nordestgaard, M.D., D.M.Sc.Thu, 28  May  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/22/1577?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary atherosclerosis develops over decades and then may suddenly lead to an acute coronary event. Often this occurs in an artery with a minor stenosis. The culprit lesion usually has...http://content.nejm.org/cgi/content/short/338/21/1539?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 21  May  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/21/1539?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Activation of platelets is central to the pathophysiology of unstable angina. We studied whether inhibition of the final common pathway for platelet aggregation with tirofiban, a nonpeptide glycoprotein IIb/IIIa...http://content.nejm.org/cgi/content/short/338/21/1498?rss=1&ssource=collectionSearchRss&queryTerm=10The Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Study InvestigatorsThu, 21  May  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/21/1498?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Antithrombotic therapy improves the prognosis of patients with acute coronary syndromes, yet the syndromes remain a therapeutic challenge. We evaluated tirofiban, a specific inhibitor of the platelet glycoprotein IIb/IIIa...http://content.nejm.org/cgi/content/short/338/21/1488?rss=1&ssource=collectionSearchRss&queryTerm=10The Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) Study InvestigatorsThu, 21  May  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/21/1488?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The Food and Drug Administration (FDA) has recommended that cereal-grain products be fortified with folic acid to prevent congenital neural-tube defects. Since folic acid supplementation reduces levels of plasma...http://content.nejm.org/cgi/content/short/338/15/1009?rss=1&ssource=collectionSearchRss&queryTerm=10Manuel R. Malinow, M.D., Paul B. Duell, M.D., David L. Hess, Ph.D., Peter H. Anderson, Ph.D., Warren D. Kruger, M.D., Beverley E. Phillipson, M.D., Robert A. Gluckman, M.D., Peter C. Block, M.D., and Barbara M. Upson, B.S.Thu, 09  Apr  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/15/1009?rss=1&ssource=collectionSearchRss&queryTerm=10Hemodynamically important right ventricular myocardial infarction is an infrequent consequence of inferior myocardial infarction.1 The clinical triad of hypotension, clear lung fields, and elevated jugular venous pressure occurs in less...http://content.nejm.org/cgi/content/short/338/14/978?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 02  Apr  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/14/978?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Right ventricular infarction occurs in conjunction with inferior myocardial infarction caused by proximal occlusion of the right coronary artery. However, right ventricular infarction occurs infrequently, and the reasons for...http://content.nejm.org/cgi/content/short/338/14/941?rss=1&ssource=collectionSearchRss&queryTerm=10Hiroto Shiraki, M.D., Tsutomu Yoshikawa, M.D., Toshihisa Anzai, M.D., Koji Negishi, M.D., Tetsuo Takahashi, M.D., Yasushi Asakura, M.D., Makoto Akaishi, M.D., Hideo Mitamura, M.D., and Satoshi Ogawa, M.D.Thu, 02  Apr  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/14/941?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Although the salutary effects of reperfusion in patients with left ventricular infarction are well documented, the benefits in patients with acute right ventricular infarction are less clear.<br/><br/><em>Methods:</em> To determine...http://content.nejm.org/cgi/content/short/338/14/933?rss=1&ssource=collectionSearchRss&queryTerm=10Terry R. Bowers, M.D., William W. O'Neill, M.D., Cindy Grines, M.D., Mark C. Pica, B.S., Robert D. Safian, M.D., and James A. Goldstein, M.D.Thu, 02  Apr  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/14/933?rss=1&ssource=collectionSearchRss&queryTerm=10The organic nitrates are widely used in the management of coronary artery disease. They are given not only to patients with stable angina pectoris, but also to those with unstable...http://content.nejm.org/cgi/content/short/338/8/520?rss=1&ssource=collectionSearchRss&queryTerm=10John D. Parker, M.D., and John O. Parker, M.D.Thu, 19  Feb  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/8/520?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The high-density lipoprotein (HDL) cholesterol concentration is inversely related to the risk of coronary artery disease. The cholesteryl ester transfer protein (CETP) has a central role in the metabolism...http://content.nejm.org/cgi/content/short/338/2/86?rss=1&ssource=collectionSearchRss&queryTerm=10Jan Albert Kuivenhoven, Ph.D., J. Wouter Jukema, M.D., Aeilko H. Zwinderman, Ph.D., Peter de Knijff, Ph.D., Ruth McPherson, M.D., Ph.D., Albert V.G. Bruschke, M.D., Kong I. Lie, M.D., and John J.P. Kastelein, M.D., for the Regression Growth Evaluation Statin Study GroupThu, 08  Jan  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/2/86?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> High blood levels of coagulation factor VII are associated with a risk of ischemic vascular disease. Although factor VII levels may be genetically determined, the relation between genetic polymorphisms...http://content.nejm.org/cgi/content/short/338/2/79?rss=1&ssource=collectionSearchRss&queryTerm=10Licia Iacoviello, M.D., Augusto Di Castelnuovo, M.S., Peter de Knijff, Ph.D., Andria D'Orazio, B.S., Concetta Amore, B.S., Rosa Arboretti, M.S., Cornelis Kluft, Ph.D., and Maria Benedetta Donati, M.D., Ph.D.Thu, 08  Jan  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/2/79?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In previous studies, unadjusted comparisons of mortality and major morbidity after acute myocardial infarction have generally indicated that women have a poorer outcome than men. Much larger studies are...http://content.nejm.org/cgi/content/short/338/1/8?rss=1&ssource=collectionSearchRss&queryTerm=10Roberto Malacrida, M.D., Michele Genoni, M.D., Aldo Pietro Maggioni, M.D., Vito Spataro, M.D., Sarah Parish, D.Phil., Alison Palmer, M.Sc., Rory Collins, M.B., B.S., and Tiziano Moccetti, M.D., for the Third International Study of Infarct Survival Collaborative GroupThu, 01  Jan  1998 00:00:00 -05:00http://content.nejm.org/cgi/content/short/338/1/8?rss=1&ssource=collectionSearchRss&queryTerm=10Alcohol occupies a unique place in many human societies; it is a widely used drug, tolerated physiologically and socially, with a place in religious ceremony, in ritual, in spontaneous celebration,...http://content.nejm.org/cgi/content/short/337/24/1763?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 11  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/24/1763?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Alcohol consumption has both adverse and beneficial effects on survival. We examined the balance of these in a large prospective study of mortality among U.S. adults.<br/><br/><em>Methods:</em> Of 490,000 men...http://content.nejm.org/cgi/content/short/337/24/1705?rss=1&ssource=collectionSearchRss&queryTerm=10Michael J. Thun, M.D., Richard Peto, F.R.S., Alan D. Lopez, Ph.D., Jane H. Monaco, M.S., S. Jane Henley, B.A., Clark W. Heath, Jr., M.D., and Richard Doll, F.R.S.Thu, 11  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/24/1705?rss=1&ssource=collectionSearchRss&queryTerm=10Each year 5 million patients come to emergency departments with chest pain.1 Some have acute, life-threatening illness, but many others have nothing seriously wrong; some have a history of coronary...http://content.nejm.org/cgi/content/short/337/23/1687?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 04  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/23/1687?rss=1&ssource=collectionSearchRss&queryTerm=10As life expectancy continues to increase, women will soon be postmenopausal for one third of their lives. The human and economic costs of this increased longevity in an estrogen-deficient state...http://content.nejm.org/cgi/content/short/337/23/1686?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 04  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/23/1686?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Evaluation of patients with acute chest pain in emergency rooms is time-consuming and expensive, and it often results in uncertain diagnoses. We prospectively investigated the usefulness of bedside tests...http://content.nejm.org/cgi/content/short/337/23/1648?rss=1&ssource=collectionSearchRss&queryTerm=10Christian W. Hamm, M.D., Britta U. Goldmann, M.D., Christopher Heeschen, M.D., Georg Kreymann, M.D., Jürgen Berger, Ph.D., and Thomas Meinertz, M.D.Thu, 04  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/23/1648?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Long-term estrogen therapy can reduce the risk of osteoporotic fracture and cardiovascular disease in postmenopausal women. At present, however, these beneficial effects are not separable from undesirable stimulation of...http://content.nejm.org/cgi/content/short/337/23/1641?rss=1&ssource=collectionSearchRss&queryTerm=10Pierre D. Delmas, M.D., Ph.D., Nina H. Bjarnason, M.D., Bruce H. Mitlak, M.D., Anne-Catherine Ravoux, M.D., Aarti S. Shah, Ph.D., William J. Huster, Ph.D., Michael Draper, M.D., Ph.D., and Claus Christiansen, M.D.Thu, 04  Dec  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/23/1641?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Patients with coronary heart disease, left ventricular dysfunction, and abnormalities on signal-averaged electrocardiograms have an increased risk of sudden death. We evaluated the effect on survival of the prophylactic...http://content.nejm.org/cgi/content/short/337/22/1569?rss=1&ssource=collectionSearchRss&queryTerm=10J. Thomas Bigger, Jr., M.D., for the Coronary Artery Bypass Graft (CABG) Patch Trial InvestigatorsThu, 27  Nov  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/22/1569?rss=1&ssource=collectionSearchRss&queryTerm=10The value of hardened (trans) unsaturated fats in our food supply is probably best exemplified by the glazed doughnut. At room temperature, a glazed doughnut can be easily eaten with...http://content.nejm.org/cgi/content/short/337/21/1544?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 20  Nov  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/21/1544?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The relation between dietary intake of specific types of fat, particularly trans unsaturated fat, and the risk of coronary disease remains unclear. We therefore studied this relation in women...http://content.nejm.org/cgi/content/short/337/21/1491?rss=1&ssource=collectionSearchRss&queryTerm=10Frank B. Hu, M.D., Meir J. Stampfer, M.D., JoAnn E. Manson, M.D., Eric Rimm, Sc.D., Graham A. Colditz, M.D., Bernard A. Rosner, Ph.D., Charles H. Hennekens, M.D., and Walter C. Willett, M.D.Thu, 20  Nov  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/21/1491?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Accelerated infusion of alteplase (tissue plasminogen activator) over a period of 90 minutes induces more rapid lysis of coronary-artery thrombi than a 3-hour infusion. With two bolus doses of...http://content.nejm.org/cgi/content/short/337/16/1124?rss=1&ssource=collectionSearchRss&queryTerm=10The Continuous Infusion versus Double-Bolus Administration of Alteplase (COBALT) InvestigatorsThu, 16  Oct  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/16/1124?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Reteplase (recombinant plasminogen activator), a mutant of alteplase tissue plasminogen activator, has a longer half-life than its parent molecule and produced superior angiographic results in pilot studies of acute...http://content.nejm.org/cgi/content/short/337/16/1118?rss=1&ssource=collectionSearchRss&queryTerm=10The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO III) InvestigatorsThu, 16  Oct  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/16/1118?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Treatment of stenosis in saphenous-vein grafts after coronary-artery bypass surgery is a difficult challenge. The purpose of this study was to compare the effects of stent placement with those...http://content.nejm.org/cgi/content/short/337/11/740?rss=1&ssource=collectionSearchRss&queryTerm=10Michael P. Savage, M.D., John S. Douglas, Jr., M.D., David L. Fischman, M.D., Carl J. Pepine, M.D., Spencer B. King III, M.D., Jeffrey A. Werner, M.D., Steven R. Bailey, M.D., Paul A. Overlie, M.D., Sarah H. Fenton, M.D., Jeffrey A. Brinker, M.D., Martin B. Leon, M.D., and Sheldon Goldberg, M.D., Richard Heuser, M.D., Richard Smalling, M.D., Robert D. Safian, M.D., Michael Cleman, M.D. , Maurice Buchbinder, M.D., David Snead, Randal C. Rake, B.S., Sharon Gebhardt, R.N., for the Saphenous Vein De Novo Trial InvestigatorsThu, 11  Sep  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/11/740?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Postmenopausal estrogen therapy has favorable effects on serum lipoproteins in women with normal serum lipid levels, but the effect of combined estrogen and progestin therapy on lipoproteins in women...http://content.nejm.org/cgi/content/short/337/9/595?rss=1&ssource=collectionSearchRss&queryTerm=10Giselle M. Darling, M.D., Jennifer A. Johns, M.D., Philip I. McCloud, Ph.D., and Susan R. Davis, M.D., Ph.D.Thu, 28  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/9/595?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Postmenopausal estrogen therapy has favorable effects on serum lipoproteins in women with normal serum lipid levels, but the effect of combined estrogen and progestin therapy on lipoproteins in women...http://content.nejm.org/cgi/content/short/337/9/595?rss=1&ssource=collectionSearchRss&queryTerm=10Giselle M. Darling, M.D., Jennifer A. Johns, M.D., Philip I. McCloud, Ph.D., and Susan R. Davis, M.D., Ph.D.Thu, 28  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/9/595?rss=1&ssource=collectionSearchRss&queryTerm=10Unstable angina and non–Q-wave myocardial infarction together constitute a formidable medical problem. Remarkable recent advances in our understanding of the pathophysiology of acute coronary syndromes have, thus far, outpaced progress...http://content.nejm.org/cgi/content/short/337/7/492?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 14  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/7/492?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Antithrombotic therapy with heparin plus aspirin reduces the rate of ischemic events in patients with unstable coronary artery disease. Low-molecular-weight heparin has a more predictable anticoagulant effect than standard...http://content.nejm.org/cgi/content/short/337/7/447?rss=1&ssource=collectionSearchRss&queryTerm=10Marc Cohen, M.D., Christine Demers, M.D., Enrique P. Gurfinkel, M.D., Alexander G.G. Turpie, M.D., Gregg J. Fromell, M.D., Shaun Goodman, M.D., Anatoly Langer, M.D., Robert M. Califf, M.D., Keith A.A. Fox, M.B., Ch.B., Jerome Premmereur, M.D., and Frederique Bigonzi, M.D., Jim Stephens, M.S., Beth Weatherley, for the Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events Study GroupThu, 14  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/7/447?rss=1&ssource=collectionSearchRss&queryTerm=10Respite gratifying immediate results, progressive narrowing of the coronary arteries over several months all too commonly limits the benefit of balloon angioplasty and various types of atherectomy. Even coronary-artery stents,...http://content.nejm.org/cgi/content/short/337/6/418?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 07  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/6/418?rss=1&ssource=collectionSearchRss&queryTerm=10Epidemiologic studies have demonstrated an association between increased intake of antioxidant vitamins such as vitamin E and vitamin C and reduced morbidity and mortality from coronary artery disease. This association...http://content.nejm.org/cgi/content/short/337/6/408?rss=1&ssource=collectionSearchRss&queryTerm=10Marco N. Diaz, M.D., Balz Frei, Ph.D., Joseph A. Vita, M.D., and John F. Keaney, Jr., M.D.Thu, 07  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/6/408?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Oxidizing metabolites generated at the site of coronary angioplasty can induce chain reactions that may lead to restenosis. Antioxidants may counter oxidative stress and modify neointimal formation and vascular...http://content.nejm.org/cgi/content/short/337/6/365?rss=1&ssource=collectionSearchRss&queryTerm=10Jean-Claude Tardif, M.D., Gilles Côté, M.D., Jacques Lespérance, M.D., Martial Bourassa, M.D., Jean Lambert, Ph.D., Serge Doucet, M.D., Luc Bilodeau, M.D., Stanley Nattel, M.D., and Pierre de Guise, M.D., for the Multivitamins and Probucol Study GroupThu, 07  Aug  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/6/365?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Elevated plasma homocysteine levels are a risk factor for coronary heart disease, but the prognostic value of homocysteine levels in patients with established coronary artery disease has not been...http://content.nejm.org/cgi/content/short/337/4/230?rss=1&ssource=collectionSearchRss&queryTerm=10Ottar Nygård, M.D., Jan Erik Nordrehaug, M.D., Helga Refsum, M.D., Per Magne Ueland, M.D., Mikael Farstad, M.D., and Stein Emil Vollset, M.D., Dr.P.H.Thu, 24  Jul  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/337/4/230?rss=1&ssource=collectionSearchRss&queryTerm=10In this issue of the Journal, Grodstein and colleagues1 present important data from a large study of the risks and benefits associated with postmenopausal hormone-replacement therapy. Like previous investigators, they...http://content.nejm.org/cgi/content/short/336/25/1821?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 19  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/25/1821?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Postmenopausal hormone therapy has both benefits and hazards, including decreased risks of osteoporosis and cardiovascular disease and an increased risk of breast cancer.<br/><br/><em>Methods:</em> We examined the relation between the...http://content.nejm.org/cgi/content/short/336/25/1769?rss=1&ssource=collectionSearchRss&queryTerm=10Francine Grodstein, Sc.D., Meir J. Stampfer, M.D., Graham A. Colditz, M.B., B.S., Walter C. Willett, M.D., JoAnn E. Manson, M.D., Marshall Joffe, M.D., Bernard Rosner, M.D., Charles Fuchs, M.D., Susan E. Hankinson, Sc.D., David J. Hunter, M.B., B.S., Charles H. Hennekens, M.D., and Frank E. Speizer, M.D.Thu, 19  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/25/1769?rss=1&ssource=collectionSearchRss&queryTerm=10Interventions aimed at opening occluded coronary arteries continue to evolve. Two fundamental problems that limit the clinical efficacy of coronary interventions are restenosis after coronary angioplasty or atherectomy,123 reported since...http://content.nejm.org/cgi/content/short/336/24/1748?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 12  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/24/1748?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In animal models of coronary restenosis, intracoronary radiotherapy has been shown to reduce the intimal hyperplasia that is a part of restenosis. We studied the safety and efficacy of...http://content.nejm.org/cgi/content/short/336/24/1697?rss=1&ssource=collectionSearchRss&queryTerm=10Paul S. Teirstein, M.D., Vincent Massullo, M.D., Shirish Jani, Ph.D., Jeffrey J. Popma, M.D., Gary S. Mintz, M.D., Robert J. Russo, M.D., Ph.D., Richard A. Schatz, M.D., Erminia M. Guarneri, M.D., Stephen Steuterman, M.S., Nancy B. Morris, R.N., Martin B. Leon, M.D., and Prabhakar Tripuraneni, M.D.Thu, 12  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/24/1697?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Blockade of the platelet glycoprotein IIb/IIIa receptor with abciximab (a monoclonal-antibody Fab fragment directed against the receptor) has been shown to diminish ischemic complications among patients undergoing high-risk coronary...http://content.nejm.org/cgi/content/short/336/24/1689?rss=1&ssource=collectionSearchRss&queryTerm=10The EPILOG InvestigatorsThu, 12  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/24/1689?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The incidence of acute coronary-artery occlusion among patients with sudden cardiac arrest outside of the hospital is unknown, and the role of reperfusion therapy has not been determined. We...http://content.nejm.org/cgi/content/short/336/23/1629?rss=1&ssource=collectionSearchRss&queryTerm=10Christian M. Spaulding, M.D., Luc-Marie Joly, M.D., Alain Rosenberg, M.D., Mehran Monchi, M.D., Simon N. Weber, M.D., Jean-François A. Dhainaut, M.D., Ph.D., and Pierre Carli, M.D.Thu, 05  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/23/1629?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Among physicians who treat patients with acute myocardial infarction, there is controversy about the magnitude of the clinical benefit of primary (i.e., immediate) coronary angioplasty as compared with thrombolytic...http://content.nejm.org/cgi/content/short/336/23/1621?rss=1&ssource=collectionSearchRss&queryTerm=10The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy InvestigatorsThu, 05  Jun  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/23/1621?rss=1&ssource=collectionSearchRss&queryTerm=10Interventional cardiology and cardiac surgery have transformed the care of patients with ischemic heart disease in the United States. Between 1980 and 1992, rates of coronary angiography increased by 163...http://content.nejm.org/cgi/content/short/336/21/1522?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 22  May  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/21/1522?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Acute myocardial infarction is a leading cause of morbidity and mortality in the United States and Canada. We performed a population-based study to compare the use of cardiac procedures...http://content.nejm.org/cgi/content/short/336/21/1500?rss=1&ssource=collectionSearchRss&queryTerm=10Jack V. Tu, M.D., Ph.D., Chris L. Pashos, Ph.D., C. David Naylor, M.D., D.Phil., Erluo Chen, M.B., M.P.H., Sharon-Lise Normand, Ph.D., Joseph P. Newhouse, Ph.D., and Barbara J. McNeil, M.D., Ph.D.Thu, 22  May  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/21/1500?rss=1&ssource=collectionSearchRss&queryTerm=10Smoking, elevated levels of plasma lipids, and hypertension are known to increase the number of atherosclerotic plaques in the aorta and coronary arteries.12 The influence of these cardiovascular risk factors...http://content.nejm.org/cgi/content/short/336/18/1312?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 01  May  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/18/1312?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Cigarette smoking and abnormal serum cholesterol concentrations are risk factors for acute coronary syndromes, but the underlying mechanisms are poorly understood. We studied whether cigarette smoking and abnormal cholesterol...http://content.nejm.org/cgi/content/short/336/18/1276?rss=1&ssource=collectionSearchRss&queryTerm=10Allen P. Burke, M.D., Andrew Farb, M.D., Gray T. Malcom, Ph.D., You-hui Liang, M.D., John Smialek, M.D., and Renu Virmani, M.D.Thu, 01  May  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/18/1276?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The role of cardiac sympathetic nerves in regulating coronary blood flow is controversial. We sought to determine the degree to which cardiac efferent sympathetic signals modulate coronary blood flow....http://content.nejm.org/cgi/content/short/336/17/1208?rss=1&ssource=collectionSearchRss&queryTerm=10Marcelo F. Di Carli, M.D., Michael C. Tobes, M.D., Ph.D., Thomas Mangner, Ph.D., Arlene B. Levine, M.D., Otto Muzik, Ph.D., Pulak Chakroborty, Ph.D., and T. Barry Levine, M.D.Thu, 24  Apr  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/17/1208?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Epidemiologic data on the possible benefit of eating fish to reduce the risk of coronary heart disease have been inconsistent. We used data from the Chicago Western Electric Study...http://content.nejm.org/cgi/content/short/336/15/1046?rss=1&ssource=collectionSearchRss&queryTerm=10Martha L. Daviglus, M.D., Ph.D., Jeremiah Stamler, M.D., Anthony J. Orencia, M.D., Ph.D., Alan R. Dyer, Ph.D., Kiang Liu, Ph.D., Philip Greenland, M.D., Molly K. Walsh, Ph.D., Douglas Morris, M.A., and Richard B. Shekelle, Ph.D.Thu, 10  Apr  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/15/1046?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Inflammation may be important in the pathogenesis of atherothrombosis. We studied whether inflammation increases the risk of a first thrombotic event and whether treatment with aspirin decreases the risk.<br/><br/><em>Methods:</em>...http://content.nejm.org/cgi/content/short/336/14/973?rss=1&ssource=collectionSearchRss&queryTerm=10Paul M. Ridker, M.D., Mary Cushman, M.D., Meir J. Stampfer, M.D., Russell P. Tracy, Ph.D., and Charles H. Hennekens, M.D.Thu, 03  Apr  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/14/973?rss=1&ssource=collectionSearchRss&queryTerm=10Cardiac and cerebral ischemic events develop unpredictably in patients with widely varying degrees of atherosclerotic disease. Thus, a major area of research is the study of the stimuli that provoke...http://content.nejm.org/cgi/content/short/336/14/1014?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 03  Apr  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/14/1014?rss=1&ssource=collectionSearchRss&queryTerm=10In this article, we review the randomized clinical trials of aspirin, of heparin, and of fibrinolytic therapy in patients with suspected acute myocardial infarction to determine which of these treatments...http://content.nejm.org/cgi/content/short/336/12/847?rss=1&ssource=collectionSearchRss&queryTerm=10Rory Collins, M.B., B.S., Richard Peto, F.R.S., Colin Baigent, B.M., B.Ch., and Peter Sleight, D.M.Thu, 20  Mar  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/12/847?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Randomized studies have shown that the use of coronary-artery stenting as the initial treatment for coronary stenosis is associated with a lower risk of restenosis than is standard coronary...http://content.nejm.org/cgi/content/short/336/12/817?rss=1&ssource=collectionSearchRss&queryTerm=10Francesco Versaci, M.D., Achille Gaspardone, M.D., M.Phil., Fabrizio Tomai, M.D., Filippo Crea, M.D., Luigi Chiariello, M.D., and Pier A. Gioffrè, M.D.Thu, 20  Mar  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/12/817?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Cigarette smoking is known to be deleterious to patients with coronary artery disease, but the effect of smoking on the clinical outcome of percutaneous coronary revascularization is unknown.<br/><br/><em>Methods:</em> Patients...http://content.nejm.org/cgi/content/short/336/11/755?rss=1&ssource=collectionSearchRss&queryTerm=10David Hasdai, M.D., Kirk N. Garratt, M.D., Diane E. Grill, M.S., Amir Lerman, M.D., and David R. Holmes, Jr., M.D.Thu, 13  Mar  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/11/755?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Studies have reported that blacks undergo fewer coronary-revascularization procedures than whites, but it is not clear whether the clinical characteristics of the patients account for these differences or whether...http://content.nejm.org/cgi/content/short/336/7/480?rss=1&ssource=collectionSearchRss&queryTerm=10Eric D. Peterson, M.D., M.P.H., Linda K. Shaw, B.S., Elizabeth R. DeLong, Ph.D., David B. Pryor, M.D., Robert M. Califf, M.D., and Daniel B. Mark, M.D., M.P.H.Thu, 13  Feb  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/7/480?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The Scandinavian Simvastatin Survival Study (4S) showed that lowering cholesterol levels with simvastatin reduces mortality and morbidity in patients with angina pectoris or previous acute myocardial infarction. Before the...http://content.nejm.org/cgi/content/short/336/5/332?rss=1&ssource=collectionSearchRss&queryTerm=10Magnus Johannesson, Ph.D., Bengt Jönsson, Ph.D., John Kjekshus, M.D., Ph.D., Anders G. Olsson, M.D, Ph.D., Terje R. Pedersen, M.D., Ph.D., and Hans Wedel, M.D., Ph.D., for the Scandinavian Simvastatin Survival Study GroupThu, 30  Jan  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/5/332?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients who have had a myocardial infarction, the long-term risk of stroke and its relation to the extent of left ventricular dysfunction have not been determined. We studied...http://content.nejm.org/cgi/content/short/336/4/251?rss=1&ssource=collectionSearchRss&queryTerm=10Evan Loh, M.D., Martin St. John Sutton, M.D., Chuan-Chuan C. Wun, Ph.D., Jean L. Rouleau, M.D., Greg C. Flaker, M.D., Stephen S. Gottlieb, M.D., Gervasio A. Lamas, M.D., Lemuel A. Moyé, Ph.D., Samuel Z. Goldhaber, M.D., and Marc A. Pfeffer, M.D., Ph.D.Thu, 23  Jan  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/4/251?rss=1&ssource=collectionSearchRss&queryTerm=10Coronary-artery bypass grafting (CABG) has been performed for more than 30 years. After the first bypass operation with a saphenous-vein graft, in 1964,1 the technique was formally described in 19672;...http://content.nejm.org/cgi/content/short/336/3/212?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 16  Jan  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/3/212?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Obstructive changes often occur in aortocoronary saphenous-vein bypass grafts because of atherosclerosis and thrombosis. We studied whether aggressive lowering of low-density lipoprotein (LDL) cholesterol levels or low-dose anticoagulation would...http://content.nejm.org/cgi/content/short/336/3/153?rss=1&ssource=collectionSearchRss&queryTerm=10The Post Coronary Artery Bypass Graft Trial InvestigatorsThu, 16  Jan  1997 00:00:00 -05:00http://content.nejm.org/cgi/content/short/336/3/153?rss=1&ssource=collectionSearchRss&queryTerm=10Physicians have long struggled with the vexing problem of how best to treat patients with myocardial infarction, reduced left ventricular function, and asymptomatic unsustained ventricular tachycardia who may be at...http://content.nejm.org/cgi/content/short/335/26/1984?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 26  Dec  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/26/1984?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Unsustained ventricular tachycardia in patients with previous myocardial infarction and left ventricular dysfunction is associated with a two-year mortality rate of about 30 percent. We studied whether prophylactic therapy...http://content.nejm.org/cgi/content/short/335/26/1933?rss=1&ssource=collectionSearchRss&queryTerm=10Arthur J. Moss, M.D., W. Jackson Hall, Ph.D., David S. Cannom, M.D., James P. Daubert, M.D., Steven L. Higgins, M.D., Helmut Klein, M.D., Joseph H. Levine, M.D., Sanjeev Saksena, M.D., Albert L. Waldo, M.D., David Wilber, M.D., Mary W. Brown, M.S., and Moonseong Heo, Ph.D., for the Multicenter Automatic Defibrillator Implantation Trial InvestigatorsThu, 26  Dec  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/26/1933?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Acute changes in cerebral function after elective coronary bypass surgery are a difficult clinical problem. We carried out a multicenter study to determine the incidence and predictors of —...http://content.nejm.org/cgi/content/short/335/25/1857?rss=1&ssource=collectionSearchRss&queryTerm=10Gary W. Roach, M.D., Marc Kanchuger, M.D., Christina Mora Mangano, M.D., Mark Newman, M.D., Nancy Nussmeier, M.D., Richard Wolman, M.D., Anil Aggarwal, M.D., Katherine Marschall, M.D., Steven H. Graham, M.D., Ph.D., Catherine Ley, Ph.D., Gerard Ozanne, M.D., and Dennis T. Mangano, Ph.D., M.D., Ahvie Herskowitz, M.D, Vera Katseva, Ph.D, Rita Sears, R.N., M.S, for the Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation InvestigatorsThu, 19  Dec  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/25/1857?rss=1&ssource=collectionSearchRss&queryTerm=10Acute coronary syndromes have a common pathophysiologic mechanism. A coronary atherosclerotic plaque ruptures and a mural or occlusive thrombus forms, impairing or interrupting the perfusion of myocardial tissue.1 Consequently, the...http://content.nejm.org/cgi/content/short/335/18/1388?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 31  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/18/1388?rss=1&ssource=collectionSearchRss&queryTerm=10Acute coronary syndromes have a common pathophysiologic mechanism. A coronary atherosclerotic plaque ruptures and a mural or occlusive thrombus forms, impairing or interrupting the perfusion of myocardial tissue.1 Consequently, the...http://content.nejm.org/cgi/content/short/335/18/1388?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 31  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/18/1388?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients with acute coronary syndromes, it is desirable to identify a sensitive serum marker that is closely related to the degree of myocardial damage, provides prognostic information, and...http://content.nejm.org/cgi/content/short/335/18/1342?rss=1&ssource=collectionSearchRss&queryTerm=10Elliott M. Antman, M.D., Milenko J. Tanasijevic, M.D., Bruce Thompson, Ph.D., Mark schactman, M.S., Carolyn H. McCabe, B.S., Christopher P. Cannon, M.D., George A. Fischer, Ph.D., Anthony Y. Fung, M.B., B.S., Christopher Thompson, M.D., Donald Wybenga, M.D., and Eugene Braunwald, M.D.Thu, 31  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/18/1342?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients with acute coronary syndromes, it is desirable to identify a sensitive serum marker that is closely related to the degree of myocardial damage, provides prognostic information, and...http://content.nejm.org/cgi/content/short/335/18/1342?rss=1&ssource=collectionSearchRss&queryTerm=10Elliott M. Antman, M.D., Milenko J. Tanasijevic, M.D., Bruce Thompson, Ph.D., Mark schactman, M.S., Carolyn H. McCabe, B.S., Christopher P. Cannon, M.D., George A. Fischer, Ph.D., Anthony Y. Fung, M.B., B.S., Christopher Thompson, M.D., Donald Wybenga, M.D., and Eugene Braunwald, M.D.Thu, 31  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/18/1342?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The prognosis of patients hospitalized with acute myocardial ischemia is quite variable. We examined the value of serum levels of cardiac troponin T, serum creatine kinase MB (CK-MB) levels,...http://content.nejm.org/cgi/content/short/335/18/1333?rss=1&ssource=collectionSearchRss&queryTerm=10E. Magnus Ohman, M.D., Paul W. Armstrong, M.D., Robert H. Christenson, Ph.D., Christopher B. Granger, M.D., Hugo A. Katus, M.D., Christian W. Hamm, M.D., Mary Ann O'Hanesian, M.S., Galen S. Wagner, M.D., Neal S. Kleiman, M.D., Frank E. Harrell, Jr., Ph.D., Robert M. Califf, M.D., and Eric J. Topol, M.D., Kerry L. Lee, for the GUSTO-IIa InvestigatorsThu, 31  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/18/1333?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The prognosis of patients hospitalized with acute myocardial ischemia is quite variable. We examined the value of serum levels of cardiac troponin T, serum creatine kinase MB (CK-MB) levels,...http://content.nejm.org/cgi/content/short/335/18/1333?rss=1&ssource=collectionSearchRss&queryTerm=10E. Magnus Ohman, M.D., Paul W. Armstrong, M.D., Robert H. Christenson, Ph.D., Christopher B. Granger, M.D., Hugo A. Katus, M.D., Christian W. Hamm, M.D., Mary Ann O'Hanesian, M.S., Galen S. Wagner, M.D., Neal S. Kleiman, M.D., Frank E. Harrell, Jr., Ph.D., Robert M. Califf, M.D., and Eric J. Topol, M.D., Kerry L. Lee, for the GUSTO-IIa InvestigatorsThu, 31  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/18/1333?rss=1&ssource=collectionSearchRss&queryTerm=10The goal of therapy in patients with coronary artery disease is to alleviate symptoms of angina and reduce the risk of death or nonfatal myocardial infarction. Although coronary angioplasty immediately...http://content.nejm.org/cgi/content/short/335/17/1290?rss=1&ssource=collectionSearchRss&queryTerm=10John A. Bittl, M.D.Thu, 24  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/17/1290?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Several relatively small randomized trials have shown that primary angioplasty results in a better short-term outcome than thrombolytic therapy in patients with acute myocardial infarction. These results, however, have...http://content.nejm.org/cgi/content/short/335/17/1253?rss=1&ssource=collectionSearchRss&queryTerm=10Nathan R. Every, M.D., M.P.H., Lori S. Parsons, B.S., Mark Hlatky, M.D., Jenny S. Martin, R.N., and W. Douglas Weaver, M.D., for the Myocardial Infarction Triage and Intervention InvestigatorsThu, 24  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/17/1253?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Clinical trials and practice guidelines have identified clinical criteria for the use of coronary angiography and revascularization procedures after thrombolysis for acute myocardial infarction. The effect of these criteria...http://content.nejm.org/cgi/content/short/335/16/1198?rss=1&ssource=collectionSearchRss&queryTerm=10Louise Pilote, M.D., M.P.H., Dave P. Miller, M.S., Robert M. Califf, M.D., J. Sunil Rao, Ph.D., W. Douglas Weaver, M.D., and Eric J. Topol, M.D.Thu, 17  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/16/1198?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> In patients with high cholesterol levels, lowering the cholesterol level reduces the risk of coronary events, but the effect of lowering cholesterol levels in the majority of patients with...http://content.nejm.org/cgi/content/short/335/14/1001?rss=1&ssource=collectionSearchRss&queryTerm=10Frank M. Sacks, M.D., Marc A. Pfeffer, M.D., Ph.D., Lemuel A. Moye, M.D., Ph.D., Jean L. Rouleau, M.D., John D. Rutherford, M.D., Thomas G. Cole, Ph.D., Lisa Brown, M.P.H., J. Wayne Warnica, M.D., J. Malcolm O. Arnold, M.D., Chuan-Chuan Wun, Ph.D., Barry R. Davis, M.D., Ph.D., and Eugene Braunwald, M.D., for the Cholesterol and Recurrent Events Trial InvestigatorsThu, 03  Oct  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/14/1001?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a potent, direct thrombin inhibitor, recombinant hirudin, with that of heparin...http://content.nejm.org/cgi/content/short/335/11/775?rss=1&ssource=collectionSearchRss&queryTerm=10The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb InvestigatorsThu, 12  Sep  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/11/775?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Restenosis occurs commonly after coronary angioplasty and atherectomy, but the causes of restenosis are poorly understood. Recently, it has been found that cytomegalovirus (CMV) DNA is present in restenotic...http://content.nejm.org/cgi/content/short/335/9/624?rss=1&ssource=collectionSearchRss&queryTerm=10Yi Fu Zhou, M.D., Martin B. Leon, M.D., Myron A. Waclawiw, Ph.D., Jeffery J. Popma, M.D., Zu Xi Yu, M.D., Toren Finkel, M.D., Ph.D., and Stephen E. Epstein, M.D.Thu, 29  Aug  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/9/624?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Estrogen therapy in postmenopausal women has been associated with a decreased risk of heart disease. There is little information, however, about the effect of combined estrogen and progestin therapy...http://content.nejm.org/cgi/content/short/335/7/453?rss=1&ssource=collectionSearchRss&queryTerm=10Francine Grodstein, Sc.D., Meir J. Stampfer, M.D., JoAnn E. Manson, M.D., Graham A. Colditz, M.B., B.S., Walter C. Willett, M.D., Bernard Rosner, Ph.D., Frank E. Speizer, M.D., and Charles H. Hennekens, M.D.Thu, 15  Aug  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/7/453?rss=1&ssource=collectionSearchRss&queryTerm=10In this issue of the Journal, the results of the Bypass Angioplasty Revascularization Investigation (BARI), a large clinical trial comparing coronary-artery bypass grafting (CABG) with percutaneous transluminal coronary angioplasty (PTCA),...http://content.nejm.org/cgi/content/short/335/4/275?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 25  Jul  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/4/275?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Coronary-artery bypass grafting (CABG) and percutaneous transluminal coronary angioplasty (PTCA) are alternative methods of revascularization in patients with coronary artery disease. We tested the hypothesis that in selected patients...http://content.nejm.org/cgi/content/short/335/4/217?rss=1&ssource=collectionSearchRss&queryTerm=10The Bypass Angioplasty Revascularization Investigation (BARI) InvestigatorsThu, 25  Jul  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/335/4/217?rss=1&ssource=collectionSearchRss&queryTerm=10Over two centuries ago, Heberden described a strangling type of chest pain that was later associated with stenotic lesions of the coronary arteries. With the development of coronary arteriography in...http://content.nejm.org/cgi/content/short/334/26/1735?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 27  Jun  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/26/1735?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The clinical significance of coronary-artery stenoses of moderate severity can be difficult to determine. Myocardial fractional flow reserve (FFR) is a new index of the functional severity of coronary...http://content.nejm.org/cgi/content/short/334/26/1703?rss=1&ssource=collectionSearchRss&queryTerm=10Nico H.J. Pijls, M.D., Ph.D., Bernard de Bruyne, M.D., Kathinka Peels, M.D., Pepijn H. van der Voort, M.D., Hans J.R.M. Bonnier, M.D., Ph.D., Jozef Bartunek, M.D., and Jacques J. Koolen, M.D., Ph.D.Thu, 27  Jun  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/26/1703?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Official guidelines from the Centers for Disease Control and Prevention assert that the majority of health benefits from physical activity are obtained by walking 2 miles (3.2 km) briskly...http://content.nejm.org/cgi/content/short/334/20/1298?rss=1&ssource=collectionSearchRss&queryTerm=10Paul T. Williams, Ph.D.Thu, 16  May  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/20/1298?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The role of dietary antioxidant vitamins in preventing coronary heart disease has aroused considerable interest because of the knowledge that oxidative modification of low-density lipoprotein may promote atherosclerosis.<br/><br/><em>Methods:</em> We...http://content.nejm.org/cgi/content/short/334/18/1156?rss=1&ssource=collectionSearchRss&queryTerm=10Lawrence H. Kushi, Sc.D., Aaron R. Folsom, M.D., Ronald J. Prineas, M.B., B.S., Pamela J. Mink, M.P.H., Ying Wu, M.P.H., and Roberd M. Bostick, M.D.Thu, 02  May  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/18/1156?rss=1&ssource=collectionSearchRss&queryTerm=10Over a century ago, the German pathologist Rudolf Virchow presented a hypothesis that three factors — vessel injury, altered blood flow, and changes in blood coagulability — were responsible for...http://content.nejm.org/cgi/content/short/334/17/1126?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 25  Apr  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/17/1126?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, and it has an important role in platelet aggregation. It is known to be involved in...http://content.nejm.org/cgi/content/short/334/17/1090?rss=1&ssource=collectionSearchRss&queryTerm=10Ethan J. Weiss, B.A., Paul F. Bray, M.D., Matthew Tayback, Sc.D., Steven P. Schulman, M.D., Thomas S. Kickler, M.D., Lewis C. Becker, M.D., James L. Weiss, M.D., Gary Gerstenblith, M.D., and Pascal J. Goldschmidt-Clermont, M.D.Thu, 25  Apr  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/17/1090?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The clinical benefit of coronary-artery stenting performed in conjunction with coronary angioplasty is limited by the risk of thrombotic occlusion of the stent as well as hemorrhagic and vascular...http://content.nejm.org/cgi/content/short/334/17/1084?rss=1&ssource=collectionSearchRss&queryTerm=10Albert Schömig, M.D., Franz-Josef Neumann, M.D., Adnan Kastrati, M.D., Helmut Schühlen, M.D., Rudolf Blasini, M.D., Martin Hadamitzky, M.D., Hanna Walter, M.D., Eva-Maria Zitzmann-Roth, M.D., Gert Richardt, M.D., Eckhard Alt, M.D., Claus Schmitt, M.D., and Kurt Ulm, Ph.D.Thu, 25  Apr  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/17/1084?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Prospective studies suggest that hyperinsulinemia may be an important risk factor for ischemic heart disease. However, it has not been determined whether plasma insulin levels are independently related to...http://content.nejm.org/cgi/content/short/334/15/952?rss=1&ssource=collectionSearchRss&queryTerm=10Jean-Pierre Després, Ph.D., Benoît Lamarche, M.Sc., Pascale Mauriège, Ph.D., Bernard Cantin, M.D., Gilles R. Dagenais, M.D., Sital Moorjani, Ph.D., and Paul-J. Lupien, M.D.Thu, 11  Apr  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/15/952?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Mortality from coronary heart disease (CHD) has declined in the United States since the late 1960s. To understand the reasons for the decline during the period from 1985 to...http://content.nejm.org/cgi/content/short/334/14/884?rss=1&ssource=collectionSearchRss&queryTerm=10Paul G. McGovern, Ph.D., James S. Pankow, M.P.H., Eyal Shahar, M.D., Katherine M. Doliszny, Ph.D., Aaron R. Folsom, M.D., Henry Blackburn, M.D., and Russell V. Luepker, M.D., for the Minnesota Heart Survey InvestigatorsThu, 04  Apr  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/14/884?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Coronary-artery stents are known to reduce rates of restenosis after coronary angioplasty, but it is uncertain how long this benefit is maintained.<br/><br/><em>Methods:</em> We evaluated clinical and angiographic follow-up information...http://content.nejm.org/cgi/content/short/334/9/561?rss=1&ssource=collectionSearchRss&queryTerm=10Takeshi Kimura, M.D., Hiroyoshi Yokoi, M.D., Yoshihisa Nakagawa, M.D., Takashi Tamura, M.D., Satoshi Kaburagi, M.D., Yoshihiro Sawada, M.D., Yasukazu Sato, M.D., Hiroatsu Yokoi, M.D., Naoya Hamasaki, M.D., Hideyuki Nosaka, M.D., and Masakiyo Nobuyoshi, M.D.Thu, 29  Feb  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/9/561?rss=1&ssource=collectionSearchRss&queryTerm=10When a patient presents to the emergency room with an acute episode of cardiac ischemia, the challenges for the physician are to determine whether the patient is having a myocardial...http://content.nejm.org/cgi/content/short/334/8/528?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 22  Feb  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/8/528?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> The presence of left bundle-branch block on the electrocardiogram may conceal the changes of acute myocardial infarction, which can delay both its recognition and treatment. We tested electrocardiographic criteria...http://content.nejm.org/cgi/content/short/334/8/481?rss=1&ssource=collectionSearchRss&queryTerm=10Elena B. Sgarbossa, M.D., Sergio L. Pinski, M.D., Alejandro Barbagelata, M.D., Donald A. Underwood, M.D., Kathy B. Gates, Eric J. Topol, M.D., Robert M. Califf, M.D., and Galen S. Wagner, M.D., for the GUSTO-1 (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries) InvestigatorsThu, 22  Feb  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/8/481?rss=1&ssource=collectionSearchRss&queryTerm=10The development of internal-thoracic-artery grafting is the most remarkable achievement in coronary-artery surgery. In the past two decades, numerous studies have confirmed that the patency rate of internal-thoracic-artery grafts is...http://content.nejm.org/cgi/content/short/334/4/263?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 25  Jan  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/4/263?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Aortocoronary bypass surgery has been performed most often with the patient's saphenous vein as the conduit. The internal-thoracic-artery graft, which has superior patency rates, has been shown to have...http://content.nejm.org/cgi/content/short/334/4/216?rss=1&ssource=collectionSearchRss&queryTerm=10Airlie Cameron, M.D., Kathryn B. Davis, Ph.D., George Green, M.D., and Hartzell V. Schaff, M.D.Thu, 25  Jan  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/4/216?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> Passive smoking has been linked to an increased risk of dying from atherosclerotic heart disease. Since endothelial dysfunction is an early feature of atherogenesis and occurs in young adults...http://content.nejm.org/cgi/content/short/334/3/150?rss=1&ssource=collectionSearchRss&queryTerm=10David S. Celermajer, Ph.D., Mark R. Adams, M.B., B.S., Peter Clarkson, M.B., B.S., Jacqui Robinson, R.N., Robyn McCredie, B.Sc., Ann Donald, and John E. Deanfield, M.B., Ch.B.Thu, 18  Jan  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/3/150?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> After an acute myocardial infarction, it is important to determine the risk of a subsequent coronary event. We studied the prognostic value of myocardial ischemia detected by ambulatory electrocardiographic...http://content.nejm.org/cgi/content/short/334/2/65?rss=1&ssource=collectionSearchRss&queryTerm=10John B. Gill, M.D., John A. Cairns, M.D., Robin S. Roberts, M.Tech., Lorrie Costantini, B.A., Brian J. Sealey, M.D., Ernest F. Fallen, M.D., Charles W. Tomlinson, M.D., and Michael Gent, D.Sc.Thu, 11  Jan  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/2/65?rss=1&ssource=collectionSearchRss&queryTerm=10Reducing morbidity and mortality from coronary artery disease continues to be a major challenge. Many patients with coronary artery disease are asymptomatic or nearly so for long periods, and even...http://content.nejm.org/cgi/content/short/334/2/113?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 11  Jan  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/2/113?rss=1&ssource=collectionSearchRss&queryTerm=10<em>Background:</em> When a myocardial infarction is preceded by angina, the infarct tends to be smaller than when there is no preinfarction angina. Prompt recanalization of the occluded infarct-related artery is...http://content.nejm.org/cgi/content/short/334/1/7?rss=1&ssource=collectionSearchRss&queryTerm=10Felicita Andreotti, M.D., Ph.D., Vincenzo Pasceri, M.D., David R. Hackett, M.D., Graham J. Davies, M.D., Agha W. Haider, M.D., and Attilio Maseri, M.D.Thu, 04  Jan  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/1/7?rss=1&ssource=collectionSearchRss&queryTerm=10According to Herrick's description in 1912,1 and for several decades thereafter, acute myocardial infarction was considered to be an unheralded event — in lay parlance, the sudden “heart attack.” By...http://content.nejm.org/cgi/content/short/334/1/51?rss=1&ssource=collectionSearchRss&queryTerm=10Thu, 04  Jan  1996 00:00:00 -05:00http://content.nejm.org/cgi/content/short/334/1/51?rss=1&ssource=collectionSearchRss&queryTerm=10